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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063738
UUCD1 version UUC-MuM-00805
Ensembl Protein ID ENSMUSP00000001258.8
UniProt Accession Q8VDF2; Q3U9D7; Q3U9P2; Q3UI74; Q3UIE6; Q3ULF2; Q3ULQ0; Q8C6F1; Q8VIA1; Q9Z1H6; UHRF1_MOUSE
Genbank Protein ID BAA74579.1; AAK55743.1; BAC35985.1; BAE25499.1; BAE26398.1; BAE26496.1; BAE27560.1; BAE27632.1; BAE29605.1; BAE30624.1; BAE30730.1; BAE31605.1; BAE31708.1; AAH22167.1; BAB79496.1
Protein Name E3 ubiquitin-protein ligase UHRF1; Nuclear protein 95; Nuclear zinc finger protein Np95; RING-type E3 ubiquitin transferase UHRF1; Ubiquitin-like PHD and RING finger domain-containing protein 1; Ubiquitin-like-containing PHD and RING finger domains protein 1
Genbank Nucleotide ID D87908; AF274046; AK075819; AK143688; AK145376; AK145543; AK146951; AK147046; AK150489; AK151701; AK151837; AK152930; AK153083; AC026385; AB066246
Gene Name Uhrf1; Np95
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000001228.14 ENSMUST00000001258.14 ENSMUSP00000001258.8
ENSMUSG00000001228.14 ENSMUST00000113038.7 ENSMUSP00000108661.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UBQ/UBQ_Other UBQ_Other 25900245
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.0033 19.0 713 752
ULD/UDP/UBQ/UBQ_Other 5.60e-17 62.5 1 76
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+ C+e  ++ p+++ C+H  ++dCl +      +  + f+CP Cr
   Q: 713  CICCQELVFR-PVTTVCQHNVCKDCLDRS-----FRAQVFSCPACR 752
           88899999**.999************555.....6**********8 PP
   

   ULD/UDP/UBQ/UBQ_Other
   S: 1    vqvtvksldgs.eltlk.vnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekks 74
           ++++v+++dg+ ++t++ +++ + V+eL++kie+ +++ p+ qrL y+Gk +ed++tL dy+++ ++ti ll+++s
   Q: 1    MWIQVRTMDGKeTHTVNsLSRLTKVQELRKKIEEVFHVEPQLQRLFYRGKQMEDGHTLFDYDVRLNDTIQLLVRQS 76
           789*********************************************************************9976 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair.
 Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair.
Protein Sequence
(Fasta)
MWIQVRTMDG KETHTVNSLS RLTKVQELRK KIEEVFHVEP QLQRLFYRGK QMEDGHTLFD 60
YDVRLNDTIQ LLVRQSLALP LSTKERDSEL SDSDSGYGVG HSESDKSSTH GEGAAEADDK 120
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Protein Fasta Sequence


>IUUC-Mmu-063738|E3,RING;ULD,UBQ_Other|Mus musculus
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Nucleotide Sequence
(Fasta)
AGAGCCCTCC CCACCCAATT GGGGTGGAAG TCTCCCGCAG CAGCCTGTGC ACACTAATAA 60
AAACGCCCTG AGTTTTCGCG GGAAAAAAAG TCCTAGCAGC TGGAAGGAAC CCGCGCTCTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063738|E3,RING;ULD,UBQ_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015947--PUA-like_domain
IPR014722--Rib_L2_dom2
IPR003105--SRA_YDG
IPR021991--TTD_dom
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50053--UBIQUITIN_2
PS51015--YDG
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00628--PHD
PF02182--SAD_SRA
PF12148--TTD
PF00240--ubiquitin
SMART

SM00249--PHD
SM00184--RING
SM00466--SRA
SM00213--UBQ
Gene Ontology

GO:0000791--C:euchromatin
GO:0000792--C:heterochromatin
GO:0000790--C:nuclear chromatin
GO:0005720--C:nuclear heterochromatin
GO:0016363--C:nuclear matrix
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005657--C:replication fork
GO:0000987--F:core promoter proximal region sequence-specific DNA binding
GO:0044729--F:hemi-methylated DNA-binding
GO:0042393--F:histone binding
GO:0042802--F:identical protein binding
GO:0008327--F:methyl-CpG binding
GO:0035064--F:methylated histone binding
GO:0031493--F:nucleosomal histone binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0008283--P:cell proliferation
GO:0032776--P:DNA methylation on cytosine
GO:0006281--P:DNA repair
GO:0010390--P:histone monoubiquitination
GO:0016574--P:histone ubiquitination
GO:0010216--P:maintenance of DNA methylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032270--P:positive regulation of cellular protein metabolic process
GO:0051865--P:protein autoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090308--P:regulation of methylation-dependent chromatin silencing
GO:0006351--P:transcription, DNA-templated
KEGG mmu:18140
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000242 Aegilops tauschii 33.59 7.00e-46 178.00
IUUC-Aml-001285 Ailuropoda melanoleuca 72.10 0.00e+00 1134.00
IUUC-Atr-002603 Amborella trichopoda 34.69 4.00e-50 192.00
IUUC-Apl-003819 Anas platyrhynchos 65.91 0.00e+00 984.00
IUUC-Aly-006276 Arabidopsis lyrata 36.50 5.00e-53 202.00
IUUC-Ath-006667 Arabidopsis thaliana 35.59 8.00e-52 198.00
IUUC-Ame-011845 Astyanax mexicanus 63.58 0.00e+00 934.00
IUUC-Bta-012600 Bos taurus 72.75 0.00e+00 1107.00
IUUC-Bci-013703 Botrytis cinerea 30.20 3.00e-11 63.50
IUUC-Bdi-014586 Brachypodium distachyon 34.79 5.00e-46 179.00
IUUC-Bol-016567 Brassica oleracea 35.85 2.00e-48 186.00
IUUC-Bra-017880 Brassica rapa 36.10 2.00e-48 187.00
IUUC-Cja-018864 Callithrix jacchus 73.23 0.00e+00 1165.00
IUUC-Cfa-020558 Canis familiaris 72.78 0.00e+00 1131.00
IUUC-Cpo-022125 Cavia porcellus 74.62 0.00e+00 1188.00
IUUC-Cre-022645 Chlamydomonas reinhardtii 32.35 6.00e-21 96.30
IUUC-Csa-023649 Chlorocebus sabaeus 70.19 0.00e+00 1113.00
IUUC-Cin-025454 Ciona intestinalis 50.83 0.00e+00 726.00
IUUC-Cgl-026498 Colletotrichum gloeosporioides 31.25 2.00e-11 63.90
IUUC-Cne-026942 Cryptococcus neoformans 46.01 3.00e-29 120.00
IUUC-Dre-028200 Danio rerio 63.74 0.00e+00 985.00
IUUC-Dno-029523 Dasypus novemcinctus 71.14 0.00e+00 831.00
IUUC-Dor-031084 Dipodomys ordii 74.94 0.00e+00 1186.00
IUUC-Eca-033266 Equus caballus 72.94 0.00e+00 1118.00
IUUC-Eeu-035077 Erinaceus europaeus 62.61 5.00e-142 497.00
IUUC-Fca-035685 Felis catus 63.50 0.00e+00 988.00
IUUC-Fal-037550 Ficedula albicollis 65.73 0.00e+00 925.00
IUUC-Gmo-039452 Gadus morhua 60.70 0.00e+00 931.00
IUUC-Ggr-039874 Gaeumannomyces graminis 29.27 1.00e-08 54.70
IUUC-Gga-040484 Gallus gallus 66.29 0.00e+00 1058.00
IUUC-Gac-042196 Gasterosteus aculeatus 61.64 0.00e+00 944.00
IUUC-Gma-042831 Glycine max 34.33 6.00e-49 189.00
IUUC-Ggo-045414 Gorilla gorilla 72.94 0.00e+00 1169.00
IUUC-Hsa-046236 Homo sapiens 73.07 0.00e+00 1171.00
IUUC-Hvu-047471 Hordeum vulgare 36.43 3.00e-45 176.00
IUUC-Itr-047867 Ictidomys tridecemlineatus 73.40 0.00e+00 1135.00
IUUC-Lch-050162 Latimeria chalumnae 59.71 0.00e+00 889.00
IUUC-Loc-051806 Lepisosteus oculatus 64.28 0.00e+00 973.00
IUUC-Lma-052953 Leptosphaeria maculans 26.26 2.00e-11 64.30
IUUC-Laf-053671 Loxodonta africana 70.44 0.00e+00 1120.00
IUUC-Mcc-055513 Macaca mulatta 73.26 0.00e+00 1177.00
IUUC-Mpo-057318 Magnaporthe poae 31.33 3.00e-09 57.00
IUUC-Mtr-057930 Medicago truncatula 36.99 6.00e-49 189.00
IUUC-Mla-058836 Melampsora laricipopulina 41.85 1.00e-32 134.00
IUUC-Mga-059759 Meleagris gallopavo 65.51 0.00e+00 957.00
IUUC-Mvi-060378 Microbotryum violaceum 49.18 1.00e-34 140.00
IUUC-Mmr-060600 Microcebus murinus 67.84 0.00e+00 986.00
IUUC-Mdo-061911 Monodelphis domestica 68.13 0.00e+00 1054.00
IUUC-Mac-064697 Musa acuminata 35.77 1.00e-48 188.00
IUUC-Mpu-065696 Mustela putorius furo 71.57 0.00e+00 1113.00
IUUC-Mlu-067538 Myotis lucifugus 67.40 0.00e+00 1070.00
IUUC-Opr-070813 Ochotona princeps 61.71 2.00e-151 529.00
IUUC-Ont-072292 Oreochromis niloticus 62.42 0.00e+00 942.00
IUUC-Ola-086416 Oryzias latipes 61.00 0.00e+00 929.00
IUUC-Oga-088221 Otolemur garnettii 72.76 0.00e+00 1151.00
IUUC-Oar-089604 Ovis aries 68.75 0.00e+00 1011.00
IUUC-Ptr-090559 Pan troglodytes 73.00 0.00e+00 1169.00
IUUC-Pan-092855 Papio anubis 73.38 0.00e+00 1176.00
IUUC-Psi-093763 Pelodiscus sinensis 69.11 0.00e+00 759.00
IUUC-Pma-094339 Petromyzon marinus 59.49 0.00e+00 868.00
IUUC-Ppa-095940 Physcomitrella patens 37.38 2.00e-51 197.00
IUUC-Pfo-096243 Poecilia formosa 60.80 0.00e+00 922.00
IUUC-Pab-098243 Pongo abelii 72.57 0.00e+00 1145.00
IUUC-Pop-099561 Populus trichocarpa 35.52 2.00e-52 200.00
IUUC-Pca-100503 Procavia capensis 67.70 0.00e+00 1050.00
IUUC-Ppe-101961 Prunus persica 37.18 3.00e-49 189.00
IUUC-Pva-102240 Pteropus vampyrus 69.27 0.00e+00 884.00
IUUC-Pgr-103644 Puccinia graminis 47.85 5.00e-33 135.00
IUUC-Ptt-103867 Puccinia triticina 45.11 1.00e-33 137.00
IUUC-Rno-105345 Rattus norvegicus 93.48 0.00e+00 1479.00
IUUC-Sha-106618 Sarcophilus harrisii 67.87 0.00e+00 1046.00
IUUC-Smo-109556 Selaginella moellendorffii 38.44 1.00e-44 174.00
IUUC-Sit-110588 Setaria italica 35.48 5.00e-47 182.00
IUUC-Sly-111415 Solanum lycopersicum 35.27 4.00e-52 199.00
IUUC-Stu-112842 Solanum tuberosum 35.02 5.00e-52 199.00
IUUC-Sar-113651 Sorex araneus 67.74 4.00e-81 295.00
IUUC-Sre-115182 Sporisorium reilianum 47.06 2.00e-35 143.00
IUUC-Ssc-116081 Sus scrofa 69.42 0.00e+00 1105.00
IUUC-Tgu-116538 Taeniopygia guttata 68.59 0.00e+00 868.00
IUUC-Tru-117599 Takifugu rubripes 61.10 0.00e+00 927.00
IUUC-Tca-121781 Theobroma cacao 33.33 6.00e-48 185.00
IUUC-Tae-125473 Triticum aestivum 33.85 7.00e-46 179.00
IUUC-Tme-127149 Tuber melanosporum 49.42 1.00e-27 117.00
IUUC-Ttr-128522 Tursiops truncatus 72.61 0.00e+00 1138.00
IUUC-Vvi-131413 Vitis vinifera 34.47 1.00e-49 191.00
IUUC-Xtr-132432 Xenopus tropicalis 62.14 0.00e+00 978.00
IUUC-Xma-133516 Xiphophorus maculatus 61.58 0.00e+00 940.00
IUUC-Yli-134581 Yarrowia lipolytica 42.31 3.00e-07 49.30
IUUC-Zma-135894 Zea mays 35.13 2.00e-46 181.00
Created Date 25-Jun-2017

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