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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063182
UUCD1 version UUC-MuM-01148
Ensembl Protein ID ENSMUSP00000145871.1
UniProt Accession Q9CQ26; Q3UTI9; STABP_MOUSE
Genbank Protein ID BAB78604.1; BAB30832.1; BAB31909.1; BAE23188.1; BAE23991.1; AAH03497.1; AAH06939.1; AAH25111.1
Protein Name STAM-binding protein; Associated molecule with the SH3 domain of STAM
Genbank Nucleotide ID AB010123; AK017600; AK019907; AK136961; AK139391; BC003497; BC006939; BC025111
Gene Name Stambp; Amsh
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000006906.10 ENSMUST00000206400.1 ENSMUSP00000145871.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Jab_MPN 4.40e-55 186.4 256 381
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Jab_MPN
   S: 5    vvvlpkrllkkflelsdvkiavavevyGlllgelvkdkevktvvlvpkqlagvgsvqvenvedvfdlldqeGlivlGWiHthpeelkfl 93
           ++v+p++l+  fl+l+++++a+++e++G+l+g+l+++++++t+vl+p+q++g +++++en+e++f ++d  Gl +lGWiHthp++++fl
   Q: 256  HIVVPRNLCSEFLQLASANTAKGIETCGVLCGKLMRNEFTITHVLIPRQNGGPDYCHTENEEEIFFMQDDLGLLTLGWIHTHPTQTAFL 344
           89*************************************************************************************** PP
   S: 94   ssvdvathsslealkkrsvaivsspkfqelsafkltd 130
           ssvd++th+s+++++++s+aiv+spkfqe+++fkltd
   Q: 345  SSVDLHTHCSYQMMLPESIAIVCSPKFQETGFFKLTD 381
           ************************************9 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (By similarity). Involved in the ubiquitin-dependent sorting and trafficking of receptors from endosomes to lysosome. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (By similarity).
 Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (By similarity). Involved in the ubiquitin-dependent sorting and trafficking of receptors from endosomes to lysosome. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (By similarity).
Protein Sequence
(Fasta)
MSDHGDVSLP PQDRVRILSQ LGSAVELNED IPPRRYYRSG VEIIRMASVY SEEGNIEHAF 60
ILYNKYITLF IEKLPKHRDY KSAIIPEKKD AVKKLKSVAF PKAEELKTEL LRRYTKEYEQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063182|UBD,Jab_MPN|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGGGGGGGG GGCGGGGAGA GCGGGGAGTG CAACGGTAGG GATGTGAAGT GAATAAAAAG 60
ATAAATTAAT GGGGGGAAAA GCATACTGGT TTCTGCTGCA GTCCCCTCTT TCACTAGGTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063182|UBD,Jab_MPN|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0378--Hydrolase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR000555--JAMM/MPN+_dom
IPR007330--MIT
IPR015063--USP8_dimer
Pfam

PF01398--JAB
PF08969--USP8_dimer
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0032154--C:cleavage furrow
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0019904--F:protein domain specific binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0000281--P:mitotic cytokinesis
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0014067--P:negative regulation of phosphatidylinositol 3-kinase signaling
GO:0046580--P:negative regulation of Ras protein signal transduction
GO:0016579--P:protein deubiquitination
KEGG mmu:70527
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001743 Ailuropoda melanoleuca 80.90 2.00e-179 621.00
IUUC-Atr-002473 Amborella trichopoda 42.15 3.00e-43 169.00
IUUC-Apl-003743 Anas platyrhynchos 70.96 3.00e-172 597.00
IUUC-Aca-005310 Anolis carolinensis 68.21 3.00e-152 531.00
IUUC-Aly-005808 Arabidopsis lyrata 48.42 5.00e-46 178.00
IUUC-Afl-008565 Aspergillus flavus 54.36 1.00e-40 160.00
IUUC-Ani-009164 Aspergillus nidulans 55.03 5.00e-42 165.00
IUUC-Ang-009659 Aspergillus niger 53.69 6.00e-42 165.00
IUUC-Aor-010102 Aspergillus oryzae 54.36 1.00e-40 160.00
IUUC-Ate-010360 Aspergillus terreus 53.38 6.00e-42 165.00
IUUC-Ame-011255 Astyanax mexicanus 57.51 1.00e-139 489.00
IUUC-Bgr-012260 Blumeria graminis 49.72 1.00e-39 157.00
IUUC-Bta-012791 Bos taurus 80.73 8.00e-177 612.00
IUUC-Bol-015371 Brassica oleracea 48.21 7.00e-46 178.00
IUUC-Bra-017428 Brassica rapa 48.21 9.00e-46 177.00
IUUC-Cja-019600 Callithrix jacchus 83.73 0.00e+00 642.00
IUUC-Cfa-020125 Canis familiaris 71.50 8.00e-159 553.00
IUUC-Cpo-021625 Cavia porcellus 82.55 0.00e+00 670.00
IUUC-Csa-023635 Chlorocebus sabaeus 84.43 0.00e+00 667.00
IUUC-Cho-024997 Choloepus hoffmanni 66.04 7.00e-140 490.00
IUUC-Cin-025539 Ciona intestinalis 54.89 3.00e-54 205.00
IUUC-Csv-026138 Ciona savignyi 50.49 5.00e-52 198.00
IUUC-Dre-027611 Danio rerio 60.61 2.00e-137 481.00
IUUC-Dno-028859 Dasypus novemcinctus 83.02 0.00e+00 647.00
IUUC-Dme-031787 Drosophila melanogaster 55.33 8.00e-60 224.00
IUUC-Ete-032412 Echinops telfairi 72.88 5.00e-161 560.00
IUUC-Eca-033504 Equus caballus 82.08 2.00e-177 614.00
IUUC-Eeu-034539 Erinaceus europaeus 80.30 8.00e-137 480.00
IUUC-Fca-035810 Felis catus 83.02 0.00e+00 642.00
IUUC-Fal-037001 Ficedula albicollis 69.39 6.00e-136 477.00
IUUC-Fox-037879 Fusarium oxysporum 49.71 7.00e-39 155.00
IUUC-Fso-038095 Fusarium solani 52.17 9.00e-36 144.00
IUUC-Gmo-038927 Gadus morhua 65.62 1.00e-79 290.00
IUUC-Ggr-039788 Gaeumannomyces graminis 45.81 9.00e-38 151.00
IUUC-Gac-041538 Gasterosteus aculeatus 59.53 5.00e-145 507.00
IUUC-Ggo-045287 Gorilla gorilla 83.49 0.00e+00 660.00
IUUC-Hsa-046543 Homo sapiens 83.49 0.00e+00 659.00
IUUC-Hvu-047336 Hordeum vulgare 53.40 2.00e-28 120.00
IUUC-Itr-048682 Ictidomys tridecemlineatus 82.55 0.00e+00 650.00
IUUC-Lch-049666 Latimeria chalumnae 57.53 1.00e-136 479.00
IUUC-Loc-052848 Lepisosteus oculatus 69.63 6.00e-84 304.00
IUUC-Lma-053221 Leptosphaeria maculans 44.62 3.00e-38 154.00
IUUC-Laf-053773 Loxodonta africana 81.84 0.00e+00 628.00
IUUC-Mcc-055868 Macaca mulatta 84.43 0.00e+00 667.00
IUUC-Meu-056009 Macropus eugenii 74.94 2.00e-167 582.00
IUUC-Mor-057282 Magnaporthe oryzae 45.81 8.00e-39 155.00
IUUC-Mpo-057473 Magnaporthe poae 45.81 6.00e-38 152.00
IUUC-Mtr-058598 Medicago truncatula 50.00 2.00e-45 177.00
IUUC-Mla-058952 Melampsora laricipopulina 48.61 3.00e-10 56.20
IUUC-Mga-059613 Meleagris gallopavo 71.43 5.00e-175 607.00
IUUC-Mac-065426 Musa acuminata 47.18 2.00e-43 169.00
IUUC-Mlu-067130 Myotis lucifugus 78.77 0.00e+00 659.00
IUUC-Ncr-068670 Neurospora crassa 47.56 1.00e-35 144.00
IUUC-Nle-069588 Nomascus leucogenys 84.20 0.00e+00 663.00
IUUC-Ont-072010 Oreochromis niloticus 60.74 6.00e-140 490.00
IUUC-Ocu-073794 Oryctolagus cuniculus 83.49 2.00e-180 624.00
IUUC-Oga-088669 Otolemur garnettii 82.78 0.00e+00 645.00
IUUC-Oar-089535 Ovis aries 80.73 3.00e-176 611.00
IUUC-Ptr-090610 Pan troglodytes 83.49 0.00e+00 659.00
IUUC-Pan-091821 Papio anubis 79.86 4.00e-174 604.00
IUUC-Psi-093278 Pelodiscus sinensis 70.30 7.00e-153 533.00
IUUC-Pma-094125 Petromyzon marinus 53.33 9.00e-109 387.00
IUUC-Ppa-095880 Physcomitrella patens 46.39 2.00e-44 173.00
IUUC-Pfo-096766 Poecilia formosa 60.23 1.00e-146 512.00
IUUC-Pab-097770 Pongo abelii 83.96 0.00e+00 664.00
IUUC-Pop-098795 Populus trichocarpa 50.00 1.00e-47 184.00
IUUC-Pca-100291 Procavia capensis 65.85 6.00e-144 503.00
IUUC-Ppe-101461 Prunus persica 44.59 5.00e-47 181.00
IUUC-Pva-102762 Pteropus vampyrus 82.78 0.00e+00 650.00
IUUC-Pgr-103491 Puccinia graminis 50.00 2.00e-36 147.00
IUUC-Ptt-103871 Puccinia triticina 50.33 4.00e-34 139.00
IUUC-Pte-104295 Pyrenophora teres 47.72 1.00e-39 157.00
IUUC-Pyt-104611 Pyrenophora triticirepentis 50.89 3.00e-39 156.00
IUUC-Rno-104828 Rattus norvegicus 97.64 0.00e+00 738.00
IUUC-Sha-107440 Sarcophilus harrisii 75.18 9.00e-158 549.00
IUUC-Sly-111040 Solanum lycopersicum 47.12 5.00e-46 178.00
IUUC-Stu-112649 Solanum tuberosum 46.63 4.00e-45 176.00
IUUC-Ssc-116248 Sus scrofa 82.55 0.00e+00 629.00
IUUC-Tgu-117057 Taeniopygia guttata 64.93 5.00e-137 481.00
IUUC-Tru-118459 Takifugu rubripes 61.77 3.00e-145 508.00
IUUC-Tsy-119283 Tarsius syrichta 72.41 3.00e-162 564.00
IUUC-Tni-120745 Tetraodon nigroviridis 60.95 4.00e-144 504.00
IUUC-Tca-121398 Theobroma cacao 45.78 7.00e-47 181.00
IUUC-Tre-121910 Trichoderma reesei 52.17 4.00e-37 149.00
IUUC-Tvi-122647 Trichoderma virens 52.90 3.00e-37 149.00
IUUC-Tbe-128135 Tupaia belangeri 82.59 1.00e-84 306.00
IUUC-Ttr-129114 Tursiops truncatus 80.79 1.00e-170 592.00
IUUC-Vvi-131419 Vitis vinifera 47.03 2.00e-47 183.00
Created Date 25-Jun-2017

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