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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063608
UUCD1 version UUC-MuM-00867
Ensembl Protein ID ENSMUSP00000136858.2
UniProt Accession Q99KP6; Q3TP64; Q4ADG5; Q8BKZ5; Q8BVQ4; PRP19_MOUSE
Genbank Protein ID BAE16340.1; AAK49039.1; AAM21468.1; BAC33127.1; BAC36557.1; BAC40560.1; BAE37873.1; AAH04070.1
Protein Name Pre-mRNA-processing factor 19; Nuclear matrix protein 200; PRP19/PSO4 homolog; RING-type E3 ubiquitin transferase PRP19; Senescence evasion factor
Genbank Nucleotide ID AB222602; AF251503; AF386760; AK047693; AK076998; AK088769; AK164681; BC004070
Gene Name Prpf19; Prp19; Snev
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000024735.13 ENSMUST00000025642.13 ENSMUSP00000025642.8
ENSMUSG00000024735.13 ENSMUST00000179297.2 ENSMUSP00000136858.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 3.50e-15 56.9 3 64
E3 adaptor/Cullin RING/DCX/DWD 7.10e-32 109.2 409 442
UBD/Beta-Prp 1.80e-53 182.8 250 480
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 6    flCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqa 67
           ++C+Is+e++++P+v+p s+++y+r+ Iek++a++g+ +P+++qpl+ee+l++ ++ + +  +
   Q: 3    LICSISNEVPEHPCVSPvSNHVYERRLIEKYIAENGT-DPINNQPLSEEQLIDIKVAHPIRPK 64
           79**********************************9.***************9998877665 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           gH++++t++af  ++ +l++++dD ++k+WDlr+
   Q: 409  GHSGPITSIAFseNGYYLATAADDSSVKLWDLRK 442
           8**********976699**************986 PP
   

   UBD/Beta-Prp
   S: 19   spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgd 107
             d++ ++tg++d+ + v+d +t++ l++l+gh+++vt+v f+p++++  ++s D+ti++w++ + +cv+++++he+ v+ ls++++gd
   Q: 250  PSDTNKILTGGADKNVVVFDKSTEQILATLKGHTKKVTSVVFHPSQELVFSASPDATIRIWSVPNTSCVQVVRAHESAVTGLSLHATGD 338
           568899*********************************************************************************** PP
   S: 108  klvsGshdrtirvwdletgqclee.tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkel 195
           +l+s s+d++    d++tg +l + t++    + +c+++hpdg ++ +G+ D+++++Wdlk  + +  + g h ++++s++f++ng +l
   Q: 339  YLLSSSDDQYWAFSDIQTGRVLTKvTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG-HSGPITSIAFSENGYYL 426
           **********************997777777789************************************9.***************** PP
   S: 196  vsgsldgtvklwdlqtgecvrtlnghtd.nvksvrfspnderlvsgssDgsiri 248
           +++++d++vklwdl++ +  +tl+  ++  vks+ f++ +++l+ g+ D +i+i
   Q: 427  ATAADDSSVKLWDLRKLKNFKTLQLDNNfEVKSLIFDQSGTYLALGGTDVQIYI 480
           ***************999999999866527*******************99987 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Isoform 2: Forced expression leads to suppression of neuronal differentiation, and on the contrary to stimulation of astroglial cell differentiation in retinoic acid-primed P19 cells (PubMed:16352598).
 Isoform 2: Forced expression leads to suppression of neuronal differentiation, and on the contrary to stimulation of astroglial cell differentiation in retinoic acid-primed P19 cells (PubMed:16352598).
Protein Sequence
(Fasta)
MSLICSISNE VPEHPCVSPV SNHVYERRLI EKYIAENGTD PINNQPLSEE QLIDIKVAHP 60
IRPKPPSATS IPAILKALQD EWGWPNSPAL PQSSQWPTLS QDAVMLHSFT LRQQLQTTRQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063608|E3,U-box;E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGCTGGGAA AGGGCAGTTT CCGTTAGCTG CAGAAGGCTG AGGCGCGCCA CCGGCCACCT 60
CCCCACGTGA AGCAGTTGTG CGAGCATCGC CACGCTGGGC AGCTGTCTAC CCGCGTCCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063608|E3,U-box;E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0234--DNA repair
KW-0551--Lipid droplet
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013915--Pre-mRNA_splic_Prp19
IPR000772--Ricin_B_lectin
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08606--Prp19
PF04564--U-box
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00504--Ubox
SM00320--WD40
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0005662--C:DNA replication factor A complex
GO:0005811--C:lipid particle
GO:0016020--C:membrane
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0000974--C:Prp19 complex
GO:0035861--C:site of double-strand break
GO:0005819--C:spindle
GO:0005681--C:spliceosomal complex
GO:0042802--F:identical protein binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0034613--P:cellular protein localization
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0000349--P:generation of catalytic spliceosome for first transesterification step
GO:0001833--P:inner cell mass cell proliferation
GO:0008610--P:lipid biosynthetic process
GO:0000398--P:mRNA splicing, via spliceosome
GO:0045665--P:negative regulation of neuron differentiation
GO:0048711--P:positive regulation of astrocyte differentiation
GO:0048026--P:positive regulation of mRNA splicing, via spliceosome
GO:0045666--P:positive regulation of neuron differentiation
GO:0010498--P:proteasomal protein catabolic process
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0072422--P:signal transduction involved in DNA damage checkpoint
GO:0000245--P:spliceosomal complex assembly
GO:0000244--P:spliceosomal tri-snRNP complex assembly
KEGG mmu:28000
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000488 Aegilops tauschii 37.90 1.00e-93 338.00
IUUC-Aml-001230 Ailuropoda melanoleuca 92.47 0.00e+00 944.00
IUUC-Atr-002594 Amborella trichopoda 42.52 1.00e-115 410.00
IUUC-Apl-003686 Anas platyrhynchos 88.55 0.00e+00 738.00
IUUC-Aca-005272 Anolis carolinensis 93.88 0.00e+00 989.00
IUUC-Aly-005586 Arabidopsis lyrata 42.16 2.00e-115 409.00
IUUC-Ath-007696 Arabidopsis thaliana 42.24 2.00e-111 396.00
IUUC-Acl-008335 Aspergillus clavatus 34.24 1.00e-64 241.00
IUUC-Afl-008527 Aspergillus flavus 36.71 1.00e-69 257.00
IUUC-Afu-008957 Aspergillus fumigatus 36.84 1.00e-75 277.00
IUUC-Ani-009280 Aspergillus nidulans 36.28 2.00e-63 236.00
IUUC-Ang-009746 Aspergillus niger 35.09 6.00e-64 238.00
IUUC-Aor-009905 Aspergillus oryzae 36.51 2.00e-73 269.00
IUUC-Ate-010412 Aspergillus terreus 36.31 3.00e-62 232.00
IUUC-Ame-011561 Astyanax mexicanus 78.76 6.00e-108 383.00
IUUC-Bgr-012283 Blumeria graminis 31.60 4.00e-53 202.00
IUUC-Bta-013242 Bos taurus 95.98 0.00e+00 1001.00
IUUC-Bci-013901 Botrytis cinerea 32.57 2.00e-61 229.00
IUUC-Bdi-014277 Brachypodium distachyon 42.22 3.00e-120 425.00
IUUC-Bol-016207 Brassica oleracea 43.55 1.00e-114 406.00
IUUC-Bra-017902 Brassica rapa 41.60 9.00e-113 400.00
IUUC-Cel-018271 Caenorhabditis elegans 49.52 3.00e-148 518.00
IUUC-Cja-019879 Callithrix jacchus 95.42 0.00e+00 993.00
IUUC-Cfa-020175 Canis familiaris 95.60 0.00e+00 998.00
IUUC-Cpo-022379 Cavia porcellus 95.98 0.00e+00 1002.00
IUUC-Cre-022993 Chlamydomonas reinhardtii 38.52 5.00e-95 341.00
IUUC-Csa-023500 Chlorocebus sabaeus 95.79 0.00e+00 999.00
IUUC-Cho-025065 Choloepus hoffmanni 82.42 7.00e-145 506.00
IUUC-Cin-025699 Ciona intestinalis 65.27 7.00e-172 596.00
IUUC-Csv-026128 Ciona savignyi 62.71 0.00e+00 667.00
IUUC-Cgl-026507 Colletotrichum gloeosporioides 32.99 9.00e-62 231.00
IUUC-Cne-026860 Cryptococcus neoformans 36.91 5.00e-90 325.00
IUUC-Dre-028187 Danio rerio 81.87 0.00e+00 850.00
IUUC-Dno-029453 Dasypus novemcinctus 95.60 0.00e+00 998.00
IUUC-Dor-030150 Dipodomys ordii 99.58 4.00e-129 454.00
IUUC-Dse-031220 Dothistroma septosporum 30.58 6.00e-55 208.00
IUUC-Dme-031906 Drosophila melanogaster 63.36 0.00e+00 652.00
IUUC-Ete-033035 Echinops telfairi 83.75 0.00e+00 847.00
IUUC-Eca-033478 Equus caballus 95.79 0.00e+00 999.00
IUUC-Eeu-034974 Erinaceus europaeus 99.39 0.00e+00 679.00
IUUC-Fca-036194 Felis catus 94.82 0.00e+00 988.00
IUUC-Fal-037417 Ficedula albicollis 93.50 0.00e+00 985.00
IUUC-Fox-037922 Fusarium oxysporum 33.59 6.00e-61 228.00
IUUC-Fso-038256 Fusarium solani 33.01 6.00e-62 231.00
IUUC-Gmo-038713 Gadus morhua 83.02 0.00e+00 864.00
IUUC-Ggr-039854 Gaeumannomyces graminis 31.11 2.00e-50 193.00
IUUC-Gga-041143 Gallus gallus 93.50 0.00e+00 984.00
IUUC-Gac-042129 Gasterosteus aculeatus 81.87 0.00e+00 880.00
IUUC-Gma-044273 Glycine max 44.16 3.00e-118 418.00
IUUC-Ggo-045262 Gorilla gorilla 95.79 0.00e+00 999.00
IUUC-Hsa-046036 Homo sapiens 95.79 0.00e+00 999.00
IUUC-Hvu-047442 Hordeum vulgare 40.41 3.00e-65 241.00
IUUC-Itr-048169 Ictidomys tridecemlineatus 95.60 0.00e+00 959.00
IUUC-Lch-050105 Latimeria chalumnae 86.62 0.00e+00 927.00
IUUC-Lpe-050976 Leersia perrieri 42.67 7.00e-116 410.00
IUUC-Loc-052042 Lepisosteus oculatus 71.31 0.00e+00 654.00
IUUC-Lma-053143 Leptosphaeria maculans 33.27 2.00e-60 227.00
IUUC-Laf-053451 Loxodonta africana 96.18 0.00e+00 1004.00
IUUC-Mcc-055786 Macaca mulatta 95.79 0.00e+00 999.00
IUUC-Meu-056161 Macropus eugenii 97.93 1.00e-139 489.00
IUUC-Mor-057215 Magnaporthe oryzae 32.26 1.00e-53 204.00
IUUC-Mpo-057419 Magnaporthe poae 30.19 4.00e-47 182.00
IUUC-Mtr-057756 Medicago truncatula 42.32 1.00e-112 400.00
IUUC-Mla-059085 Melampsora laricipopulina 37.04 3.00e-83 302.00
IUUC-Mga-060158 Meleagris gallopavo 87.72 0.00e+00 877.00
IUUC-Mvi-060441 Microbotryum violaceum 36.97 1.00e-75 277.00
IUUC-Mmr-061085 Microcebus murinus 95.79 0.00e+00 999.00
IUUC-Mdo-061804 Monodelphis domestica 95.41 0.00e+00 997.00
IUUC-Mac-064972 Musa acuminata 42.67 1.00e-113 403.00
IUUC-Mpu-065700 Mustela putorius furo 95.60 0.00e+00 999.00
IUUC-Mlu-068223 Myotis lucifugus 95.22 0.00e+00 999.00
IUUC-Nfi-068504 Neosartorya fischeri 36.64 4.00e-75 275.00
IUUC-Ncr-068729 Neurospora crassa 35.48 6.00e-60 224.00
IUUC-Nle-069754 Nomascus leucogenys 95.79 0.00e+00 999.00
IUUC-Opr-070621 Ochotona princeps 91.67 0.00e+00 935.00
IUUC-Ont-071377 Oreochromis niloticus 81.87 0.00e+00 858.00
IUUC-Oan-073498 Ornithorhynchus anatinus 59.83 2.00e-96 345.00
IUUC-Ocu-074182 Oryctolagus cuniculus 96.38 0.00e+00 1014.00
IUUC-Oba-075509 Oryza barthii 42.22 2.00e-118 419.00
IUUC-Obr-076480 Oryza brachyantha 43.15 2.00e-119 422.00
IUUC-Ogl-077052 Oryza glaberrima 42.22 2.00e-118 419.00
IUUC-Ogu-078919 Oryza glumaepatula 42.22 2.00e-118 419.00
IUUC-Oin-079357 Oryza indica 41.53 2.00e-111 396.00
IUUC-Olo-080376 Oryza longistaminata 41.90 2.00e-106 379.00
IUUC-Ome-081973 Oryza meridionalis 41.42 3.00e-106 379.00
IUUC-Oni-082849 Oryza nivara 42.41 4.00e-119 421.00
IUUC-Opu-083243 Oryza punctata 42.04 1.00e-117 416.00
IUUC-Oru-084613 Oryza rufipogon 42.49 2.00e-118 419.00
IUUC-Osa-085407 Oryza sativa 42.19 7.00e-118 417.00
IUUC-Ola-086566 Oryzias latipes 81.10 0.00e+00 849.00
IUUC-Olu-087757 Ostreococcus lucimarinus 37.31 7.00e-90 324.00
IUUC-Oga-089010 Otolemur garnettii 91.25 0.00e+00 946.00
IUUC-Oar-089638 Ovis aries 95.98 0.00e+00 1001.00
IUUC-Ptr-091141 Pan troglodytes 95.79 0.00e+00 999.00
IUUC-Pan-092662 Papio anubis 95.79 0.00e+00 999.00
IUUC-Psi-093777 Pelodiscus sinensis 97.14 0.00e+00 821.00
IUUC-Pno-095115 Phaeosphaeria nodorum 33.74 1.00e-61 230.00
IUUC-Ppa-095841 Physcomitrella patens 43.20 4.00e-117 415.00
IUUC-Pfo-096390 Poecilia formosa 81.11 0.00e+00 858.00
IUUC-Pab-098250 Pongo abelii 94.05 0.00e+00 932.00
IUUC-Pop-099854 Populus trichocarpa 43.49 9.00e-117 414.00
IUUC-Pca-100553 Procavia capensis 95.22 0.00e+00 991.00
IUUC-Ppe-101383 Prunus persica 42.27 5.00e-110 391.00
IUUC-Pva-102189 Pteropus vampyrus 95.79 0.00e+00 1001.00
IUUC-Pgr-103304 Puccinia graminis 36.26 5.00e-81 295.00
IUUC-Ptt-103984 Puccinia triticina 36.75 1.00e-85 310.00
IUUC-Pte-104385 Pyrenophora teres 31.85 2.00e-65 243.00
IUUC-Pyt-104697 Pyrenophora triticirepentis 32.25 1.00e-66 247.00
IUUC-Rno-105581 Rattus norvegicus 96.37 0.00e+00 1005.00
IUUC-Sha-107071 Sarcophilus harrisii 96.20 0.00e+00 1010.00
IUUC-Sja-107697 Schizosaccharomyces japonicus 30.24 2.00e-32 133.00
IUUC-Spo-108315 Schizosaccharomyces pombe 30.80 5.00e-42 165.00
IUUC-Ssl-108628 Sclerotinia sclerotiorum 33.76 5.00e-61 228.00
IUUC-Smo-109648 Selaginella moellendorffii 42.99 2.00e-117 416.00
IUUC-Sit-109873 Setaria italica 42.04 5.00e-116 411.00
IUUC-Sly-111673 Solanum lycopersicum 43.74 1.00e-109 390.00
IUUC-Stu-112125 Solanum tuberosum 43.55 9.00e-109 387.00
IUUC-Sbi-114696 Sorghum bicolor 40.36 1.00e-104 373.00
IUUC-Sre-115134 Sporisorium reilianum 30.09 2.00e-67 249.00
IUUC-Ssc-116260 Sus scrofa 95.79 0.00e+00 999.00
IUUC-Tgu-116533 Taeniopygia guttata 93.50 0.00e+00 984.00
IUUC-Tru-117800 Takifugu rubripes 81.30 0.00e+00 882.00
IUUC-Tsy-118980 Tarsius syrichta 89.98 0.00e+00 906.00
IUUC-Tni-120334 Tetraodon nigroviridis 65.46 0.00e+00 690.00
IUUC-Tca-121807 Theobroma cacao 42.19 2.00e-116 412.00
IUUC-Tre-121920 Trichoderma reesei 32.11 2.00e-59 223.00
IUUC-Tvi-122294 Trichoderma virens 31.78 7.00e-52 198.00
IUUC-Tae-125713 Triticum aestivum 42.59 3.00e-121 428.00
IUUC-Tur-126664 Triticum urartu 38.44 6.00e-111 394.00
IUUC-Tme-127026 Tuber melanosporum 32.81 8.00e-65 241.00
IUUC-Tbe-127582 Tupaia belangeri 99.09 0.00e+00 675.00
IUUC-Ttr-128313 Tursiops truncatus 95.60 0.00e+00 991.00
IUUC-Uma-129626 Ustilago maydis 31.83 4.00e-70 259.00
IUUC-Vda-129699 Verticillium dahliae 33.80 1.00e-63 237.00
IUUC-Vpa-130593 Vicugna pacos 94.93 0.00e+00 889.00
IUUC-Vvi-131668 Vitis vinifera 42.27 1.00e-115 409.00
IUUC-Xtr-132186 Xenopus tropicalis 81.66 0.00e+00 756.00
IUUC-Xma-133212 Xiphophorus maculatus 80.92 0.00e+00 852.00
IUUC-Yli-134607 Yarrowia lipolytica 50.33 7.00e-38 149.00
IUUC-Zma-135662 Zea mays 43.23 2.00e-118 419.00
Created Date 25-Jun-2017

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