iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108270

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Rik1-associated factor 1; Cryptic loci regulator 8; De-localization of swi6 protein 1

Genbank Nucleotide ID

CU329672

Gene Name

raf1; clr8; cmc1; dos1; SPCC613.12c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPCC613.12c	SPCC613.12c.1	SPCC613.12c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.00e-13	47.2	550	576

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 7    tclaf.sd.tllvsGsdDgtikvWDlr 31
           +  ++ +  +l+v+G+ Dg +kvWDlr
   Q: 550  NMAQWqPKgNLFVTGGSDGIVKVWDLR 576
           5567997779***************86 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. Has a role in both mitotic and meiotic chromosome segregation.

Protein Sequence
(Fasta)

MTNSSPRVKR RTDTQYLHSV SSKLPKVDFD TNNEEFFEEE FEIYDPFYRA ELPCPKPSLS 60
ISKHSIAKVP SNVNKRLELQ LLLTSGTFLP NSRPYLSERV RKHTHLLSNS ITGDDKPSLI 120

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Nucleotide Sequence
(Fasta)

TTTGGACTTA GTAAATTCTT TATATCAATC AGTGCCTTAA ACTCACTCAG CAACCCATAA 60
CTTCTGTTAA ACTAGTGAAC TTGCACACTG AAGGATTAAA AGTAAAAAGC CCAATAATTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0034507--C:chromosome, centromeric outer repeat region
GO:0000781--C:chromosome, telomeric region
GO:0043494--C:CLRC ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0031934--C:mating-type region heterochromatin
GO:0031618--C:nuclear pericentric heterochromatin
GO:0005634--C:nucleus
GO:0034613--P:cellular protein localization
GO:0030702--P:chromatin silencing at centromere
GO:1990141--P:chromatin silencing at centromere outer repeat region
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0006348--P:chromatin silencing at telomere
GO:0031048--P:chromatin silencing by small RNA
GO:0016569--P:covalent chromatin modification
GO:0035391--P:maintenance of chromatin silencing at silent mating-type cassette
GO:0045132--P:meiotic chromosome segregation
GO:0045141--P:meiotic telomere clustering
GO:0051572--P:negative regulation of histone H3-K4 methylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051574--P:positive regulation of histone H3-K9 methylation
GO:0031494--P:regulation of mating type switching
GO:0006351--P:transcription, DNA-templated

KEGG

spo:SPCC613.12c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000846	Aegilops tauschii	23.30	5.00e-09	54.30
IUUC-Atr-002668	Amborella trichopoda	24.44	8.00e-09	53.90
IUUC-Acl-008065	Aspergillus clavatus	29.76	1.00e-17	82.00
IUUC-Afl-008436	Aspergillus flavus	25.00	4.00e-22	98.60
IUUC-Afu-009043	Aspergillus fumigatus	27.63	2.00e-24	106.00
IUUC-Ani-009382	Aspergillus nidulans	27.35	9.00e-28	117.00
IUUC-Ang-009753	Aspergillus niger	28.95	2.00e-25	109.00
IUUC-Aor-010020	Aspergillus oryzae	25.12	4.00e-22	98.60
IUUC-Ate-010564	Aspergillus terreus	27.58	1.00e-29	123.00
IUUC-Bci-013668	Botrytis cinerea	23.39	7.00e-15	74.70
IUUC-Cgl-026459	Colletotrichum gloeosporioides	25.73	2.00e-21	96.30
IUUC-Dse-031276	Dothistroma septosporum	21.01	2.00e-16	79.00
IUUC-Fox-037886	Fusarium oxysporum	23.30	1.00e-23	103.00
IUUC-Fso-038210	Fusarium solani	22.48	8.00e-23	100.00
IUUC-Ggr-039952	Gaeumannomyces graminis	22.52	4.00e-18	85.50
IUUC-Lma-053206	Leptosphaeria maculans	27.15	3.00e-24	106.00
IUUC-Mor-057085	Magnaporthe oryzae	24.41	2.00e-17	83.20
IUUC-Mpo-057324	Magnaporthe poae	23.58	5.00e-19	88.20
IUUC-Mac-064887	Musa acuminata	24.02	2.00e-09	54.70
IUUC-Nfi-068408	Neosartorya fischeri	26.26	3.00e-23	101.00
IUUC-Obr-076372	Oryza brachyantha	24.22	9.00e-09	53.50
IUUC-Ogl-076950	Oryza glaberrima	24.84	2.00e-10	59.30
IUUC-Opu-083211	Oryza punctata	24.53	7.00e-10	57.40
IUUC-Osa-085998	Oryza sativa	24.53	9.00e-10	57.00
IUUC-Pno-095108	Phaeosphaeria nodorum	25.78	3.00e-28	119.00
IUUC-Pte-104227	Pyrenophora teres	27.96	8.00e-31	127.00
IUUC-Pyt-104536	Pyrenophora triticirepentis	27.74	1.00e-31	130.00
IUUC-Sja-107870	Schizosaccharomyces japonicus	46.42	3.00e-156	543.00
IUUC-Ssl-108569	Sclerotinia sclerotiorum	23.83	1.00e-16	80.90
IUUC-Sit-110580	Setaria italica	23.84	1.00e-07	50.10
IUUC-Sbi-114718	Sorghum bicolor	22.51	3.00e-10	58.90
IUUC-Tre-122228	Trichoderma reesei	23.94	5.00e-19	88.20
IUUC-Tvi-122460	Trichoderma virens	32.12	4.00e-16	78.60
IUUC-Tae-125757	Triticum aestivum	29.20	9.00e-08	50.80
IUUC-Tur-126661	Triticum urartu	29.20	6.00e-08	50.80
IUUC-Vda-129672	Verticillium dahliae	22.44	6.00e-20	91.30
IUUC-Zma-135703	Zea mays	22.88	3.00e-10	58.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence