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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064381
Ensembl Protein ID ENSMUSP00000139427.1
UniProt Accession Q8VD65; Q56A65; Q8C948; Q8C9D7; Q9CVC5; PI3R4_MOUSE
Genbank Protein ID BAB25843.1; BAC31236.1; BAC31417.1; AAH17537.1; AAH92149.1
Protein Name Phosphoinositide 3-kinase regulatory subunit 4
Genbank Nucleotide ID AC157514; AK042361; AK042953; AK087938; BC092149
Gene Name Pik3r4; Vps15
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000032571.14 ENSMUST00000191268.6 ENSMUSP00000139427.1
ENSMUSG00000032571.14 ENSMUST00000188784.1 ENSMUSP00000140988.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.90e-16 59.6 992 1021
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclafsd..tllvsGsdDgtikvWD 29
           H++ v+ ++ sd   l++++s+Dgt+k+W+
   Q: 992  HKSAVNRIRVSDehLLFATCSNDGTVKIWN 1021
           99999999995545668************9 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity).
 Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity).
Protein Sequence
(Fasta)
MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60
TLPLTSYKQE LEELKIRLHS AQNCLPFQKA AEKASEKAAM LFRQYVRDNL YDRISTRPFL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064381|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAGTGAGGT CAACCCGGAG GCTTTCCCGG GAGTTCAGCG TTTGCCGCAG GTGAAGTCGT 60
CTTCCTGGAC GGGCACTGTC CCTGTCCCTG TCCCTGTCCA GGGCTGCTGC AAAGGCCCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064381|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR021133--HEAT_type_2
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50077--HEAT_REPEAT
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00069--Pkinase
PF00400--WD40
SMART

SM00220--S_TKc
SM00320--WD40
Gene Ontology

GO:0005776--C:autophagosome
GO:0005930--C:axoneme
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005770--C:late endosome
GO:0016020--C:membrane
GO:0015630--C:microtubule cytoskeleton
GO:0005643--C:nuclear pore
GO:0071561--C:nucleus-vacuole junction
GO:0035032--C:phosphatidylinositol 3-kinase complex, class III
GO:0034271--C:phosphatidylinositol 3-kinase complex, class III, type I
GO:0034272--C:phosphatidylinositol 3-kinase complex, class III, type II
GO:0005524--F:ATP binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0042149--P:cellular response to glucose starvation
GO:0045324--P:late endosome to vacuole transport
GO:0016236--P:macroautophagy
GO:0030242--P:pexophagy
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0006468--P:protein phosphorylation
GO:0006623--P:protein targeting to vacuole
GO:0032801--P:receptor catabolic process
GO:0032465--P:regulation of cytokinesis
KEGG mmu:75669
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000213 Aegilops tauschii 32.07 2.00e-44 174.00
IUUC-Aml-001659 Ailuropoda melanoleuca 95.14 0.00e+00 2626.00
IUUC-Atr-002968 Amborella trichopoda 45.60 5.00e-45 177.00
IUUC-Apl-003418 Anas platyrhynchos 89.74 0.00e+00 2546.00
IUUC-Aca-004344 Anolis carolinensis 88.78 0.00e+00 2263.00
IUUC-Aly-006107 Arabidopsis lyrata 46.06 2.00e-68 255.00
IUUC-Ath-007260 Arabidopsis thaliana 46.36 3.00e-69 257.00
IUUC-Ago-007721 Ashbya gossypii 24.16 1.00e-56 216.00
IUUC-Acl-008378 Aspergillus clavatus 35.49 2.00e-147 517.00
IUUC-Afl-008632 Aspergillus flavus 36.30 2.00e-140 494.00
IUUC-Afu-009020 Aspergillus fumigatus 36.55 9.00e-141 495.00
IUUC-Ani-009204 Aspergillus nidulans 36.08 3.00e-131 463.00
IUUC-Ang-009811 Aspergillus niger 34.92 2.00e-137 484.00
IUUC-Aor-010168 Aspergillus oryzae 36.30 2.00e-140 494.00
IUUC-Ate-010556 Aspergillus terreus 35.58 4.00e-138 486.00
IUUC-Ame-011955 Astyanax mexicanus 79.25 0.00e+00 1788.00
IUUC-Bgr-012050 Blumeria graminis 36.30 1.00e-138 488.00
IUUC-Bta-012432 Bos taurus 94.11 0.00e+00 2652.00
IUUC-Bci-013846 Botrytis cinerea 34.53 2.00e-141 498.00
IUUC-Bdi-015072 Brachypodium distachyon 42.69 2.00e-65 245.00
IUUC-Bol-015314 Brassica oleracea 26.92 8.00e-92 332.00
IUUC-Bra-017476 Brassica rapa 46.36 3.00e-69 258.00
IUUC-Cel-018550 Caenorhabditis elegans 32.49 5.00e-85 310.00
IUUC-Cja-019538 Callithrix jacchus 95.29 0.00e+00 2681.00
IUUC-Cfa-020483 Canis familiaris 94.99 0.00e+00 2634.00
IUUC-Cpo-021392 Cavia porcellus 95.14 0.00e+00 2664.00
IUUC-Csa-024112 Chlorocebus sabaeus 95.80 0.00e+00 2691.00
IUUC-Cho-025015 Choloepus hoffmanni 87.88 0.00e+00 924.00
IUUC-Cin-025209 Ciona intestinalis 40.87 0.00e+00 1067.00
IUUC-Csv-026334 Ciona savignyi 41.62 0.00e+00 891.00
IUUC-Cgl-026447 Colletotrichum gloeosporioides 35.94 5.00e-141 496.00
IUUC-Cne-026999 Cryptococcus neoformans 36.18 1.00e-113 404.00
IUUC-Dre-028662 Danio rerio 80.42 0.00e+00 2269.00
IUUC-Dno-029545 Dasypus novemcinctus 93.37 0.00e+00 2596.00
IUUC-Dor-030941 Dipodomys ordii 65.75 0.00e+00 723.00
IUUC-Dse-031455 Dothistroma septosporum 36.57 7.00e-135 475.00
IUUC-Dme-031726 Drosophila melanogaster 47.36 0.00e+00 747.00
IUUC-Ete-033147 Echinops telfairi 91.65 0.00e+00 993.00
IUUC-Eca-034025 Equus caballus 95.21 0.00e+00 2672.00
IUUC-Eeu-034480 Erinaceus europaeus 87.80 0.00e+00 1483.00
IUUC-Fca-035741 Felis catus 94.55 0.00e+00 2637.00
IUUC-Fal-037666 Ficedula albicollis 88.77 0.00e+00 2519.00
IUUC-Fox-037818 Fusarium oxysporum 33.87 1.00e-124 441.00
IUUC-Fso-038086 Fusarium solani 34.47 3.00e-128 453.00
IUUC-Gmo-038804 Gadus morhua 79.81 0.00e+00 730.00
IUUC-Ggr-039800 Gaeumannomyces graminis 35.56 2.00e-132 467.00
IUUC-Gga-041251 Gallus gallus 88.04 0.00e+00 1973.00
IUUC-Gac-042376 Gasterosteus aculeatus 77.96 0.00e+00 2203.00
IUUC-Gma-044095 Glycine max 45.30 6.00e-71 263.00
IUUC-Ggo-044506 Gorilla gorilla 95.29 0.00e+00 2676.00
IUUC-Hsa-045871 Homo sapiens 95.88 0.00e+00 2690.00
IUUC-Hvu-047648 Hordeum vulgare 31.83 8.00e-46 179.00
IUUC-Itr-048082 Ictidomys tridecemlineatus 96.18 0.00e+00 1182.00
IUUC-Kpa-049390 Komagataella pastoris 32.30 3.00e-124 440.00
IUUC-Lch-050284 Latimeria chalumnae 84.18 0.00e+00 2302.00
IUUC-Lpe-050880 Leersia perrieri 40.91 4.00e-63 237.00
IUUC-Loc-052815 Lepisosteus oculatus 80.49 0.00e+00 2280.00
IUUC-Lma-053324 Leptosphaeria maculans 32.34 2.00e-170 593.00
IUUC-Laf-054204 Loxodonta africana 83.31 0.00e+00 2258.00
IUUC-Mcc-054612 Macaca mulatta 95.88 0.00e+00 2692.00
IUUC-Meu-056227 Macropus eugenii 84.93 0.00e+00 838.00
IUUC-Mor-057094 Magnaporthe oryzae 36.32 2.00e-131 464.00
IUUC-Mtr-058550 Medicago truncatula 43.37 4.00e-70 260.00
IUUC-Mla-058893 Melampsora laricipopulina 35.14 2.00e-127 451.00
IUUC-Mga-059474 Meleagris gallopavo 88.37 0.00e+00 2380.00
IUUC-Mvi-060227 Microbotryum violaceum 45.01 8.00e-83 303.00
IUUC-Mmr-061543 Microcebus murinus 88.51 0.00e+00 2394.00
IUUC-Mdo-062129 Monodelphis domestica 91.79 0.00e+00 2487.00
IUUC-Mac-064455 Musa acuminata 38.49 2.00e-122 434.00
IUUC-Mpu-066151 Mustela putorius furo 96.69 0.00e+00 950.00
IUUC-Mlu-067824 Myotis lucifugus 95.58 0.00e+00 2677.00
IUUC-Nfi-068241 Neosartorya fischeri 37.77 6.00e-144 506.00
IUUC-Ncr-068964 Neurospora crassa 35.96 4.00e-137 483.00
IUUC-Nle-069152 Nomascus leucogenys 95.95 0.00e+00 2691.00
IUUC-Opr-070870 Ochotona princeps 84.48 0.00e+00 1406.00
IUUC-Ont-071293 Oreochromis niloticus 79.43 0.00e+00 2255.00
IUUC-Oan-072852 Ornithorhynchus anatinus 85.93 0.00e+00 2386.00
IUUC-Ocu-074727 Oryctolagus cuniculus 95.51 0.00e+00 2648.00
IUUC-Oba-075932 Oryza barthii 38.92 9.00e-63 236.00
IUUC-Obr-076424 Oryza brachyantha 46.52 1.00e-60 229.00
IUUC-Ogl-077491 Oryza glaberrima 38.92 9.00e-63 236.00
IUUC-Ogu-078933 Oryza glumaepatula 44.58 3.00e-66 247.00
IUUC-Oin-079604 Oryza indica 43.27 3.00e-68 254.00
IUUC-Olo-080850 Oryza longistaminata 35.09 2.00e-115 410.00
IUUC-Ome-081860 Oryza meridionalis 43.27 3.00e-68 254.00
IUUC-Oni-082895 Oryza nivara 38.92 2.00e-62 235.00
IUUC-Opu-083741 Oryza punctata 42.98 6.00e-67 249.00
IUUC-Oru-084616 Oryza rufipogon 38.62 4.00e-62 234.00
IUUC-Osa-085941 Oryza sativa 28.50 5.00e-36 145.00
IUUC-Ola-087357 Oryzias latipes 85.26 7.00e-157 546.00
IUUC-Olu-087659 Ostreococcus lucimarinus 29.78 5.00e-84 306.00
IUUC-Oga-088555 Otolemur garnettii 96.17 0.00e+00 2671.00
IUUC-Oar-089304 Ovis aries 92.50 0.00e+00 1295.00
IUUC-Ptr-091140 Pan troglodytes 95.95 0.00e+00 2692.00
IUUC-Pan-092413 Papio anubis 95.51 0.00e+00 2580.00
IUUC-Psi-093210 Pelodiscus sinensis 89.27 0.00e+00 2537.00
IUUC-Pma-094674 Petromyzon marinus 55.46 0.00e+00 720.00
IUUC-Pno-094969 Phaeosphaeria nodorum 30.88 2.00e-145 511.00
IUUC-Ppa-096017 Physcomitrella patens 46.42 6.00e-76 280.00
IUUC-Pfo-096077 Poecilia formosa 79.09 0.00e+00 2203.00
IUUC-Pab-098269 Pongo abelii 95.07 0.00e+00 2670.00
IUUC-Pop-100052 Populus trichocarpa 43.67 3.00e-62 234.00
IUUC-Pca-100377 Procavia capensis 89.49 0.00e+00 2393.00
IUUC-Ppe-101445 Prunus persica 46.08 1.00e-70 262.00
IUUC-Pva-102198 Pteropus vampyrus 95.81 0.00e+00 1764.00
IUUC-Pgr-103544 Puccinia graminis 46.86 7.00e-78 286.00
IUUC-Ptt-103964 Puccinia triticina 46.54 6.00e-75 276.00
IUUC-Pte-104196 Pyrenophora teres 36.74 7.00e-137 482.00
IUUC-Pyt-104544 Pyrenophora triticirepentis 31.16 2.00e-171 597.00
IUUC-Rno-105256 Rattus norvegicus 98.82 0.00e+00 2760.00
IUUC-Sce-106295 Saccharomyces cerevisiae 40.41 5.00e-67 250.00
IUUC-Sha-107597 Sarcophilus harrisii 91.12 0.00e+00 2525.00
IUUC-Sja-107781 Schizosaccharomyces japonicus 34.24 3.00e-111 397.00
IUUC-Spo-108031 Schizosaccharomyces pombe 43.84 5.00e-72 267.00
IUUC-Ssl-108579 Sclerotinia sclerotiorum 35.41 1.00e-132 468.00
IUUC-Smo-108679 Selaginella moellendorffii 44.01 5.00e-76 280.00
IUUC-Sit-110765 Setaria italica 41.26 6.00e-63 236.00
IUUC-Sly-111527 Solanum lycopersicum 43.65 6.00e-71 263.00
IUUC-Stu-112899 Solanum tuberosum 43.09 3.00e-70 261.00
IUUC-Sar-112986 Sorex araneus 94.62 0.00e+00 2647.00
IUUC-Sbi-114604 Sorghum bicolor 40.75 9.00e-66 246.00
IUUC-Sre-115191 Sporisorium reilianum 43.08 2.00e-63 238.00
IUUC-Ssc-115440 Sus scrofa 93.89 0.00e+00 2619.00
IUUC-Tgu-116633 Taeniopygia guttata 88.99 0.00e+00 2528.00
IUUC-Tru-118439 Takifugu rubripes 78.30 0.00e+00 2220.00
IUUC-Tsy-119472 Tarsius syrichta 87.42 0.00e+00 1394.00
IUUC-Tni-119808 Tetraodon nigroviridis 74.07 0.00e+00 2023.00
IUUC-Tca-121648 Theobroma cacao 46.99 5.00e-72 266.00
IUUC-Tre-122161 Trichoderma reesei 34.16 2.00e-120 427.00
IUUC-Tvi-122575 Trichoderma virens 32.92 3.00e-112 400.00
IUUC-Tae-123381 Triticum aestivum 45.98 3.00e-65 244.00
IUUC-Tur-126291 Triticum urartu 43.55 4.00e-66 247.00
IUUC-Tme-126979 Tuber melanosporum 37.35 1.00e-147 518.00
IUUC-Tbe-127576 Tupaia belangeri 79.65 0.00e+00 910.00
IUUC-Ttr-129106 Tursiops truncatus 96.06 0.00e+00 1290.00
IUUC-Uma-129633 Ustilago maydis 42.86 7.00e-73 270.00
IUUC-Vda-130001 Verticillium dahliae 34.89 2.00e-126 447.00
IUUC-Vpa-130733 Vicugna pacos 86.89 0.00e+00 1280.00
IUUC-Vvi-131318 Vitis vinifera 44.48 2.00e-69 258.00
IUUC-Xtr-131908 Xenopus tropicalis 84.63 0.00e+00 2418.00
IUUC-Xma-133331 Xiphophorus maculatus 78.94 0.00e+00 2216.00
IUUC-Yli-134651 Yarrowia lipolytica 37.44 3.00e-119 423.00
IUUC-Zma-135850 Zea mays 40.48 9.00e-67 249.00
Created Date 25-Jun-2017

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