iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021688

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02020673

Gene Name

USP14

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000000958.3	ENSCPOT00000000964.2	ENSCPOP00000000860.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.10e-65	221.1	107	481
ULD/UDP/UBQ/UBQ_Other	1.90e-08	34.0	6	76

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.... 85
           +Gl+NlgNtCYmN+++Qc+ ++pel+++l++ +  +l+++ +  + + ++ +l++lf ++ +++++++ p  ll+ l+++ ++f     
   Q: 107  CGLTNLGNTCYMNATVQCIRSVPELKDALKR-YAGALRASGEMASAQYITAALRDLFDSM-DKTSSSIPPIILLQFLHMAFPQFAekge 193
           7******************************.****************************.99999******************999*9 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             +y qqDa+E++ +++  l+++l+          e+++ +e++++a+  +++k+ksli++ F++++++++kc e +++ +++ + ++l
   Q: 194  qgQYLQQDANECWIQMMRVLQQKLEA--------IEDDSVKETDSSAPAVTPTKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQL 274
           999*********************44........4444444556778999***************************999999888888 PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+   ++e   + l   L+   +ee  +     ++++ +++    k+ k+++lP +L++++ Rf ++e+++++ k+ k v+fpl+Ld+
   Q: 275  QLSCFINQEV--KYLFTGLKLRLQEEITK-----QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDV 356
           8888877754..58999999999999998.....58899999999******************************************** PP
   S: 262  spfcts........................peekqke...........................kkkYeLiavvvHsG.slssGHYvay 298
            + ct                         p     +                           +  Y+L av+ H+G s+ssGHYv++
   Q: 357  YELCTPelqekmvsfrskfkdiedkkvnqqP-----NtgdkksspqkevkyepfsfaddigsnnCGYYDLQAVLTHQGrSSSSGHYVSW 440
           ******6666666666666666555555551.....0555556666667777777777777777************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetg....staYvlfY 335
           vk ++++W++fdD+kV+ v+ e++l+ +g    + aYvl+Y
   Q: 441  VKRKQDEWIKFDDDKVSIVTPEDILRLSGggdwHIAYVLLY 481
           **************************988************ PP

ULD/UDP/UBQ/UBQ_Other

   S: 3    vtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdgstihllek 72
           vtvk+ + +  ++++n +++  ++K +++ ++g++p++q+ ++kG  L + d+++++ ++k g+t++++ +
   Q: 6    VTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLkKQDDDWGNIKIKTGMTLLMMGS 76
           89*******99*************************************99999***************965 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

LILFAVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKKQDDDW 60
GNIKIKTGMT LLMMGSADAL PEEPTAKTVF VEDMTEEQLA SAMELPCGLT NLGNTCYMNA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGATTTTGT TTGCAGTTAC TGTAAAATGG GGAAAGGAGA AGTTCGAAGG CGTGGAATTG 60
AATACTGATG AACCTCCAAT GGTGTTCAAG GCACAGCTGT TTGCGCTGAC TGGAGTCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0009986--C:cell surface
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0045202--C:synapse
GO:0004866--F:endopeptidase inhibitor activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007268--P:chemical synaptic transmission
GO:1903070--P:negative regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0050920--P:regulation of chemotaxis
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	43.48	3.00e-38	152.00
IUUC-Aml-002053	Ailuropoda melanoleuca	95.97	0.00e+00	927.00
IUUC-Atr-002725	Amborella trichopoda	42.05	2.00e-101	362.00
IUUC-Apl-004031	Anas platyrhynchos	90.51	0.00e+00	895.00
IUUC-Aca-004361	Anolis carolinensis	88.28	0.00e+00	901.00
IUUC-Aly-006176	Arabidopsis lyrata	42.48	2.00e-110	392.00
IUUC-Ath-007623	Arabidopsis thaliana	41.60	8.00e-111	394.00
IUUC-Ago-007796	Ashbya gossypii	32.15	3.00e-58	219.00
IUUC-Acl-008258	Aspergillus clavatus	37.41	2.00e-65	243.00
IUUC-Afl-008732	Aspergillus flavus	33.45	9.00e-77	281.00
IUUC-Afu-008755	Aspergillus fumigatus	34.83	1.00e-79	290.00
IUUC-Ani-009148	Aspergillus nidulans	39.60	1.00e-70	261.00
IUUC-Ang-009878	Aspergillus niger	37.97	1.00e-65	244.00
IUUC-Aor-010239	Aspergillus oryzae	33.10	7.00e-73	268.00
IUUC-Ate-010243	Aspergillus terreus	33.86	1.00e-69	257.00
IUUC-Ame-011327	Astyanax mexicanus	51.20	7.00e-128	450.00
IUUC-Bgr-012231	Blumeria graminis	33.80	1.00e-75	276.00
IUUC-Bta-012553	Bos taurus	96.15	0.00e+00	940.00
IUUC-Bci-013606	Botrytis cinerea	40.21	5.00e-70	258.00
IUUC-Bdi-014567	Brachypodium distachyon	43.15	2.00e-112	399.00
IUUC-Bol-016127	Brassica oleracea	42.40	2.00e-112	399.00
IUUC-Bra-017501	Brassica rapa	42.20	1.00e-111	396.00
IUUC-Cel-018140	Caenorhabditis elegans	41.83	1.00e-99	356.00
IUUC-Cja-019516	Callithrix jacchus	96.37	0.00e+00	941.00
IUUC-Cfa-020808	Canis familiaris	97.37	0.00e+00	950.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	37.88	6.00e-81	294.00
IUUC-Csa-023429	Chlorocebus sabaeus	95.94	0.00e+00	922.00
IUUC-Cho-024347	Choloepus hoffmanni	96.35	0.00e+00	940.00
IUUC-Cin-025198	Ciona intestinalis	54.90	2.00e-152	531.00
IUUC-Csv-026007	Ciona savignyi	52.92	3.00e-152	531.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	39.21	5.00e-64	238.00
IUUC-Cne-026963	Cryptococcus neoformans	35.46	1.00e-76	280.00
IUUC-Cme-027240	Cyanidioschyzon merolae	30.69	2.00e-59	223.00
IUUC-Dre-027647	Danio rerio	82.00	0.00e+00	827.00
IUUC-Dno-029967	Dasypus novemcinctus	94.94	0.00e+00	917.00
IUUC-Dor-030886	Dipodomys ordii	90.68	0.00e+00	763.00
IUUC-Dse-031466	Dothistroma septosporum	36.00	4.00e-58	219.00
IUUC-Dme-032079	Drosophila melanogaster	55.46	9.00e-157	546.00
IUUC-Ete-032351	Echinops telfairi	85.19	0.00e+00	846.00
IUUC-Eca-033461	Equus caballus	96.37	0.00e+00	990.00
IUUC-Eeu-035220	Erinaceus europaeus	73.47	0.00e+00	686.00
IUUC-Fca-036210	Felis catus	97.57	0.00e+00	950.00
IUUC-Fal-037528	Ficedula albicollis	90.43	0.00e+00	869.00
IUUC-Fox-037805	Fusarium oxysporum	39.16	6.00e-69	254.00
IUUC-Fso-038177	Fusarium solani	37.86	5.00e-67	248.00
IUUC-Gmo-038953	Gadus morhua	78.16	0.00e+00	764.00
IUUC-Ggr-039972	Gaeumannomyces graminis	38.83	2.00e-63	236.00
IUUC-Gga-040462	Gallus gallus	90.06	0.00e+00	882.00
IUUC-Gac-041312	Gasterosteus aculeatus	81.07	0.00e+00	798.00
IUUC-Gma-043255	Glycine max	43.03	7.00e-109	387.00
IUUC-Ggo-045458	Gorilla gorilla	81.56	0.00e+00	788.00
IUUC-Hsa-045706	Homo sapiens	96.15	0.00e+00	926.00
IUUC-Hvu-047821	Hordeum vulgare	46.08	2.00e-56	211.00
IUUC-Itr-048654	Ictidomys tridecemlineatus	95.14	0.00e+00	945.00
IUUC-Lch-050464	Latimeria chalumnae	81.95	0.00e+00	822.00
IUUC-Lpe-051419	Leersia perrieri	42.12	9.00e-108	383.00
IUUC-Loc-052732	Lepisosteus oculatus	81.14	0.00e+00	837.00
IUUC-Lma-053177	Leptosphaeria maculans	40.52	6.00e-70	258.00
IUUC-Laf-053822	Loxodonta africana	96.77	0.00e+00	948.00
IUUC-Mcc-055893	Macaca mulatta	96.15	0.00e+00	923.00
IUUC-Meu-056307	Macropus eugenii	80.89	0.00e+00	793.00
IUUC-Mor-057171	Magnaporthe oryzae	38.40	1.00e-66	247.00
IUUC-Mpo-057415	Magnaporthe poae	39.34	2.00e-70	259.00
IUUC-Mtr-057901	Medicago truncatula	43.00	2.00e-112	399.00
IUUC-Mla-058897	Melampsora laricipopulina	38.89	7.00e-75	274.00
IUUC-Mga-060016	Meleagris gallopavo	90.30	0.00e+00	892.00
IUUC-Mvi-060562	Microbotryum violaceum	38.77	5.00e-67	248.00
IUUC-Mmr-060624	Microcebus murinus	96.15	0.00e+00	986.00
IUUC-Mdo-061809	Monodelphis domestica	92.34	0.00e+00	893.00
IUUC-Mmu-063869	Mus musculus	95.55	0.00e+00	933.00
IUUC-Mac-064876	Musa acuminata	39.47	1.00e-95	343.00
IUUC-Mpu-066480	Mustela putorius furo	96.96	0.00e+00	946.00
IUUC-Mlu-067866	Myotis lucifugus	95.77	0.00e+00	952.00
IUUC-Nfi-068393	Neosartorya fischeri	36.85	8.00e-66	244.00
IUUC-Ncr-068815	Neurospora crassa	36.35	2.00e-83	302.00
IUUC-Nle-070121	Nomascus leucogenys	96.05	4.00e-135	473.00
IUUC-Opr-070712	Ochotona princeps	77.80	1.00e-177	615.00
IUUC-Ont-071544	Oreochromis niloticus	81.63	0.00e+00	765.00
IUUC-Oan-073635	Ornithorhynchus anatinus	91.57	0.00e+00	756.00
IUUC-Ocu-074926	Oryctolagus cuniculus	96.55	0.00e+00	922.00
IUUC-Oba-075633	Oryza barthii	42.41	5.00e-108	384.00
IUUC-Obr-076423	Oryza brachyantha	42.24	7.00e-112	397.00
IUUC-Ogl-077913	Oryza glaberrima	42.24	3.00e-110	391.00
IUUC-Ogu-078435	Oryza glumaepatula	42.41	5.00e-108	384.00
IUUC-Oin-080072	Oryza indica	42.36	3.00e-108	385.00
IUUC-Olo-080535	Oryza longistaminata	39.03	9.00e-92	330.00
IUUC-Ome-081309	Oryza meridionalis	42.41	5.00e-108	384.00
IUUC-Oni-083113	Oryza nivara	42.41	5.00e-108	384.00
IUUC-Opu-083168	Oryza punctata	41.58	1.00e-103	369.00
IUUC-Oru-084253	Oryza rufipogon	42.41	5.00e-108	384.00
IUUC-Osa-085554	Oryza sativa	42.24	3.00e-110	392.00
IUUC-Ola-086998	Oryzias latipes	80.69	0.00e+00	789.00
IUUC-Olu-087818	Ostreococcus lucimarinus	36.31	2.00e-71	263.00
IUUC-Oga-088571	Otolemur garnettii	96.75	0.00e+00	948.00
IUUC-Oar-089526	Ovis aries	96.76	0.00e+00	944.00
IUUC-Ptr-091433	Pan troglodytes	96.15	0.00e+00	923.00
IUUC-Pan-091966	Papio anubis	95.94	0.00e+00	922.00
IUUC-Psi-093458	Pelodiscus sinensis	88.60	0.00e+00	845.00
IUUC-Pma-094343	Petromyzon marinus	68.86	6.00e-119	419.00
IUUC-Pno-095109	Phaeosphaeria nodorum	39.14	3.00e-65	242.00
IUUC-Ppa-095756	Physcomitrella patens	44.14	5.00e-111	394.00
IUUC-Pfo-096514	Poecilia formosa	82.04	0.00e+00	780.00
IUUC-Pab-098477	Pongo abelii	85.59	0.00e+00	735.00
IUUC-Pop-099221	Populus trichocarpa	40.92	2.00e-102	366.00
IUUC-Pca-100791	Procavia capensis	80.65	2.00e-180	625.00
IUUC-Ppe-101812	Prunus persica	41.57	6.00e-107	380.00
IUUC-Pva-102462	Pteropus vampyrus	92.54	0.00e+00	772.00
IUUC-Pgr-103623	Puccinia graminis	40.97	2.00e-75	276.00
IUUC-Ptt-103767	Puccinia triticina	39.70	4.00e-68	252.00
IUUC-Pte-104109	Pyrenophora teres	40.76	6.00e-70	258.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	41.39	3.00e-70	259.00
IUUC-Rno-105351	Rattus norvegicus	93.93	0.00e+00	887.00
IUUC-Sce-106168	Saccharomyces cerevisiae	32.34	2.00e-62	233.00
IUUC-Sha-107491	Sarcophilus harrisii	92.73	0.00e+00	912.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	33.93	2.00e-78	285.00
IUUC-Spo-108174	Schizosaccharomyces pombe	37.52	3.00e-81	295.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	34.70	1.00e-83	303.00
IUUC-Smo-108805	Selaginella moellendorffii	43.87	2.00e-108	385.00
IUUC-Sit-110361	Setaria italica	42.97	6.00e-113	401.00
IUUC-Sly-110965	Solanum lycopersicum	40.58	2.00e-107	382.00
IUUC-Sar-113355	Sorex araneus	84.58	0.00e+00	667.00
IUUC-Sbi-114778	Sorghum bicolor	43.88	9.00e-114	403.00
IUUC-Sre-115011	Sporisorium reilianum	36.44	3.00e-62	233.00
IUUC-Ssc-116273	Sus scrofa	96.55	0.00e+00	932.00
IUUC-Tgu-117063	Taeniopygia guttata	89.86	0.00e+00	869.00
IUUC-Tru-118381	Takifugu rubripes	79.27	0.00e+00	789.00
IUUC-Tsy-119076	Tarsius syrichta	81.42	6.00e-119	420.00
IUUC-Tni-119941	Tetraodon nigroviridis	80.57	0.00e+00	780.00
IUUC-Tca-121246	Theobroma cacao	41.49	6.00e-109	387.00
IUUC-Tre-121969	Trichoderma reesei	38.60	3.00e-67	249.00
IUUC-Tvi-122543	Trichoderma virens	33.87	2.00e-76	280.00
IUUC-Tae-125484	Triticum aestivum	42.28	1.00e-109	389.00
IUUC-Tur-126128	Triticum urartu	42.86	4.00e-39	155.00
IUUC-Tbe-128030	Tupaia belangeri	89.80	0.00e+00	849.00
IUUC-Ttr-128701	Tursiops truncatus	96.23	0.00e+00	775.00
IUUC-Uma-129657	Ustilago maydis	36.80	1.00e-64	240.00
IUUC-Vda-129723	Verticillium dahliae	31.46	2.00e-70	259.00
IUUC-Vpa-130284	Vicugna pacos	69.59	0.00e+00	631.00
IUUC-Vvi-131037	Vitis vinifera	42.25	5.00e-108	384.00
IUUC-Xtr-132235	Xenopus tropicalis	85.05	0.00e+00	871.00
IUUC-Xma-133840	Xiphophorus maculatus	82.04	0.00e+00	805.00
IUUC-Yli-134453	Yarrowia lipolytica	36.90	5.00e-82	298.00
IUUC-Zma-135669	Zea mays	36.43	4.00e-95	342.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence