iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.00e-27	92.5	262	296

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrt 32
           gHt++v+c+ f   s+ +l++Gs D+t+ +WD+r 
   Q: 262  GHTAEVNCITFnpfSEYILATGSVDKTVALWDMRN 296
           8**********99776889*************975 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Required to repress the induction of vulval development by Ras signaling.

Protein Sequence
(Fasta)

MSEAESCEET SKEHRIWKKN VPYLYDTVVT KEVEWPSLSV QWMPDVTKTE NSDSSMHRMI 60
HGTHTCGGVQ NHLMISKFTI TTDTPEFDDA KWDSEREEFG GYGEGSAAKW DTEIKINHPG 120

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Nucleotide Sequence
(Fasta)

AGCACAATGA GTGAAGCTGA ATCGTGTGAA GAAACGAGTA AAGAACATAG AATTTGGAAG 60
AAAAATGTTC CATATCTCTA CGATACAGTC GTCACAAAAG AGGTCGAGTG GCCTTCTTTA 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR022052--Histone-bd_RBBP4_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12265--CAF1C_H4-bd
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0001708--P:cell fate specification
GO:0016569--P:covalent chromatin modification
GO:0045138--P:nematode male tail tip morphogenesis
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

cel:CELE_K07A1.11

Orthology

iUUCD ID

Species

Identity

E-value

Score

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence