iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Sce-106266

UUCD1 version

UUC-SaC-00146

Ensembl Protein ID

YNL006W

UniProt Accession

P41318; D6W1H1; LST8_YEAST

Genbank Protein ID

CAA54380.1; CAA95865.1; DAA10537.1

Protein Name

Target of rapamycin complex subunit LST8; Lethal with SEC13 protein 8

Genbank Nucleotide ID

X77114; Z71282; BK006947

Gene Name

LST8; YNL006W; N2005

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YNL006W	YNL006W	YNL006W

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-40	134.2	73	110
UBD/Beta-Prp	9.80e-53	177.7	4	107

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH + vt+++f +d + +v++s DgtikvWD+r+   +
   Q: 73   GHRGNVTSVSFqQDnRWMVTSSEDGTIKVWDVRSPSIP 110
           8***********776999**************997765 PP

UBD/Beta-Prp

   S: 151  llvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlq..tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +lvs+++D t+r+W   tg + rt +   +++v+ l+++ ++  l++ +  + v+l+d++  + + v +++gh+ nv+sv f +++ ++v+ s+Dg+i++W
   Q: 4    ILVSAGYDHTIRFWEALTGVCSRTIQH-SDSQVNRLEITNDK-KLLATAGHQNVRLYDIRttNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW 102
           79***********************98.9**********986.6666666788*******666667*********************************** PP
   S: 250  dlrsg 254
           d+rs 
   Q: 103  DVRSP 107
           **985 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Essential component of both TORC1 and TORC2. TORC1 regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. LST8 is involved in the negative regulation of transcription factors GLN3 and RTG1-RTG3, limiting the synthesis of alpha-ketoglutarate, glutamate and glutamine. LST8 is required for targeting of amino acid permeases (AAPs) to the plasma membrane. TORC2 regulates cell cycle-dependent polarization of the actin-cytoskeleton, cell wall integrity, and receptor endocytosis. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway. LST8 is involved in maintenance of cell wall integrity. LST8 modulates TOR2 kinase activity.

Protein Sequence
(Fasta)

MSVILVSAGY DHTIRFWEAL TGVCSRTIQH SDSQVNRLEI TNDKKLLATA GHQNVRLYDI 60
RTTNPNPVAS FEGHRGNVTS VSFQQDNRWM VTSSEDGTIK VWDVRSPSIP RNYKHNAPVN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTGTTA TCTTAGTATC TGCTGGCTAT GACCACACAA TAAGATTTTG GGAGGCTCTT 60
ACTGGGGTTT GTTCAAGAAC AATTCAGCAT TCCGACTCAC AGGTTAATCG CTTAGAAATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0926--Vacuole
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0010008--C:endosome membrane
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0000139--C:Golgi membrane
GO:0034399--C:nuclear periphery
GO:0031931--C:TORC1 complex
GO:0031932--C:TORC2 complex
GO:0005774--C:vacuolar membrane
GO:0030295--F:protein kinase activator activity
GO:0030950--P:establishment or maintenance of actin cytoskeleton polarity
GO:0031505--P:fungal-type cell wall organization
GO:0031930--P:mitochondria-nucleus signaling pathway
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0001558--P:regulation of cell growth
GO:0007165--P:signal transduction
GO:0031929--P:TOR signaling

KEGG

sce:YNL006W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000595	Aegilops tauschii	54.25	4.00e-99	352.00
IUUC-Aml-001813	Ailuropoda melanoleuca	47.44	7.00e-84	301.00
IUUC-Atr-002512	Amborella trichopoda	52.94	7.00e-97	344.00
IUUC-Apl-003495	Anas platyrhynchos	44.33	2.00e-63	233.00
IUUC-Aca-004613	Anolis carolinensis	47.76	4.00e-84	303.00
IUUC-Aly-006340	Arabidopsis lyrata	52.32	1.00e-94	337.00
IUUC-Ath-007273	Arabidopsis thaliana	52.32	5.00e-94	335.00
IUUC-Ago-007737	Ashbya gossypii	85.81	8.00e-162	560.00
IUUC-Acl-008090	Aspergillus clavatus	65.56	5.00e-92	328.00
IUUC-Afl-008490	Aspergillus flavus	63.13	2.00e-69	254.00
IUUC-Afu-009060	Aspergillus fumigatus	64.60	1.00e-84	304.00
IUUC-Ani-009251	Aspergillus nidulans	67.08	5.00e-93	332.00
IUUC-Ang-009528	Aspergillus niger	65.50	4.00e-118	415.00
IUUC-Aor-010005	Aspergillus oryzae	65.37	2.00e-111	392.00
IUUC-Ate-010423	Aspergillus terreus	67.08	6.00e-92	328.00
IUUC-Ame-011752	Astyanax mexicanus	47.44	5.00e-84	301.00
IUUC-Bgr-012299	Blumeria graminis	60.26	8.00e-116	407.00
IUUC-Bta-013007	Bos taurus	47.74	3.00e-83	300.00
IUUC-Bci-013987	Botrytis cinerea	60.78	3.00e-119	419.00
IUUC-Bdi-014082	Brachypodium distachyon	54.25	6.00e-99	351.00
IUUC-Bol-015088	Brassica oleracea	51.83	2.00e-93	333.00
IUUC-Bra-016682	Brassica rapa	44.51	3.00e-79	286.00
IUUC-Cel-018473	Caenorhabditis elegans	26.52	9.00e-32	128.00
IUUC-Cja-019216	Callithrix jacchus	44.15	2.00e-62	230.00
IUUC-Cfa-021229	Canis familiaris	47.76	1.00e-84	304.00
IUUC-Cpo-022270	Cavia porcellus	47.76	1.00e-84	304.00
IUUC-Cre-022742	Chlamydomonas reinhardtii	54.97	3.00e-102	362.00
IUUC-Csa-023275	Chlorocebus sabaeus	47.76	8.00e-85	304.00
IUUC-Cin-025588	Ciona intestinalis	45.54	2.00e-80	290.00
IUUC-Csv-026252	Ciona savignyi	46.18	7.00e-82	295.00
IUUC-Cgl-026418	Colletotrichum gloeosporioides	65.38	2.00e-124	436.00
IUUC-Cne-027013	Cryptococcus neoformans	59.28	2.00e-107	379.00
IUUC-Cme-027131	Cyanidioschyzon merolae	34.36	2.00e-59	221.00
IUUC-Dre-028424	Danio rerio	48.08	7.00e-85	305.00
IUUC-Dno-029327	Dasypus novemcinctus	47.76	9.00e-85	304.00
IUUC-Dor-030186	Dipodomys ordii	53.79	2.00e-46	177.00
IUUC-Dse-031475	Dothistroma septosporum	63.03	3.00e-126	442.00
IUUC-Dme-031826	Drosophila melanogaster	42.11	5.00e-66	242.00
IUUC-Ete-032252	Echinops telfairi	39.64	6.00e-52	195.00
IUUC-Eca-033889	Equus caballus	45.11	2.00e-52	196.00
IUUC-Fca-035989	Felis catus	47.76	1.00e-84	304.00
IUUC-Fal-036637	Ficedula albicollis	47.76	2.00e-84	303.00
IUUC-Fox-038066	Fusarium oxysporum	64.42	5.00e-123	431.00
IUUC-Fso-038288	Fusarium solani	63.14	8.00e-118	414.00
IUUC-Gmo-039477	Gadus morhua	47.76	8.00e-85	304.00
IUUC-Ggr-039990	Gaeumannomyces graminis	63.78	1.00e-121	427.00
IUUC-Gga-040890	Gallus gallus	47.76	2.00e-84	303.00
IUUC-Gac-041502	Gasterosteus aculeatus	48.08	4.00e-85	305.00
IUUC-Gma-043580	Glycine max	53.59	3.00e-98	349.00
IUUC-Ggo-045629	Gorilla gorilla	47.45	3.00e-83	299.00
IUUC-Hsa-045824	Homo sapiens	45.68	7.00e-71	258.00
IUUC-Hvu-047767	Hordeum vulgare	54.25	4.00e-99	352.00
IUUC-Itr-047932	Ictidomys tridecemlineatus	47.76	1.00e-84	304.00
IUUC-Kpa-049173	Komagataella pastoris	78.22	3.00e-149	518.00
IUUC-Lch-049703	Latimeria chalumnae	48.08	7.00e-85	305.00
IUUC-Lpe-050744	Leersia perrieri	47.39	1.00e-80	290.00
IUUC-Loc-052507	Lepisosteus oculatus	48.08	4.00e-85	305.00
IUUC-Lma-053084	Leptosphaeria maculans	65.33	2.00e-123	432.00
IUUC-Laf-053595	Loxodonta africana	47.76	2.00e-84	303.00
IUUC-Mcc-055634	Macaca mulatta	40.00	7.00e-75	271.00
IUUC-Meu-055925	Macropus eugenii	46.40	1.00e-71	261.00
IUUC-Mor-057131	Magnaporthe oryzae	62.50	9.00e-123	431.00
IUUC-Mpo-057524	Magnaporthe poae	64.10	8.00e-122	427.00
IUUC-Mtr-057980	Medicago truncatula	53.27	1.00e-97	347.00
IUUC-Mla-059082	Melampsora laricipopulina	47.31	8.00e-87	311.00
IUUC-Mga-059552	Meleagris gallopavo	44.48	7.00e-64	234.00
IUUC-Mvi-060504	Microbotryum violaceum	54.43	2.00e-99	354.00
IUUC-Mdo-062886	Monodelphis domestica	48.08	2.00e-85	306.00
IUUC-Mmu-063477	Mus musculus	48.08	3.00e-85	306.00
IUUC-Mac-065439	Musa acuminata	53.92	9.00e-99	351.00
IUUC-Mpu-066708	Mustela putorius furo	47.44	1.00e-83	301.00
IUUC-Mlu-067311	Myotis lucifugus	45.51	5.00e-81	292.00
IUUC-Nfi-068294	Neosartorya fischeri	62.92	1.00e-85	308.00
IUUC-Ncr-068811	Neurospora crassa	62.94	2.00e-120	423.00
IUUC-Nle-069632	Nomascus leucogenys	47.76	9.00e-85	304.00
IUUC-Opr-071128	Ochotona princeps	49.16	2.00e-49	186.00
IUUC-Ont-071494	Oreochromis niloticus	47.76	1.00e-84	303.00
IUUC-Oan-073298	Ornithorhynchus anatinus	41.71	2.00e-37	146.00
IUUC-Ocu-073983	Oryctolagus cuniculus	47.44	2.00e-83	300.00
IUUC-Oba-076001	Oryza barthii	47.06	2.00e-80	290.00
IUUC-Obr-076833	Oryza brachyantha	52.29	4.00e-95	338.00
IUUC-Ogl-077680	Oryza glaberrima	52.29	3.00e-95	339.00
IUUC-Ogu-078086	Oryza glumaepatula	47.06	4.00e-80	289.00
IUUC-Oin-079336	Oryza indica	52.29	3.00e-95	339.00
IUUC-Olo-080368	Oryza longistaminata	45.26	7.00e-67	244.00
IUUC-Ome-081560	Oryza meridionalis	27.66	3.00e-18	84.30
IUUC-Oni-083046	Oryza nivara	47.06	2.00e-80	290.00
IUUC-Opu-084173	Oryza punctata	47.06	2.00e-80	290.00
IUUC-Oru-084599	Oryza rufipogon	47.06	2.00e-80	290.00
IUUC-Osa-086193	Oryza sativa	52.29	3.00e-95	339.00
IUUC-Ola-087216	Oryzias latipes	47.76	2.00e-84	303.00
IUUC-Olu-087852	Ostreococcus lucimarinus	54.30	3.00e-102	362.00
IUUC-Oga-088840	Otolemur garnettii	47.45	4.00e-83	299.00
IUUC-Oar-089294	Ovis aries	46.24	8.00e-70	254.00
IUUC-Ptr-090565	Pan troglodytes	47.76	9.00e-85	304.00
IUUC-Pan-092175	Papio anubis	47.76	8.00e-85	304.00
IUUC-Psi-093180	Pelodiscus sinensis	44.61	6.00e-65	238.00
IUUC-Pma-094705	Petromyzon marinus	48.08	7.00e-84	301.00
IUUC-Pno-095001	Phaeosphaeria nodorum	61.11	5.00e-111	391.00
IUUC-Ppa-095628	Physcomitrella patens	54.25	9.00e-100	354.00
IUUC-Pfo-097128	Poecilia formosa	47.44	3.00e-84	302.00
IUUC-Pab-098386	Pongo abelii	47.76	9.00e-85	304.00
IUUC-Pop-099064	Populus trichocarpa	53.92	4.00e-98	348.00
IUUC-Pca-100971	Procavia capensis	46.04	9.00e-72	261.00
IUUC-Ppe-101871	Prunus persica	54.25	8.00e-99	351.00
IUUC-Pva-102230	Pteropus vampyrus	52.46	7.00e-38	148.00
IUUC-Pgr-103511	Puccinia graminis	47.48	2.00e-88	316.00
IUUC-Ptt-103882	Puccinia triticina	44.85	3.00e-85	306.00
IUUC-Pte-104402	Pyrenophora teres	64.71	1.00e-122	430.00
IUUC-Pyt-104448	Pyrenophora triticirepentis	64.40	3.00e-122	429.00
IUUC-Rno-104880	Rattus norvegicus	47.44	3.00e-84	302.00
IUUC-Sha-106966	Sarcophilus harrisii	48.08	2.00e-85	306.00
IUUC-Sja-107797	Schizosaccharomyces japonicus	67.55	7.00e-127	444.00
IUUC-Spo-108366	Schizosaccharomyces pombe	67.22	9.00e-127	444.00
IUUC-Smo-108749	Selaginella moellendorffii	52.44	7.00e-94	334.00
IUUC-Sit-110807	Setaria italica	54.25	1.00e-98	350.00
IUUC-Sly-111879	Solanum lycopersicum	50.88	9.00e-68	247.00
IUUC-Sbi-114551	Sorghum bicolor	54.25	2.00e-98	350.00
IUUC-Sre-114962	Sporisorium reilianum	50.71	4.00e-104	369.00
IUUC-Ssc-115363	Sus scrofa	47.13	8.00e-83	298.00
IUUC-Tgu-116695	Taeniopygia guttata	39.12	7.00e-56	208.00
IUUC-Tru-117999	Takifugu rubripes	47.13	2.00e-83	300.00
IUUC-Tni-119973	Tetraodon nigroviridis	47.44	3.00e-84	303.00
IUUC-Tca-121688	Theobroma cacao	53.42	2.00e-97	347.00
IUUC-Tre-122158	Trichoderma reesei	63.58	6.00e-121	424.00
IUUC-Tvi-122511	Trichoderma virens	64.76	8.00e-124	434.00
IUUC-Tae-124175	Triticum aestivum	54.25	4.00e-99	352.00
IUUC-Tur-126228	Triticum urartu	49.02	2.00e-84	303.00
IUUC-Tme-127100	Tuber melanosporum	70.96	1.00e-136	476.00
IUUC-Uma-129358	Ustilago maydis	51.30	7.00e-105	371.00
IUUC-Vda-129756	Verticillium dahliae	63.58	3.00e-123	432.00
IUUC-Vvi-131283	Vitis vinifera	53.27	3.00e-97	345.00
IUUC-Xtr-132363	Xenopus tropicalis	47.76	1.00e-84	304.00
IUUC-Xma-133857	Xiphophorus maculatus	47.44	3.00e-84	302.00
IUUC-Yli-134368	Yarrowia lipolytica	72.28	1.00e-137	479.00
IUUC-Zma-135854	Zea mays	53.92	1.00e-97	347.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence