iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Dme-031800

UUCD1 version

UUC-DrM-00008

Ensembl Protein ID

FBpp0305794

UniProt Accession

Q24306; A4V1Z9; A9UN33; Q0E8E4; Q8MRM5; Q9VUX5; DIAP1_DROME

Genbank Protein ID

AAC41609.1; AAF49548.1; AAG22319.1; AAN11757.1; ABY20438.2; AAM50178.1

Protein Name

Death-associated inhibitor of apoptosis 1; Apoptosis 1 inhibitor; E3 ubiquitin-protein ligase th; Inhibitor of apoptosis 1; Protein thread; RING-type E3 ubiquitin transferase Diap1

Genbank Nucleotide ID

L49440; AE014296; AE014296; AE014296; BT031197; AY119524

Gene Name

Diap1; Iap1; th; CG12284

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0260635	FBtr0333618	FBpp0305794

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	PINA	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
BioGRID
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19498442; 17880263; 19026784; 12198495; 17205079; 12446669

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.013	16.0	391	426

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvf.hadClqkwpglknssskefrCPlCr 46
           C iC+    + + +lpCgHv  +a+C          +s   +CPlCr
   Q: 391  CKICYGAEYN-TAFLPCGHVVaCAKC----------ASSVTKCPLCR 426
           99**885545.677*****777****..........778899****8 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Anti-apoptotic protein which functions as a caspase regulator, using its E3 ubiquitin-protein ligase activity to smother caspase activity. Binds, ubiquitinates and inactivates initiator caspase Dronc, and effector caspases Drice and Dcp-1. Acts as a Nedd8-E3 ubiquitin-protein ligase for Drice. Suppresses apoptosis by targeting the apoptosome for ubiquitination and inactivation. Plays an important role in cell motility. Overexpression suppresses rpr and hid-dependent cell death in the eye. Interaction of Diap1 with Dronc is required to suppress Dronc-mediated cell death through Diap1-mediated ubiquitination of Dronc. Acts as a positive regulator of Wnt signaling.

Protein Sequence
(Fasta)

MASVVADLPS YGPIAFDQVD NNTNATQLFK NNINKTRMND LNREETRLKT FTDWPLDWLD 60
KRQLAQTGMY FTHAGDKVKC FFCGVEIGCW EQEDQPVPEH QRWSPNCPLL RRRTTNNVPI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAAAACTACG ACTTCGTGTG CTGACAGTTG TTTGTTTTTG AAATTTTAAT ATATTCAGAA 60
ATATAAATAG CTTGCAAAAT AGTTATTAAT TAAACTTAAA AAAGTTTTAA AAAAAACATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01282--BIR_REPEAT_1
PS50143--BIR_REPEAT_2
PS50089--ZF_RING_2

Pfam

PF00653--BIR

SMART

SM00238--BIR
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0089720--F:caspase binding
GO:0004869--F:cysteine-type endopeptidase inhibitor activity
GO:0043027--F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0061663--F:NEDD8 ligase activity
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0044390--F:ubiquitin-like protein conjugating enzyme binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:1990381--F:ubiquitin-specific protease binding
GO:0008270--F:zinc ion binding
GO:0048800--P:antennal morphogenesis
GO:0006915--P:apoptotic process
GO:0007298--P:border follicle cell migration
GO:0008354--P:germ cell migration
GO:0097340--P:inhibition of cysteine-type endopeptidase activity
GO:1990001--P:inhibition of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007275--P:multicellular organism development
GO:0043066--P:negative regulation of apoptotic process
GO:0046673--P:negative regulation of compound eye retinal cell programmed cell death
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001271--P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0031398--P:positive regulation of protein ubiquitination
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0045116--P:protein neddylation
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0007423--P:sensory organ development
GO:0045035--P:sensory organ precursor cell division
GO:0007289--P:spermatid nucleus differentiation
GO:0007283--P:spermatogenesis
GO:0016055--P:Wnt signaling pathway

KEGG

dme:Dmel_CG12284

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002698	Amborella trichopoda	38.46	7.00e-11	60.80
IUUC-Acl-008281	Aspergillus clavatus	48.00	2.00e-10	61.20
IUUC-Afl-008647	Aspergillus flavus	48.00	4.00e-10	60.10
IUUC-Afu-009000	Aspergillus fumigatus	48.00	2.00e-10	60.80
IUUC-Ani-009211	Aspergillus nidulans	48.00	7.00e-11	62.80
IUUC-Ang-009658	Aspergillus niger	50.00	3.00e-11	63.90
IUUC-Aor-010131	Aspergillus oryzae	48.00	4.00e-10	60.10
IUUC-Ate-010322	Aspergillus terreus	48.00	1.00e-10	61.60
IUUC-Bta-013536	Bos taurus	29.33	1.00e-27	116.00
IUUC-Cin-025222	Ciona intestinalis	24.08	5.00e-30	124.00
IUUC-Dse-031509	Dothistroma septosporum	45.61	1.00e-12	67.80
IUUC-Gmo-038790	Gadus morhua	26.78	1.00e-38	152.00
IUUC-Ggo-045535	Gorilla gorilla	29.61	4.00e-27	114.00
IUUC-Lpe-051271	Leersia perrieri	43.48	6.00e-09	58.20
IUUC-Lma-053223	Leptosphaeria maculans	50.00	4.00e-11	63.50
IUUC-Mdo-062361	Monodelphis domestica	31.67	1.00e-34	139.00
IUUC-Mpu-066228	Mustela putorius furo	33.04	2.00e-31	128.00
IUUC-Nfi-068377	Neosartorya fischeri	46.00	1.00e-09	58.20
IUUC-Oba-075143	Oryza barthii	43.48	4.00e-09	58.90
IUUC-Ogu-078339	Oryza glumaepatula	43.48	5.00e-09	58.50
IUUC-Ome-081491	Oryza meridionalis	43.48	4.00e-09	58.90
IUUC-Oni-082255	Oryza nivara	43.48	4.00e-09	58.90
IUUC-Opu-083722	Oryza punctata	44.00	1.00e-08	53.90
IUUC-Oru-084921	Oryza rufipogon	43.48	4.00e-09	58.50
IUUC-Osa-085816	Oryza sativa	43.48	3.00e-10	58.20
IUUC-Ola-086358	Oryzias latipes	27.39	5.00e-29	120.00
IUUC-Oga-088631	Otolemur garnettii	30.67	1.00e-27	116.00
IUUC-Pno-094968	Phaeosphaeria nodorum	46.00	2.00e-10	62.00
IUUC-Ppa-095606	Physcomitrella patens	39.06	5.00e-10	58.50
IUUC-Pca-100515	Procavia capensis	32.05	7.00e-30	123.00
IUUC-Ppe-101234	Prunus persica	37.31	2.00e-10	58.20
IUUC-Pva-102311	Pteropus vampyrus	30.52	3.00e-24	104.00
IUUC-Pte-104027	Pyrenophora teres	46.00	6.00e-11	63.20
IUUC-Pyt-104665	Pyrenophora triticirepentis	32.76	8.00e-06	43.90
IUUC-Sit-110764	Setaria italica	45.65	4.00e-09	58.90
IUUC-Tbe-127390	Tupaia belangeri	33.04	9.00e-32	129.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence