iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000038712.16	ENSMUST00000039537.13	ENSMUSP00000043910.7
ENSMUSG00000038712.16	ENSMUST00000107187.8	ENSMUSP00000102805.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	mUbiSiDa
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/MINDY	3.70e-63	212.2	144	266

Active Site

Position(s)	Description	Evidence
137	Nucleophile	{ECO:0000250\|UniProtKB:Q8N5J2}
319	Proton acceptor	{ECO:0000250\|UniProtKB:Q8N5J2}

Domain Profile

DUB/MINDY

   S: 1    nilllswkvklvpkkevitleelievlgdilldvkdkekseiselnyeqnvddalsllpklaeGldvnvrftGvrsfeytkecsvfdll 89
           nil+l+wkvkl+p+kevit++el+ +lg++ll++k++ekse+++ln++qnvdda+++lpkla+GldvnvrftGv++feyt+ecs+fdll
   Q: 144  NILFLQWKVKLPPQKEVITSDELLTHLGNCLLSIKPQEKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSIFDLL 232
           9**************************************************************************************** PP
   S: 90   didlyhGWlvdsqideavkavgklsyeqlveril 123
           +i+lyhGWlvd+q++eav avgklsy+qlve+i+
   Q: 233  GIPLYHGWLVDPQSPEAVSAVGKLSYNQLVEKII 266
           *********************************8 PP

Organism

Mus musculus

Functional Description
(View)

Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

Protein Sequence
(Fasta)

MEQPQTENPA PSKATSAETV ESENHEALSG PEKHPQDKDG ADADGAAGEQ EPGDQTLPPA 60
QDGENLECPP PEASSSPPGP ACGTSPKVET AEVCSRPQEL PQSPRIQQPE LDFYCVKWIP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGCCGGGCG AGGCTGGCGG CCGCCGCACA GGTTCTGCCG AAGGACCCGA CTCAAGCAAA 60
CCAAGAGACT CCTTTCTCCG GGCTCTCCCG CCTATGGCCG AAGGGCTTGG TCCTCTAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR007518--MINDY
IPR033979--MINDY_domain

Pfam

PF04424--MINDY_DUB

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0016807--F:cysteine-type carboxypeptidase activity
GO:0036435--F:K48-linked polyubiquitin binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity

KEGG

mmu:75007

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-136378	Aegilops tauschii	42.97	7.00e-27	115.00
IUUC-Aml-136381	Ailuropoda melanoleuca	80.98	4.00e-174	604.00
IUUC-Atr-136384	Amborella trichopoda	40.00	2.00e-32	134.00
IUUC-Apl-136388	Anas platyrhynchos	88.51	7.00e-143	499.00
IUUC-Aly-136393	Arabidopsis lyrata	48.72	2.00e-36	147.00
IUUC-Ath-136397	Arabidopsis thaliana	46.20	7.00e-37	149.00
IUUC-Ago-136399	Ashbya gossypii	29.48	4.00e-27	115.00
IUUC-Afu-136402	Aspergillus fumigatus	31.29	2.00e-25	110.00
IUUC-Ani-136403	Aspergillus nidulans	30.21	1.00e-26	115.00
IUUC-Ang-136404	Aspergillus niger	29.71	4.00e-26	113.00
IUUC-Aor-136405	Aspergillus oryzae	31.83	6.00e-25	109.00
IUUC-Ame-136409	Astyanax mexicanus	77.73	5.00e-124	437.00
IUUC-Bgr-136410	Blumeria graminis	31.51	3.00e-26	114.00
IUUC-Bta-136413	Bos taurus	81.45	9.00e-177	613.00
IUUC-Bci-136415	Botrytis cinerea	28.25	1.00e-25	112.00
IUUC-Bdi-136417	Brachypodium distachyon	43.40	2.00e-35	144.00
IUUC-Bol-136420	Brassica oleracea	48.00	3.00e-39	156.00
IUUC-Bra-136422	Brassica rapa	47.17	3.00e-40	159.00
IUUC-Cel-136423	Caenorhabditis elegans	40.55	9.00e-48	184.00
IUUC-Cja-136426	Callithrix jacchus	82.91	0.00e+00	654.00
IUUC-Cfa-136431	Canis familiaris	82.97	5.00e-170	590.00
IUUC-Cpo-136435	Cavia porcellus	78.44	0.00e+00	638.00
IUUC-Cre-136437	Chlamydomonas reinhardtii	35.21	1.00e-28	122.00
IUUC-Csa-136440	Chlorocebus sabaeus	84.32	5.00e-172	597.00
IUUC-Cho-136442	Choloepus hoffmanni	69.27	5.00e-63	234.00
IUUC-Cme-136451	Cyanidioschyzon merolae	33.33	3.00e-22	99.80
IUUC-Dre-136455	Danio rerio	77.73	6.00e-124	437.00
IUUC-Dno-136458	Dasypus novemcinctus	82.01	0.00e+00	662.00
IUUC-Dor-136460	Dipodomys ordii	58.41	1.00e-93	336.00
IUUC-Dse-136464	Dothistroma septosporum	29.13	8.00e-28	119.00
IUUC-Eca-136474	Equus caballus	83.37	0.00e+00	643.00
IUUC-Eeu-136475	Erinaceus europaeus	83.56	5.00e-126	443.00
IUUC-Fca-136480	Felis catus	82.19	0.00e+00	644.00
IUUC-Fso-136485	Fusarium solani	28.79	3.00e-27	117.00
IUUC-Gga-136494	Gallus gallus	85.93	2.00e-143	502.00
IUUC-Gac-136498	Gasterosteus aculeatus	75.39	2.00e-119	422.00
IUUC-Gma-136500	Glycine max	46.41	1.00e-34	141.00
IUUC-Ggo-136504	Gorilla gorilla	83.80	0.00e+00	680.00
IUUC-Hsa-136506	Homo sapiens	82.73	0.00e+00	650.00
IUUC-Hvu-136509	Hordeum vulgare	44.65	1.00e-37	150.00
IUUC-Itr-136512	Ictidomys tridecemlineatus	82.69	0.00e+00	683.00
IUUC-Kpa-136513	Komagataella pastoris	27.87	2.00e-21	96.70
IUUC-Lch-136516	Latimeria chalumnae	74.14	6.00e-119	420.00
IUUC-Lpe-136519	Leersia perrieri	44.87	3.00e-37	150.00
IUUC-Loc-136523	Lepisosteus oculatus	79.69	6.00e-124	437.00
IUUC-Laf-136529	Loxodonta africana	81.03	0.00e+00	644.00
IUUC-Mcc-136533	Macaca mulatta	81.66	0.00e+00	627.00
IUUC-Meu-136536	Macropus eugenii	78.65	1.00e-164	572.00
IUUC-Mor-136537	Magnaporthe oryzae	30.53	2.00e-25	111.00
IUUC-Mtr-136539	Medicago truncatula	46.41	1.00e-36	148.00
IUUC-Mla-136542	Melampsora laricipopulina	36.84	6.00e-16	78.20
IUUC-Mvi-136546	Microbotryum violaceum	31.49	2.00e-30	127.00
IUUC-Mmr-136550	Microcebus murinus	84.19	0.00e+00	654.00
IUUC-Mdo-136554	Monodelphis domestica	73.50	3.00e-174	604.00
IUUC-Mac-136560	Musa acuminata	44.23	6.00e-33	135.00
IUUC-Mpu-136564	Mustela putorius furo	80.90	0.00e+00	640.00
IUUC-Mlu-136567	Myotis lucifugus	82.87	0.00e+00	647.00
IUUC-Nfi-136569	Neosartorya fischeri	29.79	2.00e-25	111.00
IUUC-Nle-136574	Nomascus leucogenys	82.59	0.00e+00	659.00
IUUC-Opr-136578	Ochotona princeps	79.31	8.00e-177	613.00
IUUC-Ont-136581	Oreochromis niloticus	76.17	7.00e-122	430.00
IUUC-Ocu-136587	Oryctolagus cuniculus	79.74	3.00e-166	578.00
IUUC-Oba-136590	Oryza barthii	42.77	6.00e-36	145.00
IUUC-Obr-136591	Oryza brachyantha	42.77	8.00e-36	145.00
IUUC-Ogl-136594	Oryza glaberrima	42.77	5.00e-36	146.00
IUUC-Ogu-136596	Oryza glumaepatula	42.77	5.00e-36	146.00
IUUC-Oin-136598	Oryza indica	42.77	4.00e-36	146.00
IUUC-Olo-136600	Oryza longistaminata	42.77	1.00e-35	145.00
IUUC-Ome-136601	Oryza meridionalis	42.77	5.00e-36	146.00
IUUC-Oni-136603	Oryza nivara	42.77	6.00e-36	145.00
IUUC-Opu-136605	Oryza punctata	42.77	4.00e-36	146.00
IUUC-Oru-136607	Oryza rufipogon	42.77	6.00e-36	145.00
IUUC-Osa-136609	Oryza sativa	42.77	5.00e-36	146.00
IUUC-Oga-136618	Otolemur garnettii	80.98	0.00e+00	639.00
IUUC-Oar-136621	Ovis aries	79.10	0.00e+00	631.00
IUUC-Ptr-136625	Pan troglodytes	83.37	0.00e+00	654.00
IUUC-Pan-136630	Papio anubis	81.88	0.00e+00	629.00
IUUC-Psi-136634	Pelodiscus sinensis	75.07	9.00e-154	536.00
IUUC-Ppa-136639	Physcomitrella patens	46.58	4.00e-39	156.00
IUUC-Pfo-136643	Poecilia formosa	61.80	8.00e-124	436.00
IUUC-Pab-136648	Pongo abelii	82.73	0.00e+00	664.00
IUUC-Pop-136649	Populus trichocarpa	48.51	3.00e-30	124.00
IUUC-Pca-136654	Procavia capensis	75.84	9.00e-133	466.00
IUUC-Ppe-136657	Prunus persica	45.75	2.00e-34	141.00
IUUC-Pva-136661	Pteropus vampyrus	81.28	0.00e+00	653.00
IUUC-Pgr-136662	Puccinia graminis	27.71	1.00e-17	84.70
IUUC-Rno-136668	Rattus norvegicus	87.55	0.00e+00	730.00
IUUC-Sha-136673	Sarcophilus harrisii	76.66	2.00e-173	602.00
IUUC-Sja-136675	Schizosaccharomyces japonicus	27.70	8.00e-18	84.70
IUUC-Spo-136676	Schizosaccharomyces pombe	28.83	7.00e-19	88.20
IUUC-Ssl-136677	Sclerotinia sclerotiorum	28.12	2.00e-27	117.00
IUUC-Smo-136679	Selaginella moellendorffii	45.13	1.00e-37	151.00
IUUC-Sit-136681	Setaria italica	46.45	5.00e-32	132.00
IUUC-Sly-136682	Solanum lycopersicum	46.41	7.00e-35	142.00
IUUC-Stu-136684	Solanum tuberosum	46.41	2.00e-34	140.00
IUUC-Sar-136687	Sorex araneus	73.03	8.00e-123	434.00
IUUC-Sbi-136689	Sorghum bicolor	45.91	3.00e-38	153.00
IUUC-Sre-136690	Sporisorium reilianum	30.15	6.00e-33	136.00
IUUC-Ssc-136693	Sus scrofa	83.16	0.00e+00	674.00
IUUC-Tru-136701	Takifugu rubripes	75.78	1.00e-120	426.00
IUUC-Tsy-136705	Tarsius syrichta	72.78	1.00e-121	430.00
IUUC-Tni-136708	Tetraodon nigroviridis	66.12	4.00e-113	400.00
IUUC-Tca-136710	Theobroma cacao	48.68	3.00e-32	133.00
IUUC-Tae-136715	Triticum aestivum	44.65	2.00e-37	150.00
IUUC-Tur-136717	Triticum urartu	38.12	2.00e-27	117.00
IUUC-Tme-136718	Tuber melanosporum	31.13	2.00e-25	110.00
IUUC-Ttr-136725	Tursiops truncatus	82.48	0.00e+00	641.00
IUUC-Uma-136726	Ustilago maydis	29.81	1.00e-30	128.00
IUUC-Vvi-136733	Vitis vinifera	46.15	4.00e-34	139.00
IUUC-Xtr-136737	Xenopus tropicalis	70.36	7.00e-138	483.00
IUUC-Xma-136740	Xiphophorus maculatus	61.73	1.00e-124	439.00
IUUC-Yli-136742	Yarrowia lipolytica	31.88	2.00e-32	133.00
IUUC-Zma-136744	Zea mays	45.51	8.00e-39	155.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence