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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046195
UUCD1 version UUC-HoS-00460
Ensembl Protein ID ENSP00000470034.1
UniProt Accession Q9Y314; Q96FD2; NOSIP_HUMAN
Genbank Protein ID AAD27734.1; AAH09299.1; AAH10077.1; AAH11249.1
Protein Name Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase NOSIP; RING-type E3 ubiquitin transferase NOSIP; eNOS-interacting protein
Genbank Nucleotide ID AF132959; BC009299; BC010077; BC011249
Gene Name NOSIP; CGI-25
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000142546.13 ENST00000601015.5 ENSP00000470450.1
ENSG00000142546.13 ENST00000339093.7 ENSP00000343497.3
ENSG00000142546.13 ENST00000596358.5 ENSP00000470034.1
ENSG00000142546.13 ENST00000598296.5 ENSP00000471929.1
ENSG00000142546.13 ENST00000594932.5 ENSP00000472103.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPMSZDB
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/U-box U-box 12746455
Classification
Family E-value Score Start End
E3 activity/RING/U-box 8.50e-16 59.4 40 79
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk 41
           v ++ +C +sl++ +dPvv+p+G+ y+r++I +++ +++k
   Q: 40   VKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKK 79
           567789*****************************99887 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813).
 E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813).
Protein Sequence
(Fasta)
MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP 60
DGYLYEREAI LEYILHQKKE IARQMKAYEK QRGTRREEQK ELQRAASQDH VRGFLEKESA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046195|E3,U-box|Homo sapiens
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Nucleotide Sequence
(Fasta)
CTGGGCACAG GCCCCACCCT CCTATACGGC TCCACACATA CAACGCTGGG CCACGCCCCT 60
AGACCATTGC ATGGGGCCCC GCCCCCGCAC TCCAAGCCCC GCCCCAGGTA AGAAGGCCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046195|E3,U-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD
Pfam

PF15906--zf-NOSIP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000139--C:Golgi membrane
GO:0005634--C:nucleus
GO:0003723--F:RNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0007275--P:multicellular organism development
GO:0043086--P:negative regulation of catalytic activity
GO:0051001--P:negative regulation of nitric-oxide synthase activity
GO:0016567--P:protein ubiquitination
GO:0050999--P:regulation of nitric-oxide synthase activity
KEGG hsa:51070
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000769 Aegilops tauschii 46.51 1.00e-16 81.30
IUUC-Aml-002069 Ailuropoda melanoleuca 89.81 4.00e-161 560.00
IUUC-Atr-002661 Amborella trichopoda 32.19 3.00e-31 128.00
IUUC-Aca-004630 Anolis carolinensis 76.08 1.00e-136 478.00
IUUC-Aly-006316 Arabidopsis lyrata 30.39 5.00e-29 121.00
IUUC-Ath-007000 Arabidopsis thaliana 30.07 1.00e-28 120.00
IUUC-Acl-008175 Aspergillus clavatus 34.51 2.00e-06 46.60
IUUC-Afl-008440 Aspergillus flavus 33.90 4.00e-06 45.80
IUUC-Afu-009012 Aspergillus fumigatus 34.78 1.00e-06 47.40
IUUC-Ani-009153 Aspergillus nidulans 30.40 9.00e-03 35.00
IUUC-Ang-009556 Aspergillus niger 34.78 4.00e-06 46.20
IUUC-Aor-009892 Aspergillus oryzae 33.90 5.00e-06 45.80
IUUC-Ame-011874 Astyanax mexicanus 63.46 7.00e-110 390.00
IUUC-Bgr-012090 Blumeria graminis 27.46 4.00e-07 49.30
IUUC-Bta-012956 Bos taurus 94.37 6.00e-169 586.00
IUUC-Bci-013897 Botrytis cinerea 42.50 9.00e-10 57.80
IUUC-Bdi-014968 Brachypodium distachyon 30.41 1.00e-33 137.00
IUUC-Bol-015578 Brassica oleracea 31.05 2.00e-33 135.00
IUUC-Bra-017234 Brassica rapa 31.05 2.00e-33 135.00
IUUC-Cel-018637 Caenorhabditis elegans 39.51 4.00e-56 211.00
IUUC-Cja-019632 Callithrix jacchus 98.01 8.00e-177 612.00
IUUC-Cfa-020192 Canis familiaris 92.69 3.00e-167 581.00
IUUC-Cpo-021939 Cavia porcellus 89.04 3.00e-155 541.00
IUUC-Cre-023005 Chlamydomonas reinhardtii 34.22 2.00e-43 169.00
IUUC-Csa-023802 Chlorocebus sabaeus 99.34 3.00e-178 617.00
IUUC-Cho-024637 Choloepus hoffmanni 74.65 9.00e-80 289.00
IUUC-Cin-025180 Ciona intestinalis 51.99 5.00e-86 310.00
IUUC-Csv-026206 Ciona savignyi 48.40 6.00e-43 166.00
IUUC-Cgl-026696 Colletotrichum gloeosporioides 24.03 1.00e-11 63.90
IUUC-Cne-026827 Cryptococcus neoformans 36.36 1.00e-06 47.40
IUUC-Dre-028092 Danio rerio 65.26 8.00e-117 413.00
IUUC-Dno-029501 Dasypus novemcinctus 86.42 3.00e-140 491.00
IUUC-Dor-030542 Dipodomys ordii 90.76 3.00e-163 567.00
IUUC-Dse-031188 Dothistroma septosporum 23.60 4.00e-15 75.50
IUUC-Dme-031734 Drosophila melanogaster 48.54 6.00e-79 287.00
IUUC-Eca-033577 Equus caballus 93.69 4.00e-169 587.00
IUUC-Fca-035761 Felis catus 93.36 4.00e-167 580.00
IUUC-Fox-037703 Fusarium oxysporum 27.20 1.00e-14 73.90
IUUC-Fso-038208 Fusarium solani 27.45 1.00e-13 70.50
IUUC-Gmo-038523 Gadus morhua 59.90 5.00e-61 226.00
IUUC-Ggr-040087 Gaeumannomyces graminis 41.03 5.00e-10 58.50
IUUC-Gac-042621 Gasterosteus aculeatus 60.38 3.00e-109 388.00
IUUC-Gma-042698 Glycine max 31.16 2.00e-32 132.00
IUUC-Ggo-045357 Gorilla gorilla 100.00 1.00e-179 621.00
IUUC-Hvu-047174 Hordeum vulgare 30.74 1.00e-34 140.00
IUUC-Itr-048487 Ictidomys tridecemlineatus 94.02 6.00e-163 566.00
IUUC-Lch-050569 Latimeria chalumnae 68.93 3.00e-116 411.00
IUUC-Lpe-050992 Leersia perrieri 35.47 7.00e-23 101.00
IUUC-Loc-052522 Lepisosteus oculatus 69.67 2.00e-115 408.00
IUUC-Lma-053254 Leptosphaeria maculans 25.17 6.00e-13 68.60
IUUC-Laf-053397 Loxodonta africana 94.06 4.00e-168 583.00
IUUC-Mcc-054681 Macaca mulatta 99.34 1.00e-178 619.00
IUUC-Meu-056723 Macropus eugenii 83.17 8.00e-151 526.00
IUUC-Mor-056961 Magnaporthe oryzae 25.81 6.00e-12 65.50
IUUC-Mpo-057359 Magnaporthe poae 24.58 6.00e-07 48.10
IUUC-Mtr-058063 Medicago truncatula 32.08 4.00e-34 138.00
IUUC-Mla-059004 Melampsora laricipopulina 29.71 2.00e-25 110.00
IUUC-Mvi-060460 Microbotryum violaceum 29.46 4.00e-26 112.00
IUUC-Mmr-060847 Microcebus murinus 97.01 9.00e-175 605.00
IUUC-Mdo-062480 Monodelphis domestica 83.83 4.00e-151 527.00
IUUC-Mmu-063809 Mus musculus 90.70 1.00e-161 562.00
IUUC-Mac-064870 Musa acuminata 31.51 1.00e-33 136.00
IUUC-Mpu-066322 Mustela putorius furo 93.73 7.00e-168 583.00
IUUC-Mlu-067556 Myotis lucifugus 91.12 2.00e-156 544.00
IUUC-Nfi-068440 Neosartorya fischeri 34.78 1.00e-06 47.40
IUUC-Ncr-068898 Neurospora crassa 38.46 9.00e-08 51.20
IUUC-Nle-070049 Nomascus leucogenys 99.67 7.00e-179 619.00
IUUC-Opr-070972 Ochotona princeps 87.87 1.00e-154 538.00
IUUC-Ont-071682 Oreochromis niloticus 66.23 2.00e-117 415.00
IUUC-Oan-073296 Ornithorhynchus anatinus 98.31 2.00e-32 131.00
IUUC-Ocu-074218 Oryctolagus cuniculus 88.93 2.00e-133 468.00
IUUC-Oba-075284 Oryza barthii 31.85 3.00e-33 135.00
IUUC-Obr-076651 Oryza brachyantha 31.85 6.00e-36 144.00
IUUC-Ogl-077899 Oryza glaberrima 31.85 3.00e-33 135.00
IUUC-Ogu-078477 Oryza glumaepatula 32.19 2.00e-33 136.00
IUUC-Oin-080011 Oryza indica 31.85 3.00e-33 135.00
IUUC-Olo-080545 Oryza longistaminata 31.40 2.00e-26 113.00
IUUC-Ome-081543 Oryza meridionalis 31.85 3.00e-33 135.00
IUUC-Oni-082955 Oryza nivara 31.85 3.00e-33 135.00
IUUC-Opu-083565 Oryza punctata 31.85 1.00e-33 136.00
IUUC-Oru-084474 Oryza rufipogon 31.85 3.00e-33 135.00
IUUC-Osa-085913 Oryza sativa 31.85 3.00e-33 135.00
IUUC-Ola-086851 Oryzias latipes 67.11 8.00e-120 423.00
IUUC-Olu-087724 Ostreococcus lucimarinus 33.01 1.00e-11 63.90
IUUC-Oga-087970 Otolemur garnettii 94.70 6.00e-170 589.00
IUUC-Oar-089756 Ovis aries 90.76 3.00e-157 547.00
IUUC-Ptr-091485 Pan troglodytes 98.67 1.00e-175 608.00
IUUC-Pan-091832 Papio anubis 99.67 4.00e-179 620.00
IUUC-Pma-094551 Petromyzon marinus 61.56 3.00e-106 378.00
IUUC-Pno-094830 Phaeosphaeria nodorum 34.31 1.00e-08 53.90
IUUC-Ppa-095255 Physcomitrella patens 30.00 2.00e-32 132.00
IUUC-Pfo-096373 Poecilia formosa 65.36 6.00e-117 413.00
IUUC-Pab-098247 Pongo abelii 100.00 2.00e-179 621.00
IUUC-Pop-099186 Populus trichocarpa 31.23 1.00e-31 130.00
IUUC-Pca-100677 Procavia capensis 89.82 1.00e-136 478.00
IUUC-Ppe-101403 Prunus persica 30.38 5.00e-32 131.00
IUUC-Pva-103000 Pteropus vampyrus 93.36 5.00e-168 583.00
IUUC-Pgr-103663 Puccinia graminis 30.03 3.00e-30 126.00
IUUC-Ptt-103712 Puccinia triticina 40.00 6.00e-09 54.70
IUUC-Pte-104287 Pyrenophora teres 25.70 7.00e-17 81.60
IUUC-Pyt-104579 Pyrenophora triticirepentis 24.73 5.00e-13 68.60
IUUC-Rno-106069 Rattus norvegicus 91.69 8.00e-163 565.00
IUUC-Sha-106553 Sarcophilus harrisii 82.84 9.00e-150 522.00
IUUC-Smo-108874 Selaginella moellendorffii 31.77 3.00e-37 149.00
IUUC-Sit-110307 Setaria italica 31.85 7.00e-33 134.00
IUUC-Sly-111094 Solanum lycopersicum 33.11 3.00e-34 138.00
IUUC-Stu-112363 Solanum tuberosum 32.34 3.00e-34 138.00
IUUC-Sar-113480 Sorex araneus 92.36 1.00e-154 538.00
IUUC-Sbi-113939 Sorghum bicolor 31.85 3.00e-33 135.00
IUUC-Ssc-115644 Sus scrofa 94.68 3.00e-170 590.00
IUUC-Tru-118781 Takifugu rubripes 66.12 5.00e-120 424.00
IUUC-Tni-119672 Tetraodon nigroviridis 75.86 2.00e-35 140.00
IUUC-Tca-121795 Theobroma cacao 31.85 6.00e-36 144.00
IUUC-Tre-122037 Trichoderma reesei 36.36 2.00e-08 53.10
IUUC-Tvi-122524 Trichoderma virens 27.15 9.00e-17 81.30
IUUC-Tae-122828 Triticum aestivum 31.08 6.00e-35 141.00
IUUC-Tur-126387 Triticum urartu 31.01 3.00e-28 119.00
IUUC-Tme-127111 Tuber melanosporum 40.00 2.00e-09 57.00
IUUC-Ttr-128227 Tursiops truncatus 93.02 2.00e-166 577.00
IUUC-Vda-129924 Verticillium dahliae 26.25 6.00e-14 71.60
IUUC-Vpa-130802 Vicugna pacos 95.51 2.00e-44 172.00
IUUC-Vvi-131105 Vitis vinifera 32.88 3.00e-34 139.00
IUUC-Xtr-132830 Xenopus tropicalis 65.73 5.00e-122 430.00
IUUC-Xma-133618 Xiphophorus maculatus 65.79 5.00e-111 393.00
IUUC-Zma-135389 Zea mays 31.51 1.00e-32 133.00
Created Date 25-Jun-2017

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