iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17130289
UBD/ZnF/UBZ	UBZ	17550899

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	7.90e-06	24.8	28	65
UBD/ZnF/UBZ	4.70e-09	34.8	189	211

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C iC++ +k  p+++pCgH+f+  C+          +++ +CPlC
   Q: 28   CHICKDFLKV-PVLTPCGHTFCSLCIRTH------LNNQPNCPLC 65
           99**999988.999************777......8********* PP

UBD/ZnF/UBZ

   S: 3    vCPvCqkmvdqtdfee.HlDeCl 24
           +CP+Cq++++++++e+ HlDeCl
   Q: 189  QCPICQQFYPLKALEKtHLDECL 211
           6*********************8 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. The UBC2-RAD18 complex cooperates with RAD5 and the UBC13-MMS2 dimer to attach mono-ubiquitin chains on 'Lys-164' of POL30, which is necessary for PRR. The UBC2-RAD18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine.

Protein Sequence
(Fasta)

MDHQITTASD FTTTSIPSLY QLDTLLRCHI CKDFLKVPVL TPCGHTFCSL CIRTHLNNQP 60
NCPLCLFEFR ESLLRSEFLV SEIIQSYTSL RSSLLDALRI PKPTPVPENE EVPGPENSSW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACCACC AAATAACCAC TGCAAGCGAC TTCACGACTA CTTCAATACC GAGCCTGTAC 60
CAATTGGATA CACTTTTGAG ATGTCACATT TGTAAAGATT TTCTAAAAGT CCCCGTCTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004580--Rad18
IPR003034--SAP_dom
IPR006642--Znf_Rad18_put
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50800--SAP
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02037--SAP

SMART

SM00184--RING
SM00513--SAP
SM00734--ZnF_Rad18

Gene Ontology

GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0097505--C:Rad6-Rad18 complex
GO:0003684--F:damaged DNA binding
GO:0003697--F:single-stranded DNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0042275--P:error-free postreplication DNA repair
GO:0070987--P:error-free translesion synthesis
GO:0042276--P:error-prone translesion synthesis
GO:0006513--P:protein monoubiquitination
GO:0009411--P:response to UV

KEGG

sce:YCR066W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002086	Ailuropoda melanoleuca	24.85	7.00e-15	73.20
IUUC-Apl-003657	Anas platyrhynchos	25.49	4.00e-20	90.50
IUUC-Aca-005369	Anolis carolinensis	33.33	5.00e-11	58.20
IUUC-Ago-007876	Ashbya gossypii	41.77	2.00e-76	277.00
IUUC-Acl-008246	Aspergillus clavatus	25.39	2.00e-26	111.00
IUUC-Afl-008666	Aspergillus flavus	26.73	6.00e-27	113.00
IUUC-Afu-009052	Aspergillus fumigatus	24.19	4.00e-24	103.00
IUUC-Ani-009488	Aspergillus nidulans	25.18	5.00e-28	116.00
IUUC-Ang-009681	Aspergillus niger	25.19	8.00e-30	122.00
IUUC-Aor-010037	Aspergillus oryzae	24.87	5.00e-28	116.00
IUUC-Ate-010516	Aspergillus terreus	40.91	4.00e-17	79.30
IUUC-Ame-010630	Astyanax mexicanus	22.52	2.00e-18	84.30
IUUC-Bgr-012178	Blumeria graminis	29.52	1.00e-34	138.00
IUUC-Bta-012976	Bos taurus	31.71	2.00e-11	61.60
IUUC-Bci-013680	Botrytis cinerea	26.05	3.00e-35	140.00
IUUC-Cel-018356	Caenorhabditis elegans	47.37	3.00e-09	52.40
IUUC-Cja-019453	Callithrix jacchus	36.11	2.00e-11	62.00
IUUC-Cfa-020856	Canis familiaris	23.88	4.00e-16	77.40
IUUC-Cpo-021950	Cavia porcellus	37.33	1.00e-11	62.40
IUUC-Csa-023997	Chlorocebus sabaeus	36.00	1.00e-11	62.40
IUUC-Cho-024771	Choloepus hoffmanni	34.67	5.00e-11	60.50
IUUC-Cin-025364	Ciona intestinalis	32.14	8.00e-11	58.90
IUUC-Csv-026364	Ciona savignyi	48.84	9.00e-09	52.40
IUUC-Cgl-026668	Colletotrichum gloeosporioides	44.21	8.00e-22	95.90
IUUC-Cme-027202	Cyanidioschyzon merolae	37.18	2.00e-12	64.70
IUUC-Dre-028479	Danio rerio	23.81	1.00e-15	75.50
IUUC-Dno-028943	Dasypus novemcinctus	34.67	3.00e-11	60.80
IUUC-Dor-031046	Dipodomys ordii	29.75	4.00e-05	40.80
IUUC-Dme-031919	Drosophila melanogaster	43.59	2.00e-06	46.60
IUUC-Ete-032455	Echinops telfairi	37.93	3.00e-09	54.30
IUUC-Eca-033725	Equus caballus	36.00	1.00e-11	62.80
IUUC-Eeu-034573	Erinaceus europaeus	36.62	3.00e-11	60.80
IUUC-Fca-036495	Felis catus	24.41	2.00e-15	75.10
IUUC-Fal-036791	Ficedula albicollis	25.83	9.00e-19	86.30
IUUC-Fox-037868	Fusarium oxysporum	42.86	9.00e-23	99.00
IUUC-Fso-038144	Fusarium solani	38.78	7.00e-21	92.40
IUUC-Gmo-039315	Gadus morhua	38.98	7.00e-10	57.00
IUUC-Ggr-039737	Gaeumannomyces graminis	38.95	7.00e-20	89.70
IUUC-Gga-040788	Gallus gallus	26.12	2.00e-20	91.70
IUUC-Gac-041993	Gasterosteus aculeatus	21.34	1.00e-18	85.50
IUUC-Ggo-044889	Gorilla gorilla	36.00	9.00e-12	62.80
IUUC-Hsa-045957	Homo sapiens	36.00	1.00e-11	62.80
IUUC-Itr-048998	Ictidomys tridecemlineatus	32.93	8.00e-12	63.20
IUUC-Kpa-049300	Komagataella pastoris	29.50	5.00e-37	146.00
IUUC-Lch-050172	Latimeria chalumnae	36.00	2.00e-10	57.80
IUUC-Loc-052609	Lepisosteus oculatus	37.78	1.00e-12	65.90
IUUC-Lma-053037	Leptosphaeria maculans	23.55	2.00e-18	85.50
IUUC-Laf-054421	Loxodonta africana	43.94	3.00e-12	65.10
IUUC-Mcc-055853	Macaca mulatta	36.00	1.00e-11	62.40
IUUC-Meu-056070	Macropus eugenii	35.80	2.00e-09	55.50
IUUC-Mor-057071	Magnaporthe oryzae	25.91	2.00e-34	137.00
IUUC-Mpo-057628	Magnaporthe poae	38.46	1.00e-18	85.90
IUUC-Mla-058953	Melampsora laricipopulina	34.34	1.00e-11	62.80
