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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063954
UUCD1 version UUC-MuM-01010
Ensembl Protein ID ENSMUSP00000103817.5
UniProt Accession Q9QZ73; Q3TMX2; Q8CDZ7; DCNL1_MOUSE
Genbank Protein ID AAF04863.1; BAB25813.1; BAC26390.1; BAE33033.1; BAE38318.1; AAH20161.1; AAH31666.1; AAH37431.1
Protein Name DCN1-like protein 1; DCUN1 domain-containing protein 1; Defective in cullin neddylation protein 1-like protein 1; Testis-specific protein 3
Genbank Nucleotide ID AF198092; AK008657; AK029314; AK155081; AK165651; BC020161; BC031666; BC037431
Gene Name Dcun1d1; Dcun1l1; Rp42; Tes3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000027708.14 ENSMUST00000108182.9 ENSMUSP00000103817.5
ENSMUSG00000027708.14 ENSMUST00000197489.4 ENSMUSP00000142690.1
ENSMUSG00000027708.14 ENSMUST00000197546.4 ENSMUSP00000142421.1
ENSMUSG00000027708.14 ENSMUST00000200661.4 ENSMUSP00000143716.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndex
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 21247897
Classification
Family E-value Score Start End
E3 activity/DCUN1 6.10e-91 304.7 61 247
UBD/Alpha-Helix/UBA 7.70e-07 30.2 7 45
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/DCUN1
   S: 2    skkkleelferYkdpqed.ligieglekfcedlgvdpediavLvlawkleaatlcefsreefldgltalgcdsieklqeklktleselk 89
           ++kkle+l++rYkdpq++ +igi+g+++fc+dl++dp++i+vL++awk++aat+cefs++ef+dg+t+lgcdsiekl+++++++e+elk
   Q: 61   DRKKLEQLYTRYKDPQDEnKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQEFMDGMTELGCDSIEKLKAQIPKMEQELK 149
           78**************999********************************************************************** PP
   S: 90   deqkfkdiYrfafnfakdkgqksldldtaialwkLllaerefklldawlkfLeeekkksiskDtWnllLefskviakdlsnYdeegaWP 178
           +  +fkd+Y+f+fnfak++gqk+ldl++aia+w+L+l++r fk+ld+w+kfL e++k+si+kDtWnllL+fs +ia+d+snYdeegaWP
   Q: 150  EPGRFKDFYQFTFNFAKNPGQKGLDLEMAIAYWNLVLNGR-FKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSSMIADDMSNYDEEGAWP 237
           ***************************************9.************************************************ PP
   S: 179  vliDefveyl 188
           vliD+fve++
   Q: 238  VLIDDFVEFA 247
           ********97 PP
   

   UBD/Alpha-Helix/UBA
   S: 2    ededkleqlve.MGFdreealqaLraannnleaAveyLl 39
           +++dk++q++  +  ++++a+ +L ++++ l++A+++++
   Q: 7    SQKDKVRQFMIfTQSSEKTAVSCLSQNDWKLDVATDNFF 45
           699********9999999*******************99 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic in vivo.
 Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic in vivo.
Protein Sequence
(Fasta)
MNKLKSSQKD KVRQFMIFTQ SSEKTAVSCL SQNDWKLDVA TDNFFQNPEL YIRESVKGSL 60
DRKKLEQLYT RYKDPQDENK IGIDGIQQFC DDLALDPASI SVLIIAWKFR AATQCEFSKQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063954|UBD,UBA;E3,DCUN1|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAGCTGTCA CTTGCTCCAA GCCCAATCCT CTACCATGAG TGTGAAACAG CTAAAGTCAG 60
CAGATCCGCA GGGACCCTGA GGTGACAGAC TGGCTCTGGT GAATATTCCT ATTTTCTATT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063954|UBD,UBA;E3,DCUN1|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom
IPR009060--UBA-like
PROSITE

PS51229--DCUN1
Pfam

PF03556--Cullin_binding
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation
KEGG mmu:114893
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001879 Ailuropoda melanoleuca 98.84 8.00e-152 529.00
IUUC-Apl-003451 Anas platyrhynchos 96.93 3.00e-149 520.00
IUUC-Aca-005269 Anolis carolinensis 95.75 8.00e-149 519.00
IUUC-Ago-007806 Ashbya gossypii 23.74 3.00e-20 92.00
IUUC-Ani-009241 Aspergillus nidulans 26.60 4.00e-25 108.00
IUUC-Ang-009664 Aspergillus niger 28.40 2.00e-23 102.00
IUUC-Ate-010414 Aspergillus terreus 30.04 9.00e-31 127.00
IUUC-Ame-011763 Astyanax mexicanus 88.03 3.00e-136 477.00
IUUC-Bgr-011991 Blumeria graminis 32.60 8.00e-26 110.00
IUUC-Bta-013561 Bos taurus 99.18 2.00e-144 504.00
IUUC-Bci-013824 Botrytis cinerea 32.68 7.00e-31 127.00
IUUC-Cel-018441 Caenorhabditis elegans 36.36 8.00e-51 193.00
IUUC-Cja-019502 Callithrix jacchus 98.84 1.00e-151 528.00
IUUC-Cfa-020523 Canis familiaris 99.18 3.00e-144 504.00
IUUC-Cpo-022196 Cavia porcellus 98.06 1.00e-150 525.00
IUUC-Csa-023551 Chlorocebus sabaeus 99.23 6.00e-153 533.00
IUUC-Cho-024373 Choloepus hoffmanni 97.29 6.00e-145 506.00
IUUC-Cin-025269 Ciona intestinalis 60.85 3.00e-99 354.00
IUUC-Csv-026372 Ciona savignyi 41.41 2.00e-50 191.00
IUUC-Dre-028247 Danio rerio 88.03 1.00e-136 478.00
IUUC-Dno-028974 Dasypus novemcinctus 99.23 6.00e-153 533.00
IUUC-Dor-030696 Dipodomys ordii 88.37 2.00e-131 461.00
IUUC-Dme-032197 Drosophila melanogaster 63.05 3.00e-92 331.00
IUUC-Ete-032371 Echinops telfairi 98.84 8.00e-152 528.00
IUUC-Eca-033242 Equus caballus 99.22 3.00e-152 530.00
IUUC-Eeu-035317 Erinaceus europaeus 98.84 6.00e-152 529.00
IUUC-Fca-036061 Felis catus 98.84 2.00e-152 531.00
IUUC-Fal-037372 Ficedula albicollis 96.93 3.00e-149 520.00
IUUC-Gmo-038885 Gadus morhua 87.64 3.00e-136 477.00
IUUC-Gga-040935 Gallus gallus 98.07 9.00e-152 528.00
IUUC-Gac-041937 Gasterosteus aculeatus 87.26 9.00e-135 472.00
IUUC-Ggo-044468 Gorilla gorilla 98.08 8.00e-150 522.00
IUUC-Hsa-046089 Homo sapiens 99.23 6.00e-153 533.00
IUUC-Lch-050600 Latimeria chalumnae 94.21 3.00e-147 514.00
IUUC-Loc-052509 Lepisosteus oculatus 93.82 1.00e-144 505.00
IUUC-Lma-053103 Leptosphaeria maculans 31.18 4.00e-32 131.00
IUUC-Laf-053527 Loxodonta africana 99.22 3.00e-152 530.00
IUUC-Mcc-055699 Macaca mulatta 89.24 2.00e-146 511.00
IUUC-Meu-056626 Macropus eugenii 77.52 3.00e-111 394.00
IUUC-Mor-056909 Magnaporthe oryzae 27.46 6.00e-25 107.00
IUUC-Mla-058990 Melampsora laricipopulina 27.92 2.00e-18 86.70
IUUC-Mga-059379 Meleagris gallopavo 97.85 2.00e-135 474.00
IUUC-Mvi-060312 Microbotryum violaceum 34.09 3.00e-42 164.00
IUUC-Mmr-060851 Microcebus murinus 99.22 6.00e-152 529.00
IUUC-Mdo-063074 Monodelphis domestica 98.84 2.00e-154 540.00
IUUC-Mpu-066870 Mustela putorius furo 99.18 3.00e-144 504.00
IUUC-Mlu-067701 Myotis lucifugus 98.84 2.00e-151 527.00
IUUC-Ncr-068780 Neurospora crassa 25.09 6.00e-23 101.00
IUUC-Nle-069291 Nomascus leucogenys 99.23 6.00e-153 533.00
IUUC-Opr-070265 Ochotona princeps 72.09 1.00e-94 339.00
IUUC-Ont-071408 Oreochromis niloticus 87.98 1.00e-134 472.00
IUUC-Oan-073031 Ornithorhynchus anatinus 98.84 9.00e-152 529.00
IUUC-Ocu-074648 Oryctolagus cuniculus 99.22 3.00e-152 530.00
IUUC-Olu-087646 Ostreococcus lucimarinus 36.44 3.00e-44 172.00
IUUC-Oga-089015 Otolemur garnettii 99.22 1.00e-152 531.00
IUUC-Oar-090405 Ovis aries 99.22 1.00e-152 531.00
IUUC-Ptr-090735 Pan troglodytes 99.22 3.00e-152 530.00
IUUC-Pan-092186 Papio anubis 98.46 2.00e-149 521.00
IUUC-Psi-093110 Pelodiscus sinensis 98.36 2.00e-142 498.00
IUUC-Ppa-095306 Physcomitrella patens 43.37 6.00e-59 220.00
IUUC-Pca-100218 Procavia capensis 95.74 3.00e-149 520.00
IUUC-Pva-102983 Pteropus vampyrus 93.41 5.00e-138 483.00
IUUC-Pgr-103633 Puccinia graminis 27.18 9.00e-24 103.00
IUUC-Pyt-104428 Pyrenophora triticirepentis 30.56 6.00e-29 120.00
IUUC-Rno-105554 Rattus norvegicus 98.46 2.00e-152 531.00
IUUC-Sce-106358 Saccharomyces cerevisiae 25.37 5.00e-20 91.30
IUUC-Sha-106888 Sarcophilus harrisii 98.84 5.00e-152 530.00
IUUC-Sja-107938 Schizosaccharomyces japonicus 30.65 6.00e-23 100.00
IUUC-Smo-108750 Selaginella moellendorffii 42.51 7.00e-51 193.00
IUUC-Stu-112517 Solanum tuberosum 43.55 2.00e-59 222.00
IUUC-Sar-113509 Sorex araneus 75.19 6.00e-106 376.00
IUUC-Sre-115221 Sporisorium reilianum 27.74 2.00e-25 109.00
IUUC-Ssc-115547 Sus scrofa 99.23 6.00e-153 533.00
IUUC-Tgu-117147 Taeniopygia guttata 98.06 6.00e-151 526.00
IUUC-Tru-117740 Takifugu rubripes 85.27 2.00e-132 464.00
IUUC-Tsy-119599 Tarsius syrichta 98.84 9.00e-152 528.00
IUUC-Tme-126878 Tuber melanosporum 33.60 8.00e-39 154.00
IUUC-Ttr-129086 Tursiops truncatus 88.37 2.00e-131 461.00
IUUC-Uma-129364 Ustilago maydis 29.70 6.00e-34 137.00
IUUC-Vpa-130048 Vicugna pacos 86.43 2.00e-127 447.00
IUUC-Xtr-131888 Xenopus tropicalis 97.67 2.00e-150 524.00
Created Date 25-Jun-2017

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