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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Ath-007636
UUCD1 version UUC-ArT-01415
Ensembl Protein ID AT2G32950.1
UniProt Accession P43254; O23974; O23975; O48770; Q1JPL6; COP1_ARATH
Genbank Protein ID AAA32772.1; AAB91983.1; AEC08766.1; ABF57293.1; CAA04168.1; CAA04169.1
Protein Name E3 ubiquitin-protein ligase COP1; Constitutive photomorphogenesis protein 1; RING-type E3 ubiquitin transferase COP1
Genbank Nucleotide ID L24437; AC003033; CP002685; BT025337; AJ000535; AJ000536
Gene Name COP1; At2g32950; T21L14.11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT2G32950 AT2G32950.2 AT2G32950.2
AT2G32950 AT2G32950.1 AT2G32950.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndexPINAHINTMentha
Protein 3D Structure
PDB
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20605855; 18397371; 19794114; 12827204; 18930926; 15031264; 19061637; 20061554; 26358558
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 20605855; 18397371; 12827204; 18930926; 15031264; 20061554; 26358558
Classification
Family E-value Score Start End
E3 activity/RING/U-box 6.40e-09 36.6 48 115
E3 adaptor/Cullin RING/DCX/DWD 3.00e-32 110.1 547 584
E3 activity/RING/RING 0.0026 19.1 52 89
UBD/Beta-Prp 3.20e-44 152.2 371 672
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceen 72
           +++lCpI +++ +d   +++G+++   +I  +l+++   cP ++q+lt+++l Pn  l +l ++  +++
   Q: 48   KDLLCPICMQIIKDAFLTACGHSFCYMCIITHLRNKSD-CPCCSQHLTNNQLYPNFLLDKLLKKTSARH 115
           6799*******************************999.****************99988888777666 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sdtllvsGsdDgtikvWDlrtgvllk 37
           gH+  v+ ++f s++ l+s+s D t+++WD++++ +++
   Q: 547  GHKKAVSYVKFlSNNELASASTDSTLRLWDVKDNLPVR 584
           8999*******9889****************9998876 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlC 45
           C+iC++ +kd  +++ CgH f+  C+  ++       +++  CP C
   Q: 52   CPICMQIIKD-AFLTACGHSFCYMCIiTHL-------RNKSDCPCC 89
           **********.9*************95555.......55555**99 PP
   

   UBD/Beta-Prp
   S: 10   ksvitcvkfspdksllatgsrdgtikvwdvttgkl........lrslsgheaevtavkfspdgk.ilvtgseDrtikvwdlstgkcvhtlkghedsvl 98
            + ++++ f +d++l+at++ +++ikv+d+++           + ++s  + + +++++++++k  ++++   +++ vwd+ t++ ++ +++he++++
   Q: 371  ANIVSSIEFDRDDELFATAGVSRCIKVFDFSSVVNepadmqcpIVEMSTRS-KLSCLSWNKHEKnHIASSDYEGIVTVWDVTTRQSLMEYEEHEKRAW 467
           567899**************************5559999998888887777.79*****99987566666666************************* PP
   S: 99   slsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdl.ktgkllrtltgghtdsvyslsfdsngk 193
           s++fs++  + lvsGs+d  ++vw ++++  +   +   ++ ++cv+++p + n+++ Gs+D  +  +dl +  + l+ ++g h+++v  ++f sn +
   Q: 468  SVDFSRTEpSMLVSGSDDCKVKVWCTRQEASVI--NIDMKANICCVKYNPGSsNYIAVGSADHHIHYYDLrNISQPLHVFSG-HKKAVSYVKFLSN-N 561
           ******888***************999999996..5555666*********9******************556899*****9.************8.7 PP
   S: 194  elvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn..............ssvisvavlsfgd 277
           el+s+s+d+t++lwd++ +  vrt++ght+  + v ++ n+e+l++gs+ + ++++   ++++++ ++ h+              s +is  +++ + 
   Q: 562  ELASASTDSTLRLWDVKDNLPVRTFRGHTNEKNFVGLTVNSEYLACGSETNEVYVY---HKEITRPVTSHRfgspdmddaeeeagSYFISAVCWKSDS 656
           *******************************************************9...89999999999999999********99999999****** PP
   S: 278  nvlvlgsedskvniwk 293
           + ++++ + ++++++ 
   Q: 657  PTMLTANSQGTIKVLV 672
           ************9975 PP
   
Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors such as HY5, HYH and LAF1. Down-regulates MYB21, probably via ubiquitination process. Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm. Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways. Mediates the ubiquitination-dependent degradation of HY5 in the darkness during seedling development (e.g. hypocotyl growth) (PubMed:26474641).
 E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors such as HY5, HYH and LAF1. Down-regulates MYB21, probably via ubiquitination process. Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm. Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways. Mediates the ubiquitination-dependent degradation of HY5 in the darkness during seedling development (e.g. hypocotyl growth) (PubMed:26474641).
Protein Sequence
(Fasta)
MEEISTDPVV PAVKPDPRTS SVGEGANRHE NDDGGSGGSE IGAPDLDKDL LCPICMQIIK 60
DAFLTACGHS FCYMCIITHL RNKSDCPCCS QHLTNNQLYP NFLLDKLLKK TSARHVSKTA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ath-007636|E3,RING;E3,WD_repeat;E3,U-box;UBD,Beta-Prp|Arabidopsis thaliana
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACCACACCTC AGCCTCACTC CTCCTTCATC TCCGACGTCA TACCCAAACC ACTCTTTTCT 60
CACAATTCCG ATTTTCTCAA AAACCAAAAT CACAATCGAA GAAATCTTTT GAAAGCAAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ath-007636|E3,RING;E3,WD_repeat;E3,U-box;UBD,Beta-Prp|Arabidopsis thaliana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0607--Phytochrome signaling pathway
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00400--WD40
SMART

SM00184--RING
SM00320--WD40
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0000152--C:nuclear ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0042802--F:identical protein binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0046283--P:anthocyanin-containing compound metabolic process
GO:0006281--P:DNA repair
GO:0009649--P:entrainment of circadian clock
GO:0009640--P:photomorphogenesis
GO:0048573--P:photoperiodism, flowering
GO:0009585--P:red, far-red light phototransduction
GO:0010119--P:regulation of stomatal movement
GO:0009641--P:shade avoidance
GO:0009647--P:skotomorphogenesis
KEGG ath:AT2G32950
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000885 Aegilops tauschii 71.61 0.00e+00 942.00
IUUC-Aml-001265 Ailuropoda melanoleuca 39.88 1.00e-123 436.00
IUUC-Atr-002460 Amborella trichopoda 74.22 0.00e+00 979.00
IUUC-Apl-003796 Anas platyrhynchos 39.29 1.00e-116 412.00
IUUC-Aca-005078 Anolis carolinensis 39.04 4.00e-123 434.00
IUUC-Aly-006014 Arabidopsis lyrata 97.93 0.00e+00 1348.00
IUUC-Ame-011176 Astyanax mexicanus 57.02 2.00e-39 156.00
IUUC-Bta-012595 Bos taurus 39.94 2.00e-124 439.00
IUUC-Bdi-014152 Brachypodium distachyon 72.11 0.00e+00 953.00
IUUC-Bol-016380 Brassica oleracea 94.08 0.00e+00 1304.00
IUUC-Bra-017690 Brassica rapa 93.21 0.00e+00 1282.00
IUUC-Cja-018926 Callithrix jacchus 39.72 4.00e-124 438.00
IUUC-Cfa-021088 Canis familiaris 40.12 9.00e-125 440.00
IUUC-Cpo-022442 Cavia porcellus 39.21 1.00e-117 416.00
IUUC-Csa-024119 Chlorocebus sabaeus 39.85 1.00e-123 436.00
IUUC-Cin-025375 Ciona intestinalis 39.22 3.00e-120 425.00
IUUC-Cme-027350 Cyanidioschyzon merolae 44.54 3.00e-94 339.00
IUUC-Dre-028453 Danio rerio 38.83 9.00e-124 436.00
IUUC-Dno-029887 Dasypus novemcinctus 39.48 2.00e-124 439.00
IUUC-Dor-031110 Dipodomys ordii 50.82 6.00e-91 327.00
IUUC-Ete-033016 Echinops telfairi 51.15 9.00e-91 327.00
IUUC-Eca-034403 Equus caballus 39.19 3.00e-116 411.00
IUUC-Eeu-034690 Erinaceus europaeus 51.25 1.00e-85 309.00
IUUC-Fca-036475 Felis catus 39.42 4.00e-117 414.00
IUUC-Fal-037189 Ficedula albicollis 39.78 1.00e-122 432.00
IUUC-Gmo-039245 Gadus morhua 38.49 4.00e-120 424.00
IUUC-Gga-040806 Gallus gallus 39.66 1.00e-123 436.00
IUUC-Gac-042177 Gasterosteus aculeatus 38.23 2.00e-123 436.00
IUUC-Gma-044187 Glycine max 77.91 0.00e+00 1067.00
IUUC-Ggo-044430 Gorilla gorilla 36.20 3.00e-76 278.00
IUUC-Hsa-045853 Homo sapiens 39.94 3.00e-124 438.00
IUUC-Itr-048238 Ictidomys tridecemlineatus 51.54 2.00e-68 251.00
IUUC-Lch-050420 Latimeria chalumnae 39.69 3.00e-124 438.00
IUUC-Lpe-051219 Leersia perrieri 73.03 0.00e+00 947.00
IUUC-Loc-052728 Lepisosteus oculatus 39.63 2.00e-117 416.00
IUUC-Laf-053775 Loxodonta africana 39.88 4.00e-124 438.00
IUUC-Meu-056595 Macropus eugenii 39.27 4.00e-56 212.00
IUUC-Mtr-058555 Medicago truncatula 77.50 0.00e+00 1095.00
IUUC-Mga-059646 Meleagris gallopavo 39.29 2.00e-116 412.00
IUUC-Mmr-060990 Microcebus murinus 39.88 2.00e-123 436.00
IUUC-Mdo-062287 Monodelphis domestica 39.88 3.00e-124 438.00
IUUC-Mmu-064097 Mus musculus 39.94 2.00e-124 439.00
IUUC-Mac-065240 Musa acuminata 75.00 0.00e+00 975.00
IUUC-Mpu-066612 Mustela putorius furo 39.35 3.00e-117 414.00
IUUC-Mlu-067967 Myotis lucifugus 39.29 2.00e-115 408.00
IUUC-Nle-069543 Nomascus leucogenys 39.94 3.00e-124 438.00
IUUC-Opr-070366 Ochotona princeps 42.64 5.00e-43 168.00
IUUC-Ont-071522 Oreochromis niloticus 39.23 3.00e-123 435.00
IUUC-Oan-073409 Ornithorhynchus anatinus 39.52 2.00e-115 409.00
IUUC-Ocu-073756 Oryctolagus cuniculus 39.71 4.00e-119 421.00
IUUC-Oba-075149 Oryza barthii 72.91 0.00e+00 963.00
IUUC-Obr-076563 Oryza brachyantha 74.01 0.00e+00 966.00
IUUC-Ogl-077701 Oryza glaberrima 73.27 0.00e+00 968.00
IUUC-Ogu-078383 Oryza glumaepatula 73.27 0.00e+00 968.00
IUUC-Oin-079965 Oryza indica 69.34 0.00e+00 889.00
IUUC-Olo-080639 Oryza longistaminata 71.27 0.00e+00 952.00
IUUC-Ome-081821 Oryza meridionalis 72.82 0.00e+00 894.00
IUUC-Oni-082622 Oryza nivara 73.27 0.00e+00 968.00
IUUC-Opu-083295 Oryza punctata 73.11 0.00e+00 966.00
IUUC-Oru-084661 Oryza rufipogon 73.27 0.00e+00 968.00
IUUC-Osa-085766 Oryza sativa 73.27 0.00e+00 968.00
IUUC-Ola-086727 Oryzias latipes 37.63 2.00e-125 442.00
IUUC-Oga-088215 Otolemur garnettii 39.55 4.00e-119 421.00
IUUC-Oar-089880 Ovis aries 39.55 3.00e-119 421.00
IUUC-Ptr-090597 Pan troglodytes 39.94 3.00e-124 438.00
IUUC-Pan-091987 Papio anubis 39.94 2.00e-124 439.00
IUUC-Psi-094033 Pelodiscus sinensis 39.94 5.00e-121 427.00
IUUC-Pma-094587 Petromyzon marinus 38.72 5.00e-108 384.00
IUUC-Ppa-095401 Physcomitrella patens 62.66 0.00e+00 842.00
IUUC-Pfo-097388 Poecilia formosa 38.10 2.00e-122 432.00
IUUC-Pab-098029 Pongo abelii 39.94 3.00e-124 438.00
IUUC-Pop-099319 Populus trichocarpa 77.40 0.00e+00 1091.00
IUUC-Pca-100846 Procavia capensis 45.39 1.00e-103 370.00
IUUC-Ppe-101250 Prunus persica 67.13 0.00e+00 872.00
IUUC-Pva-102407 Pteropus vampyrus 39.78 1.00e-120 426.00
IUUC-Rno-105312 Rattus norvegicus 39.94 4.00e-124 438.00
IUUC-Sha-106514 Sarcophilus harrisii 46.32 9.00e-99 352.00
IUUC-Smo-109418 Selaginella moellendorffii 61.91 0.00e+00 792.00
IUUC-Sit-110248 Setaria italica 73.74 0.00e+00 970.00
IUUC-Sly-110895 Solanum lycopersicum 76.50 0.00e+00 1073.00
IUUC-Stu-112386 Solanum tuberosum 73.79 0.00e+00 1023.00
IUUC-Sar-113230 Sorex araneus 42.67 9.00e-68 250.00
IUUC-Sbi-113962 Sorghum bicolor 70.80 0.00e+00 945.00
IUUC-Ssc-115987 Sus scrofa 28.90 3.00e-26 112.00
IUUC-Tgu-116471 Taeniopygia guttata 39.45 2.00e-122 432.00
IUUC-Tru-118231 Takifugu rubripes 46.63 1.00e-104 373.00
IUUC-Tsy-119415 Tarsius syrichta 39.25 9.00e-116 410.00
IUUC-Tni-120893 Tetraodon nigroviridis 46.88 1.00e-104 373.00
IUUC-Tca-121619 Theobroma cacao 79.39 0.00e+00 1127.00
IUUC-Tae-125524 Triticum aestivum 73.02 0.00e+00 972.00
IUUC-Tur-126557 Triticum urartu 72.92 0.00e+00 952.00
IUUC-Tbe-127253 Tupaia belangeri 42.95 3.00e-69 255.00
IUUC-Ttr-129100 Tursiops truncatus 39.38 8.00e-116 410.00
IUUC-Vpa-130613 Vicugna pacos 35.93 3.00e-100 358.00
IUUC-Vvi-131386 Vitis vinifera 74.52 0.00e+00 1043.00
IUUC-Xtr-132033 Xenopus tropicalis 38.65 2.00e-130 459.00
IUUC-Xma-133421 Xiphophorus maculatus 38.40 2.00e-123 436.00
Created Date 25-Jun-2017

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