iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	15546359; 11713520

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.15	13.0	6	42

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 103  ldrlpeeilveilklldkee.llraarvcrrwqelas 138
             ++pee+l +++++++ ++   ++++vc++w+e+ +
   Q: 6    ALSFPEEVLEHVFSFIQLDKdRNSVSLVCKSWYEIER 42
           5679************66555************9876 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin-regulated transcription. The SCF(TIR1) E3 ubiquitin ligase complex is involved in auxin-mediated signaling pathway that regulate root and hypocotyl growth, lateral root formation, cell elongation, and gravitropism. Appears to allow pericycle cells to overcome G2 arrest prior to lateral root development. Plays a role in ethylene signaling in roots. Confers sensitivity to the virulent bacterial pathogen P.syringae.

Protein Sequence
(Fasta)

MQKRIALSFP EEVLEHVFSF IQLDKDRNSV SLVCKSWYEI ERWCRRKVFI GNCYAVSPAT 60
VIRRFPKVRS VELKGKPHFA DFNLVPDGWG GYVYPWIEAM SSSYTWLEEI RLKRMVVTDD 120

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Nucleotide Sequence
(Fasta)

CTCTCCAATA TCTCGTCCCG TTTTCTGCGG CTGCCCTTCT CTGCACAGTC GATAAGATAA 60
TCTCCCGCTT TCATTCAATC GGACGGCTGG TATTTGAAGC TTATAAGACA CGTGTCATCA 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0927--Auxin signaling pathway
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0936--Ethylene signaling pathway
KW-0539--Nucleus
KW-0611--Plant defense
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00367--LRR_CC

Gene Ontology

GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0010011--F:auxin binding
GO:0038198--F:auxin receptor activity
GO:0000822--F:inositol hexakisphosphate binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0009734--P:auxin-activated signaling pathway
GO:0007049--P:cell cycle
GO:0016036--P:cellular response to phosphate starvation
GO:0006952--P:defense response
GO:0009873--P:ethylene-activated signaling pathway
GO:0010311--P:lateral root formation
GO:0010152--P:pollen maturation
GO:0009733--P:response to auxin
GO:0048443--P:stamen development

KEGG

ath:AT3G62980

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005185	Anolis carolinensis	28.97	4.00e-12	65.50
IUUC-Aly-006112	Arabidopsis lyrata	98.46	0.00e+00	1186.00
IUUC-Bol-016359	Brassica oleracea	90.74	0.00e+00	1098.00
IUUC-Bra-016902	Brassica rapa	92.61	0.00e+00	1116.00
IUUC-Gma-044228	Glycine max	80.00	0.00e+00	968.00
IUUC-Mtr-057747	Medicago truncatula	79.04	0.00e+00	964.00
IUUC-Mac-064464	Musa acuminata	65.16	0.00e+00	764.00
IUUC-Pop-099362	Populus trichocarpa	79.38	0.00e+00	952.00
IUUC-Ppe-101435	Prunus persica	80.93	0.00e+00	994.00
IUUC-Sit-110658	Setaria italica	62.72	0.00e+00	676.00
IUUC-Sly-111582	Solanum lycopersicum	77.97	0.00e+00	943.00
IUUC-Stu-112711	Solanum tuberosum	77.45	0.00e+00	944.00
IUUC-Tca-121407	Theobroma cacao	81.94	0.00e+00	1004.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence