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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Sce-106168
UUCD1 version UUC-SaC-00242
Ensembl Protein ID YFR010W
UniProt Accession P43593; D6VTP0; UBP6_YEAST
Genbank Protein ID BAA09249.1; DAA12450.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 6; Deubiquitinating enzyme 6; Ubiquitin thioesterase 6; Ubiquitin-specific-processing protease 6
Genbank Nucleotide ID D50617; BK006940
Gene Name UBP6; YFR010W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YFR010W YFR010W YFR010W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
BioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 17190603
Classification
Family E-value Score Start End
DUB/USP 2.60e-50 169.9 230 495
Active Site
Position(s) Description Evidence
118 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
447 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP

   S: 143  sdlFqgqlksqikclecdnvs..sreepfldlslpvpgkeetkkeslqdcL.esftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfse 241
    s+ F++q+k++ik + dn +++e+ +l+++++g ++ + l + L e++ k+ l+g+n +y+ + k+++lP++L+++ Rf +++
   Q: 230 SEDFRIQFKTTIKDTANDNDItvKENESDSKLQCHISGTTNFMRNGLLEGLnEKIEKRSDLTGANSIYSVEK----------KISRLPKFLTVQYVRFFWKR 321
    567999*******8888887645777888999999*****9999999999988999999***9998776654..........49****************** PP
   S: 242 eqksrekinkkvefpleLdlspfcts.................peekqke.................................................... 274
    ++++++ki +kv fp +Ld++ ++t + e
   Q: 322 STNKKSKILRKVVFPFQLDVADMLTPeyaaekvkvrdelrkveK-----Eknekereikrrkfdpsssenvmtpreqyetqvalnesekdqwleeykkhfpp 418
    *********************99999555555555555555551.....05555566677777777777777777777777777788888888888888888 PP
   S: 275 ........kkkYeLiavvvHsG.slssGHYvayvkn..ekgkWllfdDskVtevkeeevleetg....staYvlfYk 336
    ++ Y+Li+v+ H+G +++sGHY a++++ +++kW++f+D+kV++v++e++++ g ++a +l+Yk
   Q: 419 nlekgenpSCVYNLIGVITHQGaNSESGHYQAFIRDelDENKWYKFNDDKVSVVEKEKIESLAGggesDSALILMYK 495
    88888888****************************666888*******************888************8 PP
   

Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description



     Predominant proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Has proteasome-inhibitory activity and delays the degradation of ubiquitinated proteins to provide a time window allowing gradual deubiquitination of the substrate. Stabilizes the association of HUL5 with proteasomes and works in opposition to polyubiquitin elongation activity of HUL5.
Predominant proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Has proteasome-inhibitory activity and delays the degradation of ubiquitinated proteins to provide a time window allowing gradual deubiquitination of the substrate. Stabilizes the association of HUL5 with proteasomes and works in opposition to polyubiquitin elongation activity of HUL5.
Protein Sequence
(Fasta)
MSGETFEFNI RHSGKVYPIT LSTDATSADL KSKAEELTQV PSARQKYMVK GGLSGEESIK 60
IYPLIKPGST VMLLGTPDAN LISKPAKKNN FIEDLAPEQQ VQQFAQLPVG FKNMGNTCYL 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Sce-106168|DUB,USP|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGCGGAG AAACGTTTGA GTTCAATATT AGACATTCTG GTAAAGTTTA CCCAATAACA 60
CTTTCCACTG ATGCTACTTC AGCAGATTTG AAAAGCAAAG CAGAGGAATT GACCCAAGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Sce-106168|DUB,USP|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0000502--C:proteasome complex
GO:0005838--C:proteasome regulatory particle
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG sce:YFR010W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000893 Aegilops tauschii 28.05 2.00e-21 95.10
IUUC-Aml-002053 Ailuropoda melanoleuca 32.40 2.00e-59 221.00
IUUC-Atr-002725 Amborella trichopoda 33.00 1.00e-57 215.00
IUUC-Apl-004031 Anas platyrhynchos 32.23 9.00e-59 219.00
IUUC-Aca-004361 Anolis carolinensis 32.94 1.00e-61 228.00
IUUC-Aly-006078 Arabidopsis lyrata 33.40 5.00e-62 229.00
IUUC-Ath-007623 Arabidopsis thaliana 33.26 1.00e-61 228.00
IUUC-Ago-007796 Ashbya gossypii 58.70 6.00e-174 601.00
IUUC-Acl-008258 Aspergillus clavatus 35.84 1.00e-58 218.00
IUUC-Afl-008732 Aspergillus flavus 34.99 4.00e-81 293.00
IUUC-Afu-008755 Aspergillus fumigatus 34.50 2.00e-79 288.00
IUUC-Ani-009148 Aspergillus nidulans 35.05 6.00e-78 282.00
IUUC-Ang-009878 Aspergillus niger 34.68 8.00e-78 282.00
IUUC-Aor-010239 Aspergillus oryzae 34.99 4.00e-81 293.00
IUUC-Ate-010243 Aspergillus terreus 34.59 3.00e-77 280.00
IUUC-Ame-011327 Astyanax mexicanus 50.00 8.00e-15 72.80
IUUC-Bgr-012231 Blumeria graminis 33.33 4.00e-78 283.00
IUUC-Bta-012553 Bos taurus 33.00 6.00e-60 223.00
IUUC-Bci-013606 Botrytis cinerea 34.45 9.00e-84 302.00
IUUC-Bdi-014567 Brachypodium distachyon 33.94 1.00e-68 251.00
IUUC-Bol-015565 Brassica oleracea 33.89 4.00e-66 243.00
IUUC-Bra-017297 Brassica rapa 33.82 5.00e-66 243.00
IUUC-Cel-018140 Caenorhabditis elegans 29.03 1.00e-50 191.00
IUUC-Cja-019516 Callithrix jacchus 32.02 3.00e-62 230.00
IUUC-Cfa-020808 Canis familiaris 32.80 1.00e-59 221.00
IUUC-Cpo-021688 Cavia porcellus 32.34 3.00e-59 220.00
IUUC-Cre-022663 Chlamydomonas reinhardtii 26.90 5.00e-41 159.00
IUUC-Csa-023429 Chlorocebus sabaeus 32.21 5.00e-59 219.00
IUUC-Cho-024347 Choloepus hoffmanni 32.21 7.00e-59 219.00
IUUC-Cin-025198 Ciona intestinalis 29.56 3.00e-44 170.00
IUUC-Csv-026007 Ciona savignyi 29.43 5.00e-47 179.00
IUUC-Cgl-026757 Colletotrichum gloeosporioides 33.27 1.00e-70 258.00
IUUC-Cne-026963 Cryptococcus neoformans 32.43 1.00e-65 242.00
IUUC-Cme-027240 Cyanidioschyzon merolae 30.19 3.00e-40 157.00
IUUC-Dre-027647 Danio rerio 33.40 5.00e-63 233.00
IUUC-Dno-029967 Dasypus novemcinctus 32.21 1.00e-58 218.00
IUUC-Dor-030886 Dipodomys ordii 30.40 7.00e-45 172.00
IUUC-Dse-031466 Dothistroma septosporum 32.70 3.00e-53 200.00
IUUC-Dme-032079 Drosophila melanogaster 30.45 1.00e-55 208.00
IUUC-Ete-032351 Echinops telfairi 32.43 1.00e-58 218.00
IUUC-Eca-033461 Equus caballus 32.80 2.00e-63 234.00
IUUC-Eeu-035220 Erinaceus europaeus 29.51 5.00e-28 117.00
IUUC-Fca-036210 Felis catus 33.00 7.00e-60 222.00
IUUC-Fal-037528 Ficedula albicollis 32.73 3.00e-58 217.00
IUUC-Fox-037805 Fusarium oxysporum 33.88 7.00e-61 226.00
IUUC-Fso-038177 Fusarium solani 36.63 2.00e-86 310.00
IUUC-Gmo-038953 Gadus morhua 32.40 5.00e-54 203.00
IUUC-Ggr-039972 Gaeumannomyces graminis 31.71 1.00e-71 261.00
IUUC-Gga-040462 Gallus gallus 31.85 5.00e-57 213.00
IUUC-Gac-041312 Gasterosteus aculeatus 33.01 3.00e-62 230.00
IUUC-Gma-043255 Glycine max 34.56 7.00e-66 242.00
IUUC-Ggo-045458 Gorilla gorilla 30.88 5.00e-29 120.00
IUUC-Hsa-045706 Homo sapiens 32.41 2.00e-59 221.00
IUUC-Hvu-047821 Hordeum vulgare 35.22 2.00e-29 120.00
IUUC-Itr-048654 Ictidomys tridecemlineatus 32.21 8.00e-64 235.00
IUUC-Lch-050464 Latimeria chalumnae 33.33 2.00e-60 224.00
IUUC-Lpe-051419 Leersia perrieri 32.67 4.00e-63 233.00
IUUC-Loc-052732 Lepisosteus oculatus 32.87 3.00e-62 230.00
IUUC-Lma-053177 Leptosphaeria maculans 33.79 1.00e-55 208.00
IUUC-Laf-053822 Loxodonta africana 32.80 6.00e-59 219.00
IUUC-Mcc-055893 Macaca mulatta 32.41 2.00e-59 221.00
IUUC-Meu-056307 Macropus eugenii 30.68 4.00e-54 203.00
IUUC-Mor-057171 Magnaporthe oryzae 34.42 8.00e-80 289.00
IUUC-Mpo-057415 Magnaporthe poae 32.97 6.00e-76 276.00
IUUC-Mtr-057901 Medicago truncatula 34.75 2.00e-66 244.00
IUUC-Mla-058897 Melampsora laricipopulina 33.63 8.00e-46 176.00
IUUC-Mga-060016 Meleagris gallopavo 31.98 9.00e-59 219.00
IUUC-Mvi-060562 Microbotryum violaceum 31.50 7.00e-45 172.00
IUUC-Mmr-060624 Microcebus murinus 33.07 1.00e-64 238.00
IUUC-Mdo-061809 Monodelphis domestica 32.56 2.00e-60 224.00
IUUC-Mmu-063869 Mus musculus 33.13 1.00e-59 222.00
IUUC-Mac-064876 Musa acuminata 31.33 1.00e-54 205.00
IUUC-Mpu-066480 Mustela putorius furo 33.00 4.00e-60 223.00
IUUC-Mlu-067866 Myotis lucifugus 32.80 2.00e-60 224.00
IUUC-Nfi-068393 Neosartorya fischeri 34.68 1.00e-78 285.00
IUUC-Ncr-068815 Neurospora crassa 36.30 2.00e-81 294.00
IUUC-Nle-070121 Nomascus leucogenys 36.41 2.00e-28 117.00
IUUC-Opr-070712 Ochotona princeps 29.61 2.00e-32 131.00
IUUC-Ont-071544 Oreochromis niloticus 32.82 2.00e-53 201.00
IUUC-Oan-073635 Ornithorhynchus anatinus 31.40 7.00e-48 182.00
IUUC-Ocu-074926 Oryctolagus cuniculus 32.47 8.00e-60 222.00
IUUC-Oba-075633 Oryza barthii 32.39 4.00e-64 236.00
IUUC-Obr-076423 Oryza brachyantha 37.02 2.00e-54 204.00
IUUC-Ogl-077913 Oryza glaberrima 33.40 2.00e-67 247.00
IUUC-Ogu-078435 Oryza glumaepatula 32.39 4.00e-64 236.00
IUUC-Oin-080072 Oryza indica 32.39 5.00e-64 236.00
IUUC-Olo-080535 Oryza longistaminata 31.10 1.00e-56 211.00
IUUC-Ome-081309 Oryza meridionalis 32.39 4.00e-64 236.00
IUUC-Oni-083113 Oryza nivara 32.39 4.00e-64 236.00
IUUC-Opu-083168 Oryza punctata 32.39 1.00e-62 231.00
IUUC-Oru-084253 Oryza rufipogon 32.39 4.00e-64 236.00
IUUC-Osa-085554 Oryza sativa 34.00 8.00e-68 249.00
IUUC-Ola-086998 Oryzias latipes 33.01 3.00e-61 227.00
IUUC-Olu-087818 Ostreococcus lucimarinus 28.57 1.00e-50 192.00
IUUC-Oga-088571 Otolemur garnettii 33.13 5.00e-59 219.00
IUUC-Oar-089526 Ovis aries 33.00 7.00e-60 222.00
IUUC-Ptr-091433 Pan troglodytes 32.41 2.00e-59 221.00
IUUC-Pan-091966 Papio anubis 32.21 5.00e-59 219.00
IUUC-Psi-093458 Pelodiscus sinensis 32.99 8.00e-62 229.00
IUUC-Pma-094343 Petromyzon marinus 30.85 6.00e-29 119.00
IUUC-Pno-095109 Phaeosphaeria nodorum 33.22 2.00e-72 264.00
IUUC-Ppa-095756 Physcomitrella patens 33.40 2.00e-64 237.00
IUUC-Pfo-096514 Poecilia formosa 33.59 5.00e-56 209.00
IUUC-Pab-098477 Pongo abelii 29.90 5.00e-40 156.00
IUUC-Pop-099221 Populus trichocarpa 34.21 4.00e-64 236.00
IUUC-Pca-100791 Procavia capensis 28.48 2.00e-36 144.00
IUUC-Ppe-101812 Prunus persica 33.05 1.00e-61 228.00
IUUC-Pva-102462 Pteropus vampyrus 32.15 4.00e-52 196.00
IUUC-Pgr-103623 Puccinia graminis 34.59 3.00e-48 184.00
IUUC-Ptt-103767 Puccinia triticina 35.46 2.00e-47 181.00
IUUC-Pte-104109 Pyrenophora teres 31.87 2.00e-71 261.00
IUUC-Pyt-104766 Pyrenophora triticirepentis 32.13 5.00e-53 200.00
IUUC-Rno-105351 Rattus norvegicus 32.54 6.00e-59 219.00
IUUC-Sha-107491 Sarcophilus harrisii 32.43 5.00e-60 223.00
IUUC-Sja-107769 Schizosaccharomyces japonicus 37.22 2.00e-80 290.00
IUUC-Spo-108174 Schizosaccharomyces pombe 39.52 4.00e-78 283.00
IUUC-Ssl-108659 Sclerotinia sclerotiorum 35.62 2.00e-62 231.00
IUUC-Smo-108805 Selaginella moellendorffii 31.40 6.00e-62 229.00
IUUC-Sit-110361 Setaria italica 32.93 4.00e-67 246.00
IUUC-Sly-110965 Solanum lycopersicum 33.33 6.00e-63 233.00
IUUC-Sar-113355 Sorex araneus 32.59 4.00e-39 153.00
IUUC-Sbi-114778 Sorghum bicolor 33.74 1.00e-66 245.00
IUUC-Sre-115011 Sporisorium reilianum 32.97 4.00e-49 187.00
IUUC-Ssc-116273 Sus scrofa 33.00 2.00e-58 218.00
IUUC-Tgu-117063 Taeniopygia guttata 32.73 3.00e-58 217.00
IUUC-Tru-118381 Takifugu rubripes 31.85 2.00e-54 204.00
IUUC-Tsy-119076 Tarsius syrichta 34.20 2.00e-25 107.00
IUUC-Tni-119941 Tetraodon nigroviridis 32.36 6.00e-54 202.00
IUUC-Tca-121246 Theobroma cacao 34.30 4.00e-64 236.00
IUUC-Tre-121969 Trichoderma reesei 35.23 7.00e-59 219.00
IUUC-Tvi-122543 Trichoderma virens 34.84 1.00e-79 288.00
IUUC-Tae-125744 Triticum aestivum 34.82 2.00e-70 257.00
IUUC-Tur-126128 Triticum urartu 27.54 4.00e-21 94.00
IUUC-Tbe-128030 Tupaia belangeri 30.02 1.00e-44 171.00
IUUC-Ttr-128701 Tursiops truncatus 31.61 1.00e-47 181.00
IUUC-Uma-129657 Ustilago maydis 33.89 2.00e-50 191.00
IUUC-Vda-129723 Verticillium dahliae 34.04 2.00e-79 288.00
IUUC-Vvi-131037 Vitis vinifera 33.33 5.00e-64 236.00
IUUC-Xtr-132235 Xenopus tropicalis 31.94 3.00e-61 227.00
IUUC-Xma-133840 Xiphophorus maculatus 33.59 1.00e-62 232.00
IUUC-Yli-134453 Yarrowia lipolytica 38.51 1.00e-84 305.00
IUUC-Zma-135791 Zea mays 36.06 1.00e-49 188.00
Created Date 25-Jun-2017

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