iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000140367.11	ENST00000267938.8	ENSP00000267938.4
ENSG00000140367.11	ENST00000569423.5	ENSP00000456324.1
ENSG00000140367.11	ENST00000561723.5	ENSP00000458006.1
ENSG00000140367.11	ENST00000561851.5	ENSP00000456229.1
ENSG00000140367.11	ENST00000426727.6	ENSP00000400960.2
ENSG00000140367.11	ENST00000567921.1	ENSP00000454742.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20682791

Classification

Family	E-value	Score	Start	End
E2/UBC	1.60e-17	65.2	208	360

Active Site

Position(s)	Description	Evidence
304	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdpp..eg.isakpvdesdltewevlilG.pedtpYeg...........gvFkleiefpedYPfkPPkvkfltkifhPnvye 77
           Rl+kel ++ ++++  +g +s+++ ++  l++w+v++    +d+p +            ++  l+++f++++Pf+PP v+++ +++++ +  
   Q: 208  RLMKELRDIYRSQSykTGiYSVELIND-SLYDWHVKLQKvDPDSPLHSdlqilkekegiEYILLNFSFKDNFPFDPPFVRVVLPVLSGGYVL 298
           778888887665552233145666666.5888888876544555544312222222222346799***********************9999 PP
   S: 78   n.GkvClsilkeeekWspalsvesvllsiqsll..aepnpesplneeaaellkknreeykkkvr 138
             G++C+++l +++ Ws+a+s+esv+++i+++l   +++++ ++n+++++l +++++ y+++v+
   Q: 299  GgGALCMELL-TKQGWSSAYSIESVIMQINATLvkGKARVQFGANKNQYNLARAQQS-YNSIVQ 360
           98********.59********************87789************9999998.999885 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination.

Protein Sequence
(Fasta)

MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PQQGSPHSLP PPLTLHCNIT 60
ESYPSSSPIW FVDSEDPNLT SVLERLEDTK NNNLLRQQLK WLICELCSLY NLPKHLDVEM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGCGCGCG CGCTCTGGCC TCGTGCACGC GCTGAAACCG GAGCGCGCAG GGCGCGCCAG 60
GGTGAGGGGG ACGGGGGCGG GGTGGGGGCA GCCCTTTCCC AGGCGGTAGC GGGGGCGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination

KEGG

hsa:92912

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003420	Anas platyrhynchos	87.04	1.00e-157	549.00
IUUC-Afl-008523	Aspergillus flavus	31.69	2.00e-16	81.60
IUUC-Afu-009025	Aspergillus fumigatus	35.17	8.00e-15	76.60
IUUC-Ang-009729	Aspergillus niger	31.15	2.00e-20	95.50
IUUC-Aor-010200	Aspergillus oryzae	31.69	2.00e-16	81.60
IUUC-Ate-010283	Aspergillus terreus	35.47	4.00e-17	84.00
IUUC-Ame-011351	Astyanax mexicanus	78.07	7.00e-156	543.00
IUUC-Bta-012944	Bos taurus	85.45	2.00e-171	594.00
IUUC-Bci-013792	Botrytis cinerea	33.52	3.00e-16	81.30
IUUC-Cfa-020582	Canis familiaris	90.72	0.00e+00	657.00
IUUC-Cpo-022469	Cavia porcellus	93.33	0.00e+00	664.00
IUUC-Csa-023724	Chlorocebus sabaeus	98.13	0.00e+00	687.00
IUUC-Cin-025383	Ciona intestinalis	50.26	1.00e-102	366.00
IUUC-Cgl-026471	Colletotrichum gloeosporioides	34.69	2.00e-18	88.60
IUUC-Dre-028429	Danio rerio	79.07	3.00e-161	561.00
IUUC-Dse-031418	Dothistroma septosporum	32.98	3.00e-18	88.20
IUUC-Dme-031720	Drosophila melanogaster	51.12	1.00e-109	390.00
IUUC-Ete-032744	Echinops telfairi	60.32	9.00e-86	310.00
IUUC-Eca-033376	Equus caballus	94.44	0.00e+00	682.00
IUUC-Fca-036101	Felis catus	92.08	0.00e+00	654.00
IUUC-Fal-036837	Ficedula albicollis	82.17	2.00e-172	598.00
IUUC-Fso-038245	Fusarium solani	29.19	2.00e-13	72.40
IUUC-Gmo-039573	Gadus morhua	81.48	3.00e-168	584.00
IUUC-Ggr-039776	Gaeumannomyces graminis	32.65	2.00e-15	79.00
IUUC-Gac-041518	Gasterosteus aculeatus	80.74	5.00e-170	590.00
IUUC-Lch-049959	Latimeria chalumnae	75.92	4.00e-154	537.00
IUUC-Loc-052754	Lepisosteus oculatus	79.80	2.00e-171	594.00
IUUC-Lma-052975	Leptosphaeria maculans	31.52	1.00e-21	99.80
IUUC-Meu-056480	Macropus eugenii	72.07	3.00e-148	518.00
IUUC-Mor-057265	Magnaporthe oryzae	30.20	1.00e-11	65.90
IUUC-Mpo-057298	Magnaporthe poae	31.97	2.00e-13	71.60
IUUC-Mga-059200	Meleagris gallopavo	88.29	6.00e-155	540.00
IUUC-Mvi-060299	Microbotryum violaceum	33.57	3.00e-14	74.70
IUUC-Mmr-061213	Microcebus murinus	94.18	0.00e+00	681.00
IUUC-Mdo-062562	Monodelphis domestica	79.10	1.00e-156	545.00
IUUC-Mmu-063747	Mus musculus	91.56	0.00e+00	668.00
IUUC-Mpu-066198	Mustela putorius furo	93.39	0.00e+00	673.00
IUUC-Nfi-068376	Neosartorya fischeri	34.48	5.00e-15	77.00
IUUC-Nle-069221	Nomascus leucogenys	98.93	0.00e+00	694.00
IUUC-Opr-070331	Ochotona princeps	78.36	8.00e-137	479.00
IUUC-Ont-071632	Oreochromis niloticus	79.17	5.00e-171	593.00
IUUC-Oan-072781	Ornithorhynchus anatinus	89.68	6.00e-139	486.00
IUUC-Ocu-074097	Oryctolagus cuniculus	93.33	0.00e+00	668.00
IUUC-Ola-087271	Oryzias latipes	77.66	3.00e-169	587.00
IUUC-Olu-087612	Ostreococcus lucimarinus	29.41	1.00e-10	59.70
IUUC-Oga-089115	Otolemur garnettii	93.12	0.00e+00	667.00
IUUC-Oar-090270	Ovis aries	88.37	0.00e+00	660.00
IUUC-Ptr-090599	Pan troglodytes	99.73	0.00e+00	697.00
IUUC-Pan-092455	Papio anubis	98.40	0.00e+00	691.00
IUUC-Pno-095082	Phaeosphaeria nodorum	34.22	4.00e-17	84.30
IUUC-Pfo-097215	Poecilia formosa	79.53	3.00e-171	594.00
IUUC-Pva-102975	Pteropus vampyrus	96.19	3.00e-169	587.00
IUUC-Pte-104028	Pyrenophora teres	35.20	5.00e-19	90.50
IUUC-Pyt-104588	Pyrenophora triticirepentis	35.20	4.00e-18	87.80
IUUC-Rno-105714	Rattus norvegicus	88.36	0.00e+00	630.00
IUUC-Sha-106904	Sarcophilus harrisii	78.72	1.00e-159	556.00
IUUC-Ssl-108486	Sclerotinia sclerotiorum	34.09	2.00e-17	82.00
IUUC-Sar-113657	Sorex araneus	94.29	3.00e-165	574.00
IUUC-Ssc-116046	Sus scrofa	92.33	0.00e+00	671.00
IUUC-Tgu-116888	Taeniopygia guttata	85.76	5.00e-155	540.00
IUUC-Tru-118721	Takifugu rubripes	80.84	2.00e-166	578.00
IUUC-Tsy-118894	Tarsius syrichta	87.90	2.00e-124	437.00
IUUC-Tni-120346	Tetraodon nigroviridis	80.16	2.00e-167	582.00
IUUC-Tre-122084	Trichoderma reesei	30.39	1.00e-16	82.80
IUUC-Tvi-122420	Trichoderma virens	32.97	3.00e-14	74.30
IUUC-Tme-127145	Tuber melanosporum	39.58	6.00e-18	87.00
IUUC-Ttr-128707	Tursiops truncatus	93.92	0.00e+00	681.00
IUUC-Vda-129662	Verticillium dahliae	31.33	1.00e-11	65.90
IUUC-Vpa-130455	Vicugna pacos	96.19	8.00e-170	589.00
IUUC-Xtr-132483	Xenopus tropicalis	84.31	5.00e-177	613.00
IUUC-Xma-134189	Xiphophorus maculatus	78.44	1.00e-161	562.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence