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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Mmu-064302
Ensembl Protein ID ENSMUSP00000111241.3
UniProt Accession P70362; Q923C4; UFD1_MOUSE
Genbank Protein ID AAD08719.1; BAE27708.1; BAE40849.1; EDK97535.1; AAH06630.1
Protein Name Ubiquitin fusion degradation protein 1 homolog
Genbank Nucleotide ID U64445; AK147138; AK169062; CH466521; BC006630
Gene Name Ufd1l
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000005262.12 ENSMUST00000172013.7 ENSMUSP00000128186.1
ENSMUSG00000005262.12 ENSMUST00000115578.9 ENSMUSP00000111241.3
ENSMUSG00000005262.12 ENSMUST00000163695.1 ENSMUSP00000132341.1
ENSMUSG00000005262.12 ENSMUST00000172451.1 ENSMUSP00000133217.1
Annotation
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
DUB/Other 98.70 1.00e-175 612.00 IUUC-Hsa-046680
UBD/Other/Other 98.70 1.00e-175 612.00 IUUC-Hsa-046680
UBD/Other/Other 37.65 7.00e-52 198.00 IUUC-Sce-106174
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description



     Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (By similarity).
Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (By similarity).
Protein Sequence
(Fasta)
MFSFNMFDHP IPRVFQNRFS TQYRCFSVSM LAGPNDRSDV EKGGKIIMPP SALDQLSRLN 60
ITYPMLFKLT NKNSDRMTHC GVLEFVADEG ICYLPHWMMQ NLLLEEGGLV QVESVNLQVA 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mmu-064302|DUB,DUB/Other;UBD,UBD/Other/Other|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAACATCTTT CCTCAGGCTG CGAACCTTGT TGCCGGTGTT GACGCTAACG TCCAGTCACC 60
CAAAACCACC TATGTTTGGC AGACATCTTT ACTTCGGGAA GGAAGGTCTA TTATCTGACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-064302|DUB,DUB/Other;UBD,UBD/Other/Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR004854--UFD1

Pfam

PF03152--UFD1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0036501--C:UFD1-NPL4 complex
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0036435--F:K48-linked polyubiquitin binding
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0039536--P:negative regulation of RIG-I signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG mmu:22230
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000441 Aegilops tauschii 52.25 2.00e-66 246.00
IUUC-Aml-001398 Ailuropoda melanoleuca 98.69 3.00e-176 610.00
IUUC-Atr-002449 Amborella trichopoda 49.27 8.00e-55 207.00
IUUC-Apl-004065 Anas platyrhynchos 93.51 1.00e-142 498.00
IUUC-Aca-004973 Anolis carolinensis 92.83 2.00e-171 594.00
IUUC-Aly-005501 Arabidopsis lyrata 52.56 2.00e-68 252.00
IUUC-Ath-007324 Arabidopsis thaliana 53.04 3.00e-68 251.00
IUUC-Ago-007918 Ashbya gossypii 37.58 1.00e-52 200.00
IUUC-Acl-008362 Aspergillus clavatus 42.64 3.00e-68 252.00
IUUC-Afl-008690 Aspergillus flavus 54.38 4.00e-65 241.00
IUUC-Afu-008787 Aspergillus fumigatus 42.94 3.00e-66 245.00
IUUC-Ani-009385 Aspergillus nidulans 56.57 6.00e-57 214.00
IUUC-Ang-009709 Aspergillus niger 56.44 1.00e-64 240.00
IUUC-Aor-010240 Aspergillus oryzae 54.38 4.00e-65 241.00
IUUC-Ate-010551 Aspergillus terreus 56.10 6.00e-64 238.00
IUUC-Ame-011417 Astyanax mexicanus 89.29 2.00e-159 555.00
IUUC-Bgr-011986 Blumeria graminis 56.25 9.00e-62 230.00
IUUC-Bta-012559 Bos taurus 96.48 6.00e-127 446.00
IUUC-Bci-013767 Botrytis cinerea 56.08 6.00e-58 218.00
IUUC-Bdi-014336 Brachypodium distachyon 52.44 3.00e-66 245.00
IUUC-Bol-015824 Brassica oleracea 44.95 6.00e-67 247.00
IUUC-Bra-016732 Brassica rapa 44.63 6.00e-67 247.00
IUUC-Cel-018590 Caenorhabditis elegans 40.13 6.00e-49 187.00
IUUC-Cja-019487 Callithrix jacchus 98.70 1.00e-176 612.00
IUUC-Cfa-020497 Canis familiaris 98.70 7.00e-177 612.00
IUUC-Cpo-022150 Cavia porcellus 98.37 1.00e-175 608.00
IUUC-Cre-023007 Chlamydomonas reinhardtii 50.66 5.00e-58 217.00
IUUC-Csa-023602 Chlorocebus sabaeus 98.70 6.00e-177 612.00
IUUC-Cin-025594 Ciona intestinalis 58.72 1.00e-93 335.00
IUUC-Csv-026040 Ciona savignyi 55.27 4.00e-94 337.00
IUUC-Cgl-026460 Colletotrichum gloeosporioides 47.87 3.00e-51 195.00
IUUC-Cne-026990 Cryptococcus neoformans 42.49 3.00e-39 156.00
IUUC-Cme-027323 Cyanidioschyzon merolae 34.54 6.00e-44 171.00
IUUC-Dre-027987 Danio rerio 86.69 8.00e-153 532.00
IUUC-Dor-030294 Dipodomys ordii 97.07 4.00e-173 600.00
IUUC-Dse-031411 Dothistroma septosporum 38.24 2.00e-56 213.00
IUUC-Dme-031798 Drosophila melanogaster 56.01 6.00e-93 333.00
IUUC-Ete-032432 Echinops telfairi 97.07 5.00e-174 603.00
IUUC-Eca-034427 Equus caballus 98.70 6.00e-177 612.00
IUUC-Eeu-034917 Erinaceus europaeus 100.00 2.00e-90 325.00
IUUC-Fca-035380 Felis catus 98.70 7.00e-177 612.00
IUUC-Fal-037659 Ficedula albicollis 94.04 2.00e-167 580.00
IUUC-Fox-038062 Fusarium oxysporum 44.90 5.00e-21 93.60
IUUC-Fso-038111 Fusarium solani 35.67 4.00e-52 198.00
IUUC-Gmo-039298 Gadus morhua 87.06 4.00e-146 510.00
IUUC-Ggr-039771 Gaeumannomyces graminis 50.78 1.00e-55 209.00
IUUC-Gga-040313 Gallus gallus 95.11 1.00e-171 595.00
IUUC-Gac-042009 Gasterosteus aculeatus 85.81 5.00e-147 513.00
IUUC-Gma-043844 Glycine max 52.50 8.00e-67 247.00
IUUC-Ggo-044639 Gorilla gorilla 88.05 5.00e-171 593.00
IUUC-Hsa-046680 Homo sapiens 98.70 6.00e-177 612.00
IUUC-Hvu-047860 Hordeum vulgare 52.89 2.00e-66 245.00
IUUC-Itr-047987 Ictidomys tridecemlineatus 98.69 3.00e-176 610.00
IUUC-Kpa-049136 Komagataella pastoris 36.57 4.00e-55 208.00
IUUC-Lch-050607 Latimeria chalumnae 88.74 2.00e-155 541.00
IUUC-Lpe-050726 Leersia perrieri 49.77 2.00e-60 226.00
IUUC-Loc-051848 Lepisosteus oculatus 89.64 2.00e-160 557.00
IUUC-Lma-053187 Leptosphaeria maculans 41.34 2.00e-64 239.00
IUUC-Laf-053569 Loxodonta africana 96.76 1.00e-172 598.00
IUUC-Mcc-055275 Macaca mulatta 98.37 5.00e-176 609.00
IUUC-Mor-056967 Magnaporthe oryzae 37.65 6.00e-56 211.00
IUUC-Mpo-057399 Magnaporthe poae 51.30 7.00e-56 211.00
IUUC-Mtr-058353 Medicago truncatula 51.74 6.00e-66 244.00
IUUC-Mla-058830 Melampsora laricipopulina 44.56 2.00e-42 167.00
IUUC-Mga-059803 Meleagris gallopavo 94.27 2.00e-143 501.00
IUUC-Mvi-060456 Microbotryum violaceum 46.81 3.00e-45 176.00
IUUC-Mmr-060573 Microcebus murinus 98.37 3.00e-176 610.00
IUUC-Mdo-062831 Monodelphis domestica 96.09 2.00e-172 598.00
IUUC-Mac-065200 Musa acuminata 52.21 2.00e-66 246.00
IUUC-Mpu-065922 Mustela putorius furo 98.37 9.00e-177 612.00
IUUC-Mlu-068236 Myotis lucifugus 97.41 2.00e-174 604.00
IUUC-Nfi-068417 Neosartorya fischeri 42.94 2.00e-66 246.00
IUUC-Ncr-068747 Neurospora crassa 48.44 6.00e-53 201.00
IUUC-Nle-069948 Nomascus leucogenys 88.08 4.00e-172 597.00
IUUC-Opr-070919 Ochotona princeps 83.06 3.00e-138 484.00
IUUC-Ont-071467 Oreochromis niloticus 86.41 1.00e-151 528.00
IUUC-Oan-073436 Ornithorhynchus anatinus 76.36 3.00e-69 253.00
IUUC-Ocu-074427 Oryctolagus cuniculus 97.72 1.00e-166 578.00
IUUC-Oba-075440 Oryza barthii 50.64 1.00e-66 246.00
IUUC-Obr-076275 Oryza brachyantha 51.61 2.00e-59 223.00
IUUC-Ogl-077237 Oryza glaberrima 50.64 2.00e-66 246.00
IUUC-Ogu-078934 Oryza glumaepatula 50.64 1.00e-66 246.00
IUUC-Oin-079475 Oryza indica 51.06 5.00e-67 248.00
IUUC-Olo-080285 Oryza longistaminata 60.24 9.00e-58 216.00
IUUC-Ome-081887 Oryza meridionalis 50.64 1.00e-66 246.00
IUUC-Oni-082064 Oryza nivara 51.06 6.00e-67 247.00
IUUC-Opu-083610 Oryza punctata 49.79 4.00e-65 241.00
IUUC-Oru-084911 Oryza rufipogon 43.77 4.00e-67 248.00
IUUC-Osa-085366 Oryza sativa 50.64 1.00e-66 246.00
IUUC-Ola-086846 Oryzias latipes 75.86 6.00e-138 483.00
IUUC-Olu-087879 Ostreococcus lucimarinus 46.22 3.00e-57 215.00
IUUC-Oga-089017 Otolemur garnettii 97.09 3.00e-173 600.00
IUUC-Oar-089970 Ovis aries 93.46 5.00e-166 576.00
IUUC-Ptr-091147 Pan troglodytes 89.32 4.00e-161 560.00
IUUC-Pan-091757 Papio anubis 91.23 5.00e-158 550.00
IUUC-Psi-093931 Pelodiscus sinensis 94.79 6.00e-171 592.00
IUUC-Pno-094775 Phaeosphaeria nodorum 48.17 2.00e-58 219.00
IUUC-Ppa-095156 Physcomitrella patens 51.34 3.00e-63 235.00
IUUC-Pfo-097295 Poecilia formosa 85.53 8.00e-151 526.00
IUUC-Pab-098537 Pongo abelii 98.70 6.00e-177 612.00
IUUC-Pop-099436 Populus trichocarpa 50.40 1.00e-68 253.00
IUUC-Pca-100631 Procavia capensis 85.51 7.00e-164 569.00
IUUC-Ppe-101259 Prunus persica 51.29 3.00e-67 248.00
IUUC-Pva-102679 Pteropus vampyrus 90.00 6.00e-158 550.00
IUUC-Pgr-103475 Puccinia graminis 45.59 8.00e-45 174.00
IUUC-Ptt-104012 Puccinia triticina 38.73 3.00e-32 132.00
IUUC-Pte-104071 Pyrenophora teres 50.95 4.00e-61 228.00
IUUC-Pyt-104501 Pyrenophora triticirepentis 50.95 4.00e-61 228.00
IUUC-Rno-104858 Rattus norvegicus 99.35 2.00e-178 617.00
IUUC-Sce-106174 Saccharomyces cerevisiae 39.33 3.00e-54 205.00
IUUC-Sha-107075 Sarcophilus harrisii 96.41 5.00e-173 599.00
IUUC-Sja-107663 Schizosaccharomyces japonicus 43.67 4.00e-60 224.00
IUUC-Spo-108259 Schizosaccharomyces pombe 46.32 7.00e-52 197.00
IUUC-Ssl-108473 Sclerotinia sclerotiorum 38.71 8.00e-51 194.00
IUUC-Smo-109290 Selaginella moellendorffii 53.71 1.00e-65 243.00
IUUC-Sit-109992 Setaria italica 51.06 8.00e-66 243.00
IUUC-Sly-110858 Solanum lycopersicum 51.35 3.00e-63 234.00
IUUC-Stu-112028 Solanum tuberosum 55.80 2.00e-58 219.00
IUUC-Sar-113061 Sorex araneus 97.72 1.00e-174 605.00
IUUC-Sbi-114882 Sorghum bicolor 44.59 8.00e-67 247.00
IUUC-Sre-115104 Sporisorium reilianum 47.12 3.00e-44 172.00
IUUC-Ssc-115403 Sus scrofa 98.05 5.00e-176 609.00
IUUC-Tgu-117013 Taeniopygia guttata 94.77 7.00e-171 592.00
IUUC-Tru-118307 Takifugu rubripes 86.69 2.00e-148 518.00
IUUC-Tsy-119309 Tarsius syrichta 87.32 5.00e-67 247.00
IUUC-Tni-120209 Tetraodon nigroviridis 86.08 1.00e-146 512.00
IUUC-Tca-121421 Theobroma cacao 51.74 1.00e-67 249.00
IUUC-Tre-122235 Trichoderma reesei 46.11 2.00e-51 196.00
IUUC-Tvi-122421 Trichoderma virens 46.04 5.00e-52 198.00
IUUC-Tae-124587 Triticum aestivum 52.25 8.00e-67 246.00
IUUC-Tur-126353 Triticum urartu 37.50 5.00e-25 109.00
IUUC-Tme-126918 Tuber melanosporum 53.65 1.00e-58 220.00
IUUC-Ttr-129286 Tursiops truncatus 88.43 3.00e-160 557.00
IUUC-Uma-129404 Ustilago maydis 48.17 1.00e-45 177.00
IUUC-Vda-129746 Verticillium dahliae 48.21 2.00e-52 199.00
IUUC-Vpa-130648 Vicugna pacos 98.04 3.00e-24 105.00
IUUC-Vvi-131301 Vitis vinifera 52.61 6.00e-67 247.00
IUUC-Xtr-132583 Xenopus tropicalis 90.55 2.00e-162 565.00
IUUC-Xma-133129 Xiphophorus maculatus 85.85 6.00e-151 526.00
IUUC-Yli-134515 Yarrowia lipolytica 46.63 2.00e-50 192.00
IUUC-Zma-135266 Zea mays 43.85 1.00e-66 246.00
Created Date 25-Jun-2017

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