• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063642
UUCD1 version UUC-MuM-01220
Ensembl Protein ID ENSMUSP00000055016.6
UniProt Accession Q3V0C5; Q3TM39; Q571J9; Q8VDJ1; UBP48_MOUSE
Genbank Protein ID BAD90375.1; BAE21579.1; BAE38603.1; AAH21769.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 48; Deubiquitinating enzyme 48; Ubiquitin thioesterase 48; Ubiquitin-specific-processing protease 48
Genbank Nucleotide ID AK220190; AK133251; AK166158; BC021769
Gene Name Usp48; Kiaa4202
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000043411.15 ENSMUST00000055131.12 ENSMUSP00000055016.6
ENSMUSG00000043411.15 ENSMUST00000105840.7 ENSMUSP00000101466.1
ENSMUSG00000043411.15 ENSMUST00000105839.7 ENSMUSP00000101465.1
ENSMUSG00000043411.15 ENSMUST00000153100.7 ENSMUSP00000123154.1
ENSMUSG00000043411.15 ENSMUST00000105838.7 ENSMUSP00000101464.1
ENSMUSG00000043411.15 ENSMUST00000141426.7 ENSMUSP00000118084.1
ENSMUSG00000043411.15 ENSMUST00000128065.1 ENSMUSP00000115533.1
ENSMUSG00000043411.15 ENSMUST00000131755.1 ENSMUSP00000114800.1
ENSMUSG00000043411.15 ENSMUST00000141628.7 ENSMUSP00000119691.1
ENSMUSG00000043411.15 ENSMUST00000153869.1 ENSMUSP00000117989.1
ENSMUSG00000043411.15 ENSMUST00000157012.2 ENSMUSP00000118081.1
ENSMUSG00000043411.15 ENSMUST00000151807.7 ENSMUSP00000115526.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPHOSIDA
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 5.90e-73 247.1 89 418
ULD/UDP/UBQ/UBQ_Other 2.30e-10 41.3 962 1024
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp........kepkgellkslqklfeelwkskkkavsprellkalkkea 81
           +Gl+Nlg+tCY+N  LQ+ +   elr++l    ++++++  +        + + ++++++lq lf+ l++s++++++p+ ++kal+   
   Q: 89   VGLTNLGATCYVNTFLQVWFLNLELRQALYL-CPSTCSDYTKgdgihggkDYEPQTICEHLQYLFALLQNSNRRYIDPSGFVKALG--- 173
           6*****************************9.88888877666666666677778******************************9... PP
   S: 82   eefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
             +++ +qqDaqEf + +++ le++l                       +++k+   ++++++ F g++   ++c++c+++s+  ++f+
   Q: 174  --LDTGQQQDAQEFSKLFMSLLEDTL-----------------------SKQKNPDVRNVVQQQFCGEYAYVTVCNQCGRESKLVSKFY 237
           ..78899*******************.......................457889999******************************* PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleL 259
           +l+l+++g++     +l+dc+++f kee+leg+n+y+ce+c++kq+a++k++l +lP +L l+L+Rf f++++++++k+n ++ f ++L
   Q: 238  ELELNIQGHK-----QLTDCISEFLKEERLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNAYIGFSESL 321
           **********.....9************************************************************************* PP
   S: 260  dlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg................... 327
           d++p+++++      +  YeL+av++H G s+ sGHY+a+vk+ ++g+W++f+D+ +++++ ++ +   +                   
   Q: 322  DMEPYVEHKGG----SFVYELSAVLIHRGvSAYSGHYIAHVKDpQSGEWYKFNDEDIEKMEGKKLQLGIEedlepsksqtrkpkcgkgt 406
           ******99554....68**************************44555************9999998655899**************** PP
   S: 328  ...staYvlfYk 336
              ++aY+l+Y+
   Q: 407  hcsRNAYMLVYR 418
           ***********8 PP
   

   ULD/UDP/UBQ/UBQ_Other
   S: 16   k...vnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdgstihllekks 74
           k   v+   t +eLK +i +++++ p +q+L ++GkiL +d+ tL+ +g+ ++s+i+l  +++
   Q: 962  KallVSANQTLKELKIQIMHAFSVAPFDQNLSIDGKILnDDCATLGTLGVIPESVILLKADEP 1024
           334489999************************************************988775 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites (By similarity).
 Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites (By similarity).
Protein Sequence
(Fasta)
MAPRLQLEKA AWRWAETVRP EEVSQEHIET AYRIWLEPCI RGVCRRNCRG NPNCLVGIGE 60
HIWLGEIDEN SFHSIDDPNC ERRKKNSFVG LTNLGATCYV NTFLQVWFLN LELRQALYLC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063642|DUB,USP;ULD,UBQ_Other|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAAAGCACG GGCAAGGAGC CGGAACTCGC CCAGGCTCAA GTGAAATCCT CGATCCGACT 60
GTGGCGTTCC GGCTGCCTCG GTTTCTGCTA TTATCAGGTC CCACTCACAG TCCCGGTGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063642|DUB,USP;ULD,UBQ_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR033841--USP48
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS51283--DUSP
PS50053--UBIQUITIN_2
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:170707
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000130 Aegilops tauschii 32.32 8.00e-79 288.00
IUUC-Aml-001357 Ailuropoda melanoleuca 92.32 0.00e+00 1962.00
IUUC-Atr-002976 Amborella trichopoda 27.26 4.00e-80 293.00
IUUC-Apl-003773 Anas platyrhynchos 83.56 0.00e+00 1620.00
IUUC-Aca-004466 Anolis carolinensis 80.28 0.00e+00 857.00
IUUC-Aly-006249 Arabidopsis lyrata 29.52 4.00e-72 266.00
IUUC-Ath-006700 Arabidopsis thaliana 25.75 5.00e-84 306.00
IUUC-Ame-011554 Astyanax mexicanus 67.01 0.00e+00 1418.00
IUUC-Bta-012573 Bos taurus 91.29 0.00e+00 1957.00
IUUC-Bdi-014149 Brachypodium distachyon 31.59 3.00e-81 296.00
IUUC-Bol-016289 Brassica oleracea 26.53 9.00e-83 301.00
IUUC-Bra-017205 Brassica rapa 25.50 1.00e-72 268.00
IUUC-Cel-018662 Caenorhabditis elegans 27.35 2.00e-28 121.00
IUUC-Cja-019991 Callithrix jacchus 91.75 0.00e+00 1986.00
IUUC-Cfa-020294 Canis familiaris 92.31 0.00e+00 1996.00
IUUC-Cpo-021706 Cavia porcellus 90.40 0.00e+00 1867.00
IUUC-Cre-022636 Chlamydomonas reinhardtii 35.96 9.00e-43 170.00
IUUC-Csa-023931 Chlorocebus sabaeus 92.50 0.00e+00 1988.00
IUUC-Cho-024566 Choloepus hoffmanni 86.10 6.00e-148 518.00
IUUC-Cin-025307 Ciona intestinalis 46.82 1.00e-74 273.00
IUUC-Csv-026006 Ciona savignyi 36.90 3.00e-149 523.00
IUUC-Cne-027065 Cryptococcus neoformans 28.70 2.00e-67 251.00
IUUC-Dre-027624 Danio rerio 67.66 0.00e+00 1469.00
IUUC-Dno-029633 Dasypus novemcinctus 93.25 0.00e+00 1254.00
IUUC-Dor-030809 Dipodomys ordii 95.45 0.00e+00 674.00
IUUC-Ete-032818 Echinops telfairi 88.74 0.00e+00 922.00
IUUC-Eca-033692 Equus caballus 92.60 0.00e+00 1984.00
IUUC-Eeu-035185 Erinaceus europaeus 69.65 0.00e+00 756.00
IUUC-Fca-035676 Felis catus 92.02 0.00e+00 1992.00
IUUC-Fal-036913 Ficedula albicollis 83.70 0.00e+00 1774.00
IUUC-Gmo-038532 Gadus morhua 64.24 0.00e+00 1380.00
IUUC-Gga-041041 Gallus gallus 83.51 0.00e+00 1763.00
IUUC-Gac-042570 Gasterosteus aculeatus 66.39 0.00e+00 1437.00
IUUC-Gma-044136 Glycine max 27.94 2.00e-97 350.00
IUUC-Ggo-045367 Gorilla gorilla 88.07 0.00e+00 1863.00
IUUC-Hsa-046019 Homo sapiens 92.50 0.00e+00 1988.00
IUUC-Hvu-047303 Hordeum vulgare 33.52 2.00e-64 240.00
IUUC-Itr-048319 Ictidomys tridecemlineatus 92.32 0.00e+00 1984.00
IUUC-Lch-049989 Latimeria chalumnae 73.99 0.00e+00 1599.00
IUUC-Lpe-051612 Leersia perrieri 32.11 2.00e-78 287.00
IUUC-Loc-052756 Lepisosteus oculatus 70.46 0.00e+00 1523.00
IUUC-Laf-054043 Loxodonta africana 93.16 0.00e+00 2008.00
IUUC-Mcc-054986 Macaca mulatta 91.29 0.00e+00 1980.00
IUUC-Meu-056228 Macropus eugenii 71.97 0.00e+00 811.00
IUUC-Mtr-058762 Medicago truncatula 28.10 2.00e-91 330.00
IUUC-Mga-059896 Meleagris gallopavo 82.92 0.00e+00 1662.00
IUUC-Mvi-060269 Microbotryum violaceum 37.61 2.00e-63 238.00
IUUC-Mmr-060887 Microcebus murinus 92.41 0.00e+00 1985.00
IUUC-Mdo-062506 Monodelphis domestica 88.71 0.00e+00 1907.00
IUUC-Mac-064896 Musa acuminata 31.68 7.00e-78 285.00
IUUC-Mpu-066194 Mustela putorius furo 92.31 0.00e+00 1984.00
IUUC-Mlu-067233 Myotis lucifugus 91.44 0.00e+00 1965.00
IUUC-Nle-069052 Nomascus leucogenys 91.64 0.00e+00 1982.00
IUUC-Opr-070890 Ochotona princeps 92.38 0.00e+00 1210.00
IUUC-Ont-071450 Oreochromis niloticus 64.72 0.00e+00 1365.00
IUUC-Oan-073252 Ornithorhynchus anatinus 84.41 0.00e+00 1006.00
IUUC-Ocu-073796 Oryctolagus cuniculus 91.77 0.00e+00 1694.00
IUUC-Oba-075563 Oryza barthii 31.92 2.00e-80 294.00
IUUC-Obr-076394 Oryza brachyantha 31.38 1.00e-79 291.00
IUUC-Ogl-077339 Oryza glaberrima 38.49 3.00e-40 159.00
IUUC-Ogu-079007 Oryza glumaepatula 33.10 9.00e-75 275.00
IUUC-Oin-079997 Oryza indica 31.92 8.00e-81 295.00
IUUC-Olo-080364 Oryza longistaminata 31.92 1.00e-80 295.00
IUUC-Ome-081165 Oryza meridionalis 33.10 3.00e-75 276.00
IUUC-Oni-083026 Oryza nivara 31.92 8.00e-81 295.00
IUUC-Opu-083284 Oryza punctata 33.21 1.00e-73 271.00
IUUC-Oru-084797 Oryza rufipogon 31.92 7.00e-81 295.00
IUUC-Osa-086221 Oryza sativa 38.49 3.00e-40 159.00
IUUC-Ola-086568 Oryzias latipes 66.64 0.00e+00 1433.00
IUUC-Oga-088687 Otolemur garnettii 90.90 0.00e+00 1971.00
IUUC-Oar-090345 Ovis aries 91.40 0.00e+00 1865.00
IUUC-Ptr-090734 Pan troglodytes 92.41 0.00e+00 1988.00
IUUC-Pan-091704 Papio anubis 89.32 0.00e+00 1895.00
IUUC-Psi-092937 Pelodiscus sinensis 82.98 0.00e+00 1538.00
IUUC-Ppa-095808 Physcomitrella patens 28.59 2.00e-72 268.00
IUUC-Pab-098129 Pongo abelii 92.50 0.00e+00 1988.00
IUUC-Pop-099738 Populus trichocarpa 26.32 3.00e-82 300.00
IUUC-Pca-100647 Procavia capensis 95.45 0.00e+00 672.00
IUUC-Ppe-102091 Prunus persica 29.50 9.00e-83 301.00
IUUC-Pva-102719 Pteropus vampyrus 91.75 0.00e+00 1963.00
IUUC-Rno-105363 Rattus norvegicus 96.39 0.00e+00 2074.00
IUUC-Sha-107620 Sarcophilus harrisii 85.11 0.00e+00 1768.00
IUUC-Smo-109487 Selaginella moellendorffii 28.30 8.00e-84 305.00
IUUC-Sit-110683 Setaria italica 32.70 4.00e-80 293.00
IUUC-Sly-111377 Solanum lycopersicum 30.03 6.00e-81 296.00
IUUC-Stu-111969 Solanum tuberosum 32.04 2.00e-69 256.00
IUUC-Sar-113099 Sorex araneus 91.05 0.00e+00 1659.00
IUUC-Sbi-113833 Sorghum bicolor 41.47 4.00e-56 211.00
IUUC-Ssc-115279 Sus scrofa 84.09 0.00e+00 1281.00
IUUC-Tgu-117519 Taeniopygia guttata 80.93 0.00e+00 1618.00
IUUC-Tru-117651 Takifugu rubripes 65.67 0.00e+00 1412.00
IUUC-Tsy-119201 Tarsius syrichta 88.70 0.00e+00 1729.00
IUUC-Tni-120840 Tetraodon nigroviridis 66.70 0.00e+00 1446.00
IUUC-Tca-121674 Theobroma cacao 29.00 5.00e-87 316.00
IUUC-Tae-125814 Triticum aestivum 32.16 2.00e-79 290.00
IUUC-Tur-126599 Triticum urartu 29.30 3.00e-78 287.00
IUUC-Tbe-127782 Tupaia belangeri 81.38 0.00e+00 1670.00
IUUC-Ttr-128312 Tursiops truncatus 90.80 0.00e+00 1939.00
IUUC-Vpa-130348 Vicugna pacos 91.48 0.00e+00 1872.00
IUUC-Vvi-131353 Vitis vinifera 32.67 1.00e-84 308.00
IUUC-Xtr-132172 Xenopus tropicalis 68.60 0.00e+00 1325.00
IUUC-Xma-133263 Xiphophorus maculatus 66.20 0.00e+00 1394.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved