iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000038451.13	ENSMUST00000047760.9	ENSMUSP00000041585.3
ENSMUSG00000038451.13	ENSMUST00000112473.1	ENSMUSP00000108092.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	iRefIndex
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.60e-15	57.8	222	264

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 8    rseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
            +ep SL hL+Rl++r++lg++rl +i++LPLP+++k+YLly+
   Q: 222  VEEPQSLLHLSRLCVRHALGDTRLGQISTLPLPPAMKRYLLYK 264
           578***************************************7 PP

Organism

Mus musculus

Functional Description
(View)

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MGQTALARGS SSTPTSQALY SDFSPPEGLE ELLSAPPPDL VAQRHHGWNP KDCSENIDVK 60
EGGLCFERRP VAQSTDGVRG KRGYSRGLHA WEISWPLEQR GTHAVVGVAT ALAPLQADHY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCAGGGAGT CCTGGGAGGG ACAAGAGGTT ACCCACTCAA AGAGTGTGCT CCACAAAGCA 60
TGCGCGCTTG TCCACGTCTG GAGTCGTCAC TTATTTTTTG CCTGGATTCT TTGTAGCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR001496--SOCS_box
IPR003877--SPRY_dom

PROSITE

PS50188--B302_SPRY
PS50225--SOCS

Pfam

PF07525--SOCS_box
PF00622--SPRY

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

mmu:14794

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001366	Ailuropoda melanoleuca	88.26	4.00e-123	434.00
IUUC-Cja-019350	Callithrix jacchus	88.64	1.00e-132	465.00
IUUC-Cfa-020542	Canis familiaris	89.02	5.00e-134	469.00
IUUC-Cpo-021754	Cavia porcellus	87.88	1.00e-132	465.00
IUUC-Cho-024374	Choloepus hoffmanni	83.57	3.00e-60	223.00
IUUC-Dno-029997	Dasypus novemcinctus	88.64	6.00e-110	390.00
IUUC-Eeu-034632	Erinaceus europaeus	85.98	6.00e-128	449.00
IUUC-Fca-035539	Felis catus	89.50	6.00e-122	429.00
IUUC-Ggo-044949	Gorilla gorilla	90.53	6.00e-136	476.00
IUUC-Hsa-046131	Homo sapiens	90.53	8.00e-136	475.00
IUUC-Itr-048113	Ictidomys tridecemlineatus	91.67	4.00e-140	489.00
IUUC-Laf-053755	Loxodonta africana	89.02	1.00e-127	448.00
IUUC-Mcc-055467	Macaca mulatta	81.53	2.00e-109	387.00
IUUC-Meu-056625	Macropus eugenii	79.70	8.00e-109	386.00
IUUC-Mmr-061190	Microcebus murinus	90.53	8.00e-129	452.00
IUUC-Mpu-066662	Mustela putorius furo	88.64	4.00e-133	466.00
IUUC-Nle-069267	Nomascus leucogenys	89.77	4.00e-135	473.00
IUUC-Opr-070650	Ochotona princeps	79.92	7.00e-106	376.00
IUUC-Ocu-073993	Oryctolagus cuniculus	88.26	7.00e-132	462.00
IUUC-Oga-089049	Otolemur garnettii	87.12	3.00e-122	431.00
IUUC-Pab-098113	Pongo abelii	90.15	3.00e-135	474.00
IUUC-Pca-100149	Procavia capensis	91.40	2.00e-115	407.00
IUUC-Pva-102664	Pteropus vampyrus	89.77	8.00e-127	446.00
IUUC-Rno-105741	Rattus norvegicus	97.35	8.00e-138	482.00
IUUC-Sha-107519	Sarcophilus harrisii	79.32	2.00e-108	384.00
IUUC-Spo-108215	Schizosaccharomyces pombe	35.48	1.40e+00	26.90
IUUC-Ssc-115687	Sus scrofa	88.64	3.00e-132	464.00
IUUC-Tsy-119519	Tarsius syrichta	66.67	8.00e-80	289.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence