iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	19903324

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UIM	0.012	14.2	206	224

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           dEd+++q Al+lS++Eee 
   Q: 206  DEDPDFQAALQLSKEEEEL 224
           7****************95 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Binds to membranes enriched in phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin.

Protein Sequence
(Fasta)

MSKQFVRSAK NMMKGYSSTQ VLVRDATAND SRTPSIDTLD DLAQRSYDSV DFFEIMDMLD 60
KRLNDKGKYW RHVAKSLTVL DYLVRFGSEN CVLWCRENFY VIKTLREFRH ENESGFDEGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTAAGC AGTTTGTTCG TTCTGCAAAG AACATGATGA AGGGCTACTC ATCCACACAA 60
GTGCTTGTGA GAGATGCCAC GGCGAACGAC TCGAGGACTC CATCGATAGA CACTCTCGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-1017--Isopeptide bond
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR013809--ENTH
IPR008942--ENTH_VHS
IPR003903--UIM_dom

PROSITE

PS50942--ENTH
PS50330--UIM

Pfam

PF01417--ENTH

SMART

SM00273--ENTH
SM00726--UIM

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0030276--F:clathrin binding
GO:0008289--F:lipid binding
GO:0000147--P:actin cortical patch assembly
GO:0007015--P:actin filament organization
GO:0006897--P:endocytosis

KEGG

sce:YLR206W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007809	Ashbya gossypii	62.99	1.00e-45	175.00
IUUC-Cho-024649	Choloepus hoffmanni	42.55	2.00e-30	125.00
IUUC-Cgl-026614	Colletotrichum gloeosporioides	47.30	5.00e-48	183.00
IUUC-Cne-027047	Cryptococcus neoformans	39.92	6.00e-38	149.00
IUUC-Dse-031529	Dothistroma septosporum	61.15	2.00e-45	174.00
IUUC-Dme-032149	Drosophila melanogaster	50.36	4.00e-36	144.00
IUUC-Ete-032461	Echinops telfairi	46.10	5.00e-35	140.00
IUUC-Eeu-034710	Erinaceus europaeus	46.81	7.00e-36	143.00
IUUC-Fox-037900	Fusarium oxysporum	60.75	7.00e-35	139.00
IUUC-Lma-053140	Leptosphaeria maculans	56.72	2.00e-39	156.00
IUUC-Laf-053467	Loxodonta africana	45.39	5.00e-35	140.00
IUUC-Mor-057254	Magnaporthe oryzae	57.75	1.00e-44	172.00
IUUC-Mpo-057426	Magnaporthe poae	44.25	7.00e-45	172.00
IUUC-Mvi-060293	Microbotryum violaceum	50.69	8.00e-40	155.00
IUUC-Pno-095066	Phaeosphaeria nodorum	54.39	3.00e-32	131.00
IUUC-Pte-104048	Pyrenophora teres	55.97	2.00e-39	155.00
IUUC-Sha-106764	Sarcophilus harrisii	46.81	8.00e-36	143.00
IUUC-Sre-114959	Sporisorium reilianum	55.64	4.00e-40	156.00
IUUC-Tsy-119034	Tarsius syrichta	43.97	2.00e-33	134.00
IUUC-Tbe-127749	Tupaia belangeri	44.68	8.00e-35	139.00
IUUC-Ttr-128633	Tursiops truncatus	44.60	2.00e-33	135.00
IUUC-Uma-129605	Ustilago maydis	55.64	6.00e-40	156.00
IUUC-Vda-129905	Verticillium dahliae	44.59	3.00e-45	174.00
IUUC-Vpa-130825	Vicugna pacos	43.97	9.00e-34	136.00
IUUC-Yli-134375	Yarrowia lipolytica	54.96	2.00e-42	164.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence