iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.30e-89	300.9	22	214

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQirlwG eaq++l+ ++vl+vG++glG+E++KnL+laGv+ +t++D+++v+ ++l++qFL+r  +vg+++Ae+++e++++lnp+v+
   Q: 22   YDRQIRLWGLEAQKRLRASRVLIVGMKGLGAEIAKNLILAGVKGLTMLDHEQVSPEDLGAQFLIRTGSVGQNRAEASLERAQNLNPMVD 110
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeivFfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlke 178
           v++++e+i+++ e+  Ff++fd V+l++++ +   kv+++c+ +++++++++++G++G++                       f +l+e
   Q: 111  VKVDTEDIEKKPES--FFTEFDAVCLTCCSKDVIIKVDQICHRNSIKFFTGDVFGYHGYT-----------------------FANLGE 174
           **************..********************************************.......................****** PP
   S: 179  tpnaaehtiewavlfnklleeeageeevlekldseekeegkdkv 222
           ++ ++e+t +        ++ e+g++ +++klds+e++++k+kv
   Q: 175  HEFVEEKTKVTK----VSQGVEDGPDAKRAKLDSSETTMVKKKV 214
           ********9966....88999*******************9987 PP

Organism

Rattus norvegicus

Functional Description
(View)

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity).

Protein Sequence
(Fasta)

MVEKEEVSGG GGGISEEEAA QYDRQIRLWG LEAQKRLRAS RVLIVGMKGL GAEIAKNLIL 60
AGVKGLTMLD HEQVSPEDLG AQFLIRTGSV GQNRAEASLE RAQNLNPMVD VKVDTEDIEK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGCAAGCG CGTCCCGGGT GCACGGGCTC TCCGCCGGCG GTTAGCGAGA GCGGGATCGG 60
GTGAGCTGAA AGCCGGCGCC ATGGTGGAGA AGGAGGAGGT CAGCGGCGGC GGCGGCGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0436--Ligase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR000011--UBQ/SUMO-activ_enz_E1-like

Pfam

PF00899--ThiF

PRINTS

PR01849--UBIQUITINACT

Gene Ontology

GO:0031510--C:SUMO activating enzyme complex
GO:0008022--F:protein C-terminus binding
GO:0019948--F:SUMO activating enzyme activity
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0016925--P:protein sumoylation

KEGG

rno:308384

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000695	Aegilops tauschii	30.11	5.00e-39	154.00
IUUC-Aml-001477	Ailuropoda melanoleuca	91.49	0.00e+00	629.00
IUUC-Atr-002536	Amborella trichopoda	31.44	1.00e-40	160.00
IUUC-Apl-003982	Anas platyrhynchos	71.76	5.00e-105	373.00
IUUC-Aca-004868	Anolis carolinensis	78.18	1.00e-149	522.00
IUUC-Aly-005588	Arabidopsis lyrata	32.63	2.00e-44	172.00
IUUC-Ath-006677	Arabidopsis thaliana	32.93	2.00e-44	172.00
IUUC-Ago-007891	Ashbya gossypii	32.93	3.00e-43	168.00
IUUC-Acl-008197	Aspergillus clavatus	35.47	3.00e-51	195.00
IUUC-Afl-008520	Aspergillus flavus	34.02	1.00e-51	196.00
IUUC-Afu-009107	Aspergillus fumigatus	32.84	1.00e-46	180.00
IUUC-Ani-009143	Aspergillus nidulans	32.35	1.00e-42	167.00
IUUC-Ang-009804	Aspergillus niger	34.90	8.00e-53	201.00
IUUC-Aor-010190	Aspergillus oryzae	34.02	1.00e-51	196.00
IUUC-Ame-011043	Astyanax mexicanus	68.81	5.00e-126	443.00
IUUC-Bgr-012084	Blumeria graminis	32.56	1.00e-46	180.00
IUUC-Bta-012723	Bos taurus	91.19	0.00e+00	633.00
IUUC-Bci-013809	Botrytis cinerea	33.24	2.00e-49	189.00
IUUC-Bdi-014800	Brachypodium distachyon	31.85	1.00e-43	170.00
IUUC-Bol-015744	Brassica oleracea	31.74	1.00e-40	160.00
IUUC-Bra-016683	Brassica rapa	32.34	8.00e-42	164.00
IUUC-Cel-018434	Caenorhabditis elegans	30.09	1.00e-39	156.00
IUUC-Cja-019815	Callithrix jacchus	93.05	0.00e+00	647.00
IUUC-Cfa-020329	Canis familiaris	90.27	0.00e+00	626.00
IUUC-Cpo-022208	Cavia porcellus	91.89	0.00e+00	637.00
IUUC-Csa-023592	Chlorocebus sabaeus	91.37	3.00e-153	534.00
IUUC-Cho-024345	Choloepus hoffmanni	80.43	3.00e-119	421.00
IUUC-Cin-025351	Ciona intestinalis	44.24	2.00e-83	301.00
IUUC-Cgl-026491	Colletotrichum gloeosporioides	33.71	1.00e-43	170.00
IUUC-Dre-028263	Danio rerio	68.81	1.00e-126	446.00
IUUC-Dno-030055	Dasypus novemcinctus	89.67	1.00e-180	625.00
IUUC-Dor-030864	Dipodomys ordii	90.10	6.00e-169	586.00
IUUC-Dse-031565	Dothistroma septosporum	33.14	2.00e-48	186.00
IUUC-Dme-032011	Drosophila melanogaster	39.02	1.00e-57	216.00
IUUC-Ete-032982	Echinops telfairi	79.46	5.00e-152	530.00
IUUC-Eca-034164	Equus caballus	90.45	3.00e-172	597.00
IUUC-Eeu-035135	Erinaceus europaeus	73.39	1.00e-94	339.00
IUUC-Fca-035564	Felis catus	91.79	0.00e+00	632.00
IUUC-Fox-037928	Fusarium oxysporum	32.76	2.00e-45	176.00
IUUC-Fso-038404	Fusarium solani	32.00	2.00e-44	173.00
IUUC-Gmo-038867	Gadus morhua	66.67	1.00e-122	432.00
IUUC-Ggr-040068	Gaeumannomyces graminis	35.71	1.00e-48	187.00
IUUC-Gga-041197	Gallus gallus	74.17	7.00e-129	453.00
IUUC-Gac-042609	Gasterosteus aculeatus	65.06	6.00e-123	433.00
IUUC-Gma-044135	Glycine max	31.27	6.00e-44	171.00
IUUC-Ggo-044600	Gorilla gorilla	92.10	0.00e+00	640.00
IUUC-Hsa-046731	Homo sapiens	92.10	0.00e+00	640.00
IUUC-Itr-049038	Ictidomys tridecemlineatus	93.01	0.00e+00	640.00
IUUC-Kpa-049371	Komagataella pastoris	29.11	2.00e-32	132.00
IUUC-Lch-050045	Latimeria chalumnae	75.99	2.00e-152	531.00
IUUC-Lpe-051103	Leersia perrieri	30.93	2.00e-41	162.00
IUUC-Loc-051749	Lepisosteus oculatus	62.17	4.00e-119	421.00
IUUC-Lma-053150	Leptosphaeria maculans	37.04	2.00e-51	196.00
IUUC-Laf-053875	Loxodonta africana	90.88	0.00e+00	631.00
IUUC-Mcc-055107	Macaca mulatta	91.75	5.00e-169	586.00
IUUC-Meu-056076	Macropus eugenii	61.33	3.00e-115	408.00
IUUC-Mor-057029	Magnaporthe oryzae	33.72	2.00e-46	180.00
IUUC-Mtr-058633	Medicago truncatula	30.84	1.00e-41	163.00
IUUC-Mvi-060367	Microbotryum violaceum	34.23	4.00e-49	188.00
IUUC-Mmr-061294	Microcebus murinus	91.09	7.00e-168	582.00
IUUC-Mdo-062827	Monodelphis domestica	84.04	6.00e-172	596.00
IUUC-Mmu-063568	Mus musculus	96.05	2.00e-180	624.00
IUUC-Mac-064495	Musa acuminata	29.25	1.00e-39	156.00
IUUC-Mpu-065826	Mustela putorius furo	91.19	0.00e+00	627.00
IUUC-Mlu-067751	Myotis lucifugus	89.49	5.00e-171	593.00
IUUC-Nfi-068597	Neosartorya fischeri	34.90	7.00e-54	204.00
IUUC-Ncr-068768	Neurospora crassa	33.52	3.00e-45	176.00
IUUC-Nle-069882	Nomascus leucogenys	94.34	3.00e-89	320.00
IUUC-Opr-071077	Ochotona princeps	65.96	9.00e-120	422.00
IUUC-Ont-072576	Oreochromis niloticus	68.58	5.00e-118	417.00
IUUC-Oan-073560	Ornithorhynchus anatinus	81.52	9.00e-153	532.00
IUUC-Ocu-074732	Oryctolagus cuniculus	83.23	6.00e-163	566.00
IUUC-Oba-075956	Oryza barthii	31.55	4.00e-44	171.00
IUUC-Obr-076004	Oryza brachyantha	30.56	3.00e-41	162.00
IUUC-Ogu-078335	Oryza glumaepatula	31.25	1.00e-43	170.00
IUUC-Oin-079177	Oryza indica	31.55	1.00e-44	173.00
IUUC-Olo-080537	Oryza longistaminata	29.34	1.00e-36	147.00
IUUC-Ome-081880	Oryza meridionalis	31.55	1.00e-44	173.00
IUUC-Oni-082688	Oryza nivara	31.85	2.00e-45	175.00
IUUC-Opu-083231	Oryza punctata	31.95	8.00e-46	177.00
IUUC-Oru-084759	Oryza rufipogon	31.55	1.00e-44	173.00
IUUC-Osa-085601	Oryza sativa	31.25	5.00e-44	171.00
IUUC-Ola-086496	Oryzias latipes	67.77	2.00e-118	418.00
IUUC-Oga-089005	Otolemur garnettii	85.80	1.00e-169	588.00
IUUC-Oar-089611	Ovis aries	91.19	0.00e+00	632.00
IUUC-Ptr-091337	Pan troglodytes	92.10	0.00e+00	640.00
IUUC-Pan-092401	Papio anubis	86.02	1.00e-170	592.00
IUUC-Pma-094210	Petromyzon marinus	58.91	4.00e-114	404.00
IUUC-Pno-094975	Phaeosphaeria nodorum	34.01	1.00e-47	183.00
IUUC-Ppa-095925	Physcomitrella patens	35.00	1.00e-50	193.00
IUUC-Pfo-096890	Poecilia formosa	66.57	6.00e-123	433.00
IUUC-Pab-098173	Pongo abelii	92.10	0.00e+00	641.00
IUUC-Pop-099145	Populus trichocarpa	32.13	8.00e-46	177.00
IUUC-Pca-100899	Procavia capensis	74.16	4.00e-134	470.00
IUUC-Ppe-101274	Prunus persica	27.24	9.00e-31	127.00
IUUC-Pva-102625	Pteropus vampyrus	91.19	0.00e+00	630.00
IUUC-Pgr-103426	Puccinia graminis	36.50	4.00e-54	205.00
IUUC-Pte-104082	Pyrenophora teres	34.49	1.00e-46	180.00
IUUC-Pyt-104818	Pyrenophora triticirepentis	34.49	5.00e-47	181.00
IUUC-Sce-106370	Saccharomyces cerevisiae	32.93	8.00e-42	164.00
IUUC-Sha-107120	Sarcophilus harrisii	81.27	1.00e-151	528.00
IUUC-Sja-107996	Schizosaccharomyces japonicus	30.58	1.00e-38	153.00
IUUC-Spo-108321	Schizosaccharomyces pombe	29.23	3.00e-31	128.00
IUUC-Ssl-108608	Sclerotinia sclerotiorum	32.73	5.00e-48	184.00
IUUC-Smo-109539	Selaginella moellendorffii	29.62	3.00e-34	139.00
IUUC-Sit-110166	Setaria italica	32.15	9.00e-46	177.00
IUUC-Sly-111116	Solanum lycopersicum	31.53	2.00e-43	169.00
IUUC-Stu-112638	Solanum tuberosum	31.55	9.00e-44	170.00
IUUC-Sar-113506	Sorex araneus	80.66	3.00e-158	550.00
IUUC-Sbi-114548	Sorghum bicolor	33.33	5.00e-46	177.00
IUUC-Sre-115022	Sporisorium reilianum	27.08	2.00e-29	123.00
IUUC-Ssc-115891	Sus scrofa	91.49	0.00e+00	633.00
IUUC-Tru-118469	Takifugu rubripes	64.35	1.00e-119	422.00
IUUC-Tsy-119304	Tarsius syrichta	83.07	3.00e-152	530.00
IUUC-Tni-119803	Tetraodon nigroviridis	59.82	3.00e-115	407.00
IUUC-Tca-121747	Theobroma cacao	32.63	5.00e-45	174.00
IUUC-Tre-122060	Trichoderma reesei	32.87	8.00e-45	174.00
IUUC-Tvi-122324	Trichoderma virens	33.33	3.00e-46	179.00
IUUC-Tae-123151	Triticum aestivum	32.74	9.00e-44	170.00
IUUC-Tur-126224	Triticum urartu	31.36	4.00e-43	168.00
IUUC-Tme-126939	Tuber melanosporum	35.61	1.00e-53	203.00
IUUC-Tbe-127982	Tupaia belangeri	81.16	2.00e-160	558.00
IUUC-Ttr-128758	Tursiops truncatus	91.19	0.00e+00	635.00
IUUC-Uma-129422	Ustilago maydis	28.09	1.00e-30	127.00
IUUC-Vda-129664	Verticillium dahliae	32.18	3.00e-42	166.00
IUUC-Vpa-130778	Vicugna pacos	76.25	3.00e-129	454.00
IUUC-Vvi-131399	Vitis vinifera	31.44	2.00e-43	169.00
IUUC-Xtr-131919	Xenopus tropicalis	71.39	8.00e-140	489.00
IUUC-Xma-133482	Xiphophorus maculatus	67.77	1.00e-120	426.00
IUUC-Yli-134596	Yarrowia lipolytica	29.45	2.00e-32	132.00
IUUC-Zma-135688	Zea mays	32.74	1.00e-45	177.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence