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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106319
UUCD1 version UUC-SaC-00266
Ensembl Protein ID YDL216C
UniProt Accession Q12468; D6VRD8; CSN5_YEAST
Genbank Protein ID CAA67474.1; CAA98794.1; DAA11648.1
Protein Name COP9 signalosome complex subunit 5
Genbank Nucleotide ID X99000; Z74264; BK006938
Gene Name RRI1; CSN5; JAB1; YDL216C; D0888
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YDL216C YDL216C YDL216C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
DUB/JAMM 40.29 6.00e-33 139.00 IUUC-Hsa-046659
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Catalytic component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the mating pheromone response.
 Catalytic component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the mating pheromone response.
Protein Sequence
(Fasta)
MSLSNKTVKE LRQLLKERYT VEDELTESIA LSSMRFKPSQ EPEFHALSQS SLLKTKLKQQ 60
SSTDIPSYTH VLISKLSCEK ITHYAVRGGN IEIMGILMGF TLKDNIVVMD CFNLPVVGTE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106319|DUB,JAMM|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGTCACTTT CAAATAAGAC TGTAAAGGAA TTACGACAAC TACTAAAGGA AAGGTACACC 60
GTGGAAGATG AACTAACTGA ATCTATAGCG CTATCAAGTA TGCGATTCAA GCCGTCGCAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106319|DUB,JAMM|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0736--Signalosome
KW-0862--Zinc
Interpro

IPR000555--JAMM/MPN+_dom
Pfam

PF01398--JAB
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0046872--F:metal ion binding
GO:0004222--F:metalloendopeptidase activity
GO:0000754--P:adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
GO:0070452--P:positive regulation of ergosterol biosynthetic process
GO:0000338--P:protein deneddylation
KEGG sce:YDL216C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000468 Aegilops tauschii 46.75 6.00e-40 155.00
IUUC-Aml-001429 Ailuropoda melanoleuca 39.32 3.00e-33 133.00
IUUC-Atr-003048 Amborella trichopoda 44.85 1.00e-39 155.00
IUUC-Apl-003610 Anas platyrhynchos 38.60 3.00e-33 133.00
IUUC-Aca-004662 Anolis carolinensis 39.32 6.00e-33 132.00
IUUC-Aly-006559 Arabidopsis lyrata 46.63 4.00e-41 159.00
IUUC-Ath-007612 Arabidopsis thaliana 46.06 6.00e-41 159.00
IUUC-Ago-007860 Ashbya gossypii 32.33 2.00e-55 207.00
IUUC-Acl-008155 Aspergillus clavatus 38.94 6.00e-38 149.00
IUUC-Afu-008820 Aspergillus fumigatus 39.42 1.00e-38 151.00
IUUC-Ani-009303 Aspergillus nidulans 37.50 5.00e-37 146.00
IUUC-Ang-009617 Aspergillus niger 37.61 1.00e-37 148.00
IUUC-Aor-009888 Aspergillus oryzae 38.46 2.00e-37 147.00
IUUC-Ate-010575 Aspergillus terreus 40.38 5.00e-40 155.00
IUUC-Ame-010617 Astyanax mexicanus 39.32 3.00e-33 133.00
IUUC-Bgr-012019 Blumeria graminis 37.20 2.00e-38 150.00
IUUC-Bta-013211 Bos taurus 39.32 3.00e-33 133.00
IUUC-Bci-013645 Botrytis cinerea 40.57 2.00e-39 153.00
IUUC-Bdi-014727 Brachypodium distachyon 48.12 2.00e-39 154.00
IUUC-Bol-015205 Brassica oleracea 47.85 8.00e-42 162.00
IUUC-Bra-017649 Brassica rapa 47.85 8.00e-42 162.00
IUUC-Cel-018469 Caenorhabditis elegans 51.02 5.00e-42 162.00
IUUC-Cja-019703 Callithrix jacchus 39.32 3.00e-33 133.00
IUUC-Cfa-020181 Canis familiaris 39.32 3.00e-33 133.00
IUUC-Cpo-021499 Cavia porcellus 39.32 3.00e-33 133.00
IUUC-Cre-022735 Chlamydomonas reinhardtii 39.45 6.00e-43 165.00
IUUC-Csa-024200 Chlorocebus sabaeus 39.32 3.00e-33 133.00
IUUC-Cho-024915 Choloepus hoffmanni 40.52 4.00e-23 99.80
IUUC-Cin-025353 Ciona intestinalis 40.78 2.00e-35 140.00
IUUC-Csv-026118 Ciona savignyi 39.81 7.00e-35 139.00
IUUC-Cgl-026511 Colletotrichum gloeosporioides 43.21 6.00e-38 149.00
IUUC-Cne-026988 Cryptococcus neoformans 39.16 2.00e-27 114.00
IUUC-Dre-028134 Danio rerio 38.83 6.00e-33 132.00
IUUC-Dno-029658 Dasypus novemcinctus 39.32 3.00e-33 133.00
IUUC-Dor-031074 Dipodomys ordii 39.32 3.00e-33 133.00
IUUC-Dse-031497 Dothistroma septosporum 37.50 2.00e-38 150.00
IUUC-Ete-032739 Echinops telfairi 46.88 2.00e-25 107.00
IUUC-Eca-034095 Equus caballus 39.32 2.00e-33 134.00
IUUC-Eeu-034934 Erinaceus europaeus 39.32 7.00e-33 132.00
IUUC-Fca-035569 Felis catus 39.32 3.00e-33 133.00
IUUC-Fal-037553 Ficedula albicollis 39.32 5.00e-33 132.00
IUUC-Fox-037945 Fusarium oxysporum 37.50 2.00e-42 164.00
IUUC-Fso-038385 Fusarium solani 40.28 1.00e-41 161.00
IUUC-Gmo-039438 Gadus morhua 39.32 1.00e-33 134.00
IUUC-Ggr-039968 Gaeumannomyces graminis 38.35 2.00e-37 147.00
IUUC-Gga-040344 Gallus gallus 39.32 3.00e-33 133.00
IUUC-Gac-042256 Gasterosteus aculeatus 39.32 2.00e-33 134.00
IUUC-Gma-043226 Glycine max 47.53 2.00e-40 157.00
IUUC-Ggo-044523 Gorilla gorilla 38.57 6.00e-33 132.00
IUUC-Hsa-046659 Homo sapiens 39.32 3.00e-33 133.00
IUUC-Itr-048834 Ictidomys tridecemlineatus 39.32 3.00e-33 133.00
IUUC-Kpa-049139 Komagataella pastoris 50.67 9.00e-45 172.00
IUUC-Lch-049562 Latimeria chalumnae 39.32 2.00e-33 134.00
IUUC-Lpe-050737 Leersia perrieri 44.83 2.00e-39 154.00
IUUC-Loc-051798 Lepisosteus oculatus 39.32 4.00e-33 133.00
IUUC-Lma-052979 Leptosphaeria maculans 45.39 7.00e-37 145.00
IUUC-Laf-053391 Loxodonta africana 43.21 3.00e-31 126.00
IUUC-Mcc-055667 Macaca mulatta 39.32 3.00e-33 133.00
IUUC-Mor-057084 Magnaporthe oryzae 38.99 3.00e-38 150.00
IUUC-Mpo-057347 Magnaporthe poae 35.27 4.00e-36 143.00
IUUC-Mtr-057781 Medicago truncatula 47.53 2.00e-40 157.00
IUUC-Mla-059106 Melampsora laricipopulina 37.50 2.00e-36 144.00
IUUC-Mga-059473 Meleagris gallopavo 39.32 5.00e-33 132.00
IUUC-Mvi-060540 Microbotryum violaceum 43.26 2.00e-40 157.00
IUUC-Mmr-061138 Microcebus murinus 39.47 1.00e-29 120.00
IUUC-Mdo-062893 Monodelphis domestica 39.32 2.00e-33 133.00
IUUC-Mmu-063637 Mus musculus 39.32 2.00e-33 133.00
IUUC-Mac-064683 Musa acuminata 38.67 4.00e-41 160.00
IUUC-Mpu-066096 Mustela putorius furo 40.59 4.00e-33 133.00
IUUC-Mlu-067872 Myotis lucifugus 38.83 1.00e-32 131.00
IUUC-Nfi-068443 Neosartorya fischeri 39.42 1.00e-38 151.00
IUUC-Ncr-068953 Neurospora crassa 39.05 3.00e-38 150.00
IUUC-Nle-068972 Nomascus leucogenys 39.32 3.00e-33 133.00
IUUC-Opr-070215 Ochotona princeps 38.35 9.00e-33 132.00
IUUC-Ont-072538 Oreochromis niloticus 39.32 2.00e-33 134.00
IUUC-Oan-073143 Ornithorhynchus anatinus 39.32 3.00e-33 133.00
IUUC-Ocu-074197 Oryctolagus cuniculus 39.32 3.00e-33 133.00
IUUC-Oba-075884 Oryza barthii 45.35 1.00e-39 154.00
IUUC-Obr-076874 Oryza brachyantha 48.73 7.00e-40 155.00
IUUC-Ogl-077169 Oryza glaberrima 48.73 6.00e-40 155.00
IUUC-Ogu-078258 Oryza glumaepatula 48.73 7.00e-40 155.00
IUUC-Oin-079101 Oryza indica 45.35 1.00e-39 155.00
IUUC-Olo-080708 Oryza longistaminata 47.52 4.00e-33 132.00
IUUC-Ome-081571 Oryza meridionalis 45.35 1.00e-39 155.00
IUUC-Oni-082888 Oryza nivara 45.35 1.00e-39 155.00
IUUC-Opu-083182 Oryza punctata 48.73 6.00e-40 155.00
IUUC-Oru-084895 Oryza rufipogon 45.35 1.00e-39 155.00
IUUC-Osa-085331 Oryza sativa 48.73 6.00e-40 155.00
IUUC-Ola-086850 Oryzias latipes 39.32 2.00e-33 134.00
IUUC-Olu-087607 Ostreococcus lucimarinus 49.66 5.00e-42 162.00
IUUC-Oga-088640 Otolemur garnettii 39.32 3.00e-33 133.00
IUUC-Oar-090299 Ovis aries 39.32 3.00e-33 133.00
IUUC-Ptr-091499 Pan troglodytes 39.32 3.00e-33 133.00
IUUC-Pan-091751 Papio anubis 39.32 5.00e-33 132.00
IUUC-Psi-092978 Pelodiscus sinensis 39.32 4.00e-33 133.00
IUUC-Pma-094634 Petromyzon marinus 40.30 3.00e-33 133.00
IUUC-Pno-095094 Phaeosphaeria nodorum 45.16 1.00e-37 148.00
IUUC-Ppa-095440 Physcomitrella patens 44.68 3.00e-41 160.00
IUUC-Pfo-097332 Poecilia formosa 39.32 2.00e-33 134.00
IUUC-Pab-097998 Pongo abelii 39.32 3.00e-33 133.00
IUUC-Pop-098905 Populus trichocarpa 40.37 5.00e-41 159.00
IUUC-Ppe-101309 Prunus persica 40.54 2.00e-40 157.00
IUUC-Pva-102953 Pteropus vampyrus 39.32 3.00e-33 133.00
IUUC-Pgr-103452 Puccinia graminis 46.62 3.00e-35 140.00
IUUC-Ptt-103777 Puccinia triticina 46.62 6.00e-35 139.00
IUUC-Pte-104273 Pyrenophora teres 46.05 6.00e-38 149.00
IUUC-Pyt-104627 Pyrenophora triticirepentis 37.22 1.00e-38 151.00
IUUC-Rno-105666 Rattus norvegicus 39.32 5.00e-33 132.00
IUUC-Sha-106602 Sarcophilus harrisii 39.32 2.00e-33 133.00
IUUC-Sja-107822 Schizosaccharomyces japonicus 48.46 2.00e-32 130.00
IUUC-Spo-108318 Schizosaccharomyces pombe 39.88 3.00e-35 139.00
IUUC-Ssl-108428 Sclerotinia sclerotiorum 39.62 1.00e-38 151.00
IUUC-Smo-109011 Selaginella moellendorffii 45.09 4.00e-40 156.00
IUUC-Sit-110526 Setaria italica 47.47 1.00e-38 151.00
IUUC-Sly-110851 Solanum lycopersicum 39.19 1.00e-40 158.00
IUUC-Stu-112151 Solanum tuberosum 39.19 2.00e-40 157.00
IUUC-Sar-113459 Sorex araneus 39.32 3.00e-33 133.00
IUUC-Sbi-114873 Sorghum bicolor 47.47 8.00e-39 152.00
IUUC-Sre-114919 Sporisorium reilianum 46.56 7.00e-41 159.00
IUUC-Ssc-116102 Sus scrofa 39.32 3.00e-33 133.00
IUUC-Tgu-116937 Taeniopygia guttata 39.32 4.00e-33 132.00
IUUC-Tru-118615 Takifugu rubripes 39.32 2.00e-33 134.00
IUUC-Tsy-119173 Tarsius syrichta 39.32 2.00e-33 133.00
IUUC-Tni-120246 Tetraodon nigroviridis 39.32 1.00e-33 134.00
IUUC-Tca-121859 Theobroma cacao 40.09 1.00e-40 157.00
IUUC-Tre-122030 Trichoderma reesei 39.71 4.00e-40 156.00
IUUC-Tvi-122506 Trichoderma virens 43.12 9.00e-40 155.00
IUUC-Tae-124008 Triticum aestivum 51.75 2.00e-39 153.00
IUUC-Tur-126517 Triticum urartu 46.75 8.00e-40 155.00
IUUC-Tme-127122 Tuber melanosporum 37.56 1.00e-37 147.00
IUUC-Tbe-128108 Tupaia belangeri 39.32 3.00e-33 133.00
IUUC-Ttr-128644 Tursiops truncatus 39.32 3.00e-33 133.00
IUUC-Uma-129390 Ustilago maydis 49.06 4.00e-39 153.00
IUUC-Vda-129932 Verticillium dahliae 45.27 2.00e-37 147.00
IUUC-Vpa-130110 Vicugna pacos 39.32 3.00e-33 133.00
IUUC-Vvi-131534 Vitis vinifera 41.75 4.00e-41 159.00
IUUC-Xtr-132739 Xenopus tropicalis 38.83 2.00e-33 134.00
IUUC-Xma-133919 Xiphophorus maculatus 39.32 2.00e-33 134.00
IUUC-Yli-134677 Yarrowia lipolytica 40.67 2.00e-42 164.00
IUUC-Zma-135578 Zea mays 47.47 1.00e-38 151.00
Created Date 25-Jun-2017

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