iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-042600

UUCD1 version

UUC-GaA-00182

Ensembl Protein ID

ENSGACP00000004850.1

UniProt Accession

G3NHP1; G3NHP1_GASAC

Protein Name

Uncharacterized protein

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000003677.1	ENSGACT00000004858.1	ENSGACP00000004844.1
ENSGACG00000003677.1	ENSGACT00000004864.1	ENSGACP00000004850.1
ENSGACG00000003677.1	ENSGACT00000004871.1	ENSGACP00000004857.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.00e-99	332.0	732	1055

Active Site

Position(s)	Description	Evidence
1024	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgEe++d+gGv +ef+ l++kel +p++g+f+y e+++  ++ n++      e ++lF+++G+++g+a+++  +++l
   Q: 732  DYKKPLKVIFVGEEAVDAGGVRKEFFLLIMKELLDPKYGMFRYYEESRLIWFSNKTF-----EDIDLFNLIGVICGLAIYNLTIVEL 813
           78999***********************************************99977.....69*********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll++k +l+dl+e++p++ +sl++++++ e+d+ee+ ++l+f+++ee++g t++ eL+ +Ge+i+V+++N++++v ++
   Q: 814  NFPVALYKKLLKRKPTLDDLKELMPDVGRSLQQLLDYTEDDLEET-FCLNFTITEENYGATEVLELVRNGEDISVNKSNRQDFVAAY 899
           *************************************99999987.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y +++++++ +e f++Gf++v+  ++l+lF+++el+ ++ G++++d+ +l+k t+ykg+y +d+p+i+ Fwev++++  e++k+f
   Q: 900  VDYVFNTSVASLFECFYAGFHKVCGGKVLELFQPNELQAMVIGNTNYDWTELEKSTEYKGEYWKDHPTIRLFWEVFHSLPLEKKKQF 986
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+  ++ ++ lP ++TCfn+L+LP+Y+s e+l ekLl Ai++++gF+l
   Q: 987  LLFLTGSDRIPILGMKNLK---LVIQPtSGGEHYLPVAHTCFNLLDLPKYKSLETLCEKLLQAIDHNQGFNL 1055
           *******************...5666659999**************************************87 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

MLCWGNASYG QLGLGGIDEE IVVEPRKCEF FHGKQVCDLG CGHRHTAYLL EDGTVYTCGC 60
NDLGQLGHEK SRKKPEQVVA LDAQIIVAVS CGESHTLALN DKGQVFSWGL GSDGQLGLQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATTGGAGGA GACGAATTGG GTCGGAATTT ACCCAACTCG CTGGCCTTTG ATATTTTACG 60
TCGGACGTGT GCTTGTCTGC GTTTTTAACA AGCAGCACCA GCAGCTAGCT TGCAAAACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	74.06	0.00e+00	1531.00
IUUC-Apl-003295	Anas platyrhynchos	73.07	0.00e+00	1559.00
IUUC-Aca-004336	Anolis carolinensis	73.03	0.00e+00	1565.00
IUUC-Ame-010768	Astyanax mexicanus	77.52	0.00e+00	1659.00
IUUC-Bta-013279	Bos taurus	73.96	0.00e+00	1529.00
IUUC-Cel-018150	Caenorhabditis elegans	33.98	3.00e-153	536.00
IUUC-Cja-019023	Callithrix jacchus	74.34	0.00e+00	1534.00
IUUC-Cfa-021074	Canis familiaris	74.06	0.00e+00	1530.00
IUUC-Cpo-021461	Cavia porcellus	72.13	0.00e+00	1484.00
IUUC-Csa-024261	Chlorocebus sabaeus	74.15	0.00e+00	1528.00
IUUC-Cin-025232	Ciona intestinalis	42.72	0.00e+00	825.00
IUUC-Dre-028829	Danio rerio	78.38	0.00e+00	1636.00
IUUC-Dno-029445	Dasypus novemcinctus	70.90	0.00e+00	1211.00
IUUC-Dor-030158	Dipodomys ordii	78.38	0.00e+00	726.00
IUUC-Dme-032103	Drosophila melanogaster	43.14	0.00e+00	850.00
IUUC-Ete-033072	Echinops telfairi	65.66	0.00e+00	1332.00
IUUC-Eca-033317	Equus caballus	73.68	0.00e+00	1524.00
IUUC-Fca-035682	Felis catus	73.77	0.00e+00	1524.00
IUUC-Fal-036969	Ficedula albicollis	72.29	0.00e+00	1548.00
IUUC-Gmo-038671	Gadus morhua	81.55	0.00e+00	1745.00
IUUC-Gga-041174	Gallus gallus	72.86	0.00e+00	1560.00
IUUC-Gma-043616	Glycine max	37.94	1.00e-51	197.00
IUUC-Ggo-044589	Gorilla gorilla	73.96	0.00e+00	1550.00
IUUC-Hsa-046772	Homo sapiens	73.87	0.00e+00	1543.00
IUUC-Lch-050147	Latimeria chalumnae	70.98	0.00e+00	1259.00
IUUC-Loc-052684	Lepisosteus oculatus	77.40	0.00e+00	1622.00
IUUC-Laf-053844	Loxodonta africana	73.40	0.00e+00	1520.00
IUUC-Mcc-055531	Macaca mulatta	72.42	0.00e+00	1513.00
IUUC-Mga-060151	Meleagris gallopavo	70.76	0.00e+00	1266.00
IUUC-Mmr-060954	Microcebus murinus	74.15	0.00e+00	1534.00
IUUC-Mdo-062246	Monodelphis domestica	72.41	0.00e+00	1395.00
IUUC-Mmu-063369	Mus musculus	73.68	0.00e+00	1562.00
IUUC-Mpu-065936	Mustela putorius furo	73.60	0.00e+00	1403.00
IUUC-Mlu-067326	Myotis lucifugus	73.96	0.00e+00	1498.00
IUUC-Nle-069453	Nomascus leucogenys	73.77	0.00e+00	1521.00
IUUC-Ont-071720	Oreochromis niloticus	89.61	0.00e+00	1879.00
IUUC-Oan-073464	Ornithorhynchus anatinus	73.30	0.00e+00	1416.00
IUUC-Ocu-074207	Oryctolagus cuniculus	71.53	0.00e+00	1385.00
IUUC-Ola-086762	Oryzias latipes	85.17	0.00e+00	1754.00
IUUC-Oga-088435	Otolemur garnettii	74.43	0.00e+00	1536.00
IUUC-Oar-089233	Ovis aries	73.87	0.00e+00	1528.00
IUUC-Ptr-091368	Pan troglodytes	73.96	0.00e+00	1546.00
IUUC-Pan-092300	Papio anubis	74.15	0.00e+00	1528.00
IUUC-Psi-093406	Pelodiscus sinensis	73.42	0.00e+00	1567.00
IUUC-Pma-094113	Petromyzon marinus	65.83	0.00e+00	1065.00
IUUC-Ppa-095354	Physcomitrella patens	32.93	1.00e-150	527.00
IUUC-Pfo-097021	Poecilia formosa	83.76	0.00e+00	1841.00
IUUC-Pab-098327	Pongo abelii	73.96	0.00e+00	1545.00
IUUC-Pva-102909	Pteropus vampyrus	65.85	0.00e+00	1278.00
IUUC-Rno-105457	Rattus norvegicus	74.25	0.00e+00	1571.00
IUUC-Sha-106632	Sarcophilus harrisii	72.83	0.00e+00	1534.00
IUUC-Sar-113679	Sorex araneus	62.94	0.00e+00	806.00
IUUC-Tgu-116849	Taeniopygia guttata	69.18	0.00e+00	1459.00
IUUC-Tru-118206	Takifugu rubripes	84.27	0.00e+00	1701.00
IUUC-Tsy-119521	Tarsius syrichta	62.45	0.00e+00	1203.00
IUUC-Tni-120233	Tetraodon nigroviridis	82.75	0.00e+00	1681.00
IUUC-Vpa-130448	Vicugna pacos	73.77	0.00e+00	1525.00
IUUC-Xtr-132719	Xenopus tropicalis	63.64	0.00e+00	1245.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence