iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000167549.18	ENST00000345068.9	ENSP00000344562.5
ENSG00000167549.18	ENST00000580212.5	ENSP00000463723.1
ENSG00000167549.18	ENST00000480954.6	ENSP00000464621.1
ENSG00000167549.18	ENST00000584969.5	ENSP00000462627.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
ClinVar
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.70e-16	60.7	79	110

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWD 29
           gHt++v ++++   +d+ ++s+sdD ti+vW 
   Q: 79   GHTAPVLDIDWcphNDNVIASASDDTTIMVWQ 110
           8***********9877***************7 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MSRRVVRQSK FRHVFGQAAK ADQAYEDIRV SKVTWDSSFC AVNPKFLAII VEAGGGGAFI 60
VLPLAKTGRV DKNYPLVTGH TAPVLDIDWC PHNDNVIASA SDDTTIMVWQ IPDYTPMRNI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTAGGTTGA TGGCAGCGGC AGCTGGGGCT GCAGCGGCGC CGGGCTCTAG AGAGCCGCAG 60
GATCGGCCAG AGTGCGGAGC TGGACACCCG GGTCCCAGAT ACTACAGACA CCCGGAGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR024977--Apc4_WD40_dom
IPR027337--CORO6
IPR015505--Coronin
IPR015048--DUF1899
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF08953--DUF1899
PF00400--WD40

SMART

SM01166--DUF1899
SM00320--WD40

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0051015--F:actin filament binding
GO:0030036--P:actin cytoskeleton organization

KEGG

hsa:84940

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001462	Ailuropoda melanoleuca	95.80	0.00e+00	938.00
IUUC-Aca-005215	Anolis carolinensis	81.14	0.00e+00	804.00
IUUC-Ago-007901	Ashbya gossypii	40.63	2.00e-90	326.00
IUUC-Ame-011142	Astyanax mexicanus	74.73	0.00e+00	764.00
IUUC-Bgr-011990	Blumeria graminis	39.96	1.00e-97	350.00
IUUC-Bta-013160	Bos taurus	89.19	0.00e+00	855.00
IUUC-Cel-018669	Caenorhabditis elegans	53.42	5.00e-116	411.00
IUUC-Cja-019934	Callithrix jacchus	98.09	0.00e+00	961.00
IUUC-Cfa-020414	Canis familiaris	98.09	0.00e+00	965.00
IUUC-Cpo-022256	Cavia porcellus	94.49	0.00e+00	932.00
IUUC-Csa-023319	Chlorocebus sabaeus	98.94	0.00e+00	939.00
IUUC-Dre-028652	Danio rerio	76.71	0.00e+00	732.00
IUUC-Dor-030506	Dipodomys ordii	97.46	0.00e+00	958.00
IUUC-Eca-033550	Equus caballus	95.97	0.00e+00	945.00
IUUC-Eeu-035286	Erinaceus europaeus	97.99	8.00e-176	608.00
IUUC-Fca-035787	Felis catus	95.34	0.00e+00	942.00
IUUC-Fal-036912	Ficedula albicollis	83.69	0.00e+00	843.00
IUUC-Gmo-038645	Gadus morhua	72.40	0.00e+00	738.00
IUUC-Gga-040968	Gallus gallus	82.42	0.00e+00	822.00
IUUC-Gac-042489	Gasterosteus aculeatus	71.19	0.00e+00	721.00
IUUC-Ggo-044731	Gorilla gorilla	99.36	0.00e+00	968.00
IUUC-Itr-048296	Ictidomys tridecemlineatus	98.52	0.00e+00	942.00
IUUC-Kpa-049089	Komagataella pastoris	44.74	2.00e-96	347.00
IUUC-Lch-049723	Latimeria chalumnae	71.52	0.00e+00	706.00
IUUC-Loc-052779	Lepisosteus oculatus	70.51	0.00e+00	716.00
IUUC-Laf-054086	Loxodonta africana	97.67	0.00e+00	964.00
IUUC-Mcc-055571	Macaca mulatta	95.76	0.00e+00	909.00
IUUC-Mga-059353	Meleagris gallopavo	79.96	0.00e+00	805.00
IUUC-Mvi-060569	Microbotryum violaceum	39.40	8.00e-88	318.00
IUUC-Mmr-060830	Microcebus murinus	98.52	0.00e+00	970.00
IUUC-Mdo-062184	Monodelphis domestica	91.56	0.00e+00	879.00
IUUC-Mmu-064073	Mus musculus	93.43	0.00e+00	889.00
IUUC-Mpu-066824	Mustela putorius furo	98.52	0.00e+00	968.00
IUUC-Mlu-066994	Myotis lucifugus	94.92	0.00e+00	927.00
IUUC-Nle-069218	Nomascus leucogenys	100.00	0.00e+00	981.00
IUUC-Opr-071137	Ochotona princeps	98.31	0.00e+00	966.00
IUUC-Ont-071691	Oreochromis niloticus	73.25	0.00e+00	729.00
IUUC-Oan-073671	Ornithorhynchus anatinus	84.53	0.00e+00	793.00
IUUC-Ocu-074167	Oryctolagus cuniculus	96.82	0.00e+00	956.00
IUUC-Ola-086676	Oryzias latipes	71.05	0.00e+00	739.00
IUUC-Oga-088077	Otolemur garnettii	98.94	0.00e+00	969.00
IUUC-Oar-089260	Ovis aries	97.67	0.00e+00	957.00
IUUC-Ptr-090488	Pan troglodytes	99.36	0.00e+00	968.00
IUUC-Pan-091682	Papio anubis	99.15	0.00e+00	945.00
IUUC-Pfo-096186	Poecilia formosa	73.04	0.00e+00	725.00
IUUC-Pab-098768	Pongo abelii	91.10	0.00e+00	866.00
IUUC-Pca-100926	Procavia capensis	93.32	0.00e+00	809.00
IUUC-Pva-102483	Pteropus vampyrus	93.64	0.00e+00	894.00
IUUC-Rno-104937	Rattus norvegicus	96.40	0.00e+00	924.00
IUUC-Sce-106378	Saccharomyces cerevisiae	41.57	4.00e-93	335.00
IUUC-Sha-107180	Sarcophilus harrisii	83.89	0.00e+00	681.00
IUUC-Spo-108364	Schizosaccharomyces pombe	43.67	7.00e-98	351.00
IUUC-Ssc-116384	Sus scrofa	83.26	0.00e+00	776.00
IUUC-Tgu-117038	Taeniopygia guttata	81.54	0.00e+00	745.00
IUUC-Tru-118281	Takifugu rubripes	70.89	0.00e+00	721.00
IUUC-Tni-120360	Tetraodon nigroviridis	71.82	0.00e+00	720.00
IUUC-Tbe-127703	Tupaia belangeri	93.31	0.00e+00	676.00
IUUC-Ttr-128355	Tursiops truncatus	92.80	0.00e+00	890.00
IUUC-Xtr-132642	Xenopus tropicalis	70.40	0.00e+00	714.00
IUUC-Xma-133704	Xiphophorus maculatus	73.04	0.00e+00	723.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence