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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Spo-108145
UUCD1 version UUC-ScP-00127
Ensembl Protein ID SPCC1672.10.1:pep
UniProt Accession O94244; HAT2_SCHPO
Genbank Protein ID CAA20448.1
Protein Name Histone acetyltransferase type B subunit 2; Kinetochore protein mis16
Genbank Nucleotide ID CU329672
Gene Name mis16; hat2; SPCC1672.10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPCC1672.10 SPCC1672.10.1 SPCC1672.10.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
iRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProt
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.30e-35 116.1 323 360
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
           gH+d+v++l++  +d ++l+s+s D  + +WDl +   
   Q: 323  GHEDEVYGLEWspHDePILASSSTDRRVCIWDLEKIGE 360
           8***********9778****************977655 PP
   
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing (By similarity). Required for correct chromosome segregation where it has a role in the formation and/or maintenance of specialized chromatin at the centromere. Has a role in kinetochore assembly. Maintains the deacetylated state of histones specifically in the central core of the centromeres.
 Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing (By similarity). Required for correct chromosome segregation where it has a role in the formation and/or maintenance of specialized chromatin at the centromere. Has a role in kinetochore assembly. Maintains the deacetylated state of histones specifically in the central core of the centromeres.
Protein Sequence
(Fasta)
MSEEVVQDAP LENNELNAEI DLQKTIQEEY KLWKQNVPFL YDLVITHALE WPSLTIQWLP 60
DKKTIPGTDY SIQRLILGTH TSGNDQNYLQ IASVQLPNFD EDTTEFTPST IRRAQATGSY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Spo-108145|E3,WD_repeat|Schizosaccharomyces pombe
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGTGTAGTTG CCCAAAACAT GTCAGAGGAA GTAGTCCAGG ATGCACCTCT CGAGAATAAT 60
GAACTCAATG CCGAGATAGA CTTACAAAAA ACAATACAAG AAGGTATGAT TAAAGGGAAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Spo-108145|E3,WD_repeat|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0995--Kinetochore
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR022052--Histone-bd_RBBP4_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12265--CAF1C_H4-bd
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0098654--C:CENP-A recruiting complex
GO:0000778--C:condensed nuclear chromosome kinetochore
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0061641--P:CENP-A containing chromatin organization
GO:0016569--P:covalent chromatin modification
GO:0051382--P:kinetochore assembly
GO:0000070--P:mitotic sister chromatid segregation
GO:0070317--P:negative regulation of G0 to G1 transition
KEGG spo:SPCC1672.10
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000757 Aegilops tauschii 45.48 5.00e-97 345.00
IUUC-Aml-001339 Ailuropoda melanoleuca 51.97 1.00e-117 414.00
IUUC-Atr-003075 Amborella trichopoda 47.95 6.00e-110 389.00
IUUC-Apl-003952 Anas platyrhynchos 52.22 4.00e-120 422.00
IUUC-Aca-004508 Anolis carolinensis 52.22 3.00e-120 422.00
IUUC-Aly-006342 Arabidopsis lyrata 48.15 4.00e-108 382.00
IUUC-Ath-006855 Arabidopsis thaliana 48.15 5.00e-108 382.00
IUUC-Ago-007892 Ashbya gossypii 37.97 3.00e-77 280.00
IUUC-Acl-008163 Aspergillus clavatus 51.22 6.00e-119 418.00
IUUC-Afl-008645 Aspergillus flavus 51.20 2.00e-118 417.00
IUUC-Afu-009091 Aspergillus fumigatus 50.73 1.00e-118 417.00
IUUC-Ani-009478 Aspergillus nidulans 47.80 5.00e-100 355.00
IUUC-Ang-009707 Aspergillus niger 51.46 3.00e-117 413.00
IUUC-Aor-010028 Aspergillus oryzae 51.20 2.00e-118 417.00
IUUC-Ate-010416 Aspergillus terreus 50.73 2.00e-117 414.00
IUUC-Ame-011771 Astyanax mexicanus 50.97 5.00e-121 425.00
IUUC-Bgr-012001 Blumeria graminis 50.48 5.00e-107 379.00
IUUC-Bta-012851 Bos taurus 52.22 3.00e-120 423.00
IUUC-Bci-013815 Botrytis cinerea 51.44 3.00e-122 429.00
IUUC-Bdi-014926 Brachypodium distachyon 48.00 3.00e-106 376.00
IUUC-Bol-015856 Brassica oleracea 48.03 1.00e-107 381.00
IUUC-Bra-016725 Brassica rapa 46.44 5.00e-107 379.00
IUUC-Cel-018587 Caenorhabditis elegans 48.13 7.00e-107 378.00
IUUC-Cja-019884 Callithrix jacchus 52.22 3.00e-120 423.00
IUUC-Cfa-020343 Canis familiaris 52.22 3.00e-120 423.00
IUUC-Cpo-021591 Cavia porcellus 52.22 3.00e-120 423.00
IUUC-Cre-022563 Chlamydomonas reinhardtii 50.25 3.00e-114 402.00
IUUC-Csa-023738 Chlorocebus sabaeus 49.52 7.00e-117 411.00
IUUC-Cho-024506 Choloepus hoffmanni 51.97 3.00e-118 416.00
IUUC-Cin-025589 Ciona intestinalis 51.86 1.00e-116 410.00
IUUC-Csv-026216 Ciona savignyi 52.11 2.00e-117 413.00
IUUC-Cgl-026564 Colletotrichum gloeosporioides 48.65 8.00e-113 398.00
IUUC-Cne-026792 Cryptococcus neoformans 46.39 1.00e-105 374.00
IUUC-Cme-027307 Cyanidioschyzon merolae 43.33 1.00e-98 351.00
IUUC-Dre-028742 Danio rerio 51.72 4.00e-120 422.00
IUUC-Dno-029114 Dasypus novemcinctus 52.22 3.00e-120 423.00
IUUC-Dse-031282 Dothistroma septosporum 46.67 2.00e-98 350.00
IUUC-Dme-032126 Drosophila melanogaster 50.24 7.00e-118 415.00
IUUC-Ete-032731 Echinops telfairi 52.22 3.00e-120 423.00
IUUC-Eca-033533 Equus caballus 52.46 1.00e-119 420.00
IUUC-Eeu-034644 Erinaceus europaeus 43.91 4.00e-45 173.00
IUUC-Fca-036202 Felis catus 52.22 3.00e-120 423.00
IUUC-Fal-037084 Ficedula albicollis 52.22 3.00e-120 422.00
IUUC-Fox-037974 Fusarium oxysporum 47.92 1.00e-113 400.00
IUUC-Fso-038246 Fusarium solani 48.70 7.00e-104 368.00
IUUC-Gmo-039214 Gadus morhua 52.33 1.00e-120 424.00
IUUC-Ggr-039741 Gaeumannomyces graminis 47.67 4.00e-108 382.00
IUUC-Gga-040396 Gallus gallus 52.22 3.00e-120 423.00
IUUC-Gac-041389 Gasterosteus aculeatus 52.24 2.00e-120 423.00
IUUC-Gma-042791 Glycine max 47.89 5.00e-106 375.00
IUUC-Ggo-045422 Gorilla gorilla 48.04 2.00e-101 360.00
IUUC-Hsa-045683 Homo sapiens 52.22 3.00e-120 423.00
IUUC-Hvu-047457 Hordeum vulgare 51.09 4.00e-51 191.00
IUUC-Itr-047950 Ictidomys tridecemlineatus 52.22 3.00e-120 423.00
IUUC-Kpa-049258 Komagataella pastoris 37.10 8.00e-79 285.00
IUUC-Lch-050545 Latimeria chalumnae 50.24 2.00e-118 417.00
IUUC-Lpe-051337 Leersia perrieri 47.90 1.00e-108 384.00
IUUC-Loc-052050 Lepisosteus oculatus 50.84 1.00e-120 424.00
IUUC-Lma-053275 Leptosphaeria maculans 45.34 9.00e-69 251.00
IUUC-Laf-054114 Loxodonta africana 52.22 3.00e-120 423.00
IUUC-Mcc-055648 Macaca mulatta 52.22 3.00e-120 422.00
IUUC-Meu-056490 Macropus eugenii 52.22 3.00e-120 423.00
IUUC-Mor-056947 Magnaporthe oryzae 49.51 3.00e-113 399.00
IUUC-Mpo-057602 Magnaporthe poae 47.91 7.00e-110 388.00
IUUC-Mtr-057853 Medicago truncatula 47.72 4.00e-104 369.00
IUUC-Mla-058884 Melampsora laricipopulina 47.24 6.00e-104 368.00
IUUC-Mga-059452 Meleagris gallopavo 52.22 3.00e-120 422.00
IUUC-Mvi-060450 Microbotryum violaceum 47.68 6.00e-103 365.00
IUUC-Mmr-060678 Microcebus murinus 52.88 4.00e-120 422.00
IUUC-Mdo-062450 Monodelphis domestica 52.23 3.00e-120 422.00
IUUC-Mmu-063282 Mus musculus 52.22 3.00e-120 423.00
IUUC-Mac-065480 Musa acuminata 47.75 2.00e-106 376.00
IUUC-Mpu-066529 Mustela putorius furo 51.48 3.00e-118 416.00
IUUC-Mlu-068072 Myotis lucifugus 52.22 3.00e-120 423.00
IUUC-Nfi-068374 Neosartorya fischeri 50.49 5.00e-116 409.00
IUUC-Ncr-068794 Neurospora crassa 47.26 4.00e-110 389.00
IUUC-Nle-069577 Nomascus leucogenys 52.22 3.00e-120 423.00
IUUC-Opr-070245 Ochotona princeps 42.82 2.00e-88 317.00
IUUC-Ont-071809 Oreochromis niloticus 51.97 2.00e-120 424.00
IUUC-Oan-072839 Ornithorhynchus anatinus 52.33 5.00e-120 422.00
IUUC-Ocu-074778 Oryctolagus cuniculus 49.52 4.00e-117 412.00
IUUC-Oba-075719 Oryza barthii 43.38 1.00e-92 331.00
IUUC-Obr-076859 Oryza brachyantha 47.90 2.00e-108 383.00
IUUC-Ogl-077920 Oryza glaberrima 47.65 7.00e-108 382.00
IUUC-Ogu-078048 Oryza glumaepatula 43.38 5.00e-92 330.00
IUUC-Oin-079872 Oryza indica 44.36 2.00e-87 314.00
IUUC-Olo-080553 Oryza longistaminata 41.55 5.00e-89 319.00
IUUC-Ome-081835 Oryza meridionalis 47.65 4.00e-108 383.00
IUUC-Oni-082494 Oryza nivara 43.14 5.00e-91 326.00
IUUC-Opu-083913 Oryza punctata 47.16 8.00e-101 358.00
IUUC-Oru-084666 Oryza rufipogon 47.65 7.00e-108 382.00
IUUC-Osa-085884 Oryza sativa 47.65 7.00e-108 382.00
IUUC-Ola-086664 Oryzias latipes 51.97 1.00e-120 424.00
IUUC-Olu-087579 Ostreococcus lucimarinus 48.99 4.00e-109 385.00
IUUC-Oga-088364 Otolemur garnettii 49.00 9.00e-110 388.00
IUUC-Oar-089652 Ovis aries 52.22 3.00e-120 423.00
IUUC-Ptr-091598 Pan troglodytes 49.52 9.00e-117 411.00
IUUC-Pan-092412 Papio anubis 49.52 7.00e-117 411.00
IUUC-Psi-093300 Pelodiscus sinensis 51.30 3.00e-109 386.00
IUUC-Pma-094307 Petromyzon marinus 50.48 6.00e-119 418.00
IUUC-Pno-095153 Phaeosphaeria nodorum 49.88 5.00e-110 389.00
IUUC-Ppa-095800 Physcomitrella patens 48.99 7.00e-112 395.00
IUUC-Pfo-097240 Poecilia formosa 49.66 5.00e-121 425.00
IUUC-Pab-097697 Pongo abelii 52.22 3.00e-120 423.00
IUUC-Pop-099709 Populus trichocarpa 46.76 1.00e-109 387.00
IUUC-Pca-100642 Procavia capensis 45.36 6.00e-96 342.00
IUUC-Ppe-101212 Prunus persica 47.65 2.00e-108 383.00
IUUC-Pva-102253 Pteropus vampyrus 52.22 3.00e-120 423.00
IUUC-Pgr-103441 Puccinia graminis 47.52 4.00e-99 352.00
IUUC-Pte-104332 Pyrenophora teres 49.37 1.00e-109 387.00
IUUC-Pyt-104516 Pyrenophora triticirepentis 49.37 3.00e-109 386.00
IUUC-Rno-105678 Rattus norvegicus 52.22 3.00e-120 423.00
IUUC-Sce-106364 Saccharomyces cerevisiae 36.71 5.00e-70 256.00
IUUC-Sha-106663 Sarcophilus harrisii 52.22 4.00e-120 422.00
IUUC-Sja-108001 Schizosaccharomyces japonicus 63.72 7.00e-163 564.00
IUUC-Smo-109159 Selaginella moellendorffii 50.00 2.00e-111 394.00
IUUC-Sit-110144 Setaria italica 48.12 4.00e-107 379.00
IUUC-Sly-111680 Solanum lycopersicum 47.24 3.00e-110 389.00
IUUC-Stu-111931 Solanum tuberosum 47.24 3.00e-110 389.00
IUUC-Sar-113236 Sorex araneus 44.82 3.00e-96 343.00
IUUC-Sbi-114637 Sorghum bicolor 47.90 5.00e-108 382.00
IUUC-Sre-114980 Sporisorium reilianum 47.60 9.00e-113 398.00
IUUC-Ssc-116352 Sus scrofa 49.52 8.00e-117 411.00
IUUC-Tgu-116925 Taeniopygia guttata 51.97 7.00e-120 421.00
IUUC-Tru-117549 Takifugu rubripes 52.49 4.00e-121 426.00
IUUC-Tsy-118854 Tarsius syrichta 49.52 2.00e-116 410.00
IUUC-Tni-120398 Tetraodon nigroviridis 51.96 8.00e-121 424.00
IUUC-Tca-121841 Theobroma cacao 47.16 1.00e-107 380.00
IUUC-Tre-122190 Trichoderma reesei 48.90 4.00e-104 369.00
IUUC-Tvi-122304 Trichoderma virens 48.90 5.00e-114 402.00
IUUC-Tae-124648 Triticum aestivum 47.62 8.00e-105 371.00
IUUC-Tur-126850 Triticum urartu 45.45 4.00e-74 270.00
IUUC-Tme-126949 Tuber melanosporum 52.83 3.00e-127 446.00
IUUC-Tbe-128010 Tupaia belangeri 43.75 2.00e-94 337.00
IUUC-Ttr-128558 Tursiops truncatus 45.15 2.00e-103 367.00
IUUC-Uma-129424 Ustilago maydis 45.87 1.00e-110 390.00
IUUC-Vda-129873 Verticillium dahliae 48.66 8.00e-115 405.00
IUUC-Vpa-130079 Vicugna pacos 51.97 6.00e-119 418.00
IUUC-Vvi-131585 Vitis vinifera 47.62 4.00e-107 379.00
IUUC-Xtr-132005 Xenopus tropicalis 48.03 7.00e-117 411.00
IUUC-Xma-133485 Xiphophorus maculatus 50.23 1.00e-121 427.00
IUUC-Yli-134334 Yarrowia lipolytica 38.21 3.00e-78 283.00
IUUC-Zma-135067 Zea mays 47.93 7.00e-108 382.00
Created Date 25-Jun-2017

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