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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063637
UUCD1 version UUC-MuM-01141
Ensembl Protein ID ENSMUSP00000027050.3
UniProt Accession O35864; Q3UA70; Q8C1S1; CSN5_MOUSE
Genbank Protein ID AAD03470.1; AAF61318.1; AAC17179.1; BAB28282.1; BAE27030.1; BAE30445.1; AAH46753.1
Protein Name COP9 signalosome complex subunit 5; Jun activation domain-binding protein 1; Kip1 C-terminus-interacting protein 2
Genbank Nucleotide ID U70736; AF068223; AF065386; AK012499; AK146271; AK151492; BC046753
Gene Name Cops5; Csn5; Jab1; Kic2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025917.9 ENSMUST00000027050.9 ENSMUSP00000027050.3
ENSMUSG00000025917.9 ENSMUST00000190155.6 ENSMUSP00000140054.1
ENSMUSG00000025917.9 ENSMUST00000186528.6 ENSMUSP00000140633.1
ENSMUSG00000025917.9 ENSMUST00000188619.1 ENSMUSP00000140115.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/JAMM 2.40e-07 31.7 138 151
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/JAMM
   S: 1    HSHPgftcwlSsVD 14
           HSHPg++cwlS++D
   Q: 138  HSHPGYGCWLSGID 151
           *************9 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS6 and COPS7 (COPS7A or COPS7B) and COPS9. The CSN complex interacts with the BRISC complex. Also exists as monomeric form. Interacts with TP53, MIF, JUN, UCHL1, NCOA1, BCL3, GFER, PGR, LHCGR, SMAD4, SMAD7, ITGB2 and TOP2A. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interacts with CDKN1B, HIF1A, ID1 and ID3. Interacts with IFIT3. Interacts with BRSK2 (By similarity). Interacts with ZDHHC16 (By similarity).
 Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS6 and COPS7 (COPS7A or COPS7B) and COPS9. The CSN complex interacts with the BRISC complex. Also exists as monomeric form. Interacts with TP53, MIF, JUN, UCHL1, NCOA1, BCL3, GFER, PGR, LHCGR, SMAD4, SMAD7, ITGB2 and TOP2A. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interacts with CDKN1B, HIF1A, ID1 and ID3. Interacts with IFIT3. Interacts with BRSK2 (By similarity). Interacts with ZDHHC16 (By similarity).
Protein Sequence
(Fasta)
MAASGSGMAQ KTWELANNMQ EAQSIDEIYK YDKKQQQEIL AAKPWTKDHH YFKYCKISAL 60
ALLKMVMHAR SGGNLEVMGL MLGKVDGETM IIMDSFALPV EGTETRVNAQ AAAYEYMAAY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063637|DUB,JAMM|Mus musculus
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Nucleotide Sequence
(Fasta)
CCCGCCTTCC GGCGCGAAAG GCTGTACCAT TCCCACACCG AGGCTTTGCG TCCCTCGCAG 60
TTCACACGAA CGGATTTCCG AGCCAGCATG TTCTCGTTTC ACCGGCAAGA CTGATCTTAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063637|DUB,JAMM|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0736--Signalosome
KW-0770--Synapse
KW-0862--Zinc
Interpro

IPR000555--JAMM/MPN+_dom
Pfam

PF01398--JAB
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0030054--C:cell junction
GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0008021--C:synaptic vesicle
GO:0005667--C:transcription factor complex
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:1990182--P:exosomal secretion
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0000338--P:protein deneddylation
GO:0016579--P:protein deubiquitination
GO:0051726--P:regulation of cell cycle
GO:1903894--P:regulation of IRE1-mediated unfolded protein response
GO:0046328--P:regulation of JNK cascade
GO:0006355--P:regulation of transcription, DNA-templated
KEGG mmu:26754
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000468 Aegilops tauschii 66.57 3.00e-122 431.00
IUUC-Aml-001429 Ailuropoda melanoleuca 99.38 0.00e+00 625.00
IUUC-Atr-003048 Amborella trichopoda 68.24 3.00e-125 441.00
IUUC-Apl-003610 Anas platyrhynchos 90.36 6.00e-164 569.00
IUUC-Aca-004662 Anolis carolinensis 98.62 1.00e-156 545.00
IUUC-Aly-005914 Arabidopsis lyrata 67.06 6.00e-123 433.00
IUUC-Ath-007496 Arabidopsis thaliana 67.16 1.00e-122 432.00
IUUC-Ago-007860 Ashbya gossypii 41.88 1.00e-47 183.00
IUUC-Acl-008155 Aspergillus clavatus 54.88 5.00e-98 350.00
IUUC-Afu-008820 Aspergillus fumigatus 55.18 2.00e-98 352.00
IUUC-Ani-009303 Aspergillus nidulans 54.74 2.00e-96 345.00
IUUC-Ang-009617 Aspergillus niger 54.09 8.00e-94 337.00
IUUC-Aor-009888 Aspergillus oryzae 56.49 1.00e-95 342.00
IUUC-Ate-010575 Aspergillus terreus 56.75 3.00e-100 358.00
IUUC-Ame-010617 Astyanax mexicanus 95.51 7.00e-180 622.00
IUUC-Bgr-012019 Blumeria graminis 56.17 3.00e-100 358.00
IUUC-Bta-013211 Bos taurus 99.10 0.00e+00 642.00
IUUC-Bci-013645 Botrytis cinerea 57.89 2.00e-104 372.00
IUUC-Bdi-014727 Brachypodium distachyon 67.76 1.00e-118 419.00
IUUC-Bol-015205 Brassica oleracea 67.37 6.00e-121 427.00
IUUC-Bra-017649 Brassica rapa 67.37 6.00e-121 427.00
IUUC-Cel-018469 Caenorhabditis elegans 57.06 2.00e-104 372.00
IUUC-Cja-019703 Callithrix jacchus 99.40 0.00e+00 643.00
IUUC-Cfa-020181 Canis familiaris 99.70 0.00e+00 644.00
IUUC-Cpo-021499 Cavia porcellus 99.40 0.00e+00 643.00
IUUC-Cre-022735 Chlamydomonas reinhardtii 60.31 6.00e-112 397.00
IUUC-Csa-024200 Chlorocebus sabaeus 99.40 0.00e+00 643.00
IUUC-Cho-024915 Choloepus hoffmanni 97.12 7.00e-119 419.00
IUUC-Cin-025353 Ciona intestinalis 79.94 6.00e-138 483.00
IUUC-Csv-026118 Ciona savignyi 80.24 9.00e-139 486.00
IUUC-Cgl-026511 Colletotrichum gloeosporioides 52.37 2.00e-95 342.00
IUUC-Cne-026988 Cryptococcus neoformans 49.14 2.00e-85 308.00
IUUC-Dre-028134 Danio rerio 96.07 3.00e-179 620.00
IUUC-Dno-029658 Dasypus novemcinctus 99.40 0.00e+00 643.00
IUUC-Dor-031074 Dipodomys ordii 99.40 0.00e+00 643.00
IUUC-Dse-031497 Dothistroma septosporum 56.68 2.00e-98 352.00
IUUC-Dme-032199 Drosophila melanogaster 74.47 2.00e-143 501.00
IUUC-Ete-032739 Echinops telfairi 98.82 1.00e-86 313.00
IUUC-Eca-034095 Equus caballus 99.10 0.00e+00 642.00
IUUC-Eeu-034934 Erinaceus europaeus 84.43 1.00e-148 519.00
IUUC-Fca-035569 Felis catus 99.40 0.00e+00 643.00
IUUC-Fal-037553 Ficedula albicollis 99.30 2.00e-156 544.00
IUUC-Fox-037945 Fusarium oxysporum 49.85 6.00e-88 317.00
IUUC-Fso-038385 Fusarium solani 54.38 1.00e-94 339.00
IUUC-Gmo-039438 Gadus morhua 94.61 3.00e-175 607.00
IUUC-Ggr-039968 Gaeumannomyces graminis 60.36 3.00e-95 342.00
IUUC-Gga-040344 Gallus gallus 99.08 3.00e-180 624.00
IUUC-Gac-042256 Gasterosteus aculeatus 95.81 1.00e-176 612.00
IUUC-Gma-043226 Glycine max 67.05 1.00e-124 439.00
IUUC-Ggo-044523 Gorilla gorilla 92.40 6.00e-163 566.00
IUUC-Hsa-046659 Homo sapiens 99.40 0.00e+00 643.00
IUUC-Itr-048834 Ictidomys tridecemlineatus 100.00 0.00e+00 641.00
IUUC-Kpa-049139 Komagataella pastoris 58.49 1.00e-52 201.00
IUUC-Lch-049562 Latimeria chalumnae 96.98 1.00e-180 625.00
IUUC-Lpe-050737 Leersia perrieri 67.66 1.00e-127 449.00
IUUC-Loc-051798 Lepisosteus oculatus 97.23 7.00e-175 606.00
IUUC-Lma-052979 Leptosphaeria maculans 52.51 3.00e-93 335.00
IUUC-Laf-053391 Loxodonta africana 100.00 2.00e-121 427.00
IUUC-Mcc-055667 Macaca mulatta 99.40 0.00e+00 643.00
IUUC-Meu-056067 Macropus eugenii 68.60 2.00e-83 301.00
IUUC-Mor-057084 Magnaporthe oryzae 53.31 2.00e-97 348.00
IUUC-Mpo-057347 Magnaporthe poae 54.01 1.00e-97 349.00
IUUC-Mtr-057781 Medicago truncatula 68.67 8.00e-126 443.00
IUUC-Mla-059106 Melampsora laricipopulina 51.56 3.00e-104 371.00
IUUC-Mga-059473 Meleagris gallopavo 99.30 2.00e-156 544.00
IUUC-Mvi-060540 Microbotryum violaceum 54.44 1.00e-108 386.00
IUUC-Mmr-061138 Microcebus murinus 96.41 1.00e-97 348.00
IUUC-Mdo-062893 Monodelphis domestica 99.10 0.00e+00 642.00
IUUC-Mac-064683 Musa acuminata 67.16 6.00e-128 450.00
IUUC-Mpu-066096 Mustela putorius furo 86.27 4.00e-151 527.00
IUUC-Mlu-067872 Myotis lucifugus 96.11 3.00e-178 617.00
IUUC-Nfi-068443 Neosartorya fischeri 54.88 4.00e-97 347.00
IUUC-Ncr-068953 Neurospora crassa 52.61 7.00e-91 327.00
IUUC-Nle-068972 Nomascus leucogenys 99.40 0.00e+00 643.00
IUUC-Opr-070215 Ochotona princeps 88.92 4.00e-158 550.00
IUUC-Ont-072538 Oreochromis niloticus 96.37 9.00e-176 609.00
IUUC-Oan-073143 Ornithorhynchus anatinus 98.50 0.00e+00 639.00
IUUC-Ocu-074197 Oryctolagus cuniculus 99.40 0.00e+00 643.00
IUUC-Oba-075884 Oryza barthii 62.50 3.00e-120 424.00
IUUC-Obr-076874 Oryza brachyantha 66.77 1.00e-124 439.00
IUUC-Ogl-077169 Oryza glaberrima 67.46 4.00e-124 437.00
IUUC-Ogu-078258 Oryza glumaepatula 67.46 6.00e-124 437.00
IUUC-Oin-079101 Oryza indica 62.78 2.00e-120 425.00
IUUC-Olo-080708 Oryza longistaminata 55.56 2.00e-96 345.00
IUUC-Ome-081571 Oryza meridionalis 62.78 2.00e-120 425.00
IUUC-Oni-082888 Oryza nivara 62.78 2.00e-120 425.00
IUUC-Opu-083182 Oryza punctata 67.46 4.00e-124 437.00
IUUC-Oru-084895 Oryza rufipogon 62.78 2.00e-120 425.00
IUUC-Osa-085331 Oryza sativa 67.46 4.00e-124 437.00
IUUC-Ola-086850 Oryzias latipes 96.68 9.00e-177 612.00
IUUC-Olu-087607 Ostreococcus lucimarinus 57.69 2.00e-80 292.00
IUUC-Oga-088640 Otolemur garnettii 99.38 0.00e+00 626.00
IUUC-Oar-090299 Ovis aries 99.08 2.00e-180 624.00
IUUC-Ptr-091499 Pan troglodytes 99.40 0.00e+00 643.00
IUUC-Pan-091751 Papio anubis 99.30 4.00e-156 543.00
IUUC-Psi-092978 Pelodiscus sinensis 98.15 6.00e-179 619.00
IUUC-Pma-094634 Petromyzon marinus 93.52 2.00e-170 591.00
IUUC-Pno-095094 Phaeosphaeria nodorum 52.38 2.00e-93 335.00
IUUC-Ppa-095440 Physcomitrella patens 68.91 6.00e-128 450.00
IUUC-Pfo-097332 Poecilia formosa 96.68 1.00e-176 612.00
IUUC-Pab-097998 Pongo abelii 99.40 0.00e+00 643.00
IUUC-Pop-098905 Populus trichocarpa 66.37 5.00e-130 457.00
IUUC-Pca-100521 Procavia capensis 100.00 1.00e-61 229.00
IUUC-Ppe-101309 Prunus persica 67.75 2.00e-130 458.00
IUUC-Pva-102953 Pteropus vampyrus 99.40 0.00e+00 643.00
IUUC-Pgr-103452 Puccinia graminis 60.59 6.00e-91 327.00
IUUC-Ptt-103777 Puccinia triticina 62.65 6.00e-88 317.00
IUUC-Pte-104273 Pyrenophora teres 52.38 4.00e-94 337.00
IUUC-Pyt-104627 Pyrenophora triticirepentis 53.56 6.00e-93 333.00
IUUC-Rno-105666 Rattus norvegicus 99.70 0.00e+00 640.00
IUUC-Sce-106319 Saccharomyces cerevisiae 40.29 2.00e-34 139.00
IUUC-Sha-106602 Sarcophilus harrisii 99.10 0.00e+00 642.00
IUUC-Sja-107822 Schizosaccharomyces japonicus 45.89 1.00e-47 182.00
IUUC-Spo-108318 Schizosaccharomyces pombe 40.58 2.00e-64 239.00
IUUC-Ssl-108428 Sclerotinia sclerotiorum 58.51 1.00e-105 376.00
IUUC-Smo-108821 Selaginella moellendorffii 66.18 1.00e-124 439.00
IUUC-Sit-110526 Setaria italica 66.37 1.00e-117 416.00
IUUC-Sly-111466 Solanum lycopersicum 67.16 5.00e-132 464.00
IUUC-Stu-112776 Solanum tuberosum 67.74 2.00e-132 465.00
IUUC-Sar-113459 Sorex araneus 99.70 0.00e+00 644.00
IUUC-Sbi-114873 Sorghum bicolor 66.96 2.00e-121 429.00
IUUC-Sre-114919 Sporisorium reilianum 64.64 9.00e-93 333.00
IUUC-Ssc-116102 Sus scrofa 99.40 0.00e+00 643.00
IUUC-Tgu-116937 Taeniopygia guttata 99.61 2.00e-139 487.00
IUUC-Tru-118615 Takifugu rubripes 96.98 4.00e-177 613.00
IUUC-Tsy-119173 Tarsius syrichta 99.36 1.00e-172 598.00
IUUC-Tni-120246 Tetraodon nigroviridis 96.70 8.00e-178 615.00
IUUC-Tca-121859 Theobroma cacao 68.48 3.00e-128 451.00
IUUC-Tre-122030 Trichoderma reesei 52.44 2.00e-95 342.00
IUUC-Tvi-122506 Trichoderma virens 53.80 3.00e-100 358.00
IUUC-Tae-125382 Triticum aestivum 66.57 6.00e-122 430.00
IUUC-Tur-126517 Triticum urartu 68.71 5.00e-119 420.00
IUUC-Tme-127122 Tuber melanosporum 55.99 5.00e-102 363.00
IUUC-Tbe-128108 Tupaia belangeri 98.20 0.00e+00 627.00
IUUC-Ttr-128644 Tursiops truncatus 99.40 0.00e+00 643.00
IUUC-Uma-129390 Ustilago maydis 52.23 8.00e-94 337.00
IUUC-Vda-129932 Verticillium dahliae 47.84 4.00e-89 321.00
IUUC-Vpa-130110 Vicugna pacos 99.40 0.00e+00 643.00
IUUC-Vvi-131534 Vitis vinifera 68.56 2.00e-131 462.00
IUUC-Xtr-132739 Xenopus tropicalis 97.31 0.00e+00 632.00
IUUC-Xma-133919 Xiphophorus maculatus 96.68 1.00e-176 612.00
IUUC-Yli-134677 Yarrowia lipolytica 50.15 2.00e-90 326.00
IUUC-Zma-135578 Zea mays 67.56 2.00e-122 431.00
Created Date 25-Jun-2017

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