iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	PINA
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/OTU	32.37	6.00e-36	146.00	IUUC-Sce-106323
ULD/UDP/UFD/UBX	32.37	6.00e-36	146.00	IUUC-Sce-106323

Active Site

Position(s)	Description	Evidence
152	N/A	{ECO:0000250\|UniProtKB:Q96FW1}
155	Nucleophile	{ECO:0000250\|UniProtKB:Q5VVQ6}
262		{ECO:0000250\|UniProtKB:Q5VVQ6}
337		{ECO:0000250\|UniProtKB:Q96FW1}

Organism

Rattus norvegicus

Functional Description
(View)

Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin (By similarity).

Protein Sequence
(Fasta)

MFGGAKGGHF GVPPAGCSGA VSQAAAGTKA GPAGGRPADT MWRLRCKAKG GTHVLQGLSN 60
RTRLRELQGQ IAAITGIAPG SQRILVGYPP ECLDLSDRDI TLGDLPIQSG DMLIVEEDQT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGCAGCCA GGAACTCGTC AGCAGAGTGA CTGTTTGGCA GGTCCTTTGA CCTTTCTTGG 60
CATTTGTTTA CCTTCTCAAG GATGAGTCTG CTTTGCCTGG TGTTTGGGTG GCTGCTTTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0834--Unfolded protein response
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003323--OTU_dom
IPR029071--Ubiquitin-rel_dom
IPR013087--Znf_C2H2_type

PROSITE

PS50802--OTU
PS00028--ZINC_FINGER_C2H2_1

Pfam

PF02338--OTU

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904265--F:ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:1990167--P:protein K27-linked deubiquitination
GO:0035523--P:protein K29-linked deubiquitination
GO:1990168--P:protein K33-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

rno:363982

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000271	Aegilops tauschii	48.15	7.00e-45	173.00
IUUC-Aml-001860	Ailuropoda melanoleuca	90.23	0.00e+00	640.00
IUUC-Atr-002548	Amborella trichopoda	50.00	3.00e-50	191.00
IUUC-Apl-004025	Anas platyrhynchos	79.17	2.00e-105	374.00
IUUC-Aca-004505	Anolis carolinensis	73.94	3.00e-136	477.00
IUUC-Aly-005999	Arabidopsis lyrata	44.98	2.00e-47	181.00
IUUC-Ath-006774	Arabidopsis thaliana	46.12	7.00e-48	183.00
IUUC-Ago-007741	Ashbya gossypii	38.89	1.00e-37	150.00
IUUC-Acl-008278	Aspergillus clavatus	32.83	5.00e-42	164.00
IUUC-Afl-008710	Aspergillus flavus	34.34	7.00e-43	167.00
IUUC-Afu-009009	Aspergillus fumigatus	34.38	3.00e-44	172.00
IUUC-Ani-009430	Aspergillus nidulans	31.33	5.00e-40	157.00
IUUC-Ang-009508	Aspergillus niger	33.22	9.00e-37	147.00
IUUC-Aor-009992	Aspergillus oryzae	34.64	1.00e-43	170.00
IUUC-Ate-010440	Aspergillus terreus	34.81	4.00e-46	178.00
IUUC-Ame-011038	Astyanax mexicanus	69.31	2.00e-125	441.00
IUUC-Bgr-012262	Blumeria graminis	34.95	1.00e-34	140.00
IUUC-Bta-012864	Bos taurus	88.22	2.00e-180	624.00
IUUC-Bci-013986	Botrytis cinerea	34.45	3.00e-35	142.00
IUUC-Bdi-014194	Brachypodium distachyon	48.78	6.00e-51	193.00
IUUC-Bol-016166	Brassica oleracea	46.60	9.00e-49	186.00
IUUC-Bra-017783	Brassica rapa	47.09	4.00e-49	187.00
IUUC-Cja-019488	Callithrix jacchus	88.22	0.00e+00	625.00
IUUC-Cpo-021728	Cavia porcellus	87.36	6.00e-180	622.00
IUUC-Cre-022819	Chlamydomonas reinhardtii	45.59	1.00e-41	162.00
IUUC-Csa-024237	Chlorocebus sabaeus	92.74	2.00e-167	581.00
IUUC-Cho-024544	Choloepus hoffmanni	88.22	0.00e+00	628.00
IUUC-Cin-025549	Ciona intestinalis	44.92	4.00e-73	268.00
IUUC-Cgl-026552	Colletotrichum gloeosporioides	30.24	4.00e-34	139.00
IUUC-Cne-027022	Cryptococcus neoformans	43.56	1.00e-43	170.00
IUUC-Cme-027196	Cyanidioschyzon merolae	37.43	6.00e-47	181.00
IUUC-Dre-027799	Danio rerio	69.31	5.00e-120	423.00
IUUC-Dno-029863	Dasypus novemcinctus	87.36	8.00e-180	622.00
IUUC-Dor-030804	Dipodomys ordii	82.52	1.00e-162	565.00
IUUC-Dse-031494	Dothistroma septosporum	40.67	1.00e-40	160.00
IUUC-Dme-032065	Drosophila melanogaster	41.21	8.00e-68	250.00
IUUC-Ete-033193	Echinops telfairi	87.64	2.00e-176	611.00
IUUC-Eca-033993	Equus caballus	89.37	0.00e+00	632.00
IUUC-Fca-035949	Felis catus	90.23	0.00e+00	641.00
IUUC-Fal-037473	Ficedula albicollis	76.27	5.00e-101	360.00
IUUC-Fox-037779	Fusarium oxysporum	31.06	2.00e-28	119.00
IUUC-Fso-038370	Fusarium solani	35.56	8.00e-28	117.00
IUUC-Gmo-038778	Gadus morhua	57.24	7.00e-90	323.00
IUUC-Ggr-039940	Gaeumannomyces graminis	32.82	7.00e-36	144.00
IUUC-Gga-041102	Gallus gallus	70.23	1.00e-125	442.00
IUUC-Gac-041954	Gasterosteus aculeatus	68.51	8.00e-123	432.00
IUUC-Gma-043608	Glycine max	47.57	6.00e-49	186.00
IUUC-Ggo-044753	Gorilla gorilla	88.51	3.00e-179	620.00
IUUC-Hsa-045714	Homo sapiens	88.20	2.00e-158	551.00
IUUC-Hvu-047600	Hordeum vulgare	48.78	2.00e-51	195.00
IUUC-Itr-048026	Ictidomys tridecemlineatus	90.52	0.00e+00	643.00
IUUC-Kpa-049360	Komagataella pastoris	31.23	2.00e-39	156.00
IUUC-Lch-049900	Latimeria chalumnae	73.68	1.00e-124	438.00
IUUC-Lpe-050984	Leersia perrieri	40.20	3.00e-32	131.00
IUUC-Loc-052567	Lepisosteus oculatus	70.82	4.00e-129	454.00
IUUC-Lma-053247	Leptosphaeria maculans	31.80	4.00e-40	158.00
IUUC-Laf-053361	Loxodonta africana	87.64	2.00e-171	594.00
IUUC-Meu-056137	Macropus eugenii	74.86	4.00e-147	513.00
IUUC-Mor-057191	Magnaporthe oryzae	30.51	1.00e-26	113.00
IUUC-Mpo-057565	Magnaporthe poae	38.27	1.00e-31	130.00
IUUC-Mtr-058196	Medicago truncatula	46.60	4.00e-49	187.00
IUUC-Mla-059096	Melampsora laricipopulina	33.74	7.00e-40	157.00
IUUC-Mga-059489	Meleagris gallopavo	79.66	1.00e-111	395.00
IUUC-Mvi-060300	Microbotryum violaceum	36.73	4.00e-42	165.00
IUUC-Mmr-061618	Microcebus murinus	91.25	3.00e-162	563.00
IUUC-Mdo-061909	Monodelphis domestica	85.26	2.00e-159	555.00
IUUC-Mmu-063434	Mus musculus	96.50	0.00e+00	684.00
IUUC-Mac-064676	Musa acuminata	49.03	7.00e-51	193.00
IUUC-Mpu-066733	Mustela putorius furo	89.94	0.00e+00	639.00
IUUC-Mlu-066990	Myotis lucifugus	85.19	1.00e-174	605.00
IUUC-Nfi-068249	Neosartorya fischeri	42.57	5.00e-43	167.00
IUUC-Ncr-068764	Neurospora crassa	33.85	2.00e-35	142.00
IUUC-Nle-069094	Nomascus leucogenys	89.08	0.00e+00	625.00
IUUC-Oan-073585	Ornithorhynchus anatinus	85.53	2.00e-156	545.00
IUUC-Oba-075949	Oryza barthii	49.03	3.00e-49	187.00
IUUC-Obr-076096	Oryza brachyantha	49.03	6.00e-50	190.00
IUUC-Ogl-077106	Oryza glaberrima	48.54	9.00e-49	186.00
IUUC-Ogu-078024	Oryza glumaepatula	49.03	4.00e-49	187.00
IUUC-Oin-079635	Oryza indica	48.06	4.00e-49	187.00
IUUC-Olo-080299	Oryza longistaminata	49.03	6.00e-49	186.00
IUUC-Ome-081359	Oryza meridionalis	49.03	3.00e-49	187.00
IUUC-Oni-082459	Oryza nivara	48.54	9.00e-49	186.00
IUUC-Opu-083167	Oryza punctata	50.00	2.00e-50	192.00
IUUC-Oru-084577	Oryza rufipogon	48.06	4.00e-49	187.00
IUUC-Osa-085746	Oryza sativa	52.94	2.00e-12	63.20
IUUC-Ola-086890	Oryzias latipes	69.18	4.00e-125	440.00
IUUC-Olu-087585	Ostreococcus lucimarinus	42.29	1.00e-42	165.00
IUUC-Oga-088190	Otolemur garnettii	89.74	1.00e-165	575.00
IUUC-Oar-089631	Ovis aries	88.79	0.00e+00	629.00
IUUC-Pan-091892	Papio anubis	89.08	2.00e-180	624.00
IUUC-Pma-094491	Petromyzon marinus	57.14	4.00e-89	321.00
IUUC-Pno-094993	Phaeosphaeria nodorum	32.11	1.00e-41	164.00
IUUC-Ppa-095791	Physcomitrella patens	50.97	5.00e-52	197.00
IUUC-Pfo-096301	Poecilia formosa	69.51	2.00e-126	444.00
IUUC-Pab-097873	Pongo abelii	89.08	2.00e-180	624.00
IUUC-Pop-099482	Populus trichocarpa	47.09	5.00e-50	190.00
IUUC-Pca-100817	Procavia capensis	88.52	3.00e-160	557.00
IUUC-Ppe-101624	Prunus persica	49.76	9.00e-52	196.00
IUUC-Pva-102120	Pteropus vampyrus	86.78	3.00e-176	610.00
IUUC-Pgr-103368	Puccinia graminis	30.24	7.00e-42	164.00
IUUC-Ptt-103923	Puccinia triticina	38.15	8.00e-41	160.00
IUUC-Pte-104199	Pyrenophora teres	36.91	2.00e-40	159.00
IUUC-Pyt-104502	Pyrenophora triticirepentis	31.52	4.00e-41	161.00
IUUC-Sce-106323	Saccharomyces cerevisiae	32.37	6.00e-32	131.00
IUUC-Sha-107176	Sarcophilus harrisii	85.93	5.00e-136	476.00
IUUC-Sja-107812	Schizosaccharomyces japonicus	37.38	4.00e-36	145.00
IUUC-Spo-108085	Schizosaccharomyces pombe	31.53	4.00e-40	158.00
IUUC-Smo-109050	Selaginella moellendorffii	47.09	4.00e-49	187.00
IUUC-Sit-110056	Setaria italica	47.80	1.00e-49	189.00
IUUC-Sly-111869	Solanum lycopersicum	50.29	2.00e-44	171.00
IUUC-Stu-112452	Solanum tuberosum	48.78	1.00e-50	192.00
IUUC-Sar-113629	Sorex araneus	81.97	6.00e-56	211.00
IUUC-Sbi-114422	Sorghum bicolor	48.54	1.00e-50	192.00
IUUC-Sre-115105	Sporisorium reilianum	42.00	1.00e-32	133.00
IUUC-Ssc-115553	Sus scrofa	89.66	0.00e+00	631.00
IUUC-Tgu-116921	Taeniopygia guttata	77.37	5.00e-102	363.00
IUUC-Tru-117830	Takifugu rubripes	68.21	7.00e-124	436.00
IUUC-Tsy-119320	Tarsius syrichta	89.66	0.00e+00	630.00
IUUC-Tni-119706	Tetraodon nigroviridis	67.00	1.00e-117	416.00
IUUC-Tca-121238	Theobroma cacao	48.54	4.00e-50	190.00
IUUC-Tae-124711	Triticum aestivum	49.03	4.00e-51	194.00
IUUC-Tme-126966	Tuber melanosporum	35.42	8.00e-51	193.00
IUUC-Tbe-127712	Tupaia belangeri	94.95	2.00e-110	391.00
IUUC-Ttr-129168	Tursiops truncatus	87.07	3.00e-179	620.00
IUUC-Uma-129461	Ustilago maydis	40.00	8.00e-38	150.00
IUUC-Vda-129890	Verticillium dahliae	35.56	4.00e-26	111.00
IUUC-Vpa-130616	Vicugna pacos	88.51	3.00e-180	624.00
IUUC-Vvi-131250	Vitis vinifera	49.03	3.00e-50	191.00
IUUC-Xtr-132126	Xenopus tropicalis	70.72	4.00e-130	457.00
IUUC-Xma-133596	Xiphophorus maculatus	69.51	4.00e-126	444.00
IUUC-Yli-134562	Yarrowia lipolytica	32.99	3.00e-33	135.00
IUUC-Zma-135205	Zea mays	48.06	6.00e-50	190.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence