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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Cel-018369
UUCD1 version UUC-CaE-00330
Ensembl Protein ID F45E12.3
UniProt Accession Q17392; Q20428; CUL4_CAEEL
Genbank Protein ID CCD66265.1; AAC47123.1
Protein Name Cullin-4
Genbank Nucleotide ID FO080734; U58086
Gene Name cul-4; F45E12.3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00000839 F45E12.3 F45E12.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/Cullin 2.60e-95 320.7 127 741
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin

   S: 4    eavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefikqvkkkveesed........eqlLktynreWekfreqlkvlrkifayldrtyvk 96
    + v +il+ + +++e l+++v +c ++ ++ lY++l ++++f k +k++ ++ e+ eq L+++ + W+ + +++ +r+if++ldr +
   Q: 127 DNVFAILEDRKTVTTLEGLFSKVRSVCDKNQSKVLYDRLVAIVVQFAKSLKESLNAVEQvplaedncEQYLEKFGQIWQAYPVKINLIRNIFLHLDRIALG 227
    567788888888999*******************************99998776553321111122256****************************9988 PP
   S: 97 k.skkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfleatqefykaesaeflqenevdeY 196
    +++ + ++ +++++k ++ +i k+ + l ++++r + + +slv++ ++ ++ e F + + +e y++e + + ++++Y
   Q: 228 AtDTEILPLWECFMQIFQKTFFPNIFKEFKATKLFNALYMAMQKIMQRYPVDSPLRSLVDML-QTVHV-SEEFAKFLISQLREHYNNERIDKVPKMNCNDY 326
    7577889************9999976665554444333444455566666677777777763.33344.467888888999******************** PP
   S: 197 lkkvearlneeeeraar.yleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykLlsrvlngleellkeleshikeqgkaaltaeekek 295
    ++++e ++n ++ ++ + e+s ++ + ++v ++li++ + ++l ++++ l+++++ +d++rm++L+++ g +e++ ++++++k+ g+++++ + ++
   Q: 327 MEYCEDQINRYSQLVKVnFDEPSALKDVQATVTNCLIQQAIPEILtHDFDDLIDSDNISDIGRMFNLCRQCVGGEDEVRTQFSKYLKKRGEKLIA-TCPDE 426
    ************99986156789999**************99998799******************************************99775.55666 PP
   S: 296 dpkkyVerllelknklqklvseaFnnda...kFlkaldkafetfvnknsvlkaakspEllAryiDqlLrksskglte.eeleaqldkvllvfkyisekdvF 392
    d V +ll +k+k++ ++ +F+ + k + l afe+fvnk+ + +s+El++++ lL +s+k++ + l+++ d+++++f+y+ +kdvF
   Q: 427 D---LVSELLAFKKKVDFIMTGSFKSANdpvKMRQCLSDAFESFVNKQ----VDRSAELISKHFHTLLHSSNKNVSDdTTLDQMVDEAIVLFRYLRGKDVF 520
    7...8*******************8554123677899***********....89*****************99987615678889**************** PP
   S: 393 ekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfqdlkvSedlnrqFkeekenteesesvelsvlvLsagaWptasetekvsLPaelek 493
    e+yYk+ LakRL ++ sas +aE+ v+ kLk+ecg +ft kLe+Mf+d+ +Se+ r F++ e++ ++e+ +++ +v+++++Wpt+ ++e +++P+e+++
   Q: 521 EAYYKRGLAKRLFLERSASVDAEKMVLCKLKTECGSAFTYKLEGMFKDMDASENYGRLFNQYLEHM-NKEKANFTARVITPEYWPTYDTYE-INIPKEMRD 619
    ************************************************************999888.677899**************8877.********* PP
   S: 494 tiekfeefYlekhsgRkLqWqhtlgraelkaelkkg.kyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqvlkkepes.k 590
    t+ +++ fY +h R ++W+h l++a + a + g k+el ++ +Q+++LL+fn+ e+++v e+ + t++ e e + + L+ ++ +vl+ + + +
   Q: 620 TLTDYQDFYRVQHGNRNVKWHHGLASAVISASFRPGcKKELIATMYQTVILLLFNKCETWTVAEIVEHTKILEIEVVKNVLALLGGRdkPKVLQRVEGGgS 720
    ************************************************************************99999999999987776555554332212 PP
   S: 591 e.......ieeedlfsvNqef 604
    e ++++f+vN++f
   Q: 721 EkkegtveNLKNEKFVVNSKF 741
    233477333467889999887 PP
   

Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description



     Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1.
Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1.
Protein Sequence
(Fasta)
MTSGAPPTIS TEKSRSKQLR KSSKRTASTV EGTEAKQMRG DTENRSDGEM DDVSTSSEIR 60
HGNGFIENFR SQTGNSSRTT ATNERIKKKL VIKNFKANAN QNDVAMGDTN IDSTDGSVGR 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Cel-018369|E3,Cullin|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AACAAATTGG ATGACATCTG GAGCACCACC GACTATTTCA ACAGAAAAAA GTCGAAGTAA 60
ACAGCTTCGA AAATCGTCAA AGCGCACAGC CAGCACCGTT GAAGGTACAG AGGTAGTAAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Cel-018369|E3,Cullin|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031461--C:cullin-RING ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG cel:CELE_F45E12.3
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Bci-013744 Botrytis cinerea 27.95 5.00e-67 248.00
IUUC-Cho-024899 Choloepus hoffmanni 38.80 2.00e-95 341.00
IUUC-Cne-027026 Cryptococcus neoformans 33.50 1.00e-53 203.00
IUUC-Cme-027355 Cyanidioschyzon merolae 25.13 4.00e-66 244.00
IUUC-Pca-100391 Procavia capensis 41.04 2.00e-76 278.00
IUUC-Pva-102995 Pteropus vampyrus 38.80 2.00e-93 336.00
IUUC-Sja-107940 Schizosaccharomyces japonicus 28.97 2.00e-53 202.00
IUUC-Spo-108109 Schizosaccharomyces pombe 26.87 6.00e-57 214.00
IUUC-Ssl-108537 Sclerotinia sclerotiorum 28.12 4.00e-68 251.00
IUUC-Sar-112956 Sorex araneus 42.11 5.00e-76 277.00
IUUC-Sre-114943 Sporisorium reilianum 28.49 1.00e-77 283.00
IUUC-Tsy-119517 Tarsius syrichta 43.21 5.00e-78 284.00
IUUC-Ttr-129112 Tursiops truncatus 42.69 1.00e-88 320.00
Created Date 25-Jun-2017

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