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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Sce-106218
UUCD1 version UUC-SaC-00035
Ensembl Protein ID YGR225W
UniProt Accession P50082; D6VV07; Q96VQ3; AMA1_YEAST
Genbank Protein ID AAK61800.1; CAA61174.1; CAA97253.1; DAA08318.1
Protein Name Meiosis-specific APC/C activator protein AMA1; Activator of meiotic APC/C protein 1; Sporulation-specific protein 70
Genbank Nucleotide ID AY033394; X87941; Z73010; BK006941
Gene Name AMA1; SPO70; YGR225W; G8541
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YGR225W YGR225W YGR225W
Annotation
mRNA Expression
GEO
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17459880; 11114178; 15797380
E3 adaptor/Cullin RING/APC_C/CDC20 CDC20 11114178; 15797380
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.40e-15 53.2 391 423
E3 adaptor/Cullin RING/APC_C/CDC20 1.80e-123 410.1 216 561
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 4    dsvtclafsd..tllvsGsdDgtikvWDlrtgv 34
    v+++++++ +ll++G++D+++ +WD+++ +
   Q: 391 QQVCGISLNEhaNLLAVGGNDNSCSLWDISDLD 423
    5699999944479***************87765 PP
   


   E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWs.sknvlavaLgssvylwsaktgdvskladl...eekdlvtsvswieegtllavGtkkgeveiyD.........veekkkv 89
    p++vldap+lr+dfy+nL++Ws ++n+++v+Lg+svy+ws+k+g+vs+l+++ e++dlvt+vs+++++t+++vGtk+g++ +yD ++ek++v
   Q: 216 PYRVLDAPCLRNDFYSNLISWSrTTNNVLVGLGCSVYIWSEKEGAVSILDHQylsEKRDLVTCVSFCPYNTYFIVGTKFGRILLYDqkeffhssnTNEKEPV 317
    79********************999**************************99999********************************************** PP
   S: 90 rtl.tghsarvgaLsW....naevlssGsrdgeilhrdvr...................vkelkl.stlqahaqevCGlkwnedaklLasGGnDnsvsvwda 166
    +++ t++++++++L+W + +++++G+++g++++++++ +++lkl st+qa+aq+vCG+++ne+a+lLa+GGnDns+s+wd+
   Q: 318 FVFqTESFKGICCLEWfkpgEICKFYVGEENGNVSLFEIKslhfpiknwskrqkledenLIGLKLhSTYQAQAQQVCGISLNEHANLLAVGGNDNSCSLWDI 419
    ***99**************99**************************************9999998************************************ PP
   S: 167 ssse.Plkkfk.ehkaavkaiawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenk....itlwkypslskvae 262
    s+ + P+kkf +hkaavkaia++Pw+kslLa+GGG++Drcikfw+t+tg+ll+ei+t++qv+sl+ws ++k++v+t+Gf+++k itl++yp+lsk++e
   Q: 420 SDLDkPIKKFVlPHKAAVKAIAFCPWSKSLLATGGGSKDRCIKFWHTSTGTLLDEICTSGQVTSLIWSLRHKQIVATFGFGDTKnpvlITLYSYPKLSKLLE 521
    **988******9***********************************************************************99**9************** PP
   S: 263 .lkgheaRvlslalspdgeaivtaagDetlrfwklfdkkk 301
    ++++++Rvls+++sp+++ai++a++Det+rf++l++ k+
   Q: 522 vRSPNPLRVLSAVISPSSMAICVATNDETIRFYELWNDKE 561
    899********************************99875 PP
   

Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description



     Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). Required for the ubiquitination and subsequent degradation of the B-type cyclin CLB1 by the APC/C complex during meiosis. Required for meiosis I, late meiotic gene expression and spore wall assembly.
Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). Required for the ubiquitination and subsequent degradation of the B-type cyclin CLB1 by the APC/C complex during meiosis. Required for meiosis I, late meiotic gene expression and spore wall assembly.
Protein Sequence
(Fasta)
MATPHLYHRY NSKSSNKNIN SSGNSTEVDR FIPKSVSRNA YKSIPMLNGF DISYSELCEK 60
SPSPERLSSP EFFNELRNTG HYESISTTNE FSMSSISSSS ESQVTRSGSA RASRNDYSKL 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Sce-106218|E3,WD_repeat;E3,CDC20|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCTACTC CCCATTTATA TCACAGATAT AACTCCAAAA GCTCTAACAA AAATATCAAT 60
TCGAGCGGAA ATTCTACAGA GGTTGACCGT TTCATTCCAA AATCAGTTTC GAGAAATGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Sce-106218|E3,WD_repeat;E3,CDC20|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0469--Meiosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0008047--F:enzyme activator activity
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0030437--P:ascospore formation
GO:0030476--P:ascospore wall assembly
GO:0051301--P:cell division
GO:0007127--P:meiosis I
GO:0045132--P:meiotic chromosome segregation
GO:0044778--P:meiotic DNA integrity checkpoint
GO:0045732--P:positive regulation of protein catabolic process
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0006508--P:proteolysis
GO:0007130--P:synaptonemal complex assembly

KEGG sce:YGR225W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ago-007974 Ashbya gossypii 42.76 8.00e-131 458.00
IUUC-Ang-009869 Aspergillus niger 32.89 2.00e-48 185.00
IUUC-Bgr-012141 Blumeria graminis 30.47 3.00e-49 187.00
IUUC-Dse-031395 Dothistroma septosporum 29.58 1.00e-47 182.00
IUUC-Kpa-049263 Komagataella pastoris 44.56 1.00e-92 331.00
IUUC-Ncr-068731 Neurospora crassa 29.42 1.00e-50 192.00
IUUC-Sja-107680 Schizosaccharomyces japonicus 32.78 2.00e-52 197.00
IUUC-Spo-108320 Schizosaccharomyces pombe 29.62 6.00e-47 179.00
IUUC-Tme-127146 Tuber melanosporum 28.16 3.00e-51 194.00
Created Date 25-Jun-2017

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