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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063177
Ensembl Protein ID ENSMUSP00000098677.2
UniProt Accession Q8CCI5; B2RRB6; Q9WVK2; RYBP_MOUSE
Genbank Protein ID BAC28131.1; AAH53016.1; AAH80287.1; AAI38325.1; AAI38326.1; AAD42945.1
Protein Name RING1 and YY1-binding protein; Death effector domain-associated factor
Genbank Nucleotide ID AK033024; BC053016; BC080287; BC138324; BC138325; AF101779
Gene Name Rybp; Dedaf
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000072872.3 ENSMUST00000101118.3 ENSMUSP00000098677.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDABioGRIDmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/ZnF/NZF NZF 17070805
Classification
Family E-value Score Start End
UBD/ZnF/NZF 7.60e-14 52.0 21 50
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/NZF
   S: 1    aeaqWaCsaCTflNePeavkCemCsrpRgc 30
           +e++W+Cs+CTf+N++ea+kC++C+ ++g+
   Q: 21   DEGFWDCSVCTFRNSAEAFKCSICDVRKGT 50
           589*************************95 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis (By similarity).
 Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis (By similarity).
Protein Sequence
(Fasta)
MTMGDKKSPT RPKRQAKPAA DEGFWDCSVC TFRNSAEAFK CSICDVRKGT STRKPRINSQ 60
LVAQQVAQQY ATPPPPKKEK KEKVEKPDKE KPEKDKDISP SVTKKNTNKK TKPKSDILKD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063177|UBD,NZF|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCGGCGGAGG CGGCGCTGGC GGGGACTAGT CTCGTCCGGA GACTGGCGGC GGCAGCGGCG 60
GCGGCGGCGG CGGCTGGAGC TCGAGCCCAG CAGCGGAGGG CGGGCGGGCG GCGCGGGAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063177|UBD,NZF|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR033774--YAF2_RYBP
IPR001876--Znf_RanBP2
PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
Pfam

PF17219--YAF2_RYBP
PF00641--zf-RanBP
SMART

SM00547--ZnF_RBZ
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0003677--F:DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0035518--P:histone H2A monoubiquitination
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
KEGG mmu:56353
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002182 Ailuropoda melanoleuca 99.08 8.00e-64 237.00
IUUC-Apl-003475 Anas platyrhynchos 95.43 1.00e-61 229.00
IUUC-Aca-004725 Anolis carolinensis 93.42 2.00e-66 245.00
IUUC-Ame-011035 Astyanax mexicanus 86.21 1.00e-27 117.00
IUUC-Bta-012724 Bos taurus 99.24 2.00e-36 144.00
IUUC-Cja-019921 Callithrix jacchus 99.08 3.00e-64 237.00
IUUC-Cfa-020363 Canis familiaris 99.07 1.00e-62 232.00
IUUC-Cpo-022408 Cavia porcellus 100.00 5.00e-37 146.00
IUUC-Csa-023628 Chlorocebus sabaeus 99.12 2.00e-70 258.00
IUUC-Cho-024871 Choloepus hoffmanni 98.51 5.00e-40 156.00
IUUC-Cne-026853 Cryptococcus neoformans 43.48 5.90e-02 32.70
IUUC-Dre-027750 Danio rerio 96.49 1.00e-29 123.00
IUUC-Dno-029292 Dasypus novemcinctus 100.00 6.00e-37 146.00
IUUC-Dor-030691 Dipodomys ordii 100.00 6.00e-37 146.00
IUUC-Ete-032320 Echinops telfairi 98.17 9.00e-63 233.00
IUUC-Eca-034330 Equus caballus 99.08 3.00e-64 237.00
IUUC-Eeu-035193 Erinaceus europaeus 83.49 2.00e-44 171.00
IUUC-Fca-035645 Felis catus 100.00 6.00e-37 146.00
IUUC-Fal-036647 Ficedula albicollis 95.79 6.00e-59 220.00
IUUC-Gmo-039120 Gadus morhua 90.00 1.00e-24 107.00
IUUC-Gga-040262 Gallus gallus 95.61 2.00e-67 248.00
IUUC-Ggo-045026 Gorilla gorilla 100.00 5.00e-37 146.00
IUUC-Hsa-046566 Homo sapiens 99.12 4.00e-69 254.00
IUUC-Itr-048728 Ictidomys tridecemlineatus 97.71 3.00e-35 140.00
IUUC-Lch-050014 Latimeria chalumnae 98.31 9.00e-32 130.00
IUUC-Loc-051746 Lepisosteus oculatus 72.48 5.00e-69 253.00
IUUC-Laf-054352 Loxodonta africana 98.62 1.00e-62 232.00
IUUC-Mcc-055623 Macaca mulatta 99.08 2.00e-63 235.00
IUUC-Mpo-057432 Magnaporthe poae 43.75 1.40e-01 31.20
IUUC-Mga-059812 Meleagris gallopavo 96.18 3.00e-34 137.00
IUUC-Mmr-061669 Microcebus murinus 97.71 1.00e-41 162.00
IUUC-Mdo-061964 Monodelphis domestica 96.35 6.00e-63 233.00
IUUC-Mac-065491 Musa acuminata 42.86 1.00e-03 36.20
IUUC-Mpu-065711 Mustela putorius furo 99.08 2.00e-64 238.00
IUUC-Mlu-067973 Myotis lucifugus 97.59 2.00e-17 80.90
IUUC-Nle-069817 Nomascus leucogenys 99.08 4.00e-64 237.00
IUUC-Opr-070623 Ochotona princeps 100.00 6.00e-37 146.00
IUUC-Ont-071994 Oreochromis niloticus 63.84 6.00e-50 190.00
IUUC-Oan-072949 Ornithorhynchus anatinus 96.49 5.00e-69 253.00
IUUC-Ocu-074013 Oryctolagus cuniculus 99.53 2.00e-61 228.00
IUUC-Oar-090312 Ovis aries 99.24 2.00e-36 145.00
IUUC-Ptr-091316 Pan troglodytes 99.07 5.00e-62 231.00
IUUC-Pan-091877 Papio anubis 99.12 2.00e-70 258.00
IUUC-Psi-093195 Pelodiscus sinensis 95.39 4.00e-60 224.00
IUUC-Pfo-096909 Poecilia formosa 62.83 7.00e-50 190.00
IUUC-Pab-098578 Pongo abelii 99.07 2.00e-62 232.00
IUUC-Pca-100706 Procavia capensis 95.36 2.00e-42 165.00
IUUC-Pva-102682 Pteropus vampyrus 98.17 2.00e-61 228.00
IUUC-Rno-105156 Rattus norvegicus 100.00 5.00e-64 237.00
IUUC-Sha-107156 Sarcophilus harrisii 97.71 5.00e-35 140.00
IUUC-Sar-113234 Sorex araneus 93.02 2.00e-57 215.00
IUUC-Ssc-116262 Sus scrofa 100.00 5.00e-37 146.00
IUUC-Tgu-116730 Taeniopygia guttata 95.43 8.00e-62 229.00
IUUC-Tsy-119328 Tarsius syrichta 100.00 6.00e-37 146.00
IUUC-Tni-120066 Tetraodon nigroviridis 58.15 3.00e-50 191.00
IUUC-Tre-121881 Trichoderma reesei 38.71 2.20e-02 33.50
IUUC-Tvi-122470 Trichoderma virens 44.83 3.00e-03 36.20
IUUC-Tbe-127332 Tupaia belangeri 98.62 1.00e-63 236.00
IUUC-Ttr-128963 Tursiops truncatus 99.08 3.00e-64 237.00
IUUC-Vpa-130270 Vicugna pacos 97.67 8.00e-36 142.00
Created Date 25-Jun-2017

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