iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000018189.12	ENSMUST00000189936.6	ENSMUSP00000140106.1
ENSMUSG00000018189.12	ENSMUST00000018333.12	ENSMUSP00000018333.7
ENSMUSG00000018189.12	ENSMUST00000185493.6	ENSMUSP00000139668.1
ENSMUSG00000018189.12	ENSMUST00000185539.1	ENSMUSP00000140681.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.60e-99	334.0	1	321

Active Site

Position(s)	Description	Evidence
88	Nucleophile	ECO:0000250}
164	Proton donor	ECO:0000250}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m+s++ ew+ +esdPg+ft+l++ fg+++  qvee++sL+pe+++++ +pv+gl++lFk+++ +e +          +vv+++ ++tif
   Q: 1    MSSNAGEWCLMESDPGVFTELIKGFGCRGA-QVEEIWSLEPESFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLETIF 78
           88999*************************.****************.********************.........899********* PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc+++ ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ ++++ ++    +++af
   Q: 79   FAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTPAK----EEDAF 163
           *****************************************************************************888....79*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........ 259
           hfvsyv++ngrlyeldgl++ P+dlg+ ++++++  +++ v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +        
   Q: 164  HFVSYVPVNGRLYELDGLREGPIDLGA-CNQDDWITAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQlaeeepmd 249
           **************************9.78899*********..******************************976665566777777 PP
   S: 260  .keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefg 333
             +   +l++i+se++++++ +++e++k k++ki++irR++ny  fi++++k+la++++l  lve+    + +++
   Q: 250  tDQGSTVLSAIQSEVARNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQN 321
           6555689*********************************************************993...33344 PP

Organism

Mus musculus

Functional Description
(View)

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity).

Protein Sequence
(Fasta)

MSSNAGEWCL MESDPGVFTE LIKGFGCRGA QVEEIWSLEP ESFEKLKPVH GLIFLFKWQP 60
GEEPAGSVVQ DSRLETIFFA KQVINNACAT QAIVSVLLNC THQDVHLGET LSEFKEFSQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCGGGGTG ACGTGGGGTT GACGCTCGGC GGCGGGTTTT GCTGAGGTCT GCGGCCGGTG 60
GCAGCTTGTG CTGCGGGGCT CCGGAGAGCG CGAGGTGGAA GCGGGGCGGT GTGTGTGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031597--C:cytosolic proteasome complex
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004866--F:endopeptidase inhibitor activity
GO:0070628--F:proteasome binding
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006310--P:DNA recombination
GO:0006281--P:DNA repair
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:56207

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	47.29	3.00e-84	305.00
IUUC-Aml-001866	Ailuropoda melanoleuca	96.49	0.00e+00	635.00
IUUC-Atr-002966	Amborella trichopoda	48.81	3.00e-81	295.00
IUUC-Apl-003306	Anas platyrhynchos	84.08	5.00e-174	603.00
IUUC-Aca-004763	Anolis carolinensis	93.27	1.00e-176	612.00
IUUC-Aly-005581	Arabidopsis lyrata	49.09	1.00e-79	289.00
IUUC-Ath-007283	Arabidopsis thaliana	49.39	5.00e-82	297.00
IUUC-Ago-007999	Ashbya gossypii	33.44	1.00e-33	136.00
IUUC-Acl-008231	Aspergillus clavatus	44.21	3.00e-53	201.00
IUUC-Afl-008557	Aspergillus flavus	38.11	2.00e-55	208.00
IUUC-Afu-008988	Aspergillus fumigatus	45.23	1.00e-54	206.00
IUUC-Ani-009420	Aspergillus nidulans	38.24	4.00e-54	205.00
IUUC-Ang-009859	Aspergillus niger	40.65	2.00e-49	189.00
IUUC-Aor-010145	Aspergillus oryzae	38.11	2.00e-55	208.00
IUUC-Ate-010347	Aspergillus terreus	41.96	4.00e-54	204.00
IUUC-Ame-010791	Astyanax mexicanus	88.75	5.00e-179	620.00
IUUC-Bgr-012298	Blumeria graminis	37.50	9.00e-49	187.00
IUUC-Bta-013251	Bos taurus	96.49	0.00e+00	630.00
IUUC-Bci-013786	Botrytis cinerea	37.76	3.00e-57	215.00
IUUC-Bdi-014132	Brachypodium distachyon	48.62	6.00e-82	297.00
IUUC-Bol-015611	Brassica oleracea	50.00	2.00e-84	305.00
IUUC-Bra-017769	Brassica rapa	50.00	3.00e-84	305.00
IUUC-Cel-018604	Caenorhabditis elegans	46.67	2.00e-81	295.00
IUUC-Cja-019768	Callithrix jacchus	88.27	7.00e-178	616.00
IUUC-Cfa-020207	Canis familiaris	96.49	0.00e+00	635.00
IUUC-Cpo-021925	Cavia porcellus	92.33	2.00e-174	604.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	45.21	8.00e-74	270.00
IUUC-Csa-023958	Chlorocebus sabaeus	96.49	0.00e+00	629.00
IUUC-Cho-024928	Choloepus hoffmanni	98.70	6.00e-42	164.00
IUUC-Cin-025771	Ciona intestinalis	54.80	9.00e-101	360.00
IUUC-Csv-026149	Ciona savignyi	58.12	8.00e-104	370.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	38.24	8.00e-52	197.00
IUUC-Cne-026955	Cryptococcus neoformans	38.76	2.00e-55	209.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.33	2.00e-48	186.00
IUUC-Dre-027409	Danio rerio	87.23	4.00e-175	607.00
IUUC-Dno-028921	Dasypus novemcinctus	95.85	0.00e+00	630.00
IUUC-Dse-031170	Dothistroma septosporum	40.00	5.00e-59	221.00
IUUC-Dme-031677	Drosophila melanogaster	60.36	3.00e-116	411.00
IUUC-Ete-032707	Echinops telfairi	67.71	8.00e-118	416.00
IUUC-Eca-033776	Equus caballus	96.53	1.00e-167	582.00
IUUC-Eeu-035305	Erinaceus europaeus	78.19	1.00e-82	299.00
IUUC-Fca-035846	Felis catus	88.82	4.00e-178	617.00
IUUC-Fal-037597	Ficedula albicollis	93.40	6.00e-156	543.00
IUUC-Fox-037670	Fusarium oxysporum	43.79	2.00e-56	213.00
IUUC-Fso-038243	Fusarium solani	43.46	3.00e-55	208.00
IUUC-Gmo-038499	Gadus morhua	83.39	3.00e-160	557.00
IUUC-Ggr-039975	Gaeumannomyces graminis	41.46	2.00e-48	186.00
IUUC-Gga-040904	Gallus gallus	92.97	0.00e+00	637.00
IUUC-Gac-042058	Gasterosteus aculeatus	87.22	2.00e-168	584.00
IUUC-Gma-043763	Glycine max	48.66	5.00e-84	304.00
IUUC-Ggo-044699	Gorilla gorilla	90.88	2.00e-167	581.00
IUUC-Hsa-046227	Homo sapiens	96.81	0.00e+00	638.00
IUUC-Hvu-047359	Hordeum vulgare	47.72	1.00e-82	299.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	87.79	5.00e-178	616.00
IUUC-Lch-049829	Latimeria chalumnae	90.10	2.00e-171	594.00
IUUC-Lpe-050899	Leersia perrieri	48.58	7.00e-78	283.00
IUUC-Loc-052264	Lepisosteus oculatus	88.54	7.00e-170	589.00
IUUC-Lma-053110	Leptosphaeria maculans	39.02	2.00e-49	189.00
IUUC-Laf-053639	Loxodonta africana	96.49	0.00e+00	635.00
IUUC-Mcc-055506	Macaca mulatta	96.49	0.00e+00	629.00
IUUC-Mor-057001	Magnaporthe oryzae	46.22	3.00e-56	212.00
IUUC-Mpo-057608	Magnaporthe poae	40.22	8.00e-33	133.00
IUUC-Mtr-057731	Medicago truncatula	48.96	2.00e-85	308.00
IUUC-Mla-059016	Melampsora laricipopulina	43.78	2.00e-43	168.00
IUUC-Mga-060178	Meleagris gallopavo	93.09	2.00e-170	590.00
IUUC-Mvi-060353	Microbotryum violaceum	39.70	5.00e-56	211.00
IUUC-Mmr-060738	Microcebus murinus	96.17	0.00e+00	634.00
IUUC-Mdo-062266	Monodelphis domestica	96.08	3.00e-118	417.00
IUUC-Mac-065301	Musa acuminata	50.79	4.00e-88	317.00
IUUC-Mpu-066058	Mustela putorius furo	96.81	0.00e+00	636.00
IUUC-Mlu-067292	Myotis lucifugus	96.49	0.00e+00	631.00
IUUC-Nfi-068275	Neosartorya fischeri	38.66	1.00e-55	210.00
IUUC-Ncr-068713	Neurospora crassa	39.62	6.00e-59	221.00
IUUC-Nle-069013	Nomascus leucogenys	96.17	0.00e+00	628.00
IUUC-Opr-070628	Ochotona princeps	85.59	4.00e-169	587.00
IUUC-Ont-072688	Oreochromis niloticus	88.25	5.00e-169	586.00
IUUC-Oan-073004	Ornithorhynchus anatinus	94.65	8.00e-139	486.00
IUUC-Ocu-074303	Oryctolagus cuniculus	96.81	0.00e+00	637.00
IUUC-Oba-075002	Oryza barthii	48.49	6.00e-82	297.00
IUUC-Obr-076392	Oryza brachyantha	49.21	9.00e-80	290.00
IUUC-Ogl-077271	Oryza glaberrima	48.49	6.00e-82	297.00
IUUC-Ogu-078493	Oryza glumaepatula	48.49	1.00e-82	299.00
IUUC-Oin-080084	Oryza indica	48.49	1.00e-82	299.00
IUUC-Olo-080803	Oryza longistaminata	48.19	3.00e-82	298.00
IUUC-Ome-081146	Oryza meridionalis	47.59	4.00e-81	294.00
IUUC-Oni-082146	Oryza nivara	48.49	1.00e-82	299.00
IUUC-Opu-083633	Oryza punctata	49.21	2.00e-78	286.00
IUUC-Oru-084789	Oryza rufipogon	48.49	1.00e-82	299.00
IUUC-Osa-086196	Oryza sativa	48.49	1.00e-82	299.00
IUUC-Ola-087126	Oryzias latipes	88.18	3.00e-165	574.00
IUUC-Olu-087665	Ostreococcus lucimarinus	41.67	3.00e-69	254.00
IUUC-Oga-089140	Otolemur garnettii	88.53	7.00e-179	619.00
IUUC-Oar-090296	Ovis aries	96.17	0.00e+00	630.00
IUUC-Ptr-090566	Pan troglodytes	96.81	0.00e+00	638.00
IUUC-Pan-092052	Papio anubis	96.49	0.00e+00	629.00
IUUC-Psi-093723	Pelodiscus sinensis	93.06	3.00e-162	564.00
IUUC-Pma-094568	Petromyzon marinus	61.11	1.00e-105	376.00
IUUC-Pno-095120	Phaeosphaeria nodorum	39.14	3.00e-50	192.00
IUUC-Ppa-095761	Physcomitrella patens	47.37	6.00e-83	300.00
IUUC-Pfo-096210	Poecilia formosa	87.54	7.00e-169	586.00
IUUC-Pab-098463	Pongo abelii	96.81	0.00e+00	636.00
IUUC-Pop-099423	Populus trichocarpa	49.56	2.00e-84	305.00
IUUC-Pca-100108	Procavia capensis	95.53	1.00e-140	492.00
IUUC-Ppe-101176	Prunus persica	51.20	2.00e-85	309.00
IUUC-Pva-102629	Pteropus vampyrus	93.51	5.00e-145	506.00
IUUC-Pgr-103419	Puccinia graminis	39.47	2.00e-56	213.00
IUUC-Pte-104207	Pyrenophora teres	44.38	1.00e-32	132.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	39.34	3.00e-56	212.00
IUUC-Rno-105579	Rattus norvegicus	88.24	1.00e-164	572.00
IUUC-Sha-106894	Sarcophilus harrisii	94.40	1.00e-152	531.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	39.20	7.00e-60	223.00
IUUC-Spo-108371	Schizosaccharomyces pombe	41.58	2.00e-59	222.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	38.41	3.00e-47	182.00
IUUC-Smo-109396	Selaginella moellendorffii	51.38	4.00e-88	317.00
IUUC-Sit-110630	Setaria italica	49.24	7.00e-85	307.00
IUUC-Sly-110972	Solanum lycopersicum	50.16	3.00e-80	291.00
IUUC-Stu-112185	Solanum tuberosum	50.60	2.00e-88	319.00
IUUC-Sar-113294	Sorex araneus	80.97	4.00e-162	563.00
IUUC-Sbi-113951	Sorghum bicolor	49.54	3.00e-85	308.00
IUUC-Ssc-115501	Sus scrofa	95.96	1.00e-171	595.00
IUUC-Tgu-117152	Taeniopygia guttata	93.06	6.00e-156	543.00
IUUC-Tru-118388	Takifugu rubripes	86.90	2.00e-168	585.00
IUUC-Tsy-119109	Tarsius syrichta	96.49	0.00e+00	635.00
IUUC-Tni-120048	Tetraodon nigroviridis	86.90	5.00e-169	586.00
IUUC-Tca-121750	Theobroma cacao	49.12	5.00e-88	317.00
IUUC-Tre-122130	Trichoderma reesei	39.00	2.00e-55	209.00
IUUC-Tvi-122284	Trichoderma virens	39.13	1.00e-52	199.00
IUUC-Tae-124082	Triticum aestivum	47.89	2.00e-83	302.00
IUUC-Tur-126366	Triticum urartu	43.34	2.00e-66	246.00
IUUC-Tme-127187	Tuber melanosporum	41.72	1.00e-58	219.00
IUUC-Tbe-127619	Tupaia belangeri	87.46	3.00e-141	494.00
IUUC-Ttr-128867	Tursiops truncatus	86.12	7.00e-122	430.00
IUUC-Vda-129912	Verticillium dahliae	37.50	4.00e-53	201.00
IUUC-Vpa-130552	Vicugna pacos	96.65	4.00e-123	434.00
IUUC-Vvi-130881	Vitis vinifera	51.04	5.00e-85	307.00
IUUC-Xtr-131934	Xenopus tropicalis	84.80	5.00e-172	596.00
IUUC-Xma-133312	Xiphophorus maculatus	87.54	9.00e-169	585.00
IUUC-Yli-134487	Yarrowia lipolytica	35.05	4.00e-50	191.00
IUUC-Zma-135462	Zea mays	44.00	8.00e-73	267.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence