iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.50e-49	162.5	331	368
UBD/Beta-Prp	1.40e-76	257.8	105	404

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           H+++v++laf +  ++l+s +dD+t++vW+l+ +++ k
   Q: 331  HENWVRGLAFhPKgKYLISVADDKTLRVWELSAQRCMK 368
           9**********777******************999976 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdk 108
           h  +it v f+p  +++a+ s+d+tikvwd++tg+l r+l+gh+++v+++ ++  gk lv++s+D  ik+wd+  t++c+ +lkghe++v s++f p+gd+
   Q: 105  HRLPITRVIFHPLWTIMASCSEDATIKVWDYETGQLERTLKGHTDAVNDIAIDAAGKQLVSCSSDLSIKLWDFGqTYDCLKSLKGHEHTVSSVTFLPTGDF 205
           7789*******************************************************************9955************************** PP
   S: 109  lvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng...............ke 194
           ++s+s+d ti+ wd++tg+c++ t++gh+++v++++++ dg l++s+slD+tv +W+ +t++    l+  h+++v+++++ ++                  
   Q: 206  VLSASRDHTIKQWDISTGYCVY-TFRGHNDWVRMIRISNDGTLFASASLDQTVTVWSFATKSAKLVLRD-HEHAVECVEWAPDTaytnvtgqqpegnstHI 304
           **********************.********************************************98.*********99999999999999*****999 PP
   S: 195  lvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           l sgs+d+++k w++ tg+++ tl +h+++v+ ++f+p++++l+s+++D+++r+W l  + ++k+++ h++ v+ va+ + + + +++gs d + ++w+++
   Q: 305  LFSGSRDRSIKAWNINTGDVLFTLLAHENWVRGLAFHPKGKYLISVADDKTLRVWELSAQRCMKAIEAHEHFVSTVAF-HQTSPFVITGSVDMSCKVWECR 404
           99**************************************************************************99.999****************985 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division. Required for neuronal cell differentiation.

Protein Sequence
(Fasta)

MSLSERQKEE INRAIAEYMQ NNGYSESFSV FLKESSLSEN DIKPLGGILE KKWTTVLRLQ 60
RKVNDLESKL QESQREINHG APTRDKRQAA DWIPRPPETQ KLTGHRLPIT RVIFHPLWTI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCTCTCCA AAACTTCTTC TCTTCCCCAC TTCCACAATT CCCTTATTTG GGTGTGTCGT 60
CCACGAACAA CATGAGTTTG TCGGAGAGGC AAAAAGAAGA AATGTGAGTG TTGAAGCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0995--Kinetochore
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0896--Oogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005818--C:aster
GO:1904115--C:axon cytoplasm
GO:0005938--C:cell cortex
GO:0005813--C:centrosome
GO:0000777--C:condensed chromosome kinetochore
GO:0005737--C:cytoplasm
GO:0005868--C:cytoplasmic dynein complex
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0045202--C:synapse
GO:0008017--F:microtubule binding
GO:0051301--P:cell division
GO:0051026--P:chiasma assembly
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0043652--P:engulfment of apoptotic cell
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007281--P:germ cell development
GO:0040011--P:locomotion
GO:0007018--P:microtubule-based movement
GO:0007100--P:mitotic centrosome separation
GO:0022008--P:neurogenesis
GO:0048477--P:oogenesis
GO:0035046--P:pronuclear migration
GO:2000574--P:regulation of microtubule motor activity
GO:0008090--P:retrograde axonal transport
GO:0051225--P:spindle assembly
GO:0051932--P:synaptic transmission, GABAergic
GO:0048489--P:synaptic vesicle transport
GO:0047496--P:vesicle transport along microtubule

KEGG

cel:CELE_T03F6.5

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	57.50	6.00e-145	505.00
IUUC-Apl-004024	Anas platyrhynchos	57.66	4.00e-149	519.00
IUUC-Aca-004564	Anolis carolinensis	57.66	3.00e-147	513.00
IUUC-Ago-007862	Ashbya gossypii	26.72	6.00e-37	147.00
IUUC-Acl-008360	Aspergillus clavatus	42.18	2.00e-91	328.00
IUUC-Afl-008502	Aspergillus flavus	42.86	6.00e-84	303.00
IUUC-Afu-008848	Aspergillus fumigatus	42.43	4.00e-94	337.00
IUUC-Ani-009173	Aspergillus nidulans	41.96	2.00e-84	305.00
IUUC-Ang-009873	Aspergillus niger	42.42	6.00e-84	303.00
IUUC-Aor-009973	Aspergillus oryzae	41.06	3.00e-82	297.00
IUUC-Ate-010523	Aspergillus terreus	40.45	6.00e-81	293.00
IUUC-Ame-010969	Astyanax mexicanus	57.42	2.00e-149	520.00
IUUC-Bgr-011972	Blumeria graminis	42.93	1.00e-92	332.00
IUUC-Bta-013106	Bos taurus	57.42	4.00e-149	519.00
IUUC-Bci-013615	Botrytis cinerea	41.65	4.00e-88	317.00
IUUC-Cja-018755	Callithrix jacchus	56.20	1.00e-145	508.00
IUUC-Cfa-020749	Canis familiaris	57.42	4.00e-149	519.00
IUUC-Cpo-022371	Cavia porcellus	57.42	4.00e-149	519.00
IUUC-Cre-022578	Chlamydomonas reinhardtii	33.22	3.00e-45	174.00
IUUC-Csa-023524	Chlorocebus sabaeus	57.68	7.00e-126	442.00
IUUC-Cho-024764	Choloepus hoffmanni	53.13	6.00e-119	419.00
IUUC-Cin-025753	Ciona intestinalis	53.27	1.00e-134	471.00
IUUC-Csv-025817	Ciona savignyi	53.06	4.00e-138	483.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	43.73	2.00e-85	308.00
IUUC-Cne-027087	Cryptococcus neoformans	45.34	3.00e-92	330.00
IUUC-Dre-028314	Danio rerio	57.42	3.00e-149	520.00
IUUC-Dno-029050	Dasypus novemcinctus	57.66	2.00e-149	520.00
IUUC-Dor-030222	Dipodomys ordii	53.77	4.00e-136	476.00
IUUC-Dse-031164	Dothistroma septosporum	42.30	3.00e-92	331.00
IUUC-Dme-031745	Drosophila melanogaster	56.72	4.00e-140	489.00
IUUC-Ete-032508	Echinops telfairi	57.55	2.00e-100	357.00
IUUC-Eca-034288	Equus caballus	57.50	2.00e-144	504.00
IUUC-Eeu-034984	Erinaceus europaeus	53.53	4.00e-135	473.00
IUUC-Fca-036498	Felis catus	57.42	4.00e-149	519.00
IUUC-Fal-036920	Ficedula albicollis	57.66	4.00e-149	519.00
IUUC-Fox-037996	Fusarium oxysporum	44.01	2.00e-94	337.00
IUUC-Fso-038160	Fusarium solani	40.09	2.00e-88	318.00
IUUC-Gmo-038983	Gadus morhua	56.93	2.00e-148	517.00
IUUC-Ggr-040051	Gaeumannomyces graminis	40.38	5.00e-83	300.00
IUUC-Gga-040623	Gallus gallus	57.66	4.00e-149	519.00
IUUC-Gac-041613	Gasterosteus aculeatus	56.45	7.00e-148	515.00
IUUC-Ggo-045410	Gorilla gorilla	51.76	2.00e-124	437.00
IUUC-Hsa-046358	Homo sapiens	57.42	5.00e-149	519.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	57.42	4.00e-149	519.00
IUUC-Kpa-049351	Komagataella pastoris	29.58	1.00e-41	162.00
IUUC-Lch-049936	Latimeria chalumnae	57.18	3.00e-148	516.00
IUUC-Loc-052476	Lepisosteus oculatus	57.25	2.00e-145	506.00
IUUC-Lma-053170	Leptosphaeria maculans	43.70	6.00e-91	326.00
IUUC-Laf-053713	Loxodonta africana	56.31	6.00e-146	508.00
IUUC-Mcc-054628	Macaca mulatta	57.42	8.00e-149	518.00
IUUC-Meu-055927	Macropus eugenii	50.36	2.00e-81	293.00
IUUC-Mor-056962	Magnaporthe oryzae	40.89	3.00e-83	300.00
IUUC-Mpo-057583	Magnaporthe poae	39.42	1.00e-79	288.00
IUUC-Mla-058819	Melampsora laricipopulina	42.70	3.00e-97	347.00
IUUC-Mga-059945	Meleagris gallopavo	57.66	3.00e-149	520.00
IUUC-Mvi-060403	Microbotryum violaceum	42.66	6.00e-107	379.00
IUUC-Mmr-061289	Microcebus murinus	57.50	6.00e-145	505.00
IUUC-Mdo-061912	Monodelphis domestica	57.66	5.00e-149	519.00
IUUC-Mmu-063253	Mus musculus	57.42	4.00e-149	519.00
IUUC-Mpu-066638	Mustela putorius furo	57.42	4.00e-149	519.00
IUUC-Mlu-067267	Myotis lucifugus	56.72	5.00e-146	509.00
IUUC-Nfi-068571	Neosartorya fischeri	40.24	2.00e-86	311.00
IUUC-Ncr-068895	Neurospora crassa	44.85	3.00e-92	330.00
IUUC-Nle-069087	Nomascus leucogenys	56.38	2.00e-116	410.00
IUUC-Opr-070579	Ochotona princeps	57.66	2.00e-149	520.00
IUUC-Ont-072432	Oreochromis niloticus	56.69	6.00e-149	519.00
IUUC-Oan-073072	Ornithorhynchus anatinus	57.42	4.00e-149	519.00
IUUC-Ocu-074180	Oryctolagus cuniculus	57.66	2.00e-149	520.00
IUUC-Ola-086772	Oryzias latipes	57.18	2.00e-148	517.00
IUUC-Oga-088219	Otolemur garnettii	56.97	1.00e-145	507.00
IUUC-Oar-090394	Ovis aries	57.42	4.00e-149	519.00
IUUC-Ptr-091517	Pan troglodytes	57.42	4.00e-149	519.00
IUUC-Pan-092421	Papio anubis	57.42	8.00e-149	518.00
IUUC-Psi-093370	Pelodiscus sinensis	57.91	2.00e-149	520.00
IUUC-Pma-094319	Petromyzon marinus	57.43	2.00e-122	430.00
IUUC-Pno-094815	Phaeosphaeria nodorum	43.67	6.00e-92	330.00
IUUC-Pfo-097089	Poecilia formosa	57.42	2.00e-149	520.00
IUUC-Pab-098421	Pongo abelii	57.42	4.00e-149	519.00
IUUC-Pca-100120	Procavia capensis	41.98	9.00e-91	325.00
IUUC-Pva-102960	Pteropus vampyrus	57.18	7.00e-148	515.00
IUUC-Pgr-103538	Puccinia graminis	42.73	8.00e-100	355.00
IUUC-Ptt-103990	Puccinia triticina	39.84	1.00e-37	150.00
IUUC-Pte-104261	Pyrenophora teres	43.58	4.00e-92	330.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	43.58	3.00e-92	330.00
IUUC-Rno-105123	Rattus norvegicus	57.42	4.00e-149	519.00
IUUC-Sce-106208	Saccharomyces cerevisiae	26.65	3.00e-29	121.00
IUUC-Sha-107010	Sarcophilus harrisii	57.66	4.00e-149	519.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	34.99	1.00e-64	238.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	42.37	3.00e-89	320.00
IUUC-Sar-113309	Sorex araneus	56.75	2.00e-142	497.00
IUUC-Sre-115003	Sporisorium reilianum	43.02	8.00e-106	375.00
IUUC-Ssc-116148	Sus scrofa	57.42	4.00e-149	519.00
IUUC-Tgu-117299	Taeniopygia guttata	57.66	5.00e-149	519.00
IUUC-Tru-117721	Takifugu rubripes	56.20	2.00e-147	513.00
IUUC-Tsy-119493	Tarsius syrichta	57.18	4.00e-147	513.00
IUUC-Tni-120355	Tetraodon nigroviridis	55.96	1.00e-146	511.00
IUUC-Tre-121977	Trichoderma reesei	37.00	1.00e-83	302.00
IUUC-Tvi-122661	Trichoderma virens	37.37	2.00e-83	301.00
IUUC-Tme-127031	Tuber melanosporum	44.72	8.00e-93	332.00
IUUC-Tbe-127492	Tupaia belangeri	49.23	2.00e-65	241.00
IUUC-Ttr-128929	Tursiops truncatus	57.42	7.00e-149	518.00
IUUC-Uma-129347	Ustilago maydis	41.88	9.00e-104	369.00
IUUC-Vda-129837	Verticillium dahliae	41.98	3.00e-87	314.00
IUUC-Vpa-130532	Vicugna pacos	49.61	4.00e-112	396.00
IUUC-Xtr-131985	Xenopus tropicalis	56.93	7.00e-149	518.00
IUUC-Xma-133314	Xiphophorus maculatus	57.42	2.00e-149	521.00
IUUC-Yli-134403	Yarrowia lipolytica	36.22	3.00e-72	264.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence