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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046623
Ensembl Protein ID ENSP00000252725.5
UniProt Accession O15143; Q9BU00; ARC1B_HUMAN
Genbank Protein ID AAB64189.1; AAH02562.1; AAH02988.2; AAH07555.1
Protein Name Actin-related protein 2/3 complex subunit 1B; Arp2/3 complex 41 kDa subunit; p41-ARC
Genbank Nucleotide ID AF006084; AC004922; BC002988; BC007555
Gene Name ARPC1B; ARC41
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000130429.12 ENST00000252725.9 ENSP00000252725.5
ENSG00000130429.12 ENST00000445924.5 ENSP00000408508.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanmiRecordsRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.30e-16 61.6 51 80
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H++ vt++++ ++ +++v+++ D + +vW 
   Q: 51   HNGQVTGIDWaPEsNRIVTCGTDRNAYVWT 80
           9**********888***************6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Belongs to the WD repeat ARPC1 family.
 Belongs to the WD repeat ARPC1 family.
Protein Sequence
(Fasta)
MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGA KWTKVHELKE HNGQVTGIDW 60
APESNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR CVRWAPNENK FAVGSGSRVI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046623|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGGGCCTGC ACAGTTGGCG CCCACCGGCA TCAGCGTGAA GGGAGCTCCT CGCTGGCTGC 60
CGACGGGGCT GCAGGGCTCG CTAGCCGCTC ACCTGCGTGT GAGCGCGGAG CCCGCAGTAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046623|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR030141--ARC1B
IPR017383--ARPC1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005885--C:Arp2/3 protein complex
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0036284--C:tubulobulbar complex
GO:0005200--F:structural constituent of cytoskeleton
GO:0034314--P:Arp2/3 complex-mediated actin nucleation
GO:0048013--P:ephrin receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0006928--P:movement of cell or subcellular component
GO:0032355--P:response to estradiol
GO:0043627--P:response to estrogen
KEGG hsa:10095
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000669 Aegilops tauschii 44.84 2.00e-64 239.00
IUUC-Aml-001709 Ailuropoda melanoleuca 96.54 0.00e+00 730.00
IUUC-Aly-006568 Arabidopsis lyrata 41.08 1.00e-79 290.00
IUUC-Ath-006683 Arabidopsis thaliana 41.62 6.00e-80 291.00
IUUC-Ame-011512 Astyanax mexicanus 80.86 0.00e+00 655.00
IUUC-Bta-012442 Bos taurus 95.96 0.00e+00 723.00
IUUC-Bol-016274 Brassica oleracea 40.97 4.00e-82 298.00
IUUC-Bra-016790 Brassica rapa 40.70 1.00e-80 293.00
IUUC-Cja-019899 Callithrix jacchus 97.86 0.00e+00 756.00
IUUC-Cfa-020067 Canis familiaris 96.24 0.00e+00 728.00
IUUC-Cpo-022461 Cavia porcellus 98.92 0.00e+00 739.00
IUUC-Cre-022590 Chlamydomonas reinhardtii 35.20 3.00e-35 141.00
IUUC-Csa-023277 Chlorocebus sabaeus 90.59 0.00e+00 694.00
IUUC-Dre-028141 Danio rerio 80.59 0.00e+00 647.00
IUUC-Dor-030559 Dipodomys ordii 96.77 0.00e+00 736.00
IUUC-Ete-032299 Echinops telfairi 94.35 0.00e+00 739.00
IUUC-Eca-033593 Equus caballus 96.25 0.00e+00 726.00
IUUC-Fca-036254 Felis catus 97.85 0.00e+00 738.00
IUUC-Fal-037453 Ficedula albicollis 88.50 0.00e+00 696.00
IUUC-Gmo-038471 Gadus morhua 70.05 1.00e-162 565.00
IUUC-Gga-040898 Gallus gallus 87.90 0.00e+00 698.00
IUUC-Gac-042236 Gasterosteus aculeatus 74.80 6.00e-177 613.00
IUUC-Gma-042803 Glycine max 40.80 3.00e-79 288.00
IUUC-Ggo-045355 Gorilla gorilla 83.38 2.00e-171 595.00
IUUC-Itr-048596 Ictidomys tridecemlineatus 97.85 0.00e+00 744.00
IUUC-Kpa-049288 Komagataella pastoris 41.64 9.00e-76 277.00
IUUC-Lch-049679 Latimeria chalumnae 78.98 0.00e+00 637.00
IUUC-Lpe-050869 Leersia perrieri 41.23 5.00e-78 285.00
IUUC-Loc-052140 Lepisosteus oculatus 80.59 0.00e+00 633.00
IUUC-Laf-054287 Loxodonta africana 93.09 0.00e+00 693.00
IUUC-Meu-056302 Macropus eugenii 90.59 0.00e+00 713.00
IUUC-Mtr-057659 Medicago truncatula 40.21 6.00e-82 297.00
IUUC-Mga-059279 Meleagris gallopavo 87.90 0.00e+00 699.00
IUUC-Mmr-060752 Microcebus murinus 97.51 0.00e+00 725.00
IUUC-Mdo-062836 Monodelphis domestica 86.56 0.00e+00 673.00
IUUC-Mmu-064099 Mus musculus 96.28 0.00e+00 728.00
IUUC-Mpu-066247 Mustela putorius furo 97.04 0.00e+00 717.00
IUUC-Mlu-067571 Myotis lucifugus 96.77 0.00e+00 748.00
IUUC-Nle-069492 Nomascus leucogenys 85.48 4.00e-174 603.00
IUUC-Opr-070519 Ochotona princeps 99.12 4.00e-135 474.00
IUUC-Ont-071316 Oreochromis niloticus 76.38 3.00e-176 611.00
IUUC-Oan-072692 Ornithorhynchus anatinus 88.98 0.00e+00 703.00
IUUC-Ocu-074187 Oryctolagus cuniculus 93.28 0.00e+00 714.00
IUUC-Oba-075379 Oryza barthii 41.37 1.00e-78 287.00
IUUC-Obr-076404 Oryza brachyantha 41.76 2.00e-79 289.00
IUUC-Ogl-077409 Oryza glaberrima 38.96 1.00e-72 266.00
IUUC-Ogu-078759 Oryza glumaepatula 41.37 1.00e-78 286.00
IUUC-Oin-079118 Oryza indica 41.42 2.00e-79 289.00
IUUC-Olo-081055 Oryza longistaminata 40.73 2.00e-69 256.00
IUUC-Ome-081281 Oryza meridionalis 41.37 2.00e-78 286.00
IUUC-Oni-083043 Oryza nivara 41.37 1.00e-78 287.00
IUUC-Oru-084839 Oryza rufipogon 41.37 1.00e-78 287.00
IUUC-Osa-085377 Oryza sativa 41.42 2.00e-79 289.00
IUUC-Oga-088610 Otolemur garnettii 97.85 0.00e+00 738.00
IUUC-Oar-089639 Ovis aries 94.61 0.00e+00 707.00
IUUC-Ptr-091023 Pan troglodytes 99.73 0.00e+00 745.00
IUUC-Pan-091727 Papio anubis 99.46 0.00e+00 754.00
IUUC-Pfo-097058 Poecilia formosa 74.54 4.00e-176 610.00
IUUC-Pab-098238 Pongo abelii 99.73 0.00e+00 750.00
IUUC-Pca-100580 Procavia capensis 94.35 0.00e+00 712.00
IUUC-Ppe-101681 Prunus persica 41.69 3.00e-81 295.00
IUUC-Pva-102928 Pteropus vampyrus 94.62 0.00e+00 699.00
IUUC-Rno-104846 Rattus norvegicus 96.77 0.00e+00 730.00
IUUC-Sly-111048 Solanum lycopersicum 42.32 2.00e-78 286.00
IUUC-Sar-113404 Sorex araneus 78.57 6.00e-158 550.00
IUUC-Sbi-114685 Sorghum bicolor 41.53 4.00e-78 285.00
IUUC-Tru-118106 Takifugu rubripes 74.47 5.00e-178 616.00
IUUC-Tni-120079 Tetraodon nigroviridis 75.79 1.00e-179 622.00
IUUC-Tae-125810 Triticum aestivum 37.23 4.00e-71 261.00
IUUC-Tur-126640 Triticum urartu 39.50 4.00e-69 255.00
IUUC-Ttr-128698 Tursiops truncatus 97.04 0.00e+00 734.00
IUUC-Vvi-131647 Vitis vinifera 41.76 1.00e-80 293.00
IUUC-Xtr-131893 Xenopus tropicalis 83.60 0.00e+00 663.00
Created Date 25-Jun-2017

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