iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-072527

Ensembl Protein ID

ENSONIP00000011992.1

UniProt Accession

I3JSZ7; I3JSZ7_ORENI

Genbank Protein ID

ENSONIP00000011992

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01031965

Gene Name

cul5b; cul5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000009545.1	ENSONIT00000012001.1	ENSONIP00000011992.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	2.80e-228	760.0	22	672

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesv.kkeyeelytavynlclsk..vgaklYkklkevleefikqvkkkveesedeq.lLktynreWekfreqlkvlrki 86
           +r +v k+lrqesv k+++ +l+++v+++cl++  + ak++++lke++ +fikq++++v +++d++ lLk+y++eW+kf++q+++l+k+
   Q: 22   MRPIVLKLLRQESVtKQQWFDLFSDVHAVCLWDdkGPAKIHQALKEDILDFIKQAQARVLSHQDDTaLLKAYIVEWRKFFTQCDILPKP 110
           6899****************************9999***************************************************** PP
   S: 87   fayldrtyvkk.....skkv....sevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLslnk...lai 163
           f++l+ t ++k     +       s vrkL+ld+w+++i+++ik+rl+++++kl++aeR gea+d++l+ gv+es+v+L++n    l+i
   Q: 111  FCQLEITLMGKqgsnkK--SnmedSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPddkLQI 197
           ***********776542..1557799*******************************************************99999*** PP
   S: 164  ykesFEakfleatqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetk....Llevvekeliakhlesllaelvallr 248
           y+++FE++++++t++fy++++ ++lq+n+v++Y+k+++++l+eee+ra ryle+++ ++    L+e+++++l++++ e++lae++ +++
   Q: 198  YRDNFEKAYMDSTERFYRTQAPAYLQQNGVQNYMKYADSKLREEEKRALRYLETRRDCNsvqaLMECCVNALVTSFKETILAECPGMIK 286
           ********************************************************9999999************************** PP
   S: 249  dkktedlsrmykLlsrvlngleellkeleshikeqgkaalt..aeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafet 335
           +++te+l++m++L+++v+ng+e++lk+le+hi+++g+a+++  ae+++ d++kyVe+ll+l+n++++lv+eaF++d++Fl+a+dka+++
   Q: 287  RNETEKLHLMFSLMDKVPNGIEPMLKDLEEHIMSAGLADMVasAETITSDSEKYVEQLLTLFNRFSRLVKEAFQDDPRFLTARDKAYKA 375
           ****************************************9999999****************************************** PP
   S: 336  fvnknsvlka................akspEllAryiDqlLrks..skglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLls 406
           +vn+++++k+                +k+pEllA+y+D+lLrk+  sk+lt+ee+ea+l++vllv+ky+++kdvF++y+k hL++RL++
   Q: 376  VVNDATIFKLelpmkqkgvglktqpeSKCPELLANYCDMLLRKTplSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLIL 464
           ***************************************************************************************** PP
   S: 407  gksasseaEesviekLkeec.gaeftskLerMfqdlkvSedlnrqFk.eekenteesesvelsvlvLsagaWptasetekvsLPaelek 493
           ++sa+se+Ee+++e+L+e++ +a++++kL+rMfqd+kvSedln+ Fk ++k+n+ + +++++++++L+agaW+++se++ vsLP+ele+
   Q: 465  DISADSEIEENMVEWLREVGmPADYVNKLARMFQDIKVSEDLNQSFKeMHKHNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELED 553
           ***********************************************5678888899******************************** PP
   S: 494  tiekfeefYlekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnns..ekvsveelkkatelpeeeLrrtlqsLvs.sk 579
           +i+++e fY+++hsgRkL+W+h ++++ +++++++g+y+l+V+tfQ+avL+a+n++  e++s+e+lk atelp++eLrrtl+sLv+ +k
   Q: 554  LIPEVEDFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRprERISFENLKLATELPDAELRRTLWSLVAfPK 642
           *******************************************************999****************************999 PP
   S: 580  ..kqvlkkepeske...ieeedlfsvNqef 604
             +qvl ++p  ++   ++e++lf+vNqef
   Q: 643  lkRQVLLYDPPVSSpkdFAEGTLFYVNQEF 672
           999*******9977777************9 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MATSNLLKNK GSLQFEDKWD LMRPIVLKLL RQESVTKQQW FDLFSDVHAV CLWDDKGPAK 60
IHQALKEDIL DFIKQAQARV LSHQDDTALL KAYIVEWRKF FTQCDILPKP FCQLEITLMG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTAAAAATAA CTTCCCTAAC AACAGCGATA TTTCGATAAG GTTAATGTTC GTAGGTCTTG 60
TTGTTCGCGC GAGATTTTAC GAGAGGATAA GTTGAGGGAA CATGGCGACG TCTAATTTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031461--C:cullin-RING ubiquitin ligase complex
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003564	Anas platyrhynchos	96.11	0.00e+00	1512.00
IUUC-Bta-012515	Bos taurus	96.05	0.00e+00	1486.00
IUUC-Cel-018522	Caenorhabditis elegans	51.16	0.00e+00	756.00
IUUC-Cja-018785	Callithrix jacchus	95.90	0.00e+00	1526.00
IUUC-Cfa-020932	Canis familiaris	95.92	0.00e+00	1484.00
IUUC-Csa-023949	Chlorocebus sabaeus	96.03	0.00e+00	1528.00
IUUC-Cin-025540	Ciona intestinalis	73.30	4.00e-151	527.00
IUUC-Csv-025978	Ciona savignyi	65.32	0.00e+00	1003.00
IUUC-Dno-029195	Dasypus novemcinctus	95.75	0.00e+00	1514.00
IUUC-Dor-030573	Dipodomys ordii	84.06	6.00e-168	584.00
IUUC-Dme-032083	Drosophila melanogaster	68.33	0.00e+00	927.00
IUUC-Eeu-035348	Erinaceus europaeus	96.12	0.00e+00	733.00
IUUC-Fal-037514	Ficedula albicollis	96.11	0.00e+00	1511.00
IUUC-Gmo-038577	Gadus morhua	96.55	0.00e+00	1528.00
IUUC-Gga-041096	Gallus gallus	95.87	0.00e+00	1512.00
IUUC-Gac-042108	Gasterosteus aculeatus	98.21	0.00e+00	1550.00
IUUC-Ggo-045313	Gorilla gorilla	95.51	0.00e+00	1520.00
IUUC-Hsa-045974	Homo sapiens	96.03	0.00e+00	1528.00
IUUC-Itr-049009	Ictidomys tridecemlineatus	96.03	0.00e+00	1524.00
IUUC-Laf-053601	Loxodonta africana	95.87	0.00e+00	1515.00
IUUC-Mga-059658	Meleagris gallopavo	95.88	0.00e+00	1511.00
IUUC-Mdo-061836	Monodelphis domestica	96.15	0.00e+00	1527.00
IUUC-Mpu-065823	Mustela putorius furo	95.90	0.00e+00	1525.00
IUUC-Nle-069943	Nomascus leucogenys	96.03	0.00e+00	1528.00
IUUC-Oan-072743	Ornithorhynchus anatinus	96.18	0.00e+00	1488.00
IUUC-Ocu-074586	Oryctolagus cuniculus	96.03	0.00e+00	1528.00
IUUC-Oga-088425	Otolemur garnettii	91.37	0.00e+00	1473.00
IUUC-Oar-089785	Ovis aries	96.03	0.00e+00	1528.00
IUUC-Ptr-091242	Pan troglodytes	96.03	0.00e+00	1528.00
IUUC-Pan-092246	Papio anubis	96.03	0.00e+00	1528.00
IUUC-Psi-094081	Pelodiscus sinensis	96.12	0.00e+00	1516.00
IUUC-Pma-094735	Petromyzon marinus	81.80	0.00e+00	747.00
IUUC-Pfo-096357	Poecilia formosa	97.82	0.00e+00	1543.00
IUUC-Pca-100756	Procavia capensis	85.00	0.00e+00	848.00
IUUC-Pva-102990	Pteropus vampyrus	82.71	0.00e+00	895.00
IUUC-Sha-107016	Sarcophilus harrisii	96.15	0.00e+00	1527.00
IUUC-Sar-113558	Sorex araneus	90.41	0.00e+00	1444.00
IUUC-Ssc-115414	Sus scrofa	96.03	0.00e+00	1528.00
IUUC-Tru-117565	Takifugu rubripes	99.10	0.00e+00	1561.00
IUUC-Tni-120471	Tetraodon nigroviridis	98.72	0.00e+00	1553.00
IUUC-Tbe-127838	Tupaia belangeri	90.51	0.00e+00	1461.00
IUUC-Ttr-128345	Tursiops truncatus	95.77	0.00e+00	1521.00
IUUC-Vpa-130191	Vicugna pacos	88.15	0.00e+00	837.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence