iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000130758.7	ENST00000253055.7	ENSP00000253055.2
ENSG00000130758.7	ENST00000594951.1	ENSP00000471116.1
ENSG00000130758.7	ENST00000593502.5	ENSP00000473021.1
ENSG00000130758.7	ENST00000597986.5	ENSP00000471916.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
UniProt	PHOSIDA
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.00e-14	54.4	22	77

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlvieke...eqdegWlkgvkelegkrGlfPenFve 60
            + +dyea+ d+eLtl++Gd v+v++++   + degW+ g+   +g+ G+fP+n+v+
   Q: 22   TAVFDYEAAGDEELTLRRGDRVQVLSQDcavSGDEGWWTGQ-LPSGRVGVFPSNYVA 77
           589**********************77622257*******7.99***********96 PP

Organism

Homo sapiens

Functional Description
(View)

Activates the JUN N-terminal pathway.

Protein Sequence
(Fasta)

MEEEEGAVAK EWGTTPAGPV WTAVFDYEAA GDEELTLRRG DRVQVLSQDC AVSGDEGWWT 60
GQLPSGRVGV FPSNYVAPGA PAAPAGLQLP QEIPFHELQL EEIIGVGGFG KVYRALWRGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGCGGCCA GGCCCTCTTA GCCCTCTGCC GTTTGGGGGG CACGGGTGAA CCTGCCGCCC 60
CACTCCCACC CCGCCCCGCC CCGCCCGTAC AGCCAAATCG GAAGGGACGA GCCTGCCCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0488--Methylation
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0728--SH3 domain
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR015785--MAP3K10
IPR016231--MLK1/MLK2/MLK4
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008271--Ser/Thr_kinase_AS
IPR001452--SH3_domain

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00220--S_TKc
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0043425--F:bHLH transcription factor binding
GO:0004706--F:JUN kinase kinase kinase activity
GO:0042803--F:protein homodimerization activity
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0003714--F:transcription corepressor activity
GO:0007257--P:activation of JUN kinase activity
GO:0006915--P:apoptotic process
GO:0007254--P:JNK cascade
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0018105--P:peptidyl-serine phosphorylation
GO:0018107--P:peptidyl-threonine phosphorylation
GO:0043065--P:positive regulation of apoptotic process
GO:0046330--P:positive regulation of JNK cascade
GO:0043507--P:positive regulation of JUN kinase activity
GO:0046777--P:protein autophosphorylation
GO:0007165--P:signal transduction
GO:0007224--P:smoothened signaling pathway

