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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106262
Ensembl Protein ID YCL008C
UniProt Accession P25604; D6VR04; P87010; P87279; Q86ZT3; Q8NIM6; STP22_YEAST
Genbank Protein ID AAB62820.1; CAC42964.1; AAP21748.1; DAA07473.1
Protein Name Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease; ESCRT-I complex subunit VPS23; Vacuolar protein sorting-associated protein 23
Genbank Nucleotide ID AF004731; X59720; AY260880; BK006937
Gene Name STP22; VPS23; YCL008C; YCL8C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YCL008C YCL008C YCL008C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UEV E2_UEV 20028738
UBD/UBC-like/UBD_UEV UBD_UEV 12461556; 16689637; 19380877
Classification
Family E-value Score Start End
E2/UEV 4.40e-47 158.0 12 161
UBD/UBC-like/UBD_UEV 2.80e-61 204.0 12 161
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E2/UEV
   S: 1    avseselkvvvpr......nfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtv..........rfss 86
           av+++ +kv++p+      +f+++++l++++++l+++t++++++Dg+++llls++gtI+++e+++++++I +++++v+++YP+kPP++          ++ss
   Q: 12   AVVNWLFKVIQPIyndgrtTFHDSLALLDNFHSLRPRTRVFTHSDGTPQLLLSIYGTISTGEDGSSPHSI-PVIMWVPSMYPVKPPFIsinlenfdmnTISS 112
           799*******************************************************************.******************************* PP
   S: 87   kinmaevndsnGvvdpralpvLanWkreysievvlvqlkkellskenrklqqP 139
           +++++e++dsnG++   alp+L++W++++++++++vq++++ll +e++++q+P
   Q: 113  SLPIQEYIDSNGWI---ALPILHCWDPAAMNLIMVVQELMSLL-HEPPQDQAP 161
           **************...**************************.********9 PP
   

   UBD/UBC-like/UBD_UEV
   S: 1    AvsesslkkvpskykdkrltvrellnliesykslkpktasfvlnDgesreLlrltGtipvpergit.ynipiilwlletYPekPPfvsvk.ekidmntikss 100
           Av+++ +k+++++y+d+r+t++++l+l+++++sl+p+t++f+++Dg+++ Ll+++Gti+++e+g++ ++ip+i+w++++YP+kPPf+s++ e++dmnti+ss
   Q: 12   AVVNWLFKVIQPIYNDGRTTFHDSLALLDNFHSLRPRTRVFTHSDGTPQLLLSIYGTISTGEDGSSpHSIPVIMWVPSMYPVKPPFISINlENFDMNTISSS 113
           89**************************************************************************************************** PP
   S: 101  ...nehvdpnGkialpvLhkWknpasnlvelvqelivllskeppklsrp 146
              +e++d+nG+ialp+Lh+W+++a+nl+++vqel++ll +epp++++p
   Q: 114  lpiQEYIDSNGWIALPILHCWDPAAMNLIMVVQELMSLL-HEPPQDQAP 161
           ***************************************.******997 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association to the ESCRT-0 complex. Required for vacuolar targeting of temperature-sensitive plasma membrane proteins STE2 and CAN1.
 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association to the ESCRT-0 complex. Required for vacuolar targeting of temperature-sensitive plasma membrane proteins STE2 and CAN1.
Protein Sequence
(Fasta)
MSANGKISVP EAVVNWLFKV IQPIYNDGRT TFHDSLALLD NFHSLRPRTR VFTHSDGTPQ 60
LLLSIYGTIS TGEDGSSPHS IPVIMWVPSM YPVKPPFISI NLENFDMNTI SSSLPIQEYI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106262|E2,E2/UEV;UBD,UBD_UEV|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTCTGCAA ACGGCAAGAT CTCTGTTCCC GAGGCGGTGG TCAATTGGCT GTTCAAAGTC 60
ATTCAACCCA TTTATAACGA CGGAAGAACA ACTTTCCACG ATTCTTTAGC GCTGCTGGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106262|E2,E2/UEV;UBD,UBD_UEV|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR017916--SB_dom
IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD
IPR008883--UEV_N
PROSITE

PS51312--SB
PS50127--UBIQUITIN_CONJUGAT_2
PS51322--UEV
Pfam

PF05743--UEV
PF09454--Vps23_core
Gene Ontology

GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005768--C:endosome
GO:0000813--C:ESCRT I complex
GO:0031902--C:late endosome membrane
GO:0043130--F:ubiquitin binding
GO:1904669--P:ATP export
GO:0006464--P:cellular protein modification process
GO:0045324--P:late endosome to vacuole transport
GO:1902915--P:negative regulation of protein polyubiquitination
GO:0006612--P:protein targeting to membrane
GO:0006623--P:protein targeting to vacuole
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
KEGG sce:YCL008C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001072 Aegilops tauschii 33.33 3.00e-11 60.80
IUUC-Aml-002415 Ailuropoda melanoleuca 26.12 2.00e-11 61.20
IUUC-Atr-002875 Amborella trichopoda 25.42 1.00e-12 65.90
IUUC-Apl-003473 Anas platyrhynchos 26.87 3.00e-12 64.30
IUUC-Aca-004573 Anolis carolinensis 26.12 2.00e-12 64.70
IUUC-Aly-006164 Arabidopsis lyrata 33.33 6.00e-08 49.70
IUUC-Ath-007557 Arabidopsis thaliana 33.64 7.00e-10 56.20
IUUC-Ago-007755 Ashbya gossypii 34.20 5.00e-27 113.00
IUUC-Acl-008218 Aspergillus clavatus 25.88 2.00e-13 68.90
IUUC-Afl-008597 Aspergillus flavus 35.06 8.00e-11 60.10
IUUC-Afu-009017 Aspergillus fumigatus 33.00 6.00e-13 67.00
IUUC-Ani-009468 Aspergillus nidulans 31.68 8.00e-13 66.60
IUUC-Ang-009755 Aspergillus niger 29.63 2.00e-13 68.60
IUUC-Aor-010072 Aspergillus oryzae 35.11 4.00e-15 74.30
IUUC-Ate-010400 Aspergillus terreus 27.33 2.00e-13 68.60
IUUC-Ame-011620 Astyanax mexicanus 28.80 4.00e-11 60.50
IUUC-Bgr-012136 Blumeria graminis 30.23 6.00e-13 66.60
IUUC-Bta-012557 Bos taurus 28.86 1.00e-10 58.90
IUUC-Bci-013881 Botrytis cinerea 28.91 4.00e-13 67.80
IUUC-Bdi-014001 Brachypodium distachyon 35.00 4.00e-10 57.00
IUUC-Bol-015933 Brassica oleracea 31.82 8.00e-10 56.20
IUUC-Bra-017442 Brassica rapa 31.82 6.00e-10 56.20
IUUC-Cel-018697 Caenorhabditis elegans 23.97 1.00e-05 42.40
IUUC-Cja-018963 Callithrix jacchus 28.19 4.00e-10 57.00
IUUC-Cfa-020472 Canis familiaris 26.12 7.00e-11 59.70
IUUC-Cpo-022001 Cavia porcellus 26.12 4.00e-11 60.50
IUUC-Cre-022918 Chlamydomonas reinhardtii 26.52 3.00e-08 51.20
IUUC-Csa-023959 Chlorocebus sabaeus 27.34 2.00e-11 61.20
IUUC-Cho-024389 Choloepus hoffmanni 26.79 1.00e-05 42.40
IUUC-Cin-025688 Ciona intestinalis 27.66 1.00e-13 68.60
IUUC-Cgl-026754 Colletotrichum gloeosporioides 32.20 1.10e-01 30.40
IUUC-Cne-026904 Cryptococcus neoformans 32.54 8.00e-09 53.10
IUUC-Cme-027280 Cyanidioschyzon merolae 28.97 1.00e-07 48.90
IUUC-Dre-028640 Danio rerio 28.57 3.00e-12 63.90
IUUC-Dno-029672 Dasypus novemcinctus 25.27 3.00e-19 87.40
IUUC-Dor-030175 Dipodomys ordii 27.48 3.00e-06 43.90
IUUC-Dse-031375 Dothistroma septosporum 27.45 1.00e-11 62.40
IUUC-Dme-031736 Drosophila melanogaster 26.72 5.00e-08 50.10
IUUC-Ete-032343 Echinops telfairi 26.19 2.00e-11 61.60
IUUC-Eca-033926 Equus caballus 27.34 6.00e-11 59.70
IUUC-Eeu-034940 Erinaceus europaeus 26.12 2.00e-11 61.60
IUUC-Fca-035491 Felis catus 26.12 5.00e-11 59.70
IUUC-Fal-037508 Ficedula albicollis 26.98 2.00e-12 64.70
IUUC-Fox-037937 Fusarium oxysporum 33.59 7.00e-15 73.20
IUUC-Fso-038091 Fusarium solani 31.25 8.00e-13 66.20
IUUC-Gmo-039427 Gadus morhua 27.45 8.00e-11 59.30
IUUC-Ggr-039724 Gaeumannomyces graminis 30.71 3.00e-12 64.70
IUUC-Gga-040998 Gallus gallus 28.86 1.00e-10 58.50
IUUC-Gac-041356 Gasterosteus aculeatus 28.70 1.00e-10 58.90
IUUC-Gma-043566 Glycine max 32.79 3.00e-10 57.40
IUUC-Ggo-044967 Gorilla gorilla 27.34 2.00e-11 61.20
IUUC-Hsa-046686 Homo sapiens 27.34 2.00e-11 61.20
IUUC-Hvu-047430 Hordeum vulgare 33.33 3.00e-11 60.80
IUUC-Itr-047929 Ictidomys tridecemlineatus 28.75 1.00e-09 54.70
IUUC-Kpa-049287 Komagataella pastoris 33.59 1.00e-17 82.40
IUUC-Lch-050597 Latimeria chalumnae 29.94 2.00e-10 57.80
IUUC-Lpe-051090 Leersia perrieri 35.77 2.00e-12 65.10
IUUC-Loc-052399 Lepisosteus oculatus 28.57 5.00e-12 63.20
IUUC-Lma-053249 Leptosphaeria maculans 39.13 2.00e-09 55.10
IUUC-Laf-053766 Loxodonta africana 27.14 3.00e-11 60.80
IUUC-Mcc-055641 Macaca mulatta 27.34 2.00e-11 61.20
IUUC-Meu-055919 Macropus eugenii 28.95 3.00e-11 60.50
IUUC-Mor-056970 Magnaporthe oryzae 32.28 7.00e-14 70.10
IUUC-Mpo-057345 Magnaporthe poae 30.71 2.00e-11 61.20
IUUC-Mtr-058436 Medicago truncatula 33.06 2.00e-10 57.80
IUUC-Mla-059037 Melampsora laricipopulina 28.86 1.00e-10 58.90
IUUC-Mga-059263 Meleagris gallopavo 28.86 1.00e-10 58.50
IUUC-Mvi-060463 Microbotryum violaceum 39.47 2.00e-07 48.90
IUUC-Mmr-060915 Microcebus murinus 27.14 2.00e-11 61.20
IUUC-Mdo-062449 Monodelphis domestica 27.86 2.00e-11 60.80
IUUC-Mmu-063151 Mus musculus 25.52 2.00e-10 58.20
IUUC-Mac-065020 Musa acuminata 35.20 2.00e-11 61.20
IUUC-Mpu-066621 Mustela putorius furo 26.12 2.00e-11 61.20
IUUC-Mlu-067336 Myotis lucifugus 26.43 4.00e-11 60.10
IUUC-Nfi-068530 Neosartorya fischeri 32.67 5.00e-13 67.40
IUUC-Ncr-068785 Neurospora crassa 27.78 7.00e-12 63.50
IUUC-Nle-069972 Nomascus leucogenys 27.34 2.00e-11 61.20
IUUC-Opr-071150 Ochotona princeps 26.19 3.00e-11 60.80
IUUC-Ont-071366 Oreochromis niloticus 27.73 5.00e-11 60.10
IUUC-Oan-072829 Ornithorhynchus anatinus 30.56 6.00e-10 53.50
IUUC-Ocu-074351 Oryctolagus cuniculus 26.12 3.00e-11 60.80
IUUC-Oba-075338 Oryza barthii 39.39 3.00e-10 57.00
IUUC-Obr-076135 Oryza brachyantha 34.96 4.00e-12 63.50
IUUC-Ogl-077182 Oryza glaberrima 34.75 6.00e-12 63.20
IUUC-Ogu-078281 Oryza glumaepatula 34.96 4.00e-12 63.50
IUUC-Oin-079068 Oryza indica 34.75 1.00e-11 62.80
IUUC-Olo-080460 Oryza longistaminata 27.64 2.00e-07 46.60
IUUC-Ome-081781 Oryza meridionalis 24.12 2.00e-19 88.60
IUUC-Oni-082517 Oryza nivara 23.75 7.00e-19 86.30
IUUC-Opu-084101 Oryza punctata 34.75 6.00e-12 62.80
IUUC-Oru-084556 Oryza rufipogon 34.75 7.00e-12 63.20
IUUC-Osa-086264 Oryza sativa 34.75 7.00e-12 62.80
IUUC-Ola-086920 Oryzias latipes 28.87 6.00e-12 61.20
IUUC-Olu-087610 Ostreococcus lucimarinus 40.00 4.00e-03 33.90
IUUC-Oga-088304 Otolemur garnettii 25.49 2.00e-11 61.20
IUUC-Oar-089734 Ovis aries 28.86 1.00e-10 58.90
IUUC-Ptr-091476 Pan troglodytes 27.34 2.00e-11 61.20
IUUC-Pan-092341 Papio anubis 27.34 2.00e-11 61.20
IUUC-Psi-093470 Pelodiscus sinensis 28.47 5.00e-13 66.60
IUUC-Pma-094143 Petromyzon marinus 28.78 2.00e-09 55.10
IUUC-Pno-095069 Phaeosphaeria nodorum 30.41 1.00e-09 55.80
IUUC-Ppa-095933 Physcomitrella patens 30.58 1.00e-07 48.90
IUUC-Pfo-096321 Poecilia formosa 28.17 2.00e-11 61.60
IUUC-Pab-098527 Pongo abelii 27.34 2.00e-11 61.20
IUUC-Pop-099323 Populus trichocarpa 25.58 1.00e-16 78.60
IUUC-Pca-101044 Procavia capensis 27.34 4.00e-09 53.50
IUUC-Ppe-101458 Prunus persica 29.75 7.00e-11 59.70
IUUC-Pva-102591 Pteropus vampyrus 21.97 9.00e-06 42.70
IUUC-Pgr-103615 Puccinia graminis 34.04 8.00e-10 56.60
IUUC-Ptt-103826 Puccinia triticina 34.69 1.00e-02 33.10
IUUC-Pte-104171 Pyrenophora teres 33.07 2.00e-12 65.50
IUUC-Pyt-104433 Pyrenophora triticirepentis 45.76 2.00e-09 55.10
IUUC-Rno-105957 Rattus norvegicus 25.52 2.00e-10 58.20
IUUC-Sha-107607 Sarcophilus harrisii 30.00 5.00e-11 60.10
IUUC-Sja-107877 Schizosaccharomyces japonicus 20.88 5.00e-04 37.00
IUUC-Spo-108175 Schizosaccharomyces pombe 24.50 1.00e-04 39.30
IUUC-Ssl-108672 Sclerotinia sclerotiorum 28.91 8.00e-13 66.60
IUUC-Smo-108973 Selaginella moellendorffii 32.43 2.00e-09 54.30
IUUC-Sit-110117 Setaria italica 30.23 2.00e-03 35.80
IUUC-Sly-111373 Solanum lycopersicum 32.23 7.00e-11 59.70
IUUC-Stu-112512 Solanum tuberosum 28.93 4.00e-09 53.50
IUUC-Sar-113653 Sorex araneus 29.94 4.00e-10 57.00
IUUC-Sbi-114390 Sorghum bicolor 34.15 4.00e-12 63.50
IUUC-Sre-115200 Sporisorium reilianum 33.33 2.00e-10 58.90
IUUC-Ssc-115888 Sus scrofa 29.38 4.00e-10 55.80
IUUC-Tgu-117506 Taeniopygia guttata 26.98 3.00e-12 63.90
IUUC-Tru-118063 Takifugu rubripes 24.80 2.00e-17 81.30
IUUC-Tsy-118851 Tarsius syrichta 29.31 9.00e-09 52.40
IUUC-Tni-120010 Tetraodon nigroviridis 28.35 6.00e-11 59.70
IUUC-Tca-121182 Theobroma cacao 33.33 1.00e-08 52.40
IUUC-Tre-122040 Trichoderma reesei 30.47 1.00e-12 65.90
IUUC-Tvi-122660 Trichoderma virens 27.74 3.00e-12 64.30
IUUC-Tae-124103 Triticum aestivum 33.08 4.00e-12 63.50
IUUC-Tur-126651 Triticum urartu 33.33 4.00e-11 60.10
IUUC-Tme-127184 Tuber melanosporum 35.48 6.00e-16 77.00
IUUC-Tbe-127894 Tupaia belangeri 26.12 6.00e-06 43.10
IUUC-Ttr-128264 Tursiops truncatus 26.19 9.00e-12 62.40
IUUC-Uma-129407 Ustilago maydis 33.33 2.00e-11 62.00
IUUC-Vda-130002 Verticillium dahliae 39.71 7.00e-08 50.10
IUUC-Vpa-130156 Vicugna pacos 26.12 3.00e-10 57.40
IUUC-Vvi-131479 Vitis vinifera 28.93 2.00e-09 55.10
IUUC-Xtr-132332 Xenopus tropicalis 30.48 6.00e-10 54.30
IUUC-Xma-133186 Xiphophorus maculatus 24.25 2.00e-16 77.80
IUUC-Yli-134500 Yarrowia lipolytica 40.58 1.00e-08 51.60
IUUC-Zma-135391 Zea mays 34.15 4.00e-12 63.50
Created Date 25-Jun-2017

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