IUUC-Mga-059687	Meleagris gallopavo	25.88	1.00e-16	79.30
IUUC-Mvi-060412	Microbotryum violaceum	39.18	2.00e-15	75.50
IUUC-Mmr-061563	Microcebus murinus	35.14	3.00e-11	60.80
IUUC-Mdo-062655	Monodelphis domestica	37.33	4.00e-13	67.40
IUUC-Mmu-063647	Mus musculus	40.00	1.00e-12	66.20
IUUC-Mac-065027	Musa acuminata	38.89	1.00e-11	62.80
IUUC-Mpu-065778	Mustela putorius furo	23.88	1.00e-15	75.90
IUUC-Mlu-068205	Myotis lucifugus	36.00	7.00e-11	60.10
IUUC-Nfi-068501	Neosartorya fischeri	24.27	2.00e-20	91.30
IUUC-Ncr-068917	Neurospora crassa	26.28	5.00e-32	130.00
IUUC-Nle-068990	Nomascus leucogenys	36.00	1.00e-11	62.40
IUUC-Opr-071146	Ochotona princeps	35.90	2.00e-11	61.60
IUUC-Ont-071835	Oreochromis niloticus	42.17	2.00e-13	68.60
IUUC-Oan-072827	Ornithorhynchus anatinus	33.33	5.00e-14	68.90
IUUC-Ocu-073986	Oryctolagus cuniculus	27.38	8.00e-19	86.30
IUUC-Ola-086997	Oryzias latipes	37.84	6.00e-12	62.80
IUUC-Olu-087771	Ostreococcus lucimarinus	36.84	3.00e-10	57.40
IUUC-Oga-088092	Otolemur garnettii	27.84	9.00e-18	82.80
IUUC-Oar-089651	Ovis aries	32.93	1.00e-11	62.80
IUUC-Ptr-091103	Pan troglodytes	36.00	1.00e-11	62.80
IUUC-Pan-092478	Papio anubis	36.00	1.00e-11	62.40
IUUC-Psi-093356	Pelodiscus sinensis	35.80	2.00e-13	68.20
IUUC-Pma-094517	Petromyzon marinus	36.36	3.00e-06	44.70
IUUC-Pfo-096663	Poecilia formosa	42.17	1.00e-12	65.90
IUUC-Pab-098515	Pongo abelii	36.00	1.00e-11	62.80
IUUC-Pop-098788	Populus trichocarpa	39.47	7.00e-11	59.70
IUUC-Pca-100588	Procavia capensis	30.23	8.00e-09	52.80
IUUC-Ppe-101428	Prunus persica	36.11	5.00e-11	60.10
IUUC-Pva-102377	Pteropus vampyrus	31.76	5.00e-11	60.50
IUUC-Pgr-103556	Puccinia graminis	31.46	3.00e-09	54.70
IUUC-Pte-104362	Pyrenophora teres	33.68	2.00e-15	75.10
IUUC-Pyt-104823	Pyrenophora triticirepentis	35.71	4.00e-14	70.50
IUUC-Rno-105866	Rattus norvegicus	40.00	5.00e-13	67.00
IUUC-Sha-107515	Sarcophilus harrisii	33.65	2.00e-13	67.80
IUUC-Sja-107689	Schizosaccharomyces japonicus	45.45	2.00e-25	108.00
IUUC-Spo-108248	Schizosaccharomyces pombe	27.89	1.00e-32	132.00
IUUC-Ssl-108430	Sclerotinia sclerotiorum	26.54	7.00e-32	129.00
IUUC-Sar-113220	Sorex araneus	37.88	2.00e-08	51.20
IUUC-Sre-115123	Sporisorium reilianum	50.00	2.00e-09	55.10
IUUC-Ssc-115992	Sus scrofa	27.67	1.00e-06	45.40
IUUC-Tgu-117286	Taeniopygia guttata	25.66	5.00e-24	103.00
IUUC-Tru-117959	Takifugu rubripes	48.00	7.00e-11	59.30
IUUC-Tsy-119286	Tarsius syrichta	37.74	5.00e-09	53.50
IUUC-Tni-120570	Tetraodon nigroviridis	38.55	3.00e-11	60.80
IUUC-Tre-121893	Trichoderma reesei	35.71	6.00e-17	79.70
IUUC-Tvi-122405	Trichoderma virens	35.79	3.00e-19	87.40
IUUC-Tbe-127758	Tupaia belangeri	34.67	7.00e-11	60.10
IUUC-Ttr-128841	Tursiops truncatus	36.14	1.00e-11	62.80
IUUC-Uma-129563	Ustilago maydis	51.92	3.00e-09	54.70
IUUC-Vda-130021	Verticillium dahliae	25.00	8.00e-13	65.50
IUUC-Vpa-130169	Vicugna pacos	34.18	3.00e-11	60.80
IUUC-Xtr-132308	Xenopus tropicalis	39.19	7.00e-13	66.20
IUUC-Xma-133868	Xiphophorus maculatus	52.94	4.00e-12	63.90
IUUC-Yli-134474	Yarrowia lipolytica	38.04	2.00e-18	84.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence