iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0005632	FBtr0307550	FBpp0300202
FBgn0005632	FBtr0307548	FBpp0300200
FBgn0005632	FBtr0085843	FBpp0085202
FBgn0005632	FBtr0085844	FBpp0085203

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	20146544

Classification

Family	E-value	Score	Start	End
DUB/USP	4.80e-82	275.9	1668	2061

Active Site

Position(s)	Description	Evidence
1677	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
1986	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp..........................................kepkgellkslq 54
           +GlkN g+tCYmNSvLQ+L+++p +r  +l+ +  ++ + ++                                          k+ +  +lk++q
   Q: 1668 CGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDfsgdsdltggglgsalfsgpasalvslpsssstiedglhdvrKNYHVVILKHVQ 1763
           7******************************5555555544468888899999999999999999999999999888888888888888******* PP
   S: 55   klfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgql 150
            +f++l +s  +++ pr l++++k + e ++  eqqDa Ef++ ll++l+e l                          k   +++l++ +++g++
   Q: 1764 AIFAHLGHSALQYYVPRGLWTHFKLLGEPVNLREQQDAVEFFMSLLESLDEGL--------------------------KALGQPQLMNATLGGSF 1833
           *****************************************************..........................77999************ PP
   S: 151  ksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksr 246
           ++q +c+ec +++s+eepf  +s+++++++     sl+++Le+++k e leg+++y+c+kc+kk+ ++k++ +kklP+vL ++LkRf+++ e+ + 
   Q: 1834 SDQKICQECPHRYSKEEPFSVFSVDIRNHS-----SLTESLEQYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVCA 1924
           ******************************.....9************************************************************ PP
   S: 247  ekinkkvefpleLdlspfcts..............peekqkekkkYeLiavvvHsGslssGHYvayvkn.....ekgkWllfdDskVtevkeeevl 323
           +k+n+++efp+ Ld++p+++s              +++++ e++kYeL+++vvHsG++s+GHY++y+ +      k +W++fdD +Vte+k++e +
   Q: 1925 IKFNDYFEFPRILDMEPYTVSglaklegevvevgdNCQTNVETTKYELTGIVVHSGQASGGHYFSYILSknpanGKCQWYKFDDGEVTECKMHEDE 2020
           *********************899999988888886666667*************************99666555666****************** PP
   S: 324  eetg...........................staYvlfYkr 337
           e+++                           ++aY+lfY+r
   Q: 2021 EMKAecfggeymgetydnnlkrmqyrrqkrwWNAYMLFYTR 2061
           *999***********************************98 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Ref.1 (AAF01345) sequence differs from that shown due to frameshifts in positions 2742 and 2750.

Protein Sequence
(Fasta)

MTFDTRRHTT GQPGSTAPSS SSSTTSTTTT TTSPAQSAGS GSGIGTGTGT VANSSLPGGG 60
SGSLDGNQDQ QPATDSQSSD DVAASLSANS VDSTITIVPP EKLISSFPTT KLRSLTQKIS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCAATTCAT AACTAGTTCG CCCGAACTGC ACAACCCTAG CAAAAGAAAT AGCTTAAATA 60
TAATTTATTT AACGCGAATT GGACAACGAG CGGGTAGAAA AAACCCTGTG GCCGCAACCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0378--Hydrolase
KW-0896--Oogenesis
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0716--Sensory transduction
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0844--Vision

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007349--P:cellularization
GO:0050829--P:defense response to Gram-negative bacterium
GO:0009950--P:dorsal/ventral axis specification
GO:0006897--P:endocytosis
GO:0008354--P:germ cell migration
GO:0008583--P:mystery cell differentiation
GO:0045824--P:negative regulation of innate immune response
GO:0045861--P:negative regulation of proteolysis
GO:0035192--P:nuclear cortical migration
GO:0048477--P:oogenesis
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0007601--P:visual perception

KEGG

dme:Dmel_CG1945

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001640	Ailuropoda melanoleuca	47.83	0.00e+00	2212.00
IUUC-Apl-003592	Anas platyrhynchos	48.22	0.00e+00	2233.00
IUUC-Aca-004939	Anolis carolinensis	48.29	0.00e+00	2211.00
IUUC-Acl-008140	Aspergillus clavatus	24.90	1.00e-54	208.00
IUUC-Ate-010246	Aspergillus terreus	24.74	2.00e-48	188.00
IUUC-Ame-010925	Astyanax mexicanus	48.57	0.00e+00	2238.00
IUUC-Bta-012775	Bos taurus	47.69	0.00e+00	2185.00
IUUC-Cel-018352	Caenorhabditis elegans	31.64	1.00e-38	155.00
IUUC-Cja-019464	Callithrix jacchus	48.21	0.00e+00	2166.00
IUUC-Cfa-020569	Canis familiaris	44.29	0.00e+00	1310.00
IUUC-Cpo-022430	Cavia porcellus	32.17	5.00e-142	498.00
IUUC-Csa-023405	Chlorocebus sabaeus	47.73	0.00e+00	2187.00
IUUC-Cho-024524	Choloepus hoffmanni	53.07	1.00e-133	470.00
IUUC-Cin-025551	Ciona intestinalis	49.75	5.00e-106	377.00
IUUC-Csv-025956	Ciona savignyi	44.12	0.00e+00	1961.00
IUUC-Dre-028329	Danio rerio	48.58	0.00e+00	2263.00
IUUC-Dno-028936	Dasypus novemcinctus	47.66	0.00e+00	2206.00
IUUC-Dor-030352	Dipodomys ordii	44.77	0.00e+00	950.00
IUUC-Ete-032287	Echinops telfairi	45.23	0.00e+00	1196.00
IUUC-Eca-033352	Equus caballus	47.57	0.00e+00	2209.00
IUUC-Eeu-034907	Erinaceus europaeus	43.71	0.00e+00	811.00
IUUC-Fca-035458	Felis catus	47.83	0.00e+00	2214.00
IUUC-Fal-036924	Ficedula albicollis	48.21	0.00e+00	2236.00
IUUC-Gmo-039578	Gadus morhua	47.43	0.00e+00	2234.00
IUUC-Gga-040978	Gallus gallus	48.25	0.00e+00	2239.00
IUUC-Gac-041970	Gasterosteus aculeatus	48.49	0.00e+00	2245.00
IUUC-Ggo-045575	Gorilla gorilla	47.45	0.00e+00	2200.00
IUUC-Hsa-046295	Homo sapiens	47.49	0.00e+00	2202.00
IUUC-Itr-048768	Ictidomys tridecemlineatus	47.83	0.00e+00	2210.00
IUUC-Lch-050493	Latimeria chalumnae	48.59	0.00e+00	2238.00
IUUC-Loc-052667	Lepisosteus oculatus	48.16	0.00e+00	2262.00
IUUC-Laf-054094	Loxodonta africana	48.18	0.00e+00	2221.00
IUUC-Mcc-054861	Macaca mulatta	47.18	0.00e+00	2171.00
IUUC-Meu-056849	Macropus eugenii	43.84	8.00e-135	475.00
IUUC-Mga-060159	Meleagris gallopavo	48.18	0.00e+00	2234.00
IUUC-Mmr-060732	Microcebus murinus	47.89	0.00e+00	2213.00
IUUC-Mdo-062274	Monodelphis domestica	48.33	0.00e+00	2256.00
IUUC-Mmu-064056	Mus musculus	47.67	0.00e+00	2202.00
IUUC-Mpu-066669	Mustela putorius furo	47.81	0.00e+00	2212.00
IUUC-Mlu-067516	Myotis lucifugus	47.81	0.00e+00	2199.00
IUUC-Nle-069664	Nomascus leucogenys	47.09	0.00e+00	1630.00
IUUC-Opr-070185	Ochotona princeps	54.91	5.00e-132	466.00
IUUC-Ont-072119	Oreochromis niloticus	48.44	0.00e+00	2258.00
IUUC-Oan-073154	Ornithorhynchus anatinus	48.31	0.00e+00	2259.00
IUUC-Ocu-074485	Oryctolagus cuniculus	47.64	0.00e+00	2223.00
IUUC-Ola-086350	Oryzias latipes	48.49	0.00e+00	2242.00
IUUC-Oga-088328	Otolemur garnettii	47.67	0.00e+00	2242.00
IUUC-Oar-090098	Ovis aries	47.50	0.00e+00	2201.00
IUUC-Ptr-091657	Pan troglodytes	28.44	0.00e+00	840.00
IUUC-Pan-091741	Papio anubis	48.69	0.00e+00	1776.00
IUUC-Psi-093040	Pelodiscus sinensis	48.27	0.00e+00	2236.00
IUUC-Pfo-096871	Poecilia formosa	48.61	0.00e+00	2265.00
IUUC-Pab-098374	Pongo abelii	47.69	0.00e+00	2185.00
IUUC-Pca-100801	Procavia capensis	44.17	0.00e+00	957.00
IUUC-Pva-102992	Pteropus vampyrus	53.41	0.00e+00	1043.00
IUUC-Rno-105377	Rattus norvegicus	47.71	0.00e+00	2205.00
IUUC-Sha-106648	Sarcophilus harrisii	46.59	0.00e+00	2110.00
IUUC-Smo-108879	Selaginella moellendorffii	27.23	0.00e+00	715.00
IUUC-Sar-113729	Sorex araneus	45.82	0.00e+00	1325.00
IUUC-Ssc-116261	Sus scrofa	47.80	0.00e+00	2254.00
IUUC-Tgu-117126	Taeniopygia guttata	48.21	0.00e+00	2238.00
IUUC-Tru-117676	Takifugu rubripes	48.51	0.00e+00	2237.00
IUUC-Tsy-119209	Tarsius syrichta	46.82	0.00e+00	841.00
IUUC-Tni-120207	Tetraodon nigroviridis	45.54	0.00e+00	967.00
IUUC-Tbe-128033	Tupaia belangeri	55.18	2.00e-127	450.00
IUUC-Ttr-128742	Tursiops truncatus	47.56	0.00e+00	2164.00
IUUC-Vpa-130581	Vicugna pacos	47.93	0.00e+00	2011.00
IUUC-Xtr-132145	Xenopus tropicalis	47.95	0.00e+00	2233.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence