iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	9822580

Classification

Family	E-value	Score	Start	End
E2/UBC	9.20e-48	161.6	8	149

Active Site

Position(s)	Description	Evidence
93	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdppegisakpvdesd....ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWsp 94
           Rl +e k+++kd+p g++a+p ++ d    l+ we++i G++ tp+egg++kl++ f++dYP++PPk+kf+ ++fhPnvy++G+vCls+l+ee++W+p
   Q: 8    RLGEERKAWRKDHPFGFVARPAKNPDgtlnLMIWECAIPGKKSTPWEGGLYKLRMIFKDDYPTSPPKCKFEPPLFHPNVYPSGTVCLSLLDEEKDWRP 105
           8899******************99888888******************************************************************** PP
   S: 95   alsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           a++++++ll+iq ll+epn+++p+++ea++++++nr ey+k+vr
   Q: 106  AITIKQILLGIQDLLNEPNIKDPAQAEAYTIYCQNRLEYEKRVR 149
           ******************************************98 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MSGIAITRLG EERKAWRKDH PFGFVARPAK NPDGTLNLMI WECAIPGKKS TPWEGGLYKL 60
RMIFKDDYPT SPPKCKFEPP LFHPNVYPSG TVCLSLLDEE KDWRPAITIK QILLGIQDLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTTTGTGT AGAAAAACTT ATACCTTTAG CGAGCACAAG CGTTCATTCC TGAAAAATTG 60
CGGTAAAAAT TGCGAAAAGC GCGAGTTCCC CCCGCGATTG CAAATAATTA ATTTGCTTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR027230--Ubc9
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0000940--C:condensed chromosome outer kinetochore
GO:0000780--C:condensed nuclear chromosome, centromeric region
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0031072--F:heat shock protein binding
GO:0061665--F:SUMO ligase activity
GO:0019789--F:SUMO transferase activity
GO:0008134--F:transcription factor binding
GO:0033134--F:ubiquitin activating enzyme binding
GO:0006464--P:cellular protein modification process
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0007391--P:dorsal closure
GO:0016321--P:female meiosis chromosome segregation
GO:0007143--P:female meiotic division
GO:0008354--P:germ cell migration
GO:0035172--P:hemocyte proliferation
GO:0006959--P:humoral immune response
GO:0007095--P:mitotic G2 DNA damage checkpoint
GO:0035207--P:negative regulation of hemocyte proliferation
GO:0035204--P:negative regulation of lamellocyte differentiation
GO:0045751--P:negative regulation of Toll signaling pathway
GO:0006606--P:protein import into nucleus
GO:0016925--P:protein sumoylation
GO:0030721--P:spectrosome organization
GO:0007352--P:zygotic specification of dorsal/ventral axis

KEGG

dme:Dmel_CG3018

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000510	Aegilops tauschii	60.75	2.00e-37	147.00
IUUC-Aml-002383	Ailuropoda melanoleuca	85.44	3.00e-82	296.00
IUUC-Atr-002982	Amborella trichopoda	62.50	1.00e-48	184.00
IUUC-Apl-003840	Anas platyrhynchos	85.44	3.00e-82	296.00
IUUC-Aca-004772	Anolis carolinensis	85.44	3.00e-82	296.00
IUUC-Aly-005652	Arabidopsis lyrata	62.18	6.00e-59	218.00
IUUC-Ath-007084	Arabidopsis thaliana	62.18	6.00e-59	218.00
IUUC-Ago-007998	Ashbya gossypii	55.77	1.00e-51	194.00
IUUC-Acl-008040	Aspergillus clavatus	63.87	8.00e-51	191.00
IUUC-Afl-008563	Aspergillus flavus	65.31	3.00e-50	189.00
IUUC-Afu-008873	Aspergillus fumigatus	65.28	3.00e-48	183.00
IUUC-Ani-009222	Aspergillus nidulans	65.31	1.00e-49	187.00
IUUC-Ang-009740	Aspergillus niger	67.59	1.00e-49	187.00
IUUC-Aor-010170	Aspergillus oryzae	65.99	1.00e-50	191.00
IUUC-Ate-010410	Aspergillus terreus	66.45	4.00e-52	195.00
IUUC-Ame-011711	Astyanax mexicanus	85.44	1.00e-81	293.00
IUUC-Bgr-012012	Blumeria graminis	59.44	1.00e-49	187.00
IUUC-Bta-013269	Bos taurus	85.44	3.00e-82	296.00
IUUC-Bci-013748	Botrytis cinerea	62.59	2.00e-47	180.00
IUUC-Bdi-014883	Brachypodium distachyon	61.54	1.00e-57	214.00
IUUC-Bol-016125	Brassica oleracea	63.16	8.00e-50	188.00
IUUC-Bra-017235	Brassica rapa	63.16	8.00e-50	188.00
IUUC-Cel-018448	Caenorhabditis elegans	77.71	6.00e-75	271.00
IUUC-Cja-019349	Callithrix jacchus	85.44	3.00e-82	296.00
IUUC-Cfa-021008	Canis familiaris	85.71	1.00e-58	217.00
IUUC-Cpo-021324	Cavia porcellus	85.44	3.00e-82	296.00
IUUC-Cre-022836	Chlamydomonas reinhardtii	61.84	3.00e-56	209.00
IUUC-Csa-024207	Chlorocebus sabaeus	85.44	3.00e-82	296.00
IUUC-Cin-025734	Ciona intestinalis	79.25	6.00e-77	278.00
IUUC-Csv-026049	Ciona savignyi	79.25	5.00e-76	275.00
IUUC-Cgl-026699	Colletotrichum gloeosporioides	64.58	2.00e-56	210.00
IUUC-Cne-027034	Cryptococcus neoformans	66.45	8.00e-62	228.00
IUUC-Cme-027203	Cyanidioschyzon merolae	57.89	1.00e-47	181.00
IUUC-Dre-027701	Danio rerio	85.90	8.00e-82	294.00
IUUC-Dno-030037	Dasypus novemcinctus	85.44	3.00e-82	296.00
IUUC-Dor-030622	Dipodomys ordii	86.13	5.00e-71	258.00
IUUC-Dse-031366	Dothistroma septosporum	65.99	4.00e-57	212.00
IUUC-Ete-032517	Echinops telfairi	87.59	3.00e-72	262.00
IUUC-Eca-033789	Equus caballus	85.44	3.00e-82	296.00
IUUC-Fca-035851	Felis catus	85.44	3.00e-82	296.00
IUUC-Fal-037177	Ficedula albicollis	85.44	3.00e-82	296.00
IUUC-Fox-037789	Fusarium oxysporum	64.90	1.00e-58	217.00
IUUC-Fso-038166	Fusarium solani	64.90	8.00e-58	214.00
IUUC-Gmo-039482	Gadus morhua	84.81	6.00e-82	295.00
IUUC-Ggr-039892	Gaeumannomyces graminis	68.89	3.00e-56	210.00
IUUC-Gga-041199	Gallus gallus	85.44	3.00e-82	296.00
IUUC-Gac-042250	Gasterosteus aculeatus	84.81	6.00e-82	295.00
IUUC-Gma-043827	Glycine max	64.05	1.00e-59	220.00
IUUC-Ggo-045530	Gorilla gorilla	85.44	3.00e-82	296.00
IUUC-Hsa-046248	Homo sapiens	85.44	3.00e-82	296.00
IUUC-Hvu-047363	Hordeum vulgare	60.90	8.00e-57	211.00
IUUC-Itr-048429	Ictidomys tridecemlineatus	85.44	3.00e-82	296.00
IUUC-Kpa-049362	Komagataella pastoris	59.87	6.00e-54	202.00
IUUC-Lch-050202	Latimeria chalumnae	86.08	2.00e-82	296.00
IUUC-Lpe-051643	Leersia perrieri	63.82	1.00e-58	218.00
IUUC-Loc-052357	Lepisosteus oculatus	84.81	6.00e-82	295.00
IUUC-Lma-053142	Leptosphaeria maculans	59.74	5.00e-57	212.00
IUUC-Laf-053577	Loxodonta africana	85.44	3.00e-82	296.00
IUUC-Mcc-054925	Macaca mulatta	85.44	3.00e-82	296.00
IUUC-Meu-056094	Macropus eugenii	71.53	6.00e-54	201.00
IUUC-Mor-057141	Magnaporthe oryzae	60.65	7.00e-59	218.00
IUUC-Mpo-057613	Magnaporthe poae	68.15	3.00e-55	206.00
IUUC-Mtr-058465	Medicago truncatula	65.36	1.00e-61	228.00
IUUC-Mla-059115	Melampsora laricipopulina	67.72	2.00e-64	237.00
IUUC-Mga-059384	Meleagris gallopavo	85.44	3.00e-82	296.00
IUUC-Mvi-060328	Microbotryum violaceum	64.47	2.00e-48	183.00
IUUC-Mmr-061541	Microcebus murinus	85.44	3.00e-82	296.00
IUUC-Mdo-062540	Monodelphis domestica	85.44	3.00e-82	296.00
IUUC-Mmu-063818	Mus musculus	85.44	3.00e-82	296.00
IUUC-Mac-065019	Musa acuminata	62.50	1.00e-57	214.00
IUUC-Mpu-065734	Mustela putorius furo	85.44	3.00e-82	296.00
IUUC-Mlu-067619	Myotis lucifugus	85.44	3.00e-82	296.00
IUUC-Nfi-068567	Neosartorya fischeri	63.87	2.00e-51	193.00
IUUC-Ncr-068897	Neurospora crassa	67.10	4.00e-61	226.00
IUUC-Nle-069541	Nomascus leucogenys	85.35	1.00e-81	293.00
IUUC-Ont-071585	Oreochromis niloticus	84.81	6.00e-82	295.00
IUUC-Oan-073178	Ornithorhynchus anatinus	84.21	3.00e-37	144.00
IUUC-Ocu-074588	Oryctolagus cuniculus	78.48	1.00e-72	263.00
IUUC-Oba-075803	Oryza barthii	62.82	2.00e-58	216.00
IUUC-Obr-076591	Oryza brachyantha	62.18	1.00e-58	217.00
IUUC-Ogl-077864	Oryza glaberrima	62.82	2.00e-58	216.00
IUUC-Ogu-077979	Oryza glumaepatula	62.18	2.00e-58	217.00
IUUC-Oin-080163	Oryza indica	62.82	2.00e-58	216.00
IUUC-Olo-080940	Oryza longistaminata	55.92	1.00e-48	184.00
IUUC-Ome-081909	Oryza meridionalis	62.18	2.00e-58	217.00
IUUC-Oni-082410	Oryza nivara	62.82	2.00e-58	216.00
IUUC-Opu-083206	Oryza punctata	63.16	1.00e-57	214.00
IUUC-Oru-084706	Oryza rufipogon	62.82	2.00e-58	216.00
IUUC-Osa-086079	Oryza sativa	62.82	2.00e-58	216.00
IUUC-Ola-086314	Oryzias latipes	84.81	3.00e-81	293.00
IUUC-Olu-087715	Ostreococcus lucimarinus	51.59	6.00e-47	179.00
IUUC-Oga-088729	Otolemur garnettii	87.59	2.00e-72	263.00
IUUC-Oar-090221	Ovis aries	85.44	6.00e-82	295.00
IUUC-Ptr-090528	Pan troglodytes	85.44	3.00e-82	296.00
IUUC-Pan-092834	Papio anubis	85.44	3.00e-82	296.00
IUUC-Psi-093001	Pelodiscus sinensis	85.44	3.00e-82	296.00
IUUC-Pma-094539	Petromyzon marinus	86.08	2.00e-82	296.00
IUUC-Pno-094954	Phaeosphaeria nodorum	62.00	7.00e-56	208.00
IUUC-Ppa-095314	Physcomitrella patens	63.16	7.00e-58	215.00
IUUC-Pfo-097457	Poecilia formosa	84.81	9.00e-82	294.00
IUUC-Pab-098205	Pongo abelii	85.44	3.00e-82	296.00
IUUC-Pop-099063	Populus trichocarpa	63.82	7.00e-59	218.00
IUUC-Pca-100603	Procavia capensis	87.59	6.00e-72	262.00
IUUC-Ppe-101501	Prunus persica	64.47	1.00e-49	187.00
IUUC-Pva-103251	Pteropus vampyrus	70.07	2.00e-52	197.00
IUUC-Pte-104067	Pyrenophora teres	57.42	1.00e-55	207.00
IUUC-Pyt-104436	Pyrenophora triticirepentis	57.42	5.00e-56	208.00
IUUC-Rno-105794	Rattus norvegicus	85.44	3.00e-82	296.00
IUUC-Sce-106308	Saccharomyces cerevisiae	53.85	2.00e-51	193.00
IUUC-Sha-106997	Sarcophilus harrisii	78.75	7.00e-74	268.00
IUUC-Sja-108000	Schizosaccharomyces japonicus	71.97	9.00e-59	218.00
IUUC-Spo-108311	Schizosaccharomyces pombe	69.23	2.00e-56	209.00
IUUC-Smo-108685	Selaginella moellendorffii	63.82	1.00e-49	187.00
IUUC-Sit-109792	Setaria italica	62.82	1.00e-58	217.00
IUUC-Sly-111718	Solanum lycopersicum	63.46	1.00e-53	201.00
IUUC-Stu-111975	Solanum tuberosum	65.38	1.00e-54	204.00
IUUC-Sbi-114672	Sorghum bicolor	62.82	1.00e-58	217.00
IUUC-Sre-114957	Sporisorium reilianum	71.52	9.00e-68	248.00
IUUC-Ssc-116173	Sus scrofa	85.44	3.00e-82	296.00
IUUC-Tgu-116668	Taeniopygia guttata	85.44	3.00e-82	295.00
IUUC-Tru-118365	Takifugu rubripes	84.18	8.00e-81	291.00
IUUC-Tni-120455	Tetraodon nigroviridis	84.18	2.00e-80	290.00
IUUC-Tca-120956	Theobroma cacao	63.16	3.00e-57	213.00
IUUC-Tre-121927	Trichoderma reesei	63.23	4.00e-59	219.00
IUUC-Tvi-122363	Trichoderma virens	63.87	7.00e-59	218.00
IUUC-Tae-125311	Triticum aestivum	62.18	3.00e-58	216.00
IUUC-Tur-126625	Triticum urartu	61.54	9.00e-58	214.00
IUUC-Tme-126981	Tuber melanosporum	56.05	3.00e-39	152.00
IUUC-Ttr-128280	Tursiops truncatus	90.80	7.00e-46	174.00
IUUC-Uma-129582	Ustilago maydis	72.44	3.00e-67	246.00
IUUC-Vda-129845	Verticillium dahliae	65.81	7.00e-61	224.00
IUUC-Vpa-130242	Vicugna pacos	87.59	4.00e-72	262.00
IUUC-Vvi-130948	Vitis vinifera	63.16	9.00e-58	214.00
IUUC-Xtr-132540	Xenopus tropicalis	85.44	4.00e-82	295.00
IUUC-Xma-133010	Xiphophorus maculatus	84.81	9.00e-82	294.00
IUUC-Yli-134673	Yarrowia lipolytica	54.67	1.00e-50	190.00
IUUC-Zma-135055	Zea mays	62.82	8.00e-59	218.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence