iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	miRNAMap	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.40e-40	135.1	167	205
UBD/Beta-Prp	2.00e-49	168.7	163	368

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvllk 37
           +Ht+ ++c+ f  sd+l+++Gs+D t+ +WD+ +g l++
   Q: 167  THTSYMSCCTFlrSDNLILTGSGDSTCAIWDVESGQLIQ 205
           5***********999******************998876 PP

UBD/Beta-Prp

   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp..sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvv 144
           r++  h++  ++++f +++++++tgs D t  +wd+++g+ ++ ++gh+ +v ++++ +  +g++++s+++d+   vwd+++gqc++  ++gh++ +n+v+
   Q: 163  RQVATHTSYMSCCTFLRSDNLILTGSGDSTCAIWDVESGQLIQNFHGHTGDVFAIDVPKcdTGNTFISAGADKHSLVWDIRSGQCVQ-SFEGHEADINTVR 262
           6788999999***********************************************999788***********************9.************* PP
   S: 145  vhpdgnllvsGslDrtvrlWdlktgk..llrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssD 243
           +hp+g+ +++Gs+D t+rl+dl+ ++  ++++ ++    +v+ ++f+ +g+ l +g  d +v +wd  +      l gh++ ++++r+sp+++ + s+s D
   Q: 263  FHPNGDAFATGSDDATCRLFDLRADRqvCVYEKES-ILFPVNGVDFSLSGRILFAGYGDYRVGVWDSLKCARHSVLYGHENRISCLRTSPDGTAVCSASWD 362
           **********************6655115565566.8899**************************998888999************************** PP
   S: 244  gsiriW 249
            +iriW
   Q: 363  CTIRIW 368
           *****9 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

G proteins are composed of 3 units, alpha, beta and gamma (By similarity). Interacts with G protein gamma subunits gpc-1 and gpc-2 and with egl-10 and eat-16 (PubMed:11333232).

Protein Sequence
(Fasta)

MSTIAGESSS SSKMPENSQP TTTEKGSEYL EQLANEAEEL RKKLDQERHK LNDIPIQQAA 60
ERLDVMGALG VKQRRILKGH VGKVLCMDWS LDKRHIVSSS QDGKVIVWDG FTTNKEHALT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAAAATGTG CCTCTAAACC TCAAACAAAC CGCCCATCTC TAATTGTTCT ATTCAAATTC 60
ATTTTCTTCA ACCCTCAGTC TTCTCTTCCT TTTTTTGCAT AATTCGTCTT CTGATCTCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0807--Transducer
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR016346--Guanine_nucleotide-bd_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043025--C:neuronal cell body
GO:0004871--F:signal transducer activity
GO:0007212--P:dopamine receptor signaling pathway
GO:0007631--P:feeding behavior
GO:0007213--P:G-protein coupled acetylcholine receptor signaling pathway
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0040012--P:regulation of locomotion
GO:0046662--P:regulation of oviposition
GO:0043051--P:regulation of pharyngeal pumping
GO:0032094--P:response to food

KEGG

cel:CELE_F52A8.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001811	Ailuropoda melanoleuca	63.80	6.00e-134	469.00
IUUC-Apl-003399	Anas platyrhynchos	66.13	6.00e-129	452.00
IUUC-Aca-004861	Anolis carolinensis	65.99	2.00e-142	497.00
IUUC-Ame-011851	Astyanax mexicanus	63.27	4.00e-136	476.00
IUUC-Bta-012438	Bos taurus	64.64	8.00e-140	488.00
IUUC-Cja-019086	Callithrix jacchus	64.72	3.00e-138	483.00
IUUC-Cfa-021255	Canis familiaris	65.84	3.00e-132	463.00
IUUC-Cpo-021398	Cavia porcellus	65.03	1.00e-138	484.00
IUUC-Csa-023776	Chlorocebus sabaeus	64.93	4.00e-140	489.00
IUUC-Cin-025305	Ciona intestinalis	56.01	5.00e-123	432.00
IUUC-Csv-026058	Ciona savignyi	56.08	8.00e-117	412.00
IUUC-Dre-028572	Danio rerio	62.08	1.00e-136	478.00
IUUC-Dor-031013	Dipodomys ordii	65.62	2.00e-105	374.00
IUUC-Dme-031889	Drosophila melanogaster	62.10	5.00e-140	489.00
IUUC-Eca-033977	Equus caballus	64.88	2.00e-135	473.00
IUUC-Eeu-035079	Erinaceus europaeus	64.93	6.00e-140	489.00
IUUC-Fca-035693	Felis catus	59.89	5.00e-133	466.00
IUUC-Fal-037345	Ficedula albicollis	65.22	4.00e-140	489.00
IUUC-Gmo-039222	Gadus morhua	64.81	2.00e-131	460.00
IUUC-Gga-040320	Gallus gallus	65.22	2.00e-140	490.00
IUUC-Gac-042644	Gasterosteus aculeatus	62.05	4.00e-138	483.00
IUUC-Ggo-044489	Gorilla gorilla	66.25	2.00e-131	460.00
IUUC-Hsa-046434	Homo sapiens	64.93	7.00e-140	488.00
IUUC-Itr-048771	Ictidomys tridecemlineatus	62.66	2.00e-119	420.00
IUUC-Loc-052790	Lepisosteus oculatus	65.42	5.00e-132	463.00
IUUC-Laf-054255	Loxodonta africana	64.72	1.00e-137	481.00
IUUC-Mcc-055610	Macaca mulatta	64.72	3.00e-138	483.00
IUUC-Meu-056819	Macropus eugenii	64.74	2.00e-122	431.00
IUUC-Mga-059740	Meleagris gallopavo	66.46	4.00e-131	459.00
IUUC-Mmr-061221	Microcebus murinus	65.22	6.00e-140	489.00
IUUC-Mdo-062619	Monodelphis domestica	64.93	1.00e-140	490.00
IUUC-Mmu-064266	Mus musculus	64.64	1.00e-139	488.00
IUUC-Mpu-065766	Mustela putorius furo	68.11	4.00e-127	446.00
IUUC-Mlu-067221	Myotis lucifugus	62.36	2.00e-132	464.00
IUUC-Nle-069515	Nomascus leucogenys	66.35	3.00e-132	462.00
IUUC-Opr-070195	Ochotona princeps	57.97	3.00e-118	416.00
IUUC-Ont-071535	Oreochromis niloticus	62.07	9.00e-118	415.00
IUUC-Ocu-074666	Oryctolagus cuniculus	68.44	9.00e-128	448.00
IUUC-Ola-086578	Oryzias latipes	64.89	1.00e-129	454.00
IUUC-Oga-089090	Otolemur garnettii	64.55	6.00e-138	482.00
IUUC-Oar-090017	Ovis aries	65.93	1.00e-129	454.00
IUUC-Ptr-091280	Pan troglodytes	64.85	3.00e-131	459.00
IUUC-Pan-092198	Papio anubis	66.35	4.00e-132	462.00
IUUC-Psi-093030	Pelodiscus sinensis	62.57	3.00e-132	463.00
IUUC-Pfo-097182	Poecilia formosa	65.12	5.00e-132	462.00
IUUC-Pab-098157	Pongo abelii	64.93	8.00e-140	489.00
IUUC-Pva-102232	Pteropus vampyrus	56.73	6.00e-116	409.00
IUUC-Rno-105526	Rattus norvegicus	61.92	4.00e-130	456.00
IUUC-Sha-106754	Sarcophilus harrisii	65.94	4.00e-132	462.00
IUUC-Ssc-115390	Sus scrofa	64.45	2.00e-138	484.00
IUUC-Tgu-117377	Taeniopygia guttata	66.04	5.00e-130	456.00
IUUC-Tru-117938	Takifugu rubripes	65.31	2.00e-130	457.00
IUUC-Tsy-119392	Tarsius syrichta	56.76	2.00e-114	404.00
IUUC-Tni-119834	Tetraodon nigroviridis	61.68	5.00e-118	416.00
IUUC-Tbe-127469	Tupaia belangeri	64.06	2.00e-132	464.00
IUUC-Ttr-128252	Tursiops truncatus	64.53	6.00e-138	482.00
IUUC-Vpa-130173	Vicugna pacos	62.11	2.00e-94	337.00
IUUC-Xtr-131803	Xenopus tropicalis	65.62	2.00e-131	460.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence