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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Mmu-063346
Ensembl Protein ID ENSMUSP00000111306.1
UniProt Accession Q9Z2V5; B1AUA6; HDAC6_MOUSE
Genbank Protein ID AAD09835.2; CAM17240.1
Protein Name Histone deacetylase 6; Histone deacetylase mHDA2
Genbank Nucleotide ID AF006603; AL670169
Gene Name Hdac6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031161.15 ENSMUST00000115642.7 ENSMUSP00000111306.1
ENSMUSG00000031161.15 ENSMUST00000154244.1 ENSMUSP00000123482.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
Protein-protein Interaction
IIDiRefIndexHINTMentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/ZnF/ZnF_UBP 74.57 0.00e+00 1717.00 IUUC-Hsa-046904
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description



     In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (By similarity).
In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (By similarity).
Protein Sequence
(Fasta)
MTSTGQDSST RQRKSRHNPQ SPLQESSATL KRGGKKCAVP HSSPNLAEVK KKGKMKKLSQ 60
PAEEDLVVGL QGLDLNPETR VPVGTGLVFD EQLNDFHCLW DDSFPESPER LHAIREQLIL 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mmu-063346|UBD,ZnF_UBP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGCGGAGGC TTGGAAGGGG CTGAGGGAGC CTGGTTAAAC GGTAGGCGTC TGGGAAGGGG 60
GTGGGGTCTG AAGGATTCTG ATCGAAAGGG GCAGTCCTCG GAGCAGCGGG GCACGGGGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-063346|UBD,ZnF_UBP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0009--Actin-binding
KW-0966--Cell projection
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50271--ZF_UBP

Pfam

PF00850--Hist_deacetyl
PF02148--zf-UBP

PRINTS

PR01270--HDASUPER

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0016235--C:aggresome
GO:0030424--C:axon
GO:0005901--C:caveola
GO:0044297--C:cell body
GO:0031252--C:cell leading edge
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0030286--C:dynein complex
GO:0000118--C:histone deacetylase complex
GO:0016234--C:inclusion body
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0043005--C:neuron projection
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043204--C:perikaryon
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0043014--F:alpha-tubulin binding
GO:0008013--F:beta-catenin binding
GO:0048487--F:beta-tubulin binding
GO:0001047--F:core promoter binding
GO:0070840--F:dynein complex binding
GO:0004407--F:histone deacetylase activity
GO:0042826--F:histone deacetylase binding
GO:0051879--F:Hsp90 protein binding
GO:0008017--F:microtubule binding
GO:0051787--F:misfolded protein binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0031593--F:polyubiquitin binding
GO:0048156--F:tau protein binding
GO:0042903--F:tubulin deacetylase activity
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0070842--P:aggresome assembly
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071218--P:cellular response to misfolded protein
GO:0035967--P:cellular response to topologically incorrect protein
GO:0048668--P:collateral sprouting
GO:0060997--P:dendritic spine morphogenesis
GO:0016575--P:histone deacetylation
GO:0070846--P:Hsp90 deacetylation
GO:0006886--P:intracellular protein transport
GO:0032418--P:lysosome localization
GO:0016236--P:macroautophagy
GO:0006515--P:misfolded or incompletely synthesized protein catabolic process
GO:0051646--P:mitochondrion localization
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0043242--P:negative regulation of protein complex disassembly
GO:0045861--P:negative regulation of proteolysis
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:0034983--P:peptidyl-lysine deacetylation
GO:0070845--P:polyubiquitinated misfolded protein transport
GO:0090035--P:positive regulation of chaperone-mediated protein complex assembly
GO:0010634--P:positive regulation of epithelial cell migration
GO:1901300--P:positive regulation of hydrogen peroxide-mediated programmed cell death
GO:0098779--P:positive regulation of macromitophagy in response to mitochondrial depolarization
GO:0010870--P:positive regulation of receptor biosynthetic process
GO:0009967--P:positive regulation of signal transduction
GO:0043241--P:protein complex disassembly
GO:0006476--P:protein deacetylation
GO:0000209--P:protein polyubiquitination
GO:0070201--P:regulation of establishment of protein localization
GO:0045598--P:regulation of fat cell differentiation
GO:0040029--P:regulation of gene expression, epigenetic
GO:0031647--P:regulation of protein stability
GO:0010469--P:regulation of receptor activity
GO:0006355--P:regulation of transcription, DNA-templated
GO:0070848--P:response to growth factor
GO:0051788--P:response to misfolded protein
GO:0010033--P:response to organic substance
GO:0009636--P:response to toxic substance
GO:0006351--P:transcription, DNA-templated
GO:0090042--P:tubulin deacetylation
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG mmu:15185
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000749 Aegilops tauschii 42.94 2.00e-71 263.00
IUUC-Aml-002087 Ailuropoda melanoleuca 74.74 0.00e+00 1657.00
IUUC-Atr-002745 Amborella trichopoda 45.17 3.00e-88 319.00
IUUC-Aca-004303 Anolis carolinensis 58.19 0.00e+00 991.00
IUUC-Aly-006432 Arabidopsis lyrata 45.08 4.00e-82 299.00
IUUC-Ath-007355 Arabidopsis thaliana 46.17 6.00e-88 318.00
IUUC-Acl-008187 Aspergillus clavatus 46.28 6.00e-88 318.00
IUUC-Afl-008399 Aspergillus flavus 50.00 4.00e-50 192.00
IUUC-Afu-008954 Aspergillus fumigatus 42.67 1.00e-77 284.00
IUUC-Ani-009142 Aspergillus nidulans 44.78 8.00e-81 295.00
IUUC-Ang-009522 Aspergillus niger 37.75 9.00e-26 112.00
IUUC-Ate-010291 Aspergillus terreus 45.38 7.00e-89 322.00
IUUC-Ame-010780 Astyanax mexicanus 51.22 0.00e+00 764.00
IUUC-Bta-013052 Bos taurus 72.36 0.00e+00 1562.00
IUUC-Bci-013789 Botrytis cinerea 42.23 9.00e-80 291.00
IUUC-Bdi-014007 Brachypodium distachyon 44.79 2.00e-87 317.00
IUUC-Bol-015468 Brassica oleracea 44.61 8.00e-87 314.00
IUUC-Bra-016680 Brassica rapa 44.86 6.00e-87 315.00
IUUC-Cel-018220 Caenorhabditis elegans 40.97 3.00e-153 536.00
IUUC-Cja-019473 Callithrix jacchus 71.62 0.00e+00 1589.00
IUUC-Cfa-020263 Canis familiaris 74.67 0.00e+00 1632.00
IUUC-Cpo-021691 Cavia porcellus 75.17 0.00e+00 1677.00
IUUC-Cre-022561 Chlamydomonas reinhardtii 54.19 3.00e-57 214.00
IUUC-Csa-024223 Chlorocebus sabaeus 74.62 0.00e+00 1675.00
IUUC-Cne-026978 Cryptococcus neoformans 46.15 2.00e-94 340.00
IUUC-Dre-028820 Danio rerio 56.89 0.00e+00 915.00
IUUC-Dno-029160 Dasypus novemcinctus 67.04 0.00e+00 1437.00
IUUC-Dor-030859 Dipodomys ordii 71.26 0.00e+00 1620.00
IUUC-Dse-031186 Dothistroma septosporum 42.12 2.00e-80 294.00
IUUC-Dme-031963 Drosophila melanogaster 44.58 0.00e+00 682.00
IUUC-Ete-032279 Echinops telfairi 62.95 3.00e-146 512.00
IUUC-Eca-033842 Equus caballus 73.95 0.00e+00 1654.00
IUUC-Eeu-034487 Erinaceus europaeus 74.62 6.00e-147 515.00
IUUC-Fca-036430 Felis catus 75.59 0.00e+00 1635.00
IUUC-Fox-038067 Fusarium oxysporum 40.99 3.00e-80 293.00
IUUC-Fso-038263 Fusarium solani 40.10 6.00e-81 295.00
IUUC-Ggr-040062 Gaeumannomyces graminis 44.28 2.00e-74 273.00
IUUC-Gma-043738 Glycine max 50.45 2.00e-88 320.00
IUUC-Ggo-045022 Gorilla gorilla 74.54 0.00e+00 1676.00
IUUC-Hsa-046904 Homo sapiens 74.45 0.00e+00 1673.00
IUUC-Hvu-047285 Hordeum vulgare 46.18 8.00e-83 300.00
IUUC-Itr-048484 Ictidomys tridecemlineatus 79.40 0.00e+00 1775.00
IUUC-Kpa-049281 Komagataella pastoris 41.91 2.00e-87 316.00
IUUC-Lch-050330 Latimeria chalumnae 45.86 0.00e+00 931.00
IUUC-Lma-053263 Leptosphaeria maculans 45.45 5.00e-90 325.00
IUUC-Laf-053386 Loxodonta africana 72.24 0.00e+00 1570.00
IUUC-Mcc-055530 Macaca mulatta 74.62 0.00e+00 1680.00
IUUC-Meu-056442 Macropus eugenii 67.63 0.00e+00 958.00
IUUC-Mor-057095 Magnaporthe oryzae 39.36 2.00e-83 303.00
IUUC-Mpo-057389 Magnaporthe poae 42.82 9.00e-74 271.00
IUUC-Mtr-058463 Medicago truncatula 45.45 4.00e-90 325.00
IUUC-Mmr-060637 Microcebus murinus 73.65 0.00e+00 1672.00
IUUC-Mdo-062198 Monodelphis domestica 67.12 0.00e+00 1058.00
IUUC-Mac-064630 Musa acuminata 46.79 6.00e-85 308.00
IUUC-Mpu-065884 Mustela putorius furo 74.45 0.00e+00 1663.00
IUUC-Mlu-068117 Myotis lucifugus 73.60 0.00e+00 1596.00
IUUC-Nfi-068404 Neosartorya fischeri 45.74 7.00e-88 318.00
IUUC-Ncr-068672 Neurospora crassa 41.45 2.00e-80 293.00
IUUC-Nle-069868 Nomascus leucogenys 87.70 0.00e+00 707.00
IUUC-Ont-072246 Oreochromis niloticus 45.48 0.00e+00 919.00
IUUC-Oan-072911 Ornithorhynchus anatinus 68.80 1.00e-105 377.00
IUUC-Ocu-074627 Oryctolagus cuniculus 74.96 0.00e+00 1700.00
IUUC-Oba-075489 Oryza barthii 47.26 5.00e-86 312.00
IUUC-Obr-076150 Oryza brachyantha 47.71 4.00e-87 315.00
IUUC-Ogl-077437 Oryza glaberrima 47.26 4.00e-86 312.00
IUUC-Ogu-078370 Oryza glumaepatula 47.56 5.00e-87 315.00
IUUC-Oin-079210 Oryza indica 47.56 6.00e-87 315.00
IUUC-Olo-080971 Oryza longistaminata 48.23 1.00e-74 274.00
IUUC-Oni-082031 Oryza nivara 47.56 1.00e-86 314.00
IUUC-Opu-083471 Oryza punctata 46.48 3.00e-86 312.00
IUUC-Oru-084755 Oryza rufipogon 47.56 6.00e-87 315.00
IUUC-Osa-085447 Oryza sativa 47.56 6.00e-87 315.00
IUUC-Oga-089155 Otolemur garnettii 72.46 0.00e+00 1624.00
IUUC-Oar-089620 Ovis aries 72.10 0.00e+00 1552.00
IUUC-Ptr-090812 Pan troglodytes 85.43 0.00e+00 1202.00
IUUC-Pan-092340 Papio anubis 74.54 0.00e+00 1677.00
IUUC-Pma-094386 Petromyzon marinus 53.05 0.00e+00 807.00
IUUC-Pno-095131 Phaeosphaeria nodorum 50.18 2.00e-79 290.00
IUUC-Ppa-095550 Physcomitrella patens 47.76 3.00e-87 316.00
IUUC-Pfo-096110 Poecilia formosa 47.81 0.00e+00 854.00
IUUC-Pab-098422 Pongo abelii 73.44 0.00e+00 1627.00
IUUC-Pop-099174 Populus trichocarpa 43.25 8.00e-82 298.00
IUUC-Pca-100833 Procavia capensis 69.35 0.00e+00 1419.00
IUUC-Ppe-101644 Prunus persica 38.88 5.00e-89 322.00
IUUC-Pva-102410 Pteropus vampyrus 68.91 0.00e+00 1482.00
IUUC-Ptt-103841 Puccinia triticina 39.27 1.00e-82 301.00
IUUC-Pte-104383 Pyrenophora teres 44.65 2.00e-87 317.00
IUUC-Pyt-104427 Pyrenophora triticirepentis 44.92 2.00e-87 317.00
IUUC-Rno-105131 Rattus norvegicus 91.48 0.00e+00 2019.00
IUUC-Sce-106274 Saccharomyces cerevisiae 42.02 8.00e-82 298.00
IUUC-Sha-106661 Sarcophilus harrisii 55.51 0.00e+00 805.00
IUUC-Sja-107915 Schizosaccharomyces japonicus 43.63 1.00e-92 334.00
IUUC-Spo-108300 Schizosaccharomyces pombe 47.27 4.00e-94 339.00
IUUC-Smo-109615 Selaginella moellendorffii 44.61 7.00e-89 321.00
IUUC-Sit-110160 Setaria italica 44.19 1.00e-81 297.00
IUUC-Sar-113692 Sorex araneus 64.73 0.00e+00 729.00
IUUC-Ssc-115724 Sus scrofa 73.11 0.00e+00 1521.00
IUUC-Tgu-116605 Taeniopygia guttata 48.07 0.00e+00 692.00
IUUC-Tru-117614 Takifugu rubripes 55.03 0.00e+00 837.00
IUUC-Tni-119809 Tetraodon nigroviridis 54.59 0.00e+00 783.00
IUUC-Tre-121930 Trichoderma reesei 39.09 1.00e-82 301.00
IUUC-Tvi-122373 Trichoderma virens 40.69 9.00e-83 301.00
IUUC-Tae-123064 Triticum aestivum 42.50 1.00e-78 286.00
IUUC-Tme-127027 Tuber melanosporum 43.32 6.00e-75 274.00
IUUC-Tbe-127675 Tupaia belangeri 80.37 2.00e-69 258.00
IUUC-Ttr-128411 Tursiops truncatus 72.11 0.00e+00 1603.00
IUUC-Uma-129408 Ustilago maydis 47.12 2.00e-77 283.00
IUUC-Vda-129994 Verticillium dahliae 39.70 7.00e-76 278.00
IUUC-Vpa-130525 Vicugna pacos 73.40 6.00e-52 199.00
IUUC-Vvi-131038 Vitis vinifera 43.58 3.00e-87 316.00
IUUC-Xtr-132618 Xenopus tropicalis 49.27 0.00e+00 1068.00
IUUC-Xma-133730 Xiphophorus maculatus 48.99 0.00e+00 695.00
IUUC-Yli-134680 Yarrowia lipolytica 41.31 1.00e-88 320.00
IUUC-Zma-135110 Zea mays 44.48 3.00e-82 299.00
Created Date 25-Jun-2017

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