KEGG

hsa:4294

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001187	Ailuropoda melanoleuca	96.08	0.00e+00	1007.00
IUUC-Atr-002967	Amborella trichopoda	31.27	7.00e-24	105.00
IUUC-Aca-004768	Anolis carolinensis	72.44	0.00e+00	816.00
IUUC-Aly-006459	Arabidopsis lyrata	33.45	4.00e-29	123.00
IUUC-Ath-006581	Arabidopsis thaliana	33.10	2.00e-28	121.00
IUUC-Bta-013545	Bos taurus	98.50	0.00e+00	830.00
IUUC-Bdi-014449	Brachypodium distachyon	32.36	2.00e-25	111.00
IUUC-Bol-016287	Brassica oleracea	32.38	4.00e-28	120.00
IUUC-Bra-017021	Brassica rapa	33.10	2.00e-28	121.00
IUUC-Cja-019696	Callithrix jacchus	91.54	0.00e+00	1348.00
IUUC-Cfa-020789	Canis familiaris	79.04	0.00e+00	1082.00
IUUC-Cpo-021993	Cavia porcellus	90.68	0.00e+00	958.00
IUUC-Cre-022669	Chlamydomonas reinhardtii	33.64	2.00e-19	90.10
IUUC-Csa-024243	Chlorocebus sabaeus	98.43	0.00e+00	1396.00
IUUC-Cho-024961	Choloepus hoffmanni	93.33	3.00e-107	382.00
IUUC-Dre-028573	Danio rerio	71.29	0.00e+00	769.00
IUUC-Dno-029095	Dasypus novemcinctus	91.26	0.00e+00	1221.00
IUUC-Fca-036250	Felis catus	97.23	0.00e+00	991.00
IUUC-Gmo-038497	Gadus morhua	71.38	0.00e+00	763.00
IUUC-Gma-043336	Glycine max	29.87	2.00e-25	111.00
IUUC-Ggo-045471	Gorilla gorilla	92.79	0.00e+00	956.00
IUUC-Hvu-047798	Hordeum vulgare	33.62	6.00e-24	105.00
IUUC-Itr-048231	Ictidomys tridecemlineatus	95.84	0.00e+00	981.00
IUUC-Loc-052286	Lepisosteus oculatus	67.64	0.00e+00	754.00
IUUC-Mcc-055733	Macaca mulatta	96.46	0.00e+00	1392.00
IUUC-Mtr-058733	Medicago truncatula	32.00	6.00e-26	113.00
IUUC-Mdo-062516	Monodelphis domestica	73.05	0.00e+00	1027.00
IUUC-Mmu-064082	Mus musculus	90.96	0.00e+00	1413.00
IUUC-Mac-065156	Musa acuminata	31.58	9.00e-27	115.00
IUUC-Mpu-065934	Mustela putorius furo	92.24	0.00e+00	1310.00
IUUC-Mlu-068137	Myotis lucifugus	80.51	0.00e+00	1226.00
IUUC-Opr-070869	Ochotona princeps	78.39	0.00e+00	876.00
IUUC-Ont-072492	Oreochromis niloticus	63.83	0.00e+00	781.00
IUUC-Ocu-074350	Oryctolagus cuniculus	90.42	0.00e+00	1215.00
IUUC-Oba-075616	Oryza barthii	34.88	3.00e-24	107.00
IUUC-Obr-076215	Oryza brachyantha	34.91	2.00e-25	111.00
IUUC-Ogl-077159	Oryza glaberrima	34.88	3.00e-24	107.00
IUUC-Ogu-078228	Oryza glumaepatula	35.35	9.00e-25	108.00
IUUC-Oin-079079	Oryza indica	34.93	6.00e-25	109.00
IUUC-Olo-080886	Oryza longistaminata	35.07	4.00e-24	106.00
IUUC-Oni-082428	Oryza nivara	34.88	3.00e-24	107.00
IUUC-Opu-083527	Oryza punctata	35.35	2.00e-24	108.00
IUUC-Oru-084678	Oryza rufipogon	34.93	6.00e-25	109.00
IUUC-Osa-086117	Oryza sativa	34.93	6.00e-25	109.00
IUUC-Oga-088351	Otolemur garnettii	92.80	0.00e+00	1353.00
IUUC-Ptr-091607	Pan troglodytes	99.90	0.00e+00	1444.00
IUUC-Pan-092403	Papio anubis	99.11	0.00e+00	1003.00
IUUC-Pfo-096104	Poecilia formosa	60.39	0.00e+00	788.00
IUUC-Pab-098396	Pongo abelii	99.56	0.00e+00	1059.00
IUUC-Pop-099554	Populus trichocarpa	29.59	1.00e-23	105.00
IUUC-Ppe-101208	Prunus persica	31.93	2.00e-25	111.00
IUUC-Pva-103086	Pteropus vampyrus	96.30	3.00e-179	622.00
IUUC-Rno-105688	Rattus norvegicus	90.85	0.00e+00	1422.00
IUUC-Smo-109113	Selaginella moellendorffii	33.09	1.00e-25	110.00
IUUC-Sit-110427	Setaria italica	34.58	2.00e-24	108.00
IUUC-Sly-111849	Solanum lycopersicum	35.09	3.00e-25	110.00
IUUC-Stu-112224	Solanum tuberosum	35.09	5.00e-25	109.00
IUUC-Sbi-113963	Sorghum bicolor	35.05	4.00e-25	110.00
IUUC-Ssc-115332	Sus scrofa	95.85	0.00e+00	981.00
IUUC-Tru-117692	Takifugu rubripes	63.48	0.00e+00	799.00
IUUC-Tsy-119412	Tarsius syrichta	94.85	2.00e-66	247.00
IUUC-Tca-121565	Theobroma cacao	35.85	1.00e-25	112.00
IUUC-Tae-125555	Triticum aestivum	32.10	2.00e-24	107.00
IUUC-Tur-126322	Triticum urartu	32.26	9.00e-25	108.00
IUUC-Tbe-127643	Tupaia belangeri	98.55	0.00e+00	667.00
IUUC-Ttr-128550	Tursiops truncatus	90.99	0.00e+00	1341.00
IUUC-Vvi-131372	Vitis vinifera	32.62	1.00e-23	105.00
IUUC-Xtr-132108	Xenopus tropicalis	62.36	0.00e+00	960.00
IUUC-Xma-134254	Xiphophorus maculatus	60.30	0.00e+00	807.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence