iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063311

Ensembl Protein ID

ENSMUSP00000040321.6

UniProt Accession

Q925E7; Q6ZPN5; 2ABD_MOUSE

Genbank Protein ID

AAK53703.1; BAC98196.2; AAH66022.1

Protein Name

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; PP2A subunit B isoform B55-delta; PP2A subunit B isoform PR55-delta; PP2A subunit B isoform R2-delta; PP2A subunit B isoform delta

Genbank Nucleotide ID

AF366393; AK129386; BC066022

Gene Name

Ppp2r2d; D7Ertd753e; Kiaa1541

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000041769.13	ENSMUST00000041097.12	ENSMUSP00000040321.6
ENSMUSG00000041769.13	ENSMUST00000148453.7	ENSMUSP00000119183.1
ENSMUSG00000041769.13	ENSMUST00000136824.7	ENSMUSP00000133380.1
ENSMUSG00000041769.13	ENSMUST00000172764.1	ENSMUSP00000133810.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-10	42.4	101	130

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 5    svtclaf...sd.tllvsGsdDgtikvWDl 30
           +++ +++   ++  +++ +++D+tik+W +
   Q: 101  KINKIRWlpqQNaAHFLLSTNDKTIKLWKI 130
           79999***986677788889********85 PP

Organism

Mus musculus

Functional Description
(View)

B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).

Protein Sequence
(Fasta)

MAGAGGGGCP AGGNDFQWCF SQVKGAVDED VAEADIISTV EFNYSGDLLA TGDKGGRVVI 60
FQREQENKGR AHSRGEYNVY STFQSHEPEF DYLKSLEIEE KINKIRWLPQ QNAAHFLLST 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCCTTCGA GCATCCAGTC CAGCCGGCCG CAGAAGAAAG TCTGAGGCCT TAAGAACGTA 60
GAGGGCGTCG CGTCCTAGCC TTGACACGAC TCGAGAAGGC CGCCTCTATC TGCCAGCGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR000009--PP2A_PR55
IPR018067--PP2A_PR55_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS01024--PR55_1
PS01025--PR55_2

PRINTS

PR00600--PP2APR55

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0000159--C:protein phosphatase type 2A complex
GO:0019888--F:protein phosphatase regulator activity
GO:0051301--P:cell division
GO:0032502--P:developmental process
GO:0010458--P:exit from mitosis
GO:0000278--P:mitotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0070262--P:peptidyl-serine dephosphorylation

KEGG

mmu:52432

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001982	Ailuropoda melanoleuca	97.39	0.00e+00	823.00
IUUC-Atr-002520	Amborella trichopoda	51.00	1.00e-127	449.00
IUUC-Aca-004276	Anolis carolinensis	96.82	0.00e+00	864.00
IUUC-Ath-007621	Arabidopsis thaliana	51.34	2.00e-133	469.00
IUUC-Acl-008202	Aspergillus clavatus	56.37	1.00e-132	466.00
IUUC-Afl-008646	Aspergillus flavus	56.03	2.00e-133	469.00
IUUC-Afu-009027	Aspergillus fumigatus	56.37	1.00e-133	469.00
IUUC-Ani-009191	Aspergillus nidulans	56.68	6.00e-135	474.00
IUUC-Ang-009769	Aspergillus niger	56.41	5.00e-136	477.00
IUUC-Ate-010549	Aspergillus terreus	56.40	1.00e-132	466.00
IUUC-Bci-013801	Botrytis cinerea	55.00	3.00e-138	484.00
IUUC-Cja-019573	Callithrix jacchus	97.14	0.00e+00	797.00
IUUC-Cfa-021111	Canis familiaris	98.10	0.00e+00	830.00
IUUC-Cpo-022206	Cavia porcellus	98.86	0.00e+00	881.00
IUUC-Cre-022876	Chlamydomonas reinhardtii	53.26	3.00e-133	468.00
IUUC-Csv-026097	Ciona savignyi	78.85	0.00e+00	705.00
IUUC-Cgl-026750	Colletotrichum gloeosporioides	54.89	3.00e-134	471.00
IUUC-Dno-028876	Dasypus novemcinctus	95.91	0.00e+00	861.00
IUUC-Dor-030390	Dipodomys ordii	92.14	0.00e+00	771.00
IUUC-Dse-031305	Dothistroma septosporum	56.57	8.00e-136	477.00
IUUC-Dme-032131	Drosophila melanogaster	80.18	0.00e+00	724.00
IUUC-Fal-037650	Ficedula albicollis	90.91	0.00e+00	821.00
IUUC-Fox-037988	Fusarium oxysporum	55.93	8.00e-134	470.00
IUUC-Fso-038460	Fusarium solani	55.27	1.00e-134	473.00
IUUC-Gmo-039380	Gadus morhua	93.86	0.00e+00	843.00
IUUC-Ggr-039883	Gaeumannomyces graminis	55.56	8.00e-136	477.00
IUUC-Gga-040518	Gallus gallus	97.05	0.00e+00	865.00
IUUC-Gac-042418	Gasterosteus aculeatus	94.09	0.00e+00	841.00
IUUC-Ggo-044426	Gorilla gorilla	97.38	0.00e+00	800.00
IUUC-Hsa-045992	Homo sapiens	97.27	0.00e+00	843.00
IUUC-Itr-048097	Ictidomys tridecemlineatus	96.91	0.00e+00	821.00
IUUC-Lch-050206	Latimeria chalumnae	95.45	0.00e+00	858.00
IUUC-Loc-052535	Lepisosteus oculatus	95.68	0.00e+00	857.00
IUUC-Lma-053162	Leptosphaeria maculans	55.31	1.00e-133	469.00
IUUC-Laf-054373	Loxodonta africana	96.90	0.00e+00	823.00
IUUC-Mcc-054713	Macaca mulatta	97.50	0.00e+00	843.00
IUUC-Meu-056756	Macropus eugenii	89.76	0.00e+00	746.00
IUUC-Mor-057270	Magnaporthe oryzae	55.60	2.00e-135	476.00
IUUC-Mpo-057327	Magnaporthe poae	55.77	5.00e-136	477.00
IUUC-Mla-059127	Melampsora laricipopulina	56.92	3.00e-149	521.00
IUUC-Mga-059678	Meleagris gallopavo	96.67	0.00e+00	821.00
IUUC-Mmr-061468	Microcebus murinus	97.50	0.00e+00	874.00
IUUC-Mac-065244	Musa acuminata	50.92	1.00e-127	449.00
IUUC-Mpu-066766	Mustela putorius furo	95.95	0.00e+00	818.00
IUUC-Mlu-066933	Myotis lucifugus	96.82	0.00e+00	864.00
IUUC-Nfi-068532	Neosartorya fischeri	56.37	1.00e-133	469.00
IUUC-Ncr-068905	Neurospora crassa	56.28	9.00e-137	480.00
IUUC-Nle-069157	Nomascus leucogenys	97.62	0.00e+00	798.00
IUUC-Ont-072224	Oreochromis niloticus	94.55	0.00e+00	847.00
IUUC-Oba-075715	Oryza barthii	51.22	6.00e-134	471.00
IUUC-Opu-083739	Oryza punctata	52.23	6.00e-136	477.00
IUUC-Olu-087882	Ostreococcus lucimarinus	50.51	2.00e-128	452.00
IUUC-Oga-088573	Otolemur garnettii	96.67	0.00e+00	821.00
IUUC-Ptr-090847	Pan troglodytes	97.38	0.00e+00	800.00
IUUC-Pan-092846	Papio anubis	97.50	0.00e+00	842.00
IUUC-Psi-093292	Pelodiscus sinensis	97.26	0.00e+00	865.00
IUUC-Pma-094603	Petromyzon marinus	88.66	6.00e-100	356.00
IUUC-Pno-094992	Phaeosphaeria nodorum	56.63	8.00e-136	477.00
IUUC-Pfo-097231	Poecilia formosa	94.55	0.00e+00	848.00
IUUC-Pab-098445	Pongo abelii	97.62	0.00e+00	800.00
IUUC-Pte-104403	Pyrenophora teres	55.65	2.00e-135	475.00
IUUC-Pyt-104776	Pyrenophora triticirepentis	55.99	3.00e-134	471.00
IUUC-Rno-105189	Rattus norvegicus	99.77	0.00e+00	889.00
IUUC-Sce-106284	Saccharomyces cerevisiae	56.32	1.00e-119	423.00
IUUC-Sha-107195	Sarcophilus harrisii	95.07	0.00e+00	789.00
IUUC-Sja-107757	Schizosaccharomyces japonicus	57.62	9.00e-139	486.00
IUUC-Spo-108186	Schizosaccharomyces pombe	56.96	7.00e-136	477.00
IUUC-Smo-109077	Selaginella moellendorffii	53.04	2.00e-134	472.00
IUUC-Tru-118028	Takifugu rubripes	94.32	0.00e+00	845.00
IUUC-Tni-119681	Tetraodon nigroviridis	94.32	0.00e+00	845.00
IUUC-Tre-122188	Trichoderma reesei	56.26	3.00e-133	468.00
IUUC-Tvi-122271	Trichoderma virens	56.00	1.00e-134	473.00
IUUC-Tae-124558	Triticum aestivum	50.71	5.00e-131	461.00
IUUC-Tbe-127340	Tupaia belangeri	93.33	0.00e+00	781.00
IUUC-Ttr-129227	Tursiops truncatus	94.76	0.00e+00	808.00
IUUC-Vda-130007	Verticillium dahliae	55.23	1.00e-134	473.00
IUUC-Xma-133068	Xiphophorus maculatus	94.77	0.00e+00	849.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence