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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045713
UUCD1 version UUC-HoS-00426
Ensembl Protein ID ENSP00000378350.2
UniProt Accession Q9UJX2; A8K6E5; B4E3A2; B7WP05; D3DQB7; O75433; Q53FN2; Q9BS73; CDC23_HUMAN
Genbank Protein ID BAA75628.1; BAF84299.1; BAG65414.1; AAS99353.1; BAD96970.1; EAW62155.1; EAW62154.1; EAW62156.1; AAH05258.1; AAH10944.1; AAH17713.1; AAC70920.1; AAF05755.1; AAP88812.1
Protein Name Cell division cycle protein 23 homolog; Anaphase-promoting complex subunit 8; Cyclosome subunit 8
Genbank Nucleotide ID AB011472; AK291610; AK304635; AY603103; AK223250; AC106752; CH471062; CH471062; BC005258; BC010944; BC017713; AF053977; AF191341; BT009810
Gene Name CDC23; ANAPC8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000094880.10 ENST00000394886.6 ENSP00000378350.2
ENSG00000094880.10 ENST00000483961.6 ENSP00000422505.1
ENSG00000094880.10 ENST00000511383.5 ENSP00000422902.1
ENSG00000094880.10 ENST00000394884.7 ENSP00000378348.3
ENSG00000094880.10 ENST00000505120.1 ENSP00000423704.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/APC_C/APC_C APC_C 21107322; 16763193
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 32.73 7.00e-66 246.00 IUUC-Sce-106199
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Protein Sequence
(Fasta)
MAASTSMVPV AVTAAVAPVL SINSDFSDLR EIKKQLLLIA GLTRERGLLH SSKWSAELAF 60
SLPALPLAEL QPPPPITEED AQDMDAYTLA KAYFDVKEYD RAAHFLHGCN SKKAYFLYMY 120
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Protein Fasta Sequence


>IUUC-Hsa-045713|E3,APC_C|Homo sapiens
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Nucleotide Sequence
(Fasta)
ATGATTGGCT GGAGTGGCCC GAGTCGGGAA AATGGCTGCG AGTACCTCCA TGGTCCCGGT 60
GGCTGTGACG GCGGCAGTGG CGCCTGTCCT GTCCATAAAC AGCGATTTCT CAGATTTGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045713|E3,APC_C|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR007192--APC8
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
PROSITE

PS50005--TPR
PS50293--TPR_REGION
Pfam

PF04049--ANAPC8
PF13414--TPR_11
PF13181--TPR_8
SMART

SM00028--TPR
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007091--P:metaphase/anaphase transition of mitotic cell cycle
GO:0007080--P:mitotic metaphase plate congression
GO:0007067--P:mitotic nuclear division
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0007096--P:regulation of exit from mitosis
GO:0030071--P:regulation of mitotic metaphase/anaphase transition
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:8697
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000540 Aegilops tauschii 48.76 1.00e-103 370.00
IUUC-Aml-002139 Ailuropoda melanoleuca 99.48 0.00e+00 1152.00
IUUC-Atr-002658 Amborella trichopoda 48.03 8.00e-123 434.00
IUUC-Apl-004020 Anas platyrhynchos 95.20 0.00e+00 1037.00
IUUC-Aca-005101 Anolis carolinensis 91.80 0.00e+00 1071.00
IUUC-Aly-006437 Arabidopsis lyrata 46.34 4.00e-116 412.00
IUUC-Ath-006712 Arabidopsis thaliana 46.34 2.00e-114 406.00
IUUC-Ago-007953 Ashbya gossypii 34.32 1.00e-69 257.00
IUUC-Acl-008166 Aspergillus clavatus 36.51 3.00e-89 323.00
IUUC-Afl-008420 Aspergillus flavus 36.43 3.00e-90 326.00
IUUC-Afu-009028 Aspergillus fumigatus 36.56 1.00e-88 320.00
IUUC-Ani-009390 Aspergillus nidulans 36.15 3.00e-91 329.00
IUUC-Ang-009704 Aspergillus niger 37.57 8.00e-90 324.00
IUUC-Aor-009990 Aspergillus oryzae 36.62 2.00e-90 326.00
IUUC-Ate-010510 Aspergillus terreus 36.10 2.00e-88 320.00
IUUC-Ame-011724 Astyanax mexicanus 67.86 0.00e+00 788.00
IUUC-Bgr-012007 Blumeria graminis 35.25 2.00e-79 290.00
IUUC-Bta-013310 Bos taurus 99.13 0.00e+00 1185.00
IUUC-Bci-013833 Botrytis cinerea 37.60 5.00e-84 305.00
IUUC-Bdi-014957 Brachypodium distachyon 46.22 4.00e-117 415.00
IUUC-Bol-016105 Brassica oleracea 47.04 1.00e-119 423.00
IUUC-Bra-017168 Brassica rapa 46.67 5.00e-110 391.00
IUUC-Cel-018142 Caenorhabditis elegans 37.08 4.00e-81 295.00
IUUC-Cja-019339 Callithrix jacchus 99.13 0.00e+00 1159.00
IUUC-Cfa-020690 Canis familiaris 99.48 0.00e+00 1152.00
IUUC-Cpo-021859 Cavia porcellus 98.16 0.00e+00 1167.00
IUUC-Cre-022698 Chlamydomonas reinhardtii 41.83 5.00e-76 278.00
IUUC-Csa-024176 Chlorocebus sabaeus 99.48 0.00e+00 1197.00
IUUC-Cho-024903 Choloepus hoffmanni 97.46 0.00e+00 982.00
IUUC-Cin-025468 Ciona intestinalis 45.45 1.00e-128 453.00
IUUC-Csv-026223 Ciona savignyi 44.74 2.00e-137 483.00
IUUC-Cgl-026453 Colletotrichum gloeosporioides 36.69 1.00e-81 297.00
IUUC-Cne-027038 Cryptococcus neoformans 35.40 3.00e-81 296.00
IUUC-Cme-027161 Cyanidioschyzon merolae 37.24 4.00e-72 265.00
IUUC-Dre-027972 Danio rerio 80.52 0.00e+00 938.00
IUUC-Dno-029164 Dasypus novemcinctus 98.79 0.00e+00 1153.00
IUUC-Dor-030344 Dipodomys ordii 88.93 0.00e+00 1011.00
IUUC-Dse-031277 Dothistroma septosporum 43.83 6.00e-54 204.00
IUUC-Dme-031895 Drosophila melanogaster 49.17 3.00e-144 505.00
IUUC-Ete-032942 Echinops telfairi 94.81 0.00e+00 1019.00
IUUC-Eca-034355 Equus caballus 98.78 0.00e+00 1149.00
IUUC-Eeu-035313 Erinaceus europaeus 98.74 8.00e-176 610.00
IUUC-Fca-035799 Felis catus 99.30 0.00e+00 1147.00
IUUC-Fal-037373 Ficedula albicollis 93.19 0.00e+00 1074.00
IUUC-Fox-037722 Fusarium oxysporum 34.46 5.00e-78 285.00
IUUC-Fso-038295 Fusarium solani 33.52 5.00e-72 265.00
IUUC-Gmo-039241 Gadus morhua 79.45 0.00e+00 931.00
IUUC-Ggr-039994 Gaeumannomyces graminis 41.31 4.00e-74 273.00
IUUC-Gga-040280 Gallus gallus 92.35 0.00e+00 1069.00
IUUC-Gac-042265 Gasterosteus aculeatus 80.17 0.00e+00 949.00
IUUC-Gma-043161 Glycine max 45.67 7.00e-116 411.00
IUUC-Ggo-044898 Gorilla gorilla 92.25 0.00e+00 1058.00
IUUC-Hvu-047296 Hordeum vulgare 51.40 1.00e-103 370.00
IUUC-Itr-048205 Ictidomys tridecemlineatus 99.31 0.00e+00 1158.00
IUUC-Kpa-049344 Komagataella pastoris 38.51 3.00e-72 266.00
IUUC-Lch-049878 Latimeria chalumnae 85.10 0.00e+00 973.00
IUUC-Lpe-050917 Leersia perrieri 52.13 3.00e-118 419.00
IUUC-Loc-052893 Lepisosteus oculatus 59.07 5.00e-179 620.00
IUUC-Lma-053031 Leptosphaeria maculans 37.07 3.00e-87 316.00
IUUC-Laf-053888 Loxodonta africana 98.95 0.00e+00 1150.00
IUUC-Mcc-055617 Macaca mulatta 94.64 0.00e+00 1088.00
IUUC-Meu-056377 Macropus eugenii 91.81 0.00e+00 1055.00
IUUC-Mor-057030 Magnaporthe oryzae 36.06 5.00e-79 288.00
IUUC-Mpo-057558 Magnaporthe poae 40.88 2.00e-74 273.00
IUUC-Mtr-058778 Medicago truncatula 46.17 2.00e-116 412.00
IUUC-Mla-058861 Melampsora laricipopulina 36.61 5.00e-72 265.00
IUUC-Mga-059809 Meleagris gallopavo 90.88 0.00e+00 1041.00
IUUC-Mvi-060381 Microbotryum violaceum 37.88 8.00e-80 291.00
IUUC-Mmr-060669 Microcebus murinus 94.29 0.00e+00 1082.00
IUUC-Mdo-062293 Monodelphis domestica 95.82 0.00e+00 1108.00
IUUC-Mmu-064261 Mus musculus 97.73 0.00e+00 1134.00
IUUC-Mac-065082 Musa acuminata 51.06 6.00e-119 421.00
IUUC-Mpu-066465 Mustela putorius furo 86.55 0.00e+00 976.00
IUUC-Mlu-067770 Myotis lucifugus 98.10 0.00e+00 1187.00
IUUC-Nfi-068311 Neosartorya fischeri 40.89 3.00e-86 313.00
IUUC-Ncr-068653 Neurospora crassa 37.26 1.00e-80 294.00
IUUC-Nle-069036 Nomascus leucogenys 99.65 0.00e+00 1165.00
IUUC-Opr-070229 Ochotona princeps 96.97 0.00e+00 810.00
IUUC-Ont-072218 Oreochromis niloticus 80.42 0.00e+00 968.00
IUUC-Oan-073467 Ornithorhynchus anatinus 86.15 2.00e-30 124.00
IUUC-Ocu-073869 Oryctolagus cuniculus 98.96 0.00e+00 1159.00
IUUC-Oba-075863 Oryza barthii 50.71 2.00e-115 409.00
IUUC-Obr-076071 Oryza brachyantha 51.42 3.00e-116 412.00
IUUC-Ogl-077026 Oryza glaberrima 50.90 2.00e-108 386.00
IUUC-Ogu-078601 Oryza glumaepatula 45.42 1.00e-115 410.00
IUUC-Oin-079443 Oryza indica 50.71 4.00e-115 408.00
IUUC-Olo-080836 Oryza longistaminata 51.23 1.00e-112 400.00
IUUC-Ome-081640 Oryza meridionalis 46.09 2.00e-113 403.00
IUUC-Oni-083014 Oryza nivara 50.71 3.00e-115 409.00
IUUC-Opu-083788 Oryza punctata 50.95 2.00e-115 409.00
IUUC-Oru-085205 Oryza rufipogon 50.35 4.00e-115 409.00
IUUC-Osa-085809 Oryza sativa 50.71 2.00e-115 409.00
IUUC-Ola-087272 Oryzias latipes 78.86 0.00e+00 929.00
IUUC-Olu-087775 Ostreococcus lucimarinus 42.63 6.00e-102 364.00
IUUC-Oga-088234 Otolemur garnettii 99.30 0.00e+00 1155.00
IUUC-Oar-089533 Ovis aries 99.13 0.00e+00 1185.00
IUUC-Ptr-090956 Pan troglodytes 100.00 0.00e+00 1166.00
IUUC-Pan-091781 Papio anubis 99.65 0.00e+00 1162.00
IUUC-Psi-093533 Pelodiscus sinensis 92.50 0.00e+00 1104.00
IUUC-Pma-094153 Petromyzon marinus 71.28 0.00e+00 830.00
IUUC-Pno-095099 Phaeosphaeria nodorum 36.45 8.00e-77 281.00
IUUC-Ppa-095917 Physcomitrella patens 49.36 2.00e-123 436.00
IUUC-Pfo-096378 Poecilia formosa 80.07 0.00e+00 963.00
IUUC-Pab-098457 Pongo abelii 99.83 0.00e+00 1202.00
IUUC-Pop-099359 Populus trichocarpa 46.48 4.00e-114 405.00
IUUC-Pca-100406 Procavia capensis 98.84 7.00e-156 544.00
IUUC-Ppe-101636 Prunus persica 45.61 6.00e-116 411.00
IUUC-Pva-103102 Pteropus vampyrus 97.65 0.00e+00 1158.00
IUUC-Pgr-103324 Puccinia graminis 36.54 2.00e-83 303.00
IUUC-Ptt-103755 Puccinia triticina 39.49 4.00e-79 289.00
IUUC-Pte-104290 Pyrenophora teres 37.57 4.00e-89 322.00
IUUC-Pyt-104739 Pyrenophora triticirepentis 37.25 5.00e-89 322.00
IUUC-Rno-105205 Rattus norvegicus 97.98 0.00e+00 1080.00
IUUC-Sce-106199 Saccharomyces cerevisiae 34.83 3.00e-59 223.00
IUUC-Sha-107218 Sarcophilus harrisii 95.47 0.00e+00 1105.00
IUUC-Sja-107667 Schizosaccharomyces japonicus 38.86 6.00e-98 351.00
IUUC-Spo-108380 Schizosaccharomyces pombe 42.09 2.00e-98 353.00
IUUC-Smo-109350 Selaginella moellendorffii 48.73 3.00e-118 418.00
IUUC-Sit-110418 Setaria italica 45.80 3.00e-119 422.00
IUUC-Sly-111724 Solanum lycopersicum 46.80 1.00e-115 410.00
IUUC-Stu-112247 Solanum tuberosum 49.50 1.00e-105 377.00
IUUC-Sar-113502 Sorex araneus 86.51 0.00e+00 984.00
IUUC-Sbi-113784 Sorghum bicolor 45.89 2.00e-120 426.00
IUUC-Sre-115116 Sporisorium reilianum 33.41 2.00e-57 217.00
IUUC-Ssc-115914 Sus scrofa 98.96 0.00e+00 1188.00
IUUC-Tgu-117390 Taeniopygia guttata 93.02 0.00e+00 1070.00
IUUC-Tru-118703 Takifugu rubripes 79.90 0.00e+00 946.00
IUUC-Tsy-118972 Tarsius syrichta 96.09 0.00e+00 769.00
IUUC-Tni-119710 Tetraodon nigroviridis 79.38 0.00e+00 936.00
IUUC-Tca-121327 Theobroma cacao 47.62 1.00e-115 410.00
IUUC-Tre-121974 Trichoderma reesei 37.10 1.00e-72 267.00
IUUC-Tvi-122260 Trichoderma virens 36.86 4.00e-72 266.00
IUUC-Tae-124866 Triticum aestivum 48.08 8.00e-69 254.00
IUUC-Tme-127161 Tuber melanosporum 37.94 9.00e-101 360.00
IUUC-Tbe-127932 Tupaia belangeri 98.68 0.00e+00 891.00
IUUC-Ttr-129091 Tursiops truncatus 98.95 0.00e+00 1185.00
IUUC-Uma-129376 Ustilago maydis 34.46 3.00e-58 220.00
IUUC-Vda-129821 Verticillium dahliae 32.93 1.00e-76 280.00
IUUC-Vpa-130644 Vicugna pacos 99.13 0.00e+00 1187.00
IUUC-Vvi-130971 Vitis vinifera 46.48 2.00e-115 409.00
IUUC-Xtr-132050 Xenopus tropicalis 90.24 0.00e+00 1057.00
IUUC-Xma-133078 Xiphophorus maculatus 79.90 0.00e+00 943.00
IUUC-Yli-134413 Yarrowia lipolytica 38.56 6.00e-85 308.00
IUUC-Zma-135224 Zea mays 45.60 2.00e-119 422.00
Created Date 25-Jun-2017

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