iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062892

UUCD1 version

UUC-MoD-00780

Ensembl Protein ID

ENSMODP00000023886.3

UniProt Accession

F7ECI4; F7ECI4_MONDO

Protein Name

Uncharacterized protein

Gene Name

NLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000019137.3	ENSMODT00000024310.3	ENSMODP00000023886.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.90e-67	218.5	266	303
UBD/Beta-Prp	3.60e-78	262.9	128	322

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtllvsGsdDgtikvWDlrtgvllk 37
           gHt svtc+++  d+ll s+s D tikvW++++gvl +
   Q: 266  GHTQSVTCVRWgGDGLLYSASQDRTIKVWRPHDGVLCR 303
           8**********977********************9876 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdlst ++  t +gh + vls+++sp+g+kl+sG +   i +wd +tgq l   
   Q: 128  CTSSLEGHSEAVISVAFSPTGKYLASGSGDSTVRFWDLSTETPHFTSRGHRHWVLSIAWSPDGKKLASGCKNGQILLWDPNTGQQLGRG 216
           5789************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+gh+++++++++     +p++++++s+s+D+ vr+Wd ++g++ r ltg ht+sv+++ +  +g  l s+s+d+t+k+w  + g   r
   Q: 217  LAGHSKWITGLSWeplhmNPECRYVASSSKDGSVRIWDTSMGRCDRILTG-HTQSVTCVRWGGDG-LLYSASQDRTIKVWRPHDGVLCR 303
           *********98762222267889**************************9.************98.9********************** PP
   S: 217  tlnghtdnvksvrfspnderl 237
           tl+gh  +v+ +++s  ++++
   Q: 304  TLQGHAHWVNTMALS--TDYV 322
           **************9..3333 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MEAQCRQRSR PPVSFHSTWG LGMAAEATGE GLRGDVQRLL VQFQDEGGQL LGSPFDVPVD 60
ITPDKLQLVC NALLGKEDPL PLAFYIHDSE IVTSLEKTLE SKPVETEKVL DIIYQPQAVF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCATTTGAT CAACCCGAGG TGCGAATGCT TACACAGAAA ATCTAACCAT TGGTCCCCTC 60
CTGGTCTGGA GGGGCGGACT CTAGCCGGTC CCAGAAGGAG GTGAGCTGGG GTAGCGTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005840--C:ribosome
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0000027--P:ribosomal large subunit assembly
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	57.73	1.00e-165	575.00
IUUC-Aml-001793	Ailuropoda melanoleuca	89.85	0.00e+00	892.00
IUUC-Atr-002507	Amborella trichopoda	58.21	2.00e-164	572.00
IUUC-Apl-003964	Anas platyrhynchos	84.58	0.00e+00	813.00
IUUC-Aly-006396	Arabidopsis lyrata	55.32	4.00e-161	560.00
IUUC-Ath-007278	Arabidopsis thaliana	55.32	1.00e-160	559.00
IUUC-Ago-007951	Ashbya gossypii	48.25	2.00e-129	456.00
IUUC-Acl-008298	Aspergillus clavatus	48.07	1.00e-121	430.00
IUUC-Afl-008581	Aspergillus flavus	54.60	6.00e-110	390.00
IUUC-Afu-008906	Aspergillus fumigatus	47.26	1.00e-118	419.00
IUUC-Ani-009189	Aspergillus nidulans	45.18	7.00e-118	417.00
IUUC-Ang-009630	Aspergillus niger	49.45	4.00e-124	438.00
IUUC-Aor-010038	Aspergillus oryzae	48.58	1.00e-128	453.00
IUUC-Ate-010278	Aspergillus terreus	47.80	4.00e-122	431.00
IUUC-Ame-011890	Astyanax mexicanus	81.30	0.00e+00	830.00
IUUC-Bgr-012011	Blumeria graminis	47.12	7.00e-128	450.00
IUUC-Bta-012964	Bos taurus	89.01	0.00e+00	888.00
IUUC-Bci-013592	Botrytis cinerea	46.29	6.00e-122	431.00
IUUC-Bdi-015035	Brachypodium distachyon	58.67	3.00e-168	584.00
IUUC-Bol-015501	Brassica oleracea	54.96	4.00e-161	561.00
IUUC-Bra-017642	Brassica rapa	54.96	6.00e-161	560.00
IUUC-Cel-018430	Caenorhabditis elegans	58.15	1.00e-164	572.00
IUUC-Cja-019125	Callithrix jacchus	89.22	0.00e+00	887.00
IUUC-Cfa-021013	Canis familiaris	88.45	0.00e+00	804.00
IUUC-Cpo-021743	Cavia porcellus	88.16	0.00e+00	883.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	46.07	4.00e-111	394.00
IUUC-Csa-024270	Chlorocebus sabaeus	88.77	0.00e+00	893.00
IUUC-Cin-025795	Ciona intestinalis	65.46	0.00e+00	678.00
IUUC-Csv-025953	Ciona savignyi	66.74	0.00e+00	682.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	50.66	7.00e-107	380.00
IUUC-Cne-026901	Cryptococcus neoformans	49.60	7.00e-139	487.00
IUUC-Cme-027281	Cyanidioschyzon merolae	47.23	9.00e-115	407.00
IUUC-Dre-028515	Danio rerio	78.15	0.00e+00	800.00
IUUC-Dno-029596	Dasypus novemcinctus	88.27	0.00e+00	895.00
IUUC-Dor-030494	Dipodomys ordii	86.49	0.00e+00	887.00
IUUC-Dse-031538	Dothistroma septosporum	50.10	1.00e-131	462.00
IUUC-Dme-031974	Drosophila melanogaster	59.83	8.00e-169	586.00
IUUC-Ete-032948	Echinops telfairi	89.47	1.00e-110	393.00
IUUC-Eca-033399	Equus caballus	90.23	0.00e+00	892.00
IUUC-Eeu-035013	Erinaceus europaeus	90.43	7.00e-110	390.00
IUUC-Fca-035860	Felis catus	89.85	0.00e+00	892.00
IUUC-Fal-037069	Ficedula albicollis	88.84	7.00e-134	469.00
IUUC-Fox-038059	Fusarium oxysporum	46.20	3.00e-124	438.00
IUUC-Fso-038445	Fusarium solani	47.43	6.00e-125	441.00
IUUC-Gmo-039319	Gadus morhua	76.65	0.00e+00	742.00
IUUC-Ggr-040095	Gaeumannomyces graminis	47.08	9.00e-123	433.00
IUUC-Gga-040303	Gallus gallus	86.45	2.00e-131	461.00
IUUC-Gac-042267	Gasterosteus aculeatus	77.00	0.00e+00	758.00
IUUC-Gma-043974	Glycine max	58.35	8.00e-171	593.00
IUUC-Ggo-044637	Gorilla gorilla	89.38	0.00e+00	882.00
IUUC-Hsa-046128	Homo sapiens	88.25	0.00e+00	897.00
IUUC-Hvu-047373	Hordeum vulgare	56.99	1.00e-165	575.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	86.73	0.00e+00	888.00
IUUC-Kpa-049274	Komagataella pastoris	45.19	3.00e-126	445.00
IUUC-Lch-049907	Latimeria chalumnae	83.82	0.00e+00	825.00
IUUC-Lpe-050778	Leersia perrieri	53.80	8.00e-150	523.00
IUUC-Loc-051889	Lepisosteus oculatus	81.13	0.00e+00	829.00
IUUC-Lma-053041	Leptosphaeria maculans	49.65	2.00e-115	410.00
IUUC-Laf-053598	Loxodonta africana	89.98	0.00e+00	898.00
IUUC-Mcc-055660	Macaca mulatta	88.77	0.00e+00	892.00
IUUC-Meu-056197	Macropus eugenii	82.95	0.00e+00	812.00
IUUC-Mor-056949	Magnaporthe oryzae	45.55	3.00e-117	415.00
IUUC-Mpo-057571	Magnaporthe poae	46.10	4.00e-64	238.00
IUUC-Mtr-058530	Medicago truncatula	59.50	4.00e-169	587.00
IUUC-Mla-059133	Melampsora laricipopulina	46.28	6.00e-125	441.00
IUUC-Mga-059252	Meleagris gallopavo	85.21	0.00e+00	662.00
IUUC-Mvi-060522	Microbotryum violaceum	51.01	3.00e-138	485.00
IUUC-Mmr-061117	Microcebus murinus	87.55	0.00e+00	884.00
IUUC-Mmu-064108	Mus musculus	89.03	0.00e+00	867.00
IUUC-Mac-064430	Musa acuminata	59.53	7.00e-171	593.00
IUUC-Mpu-065882	Mustela putorius furo	89.24	0.00e+00	887.00
IUUC-Mlu-068123	Myotis lucifugus	89.43	0.00e+00	892.00
IUUC-Nfi-068484	Neosartorya fischeri	47.35	1.00e-119	423.00
IUUC-Ncr-068649	Neurospora crassa	43.06	3.00e-113	402.00
IUUC-Nle-069140	Nomascus leucogenys	89.60	0.00e+00	885.00
IUUC-Opr-070220	Ochotona princeps	81.70	0.00e+00	769.00
IUUC-Ont-072643	Oreochromis niloticus	79.54	0.00e+00	810.00
IUUC-Ocu-074007	Oryctolagus cuniculus	88.58	0.00e+00	862.00
IUUC-Oba-075904	Oryza barthii	58.67	7.00e-169	587.00
IUUC-Obr-076280	Oryza brachyantha	58.67	1.00e-168	586.00
IUUC-Ogl-077425	Oryza glaberrima	58.67	6.00e-169	587.00
IUUC-Ogu-078586	Oryza glumaepatula	58.67	6.00e-169	587.00
IUUC-Oin-079489	Oryza indica	56.75	2.00e-160	558.00
IUUC-Olo-080766	Oryza longistaminata	58.55	1.00e-168	585.00
IUUC-Ome-081905	Oryza meridionalis	58.89	5.00e-169	587.00
IUUC-Oni-083022	Oryza nivara	58.67	4.00e-169	587.00
IUUC-Opu-083615	Oryza punctata	58.89	5.00e-169	587.00
IUUC-Oru-085076	Oryza rufipogon	58.67	4.00e-169	587.00
IUUC-Osa-085744	Oryza sativa	58.89	1.00e-169	589.00
IUUC-Ola-087290	Oryzias latipes	78.90	0.00e+00	802.00
IUUC-Olu-087898	Ostreococcus lucimarinus	51.36	6.00e-141	494.00
IUUC-Oga-088980	Otolemur garnettii	88.54	0.00e+00	882.00
IUUC-Oar-089580	Ovis aries	89.00	0.00e+00	772.00
IUUC-Ptr-090845	Pan troglodytes	89.38	0.00e+00	883.00
IUUC-Pan-092836	Papio anubis	88.45	0.00e+00	898.00
IUUC-Psi-093965	Pelodiscus sinensis	82.05	2.00e-57	213.00
IUUC-Pno-095052	Phaeosphaeria nodorum	46.71	1.00e-121	429.00
IUUC-Ppa-095432	Physcomitrella patens	58.21	1.00e-165	576.00
IUUC-Pfo-096963	Poecilia formosa	70.89	0.00e+00	694.00
IUUC-Pab-097716	Pongo abelii	85.99	0.00e+00	842.00
IUUC-Pop-099224	Populus trichocarpa	59.36	6.00e-172	597.00
IUUC-Pca-100682	Procavia capensis	86.76	0.00e+00	645.00
IUUC-Ppe-101819	Prunus persica	57.76	7.00e-168	583.00
IUUC-Pva-102338	Pteropus vampyrus	88.98	0.00e+00	682.00
IUUC-Pgr-103583	Puccinia graminis	54.01	2.00e-131	462.00
IUUC-Ptt-103737	Puccinia triticina	44.84	2.00e-98	353.00
IUUC-Pte-104150	Pyrenophora teres	53.20	2.00e-121	429.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	52.96	5.00e-121	427.00
IUUC-Rno-105987	Rattus norvegicus	88.56	0.00e+00	882.00
IUUC-Sce-106315	Saccharomyces cerevisiae	47.87	5.00e-129	454.00
IUUC-Sha-107273	Sarcophilus harrisii	93.61	0.00e+00	946.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	47.80	5.00e-120	424.00
IUUC-Spo-108092	Schizosaccharomyces pombe	49.66	2.00e-124	439.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	43.37	5.00e-115	407.00
IUUC-Smo-108976	Selaginella moellendorffii	56.99	4.00e-161	561.00
IUUC-Sit-110329	Setaria italica	58.67	2.00e-168	585.00
IUUC-Sly-111830	Solanum lycopersicum	60.39	8.00e-173	599.00
IUUC-Stu-112603	Solanum tuberosum	60.39	9.00e-173	599.00
IUUC-Sar-113504	Sorex araneus	85.11	2.00e-68	253.00
IUUC-Sbi-114560	Sorghum bicolor	57.82	3.00e-166	578.00
IUUC-Sre-115133	Sporisorium reilianum	40.19	5.00e-121	428.00
IUUC-Ssc-115903	Sus scrofa	90.27	0.00e+00	893.00
IUUC-Tgu-116798	Taeniopygia guttata	86.05	0.00e+00	858.00
IUUC-Tru-118361	Takifugu rubripes	78.06	0.00e+00	801.00
IUUC-Tsy-118849	Tarsius syrichta	88.47	0.00e+00	887.00
IUUC-Tni-120094	Tetraodon nigroviridis	78.20	0.00e+00	803.00
IUUC-Tca-121634	Theobroma cacao	58.51	1.00e-166	579.00
IUUC-Tre-122051	Trichoderma reesei	47.13	5.00e-120	424.00
IUUC-Tvi-122322	Trichoderma virens	47.34	3.00e-123	435.00
IUUC-Tae-125822	Triticum aestivum	57.60	9.00e-166	576.00
IUUC-Tur-126766	Triticum urartu	50.84	1.00e-157	549.00
IUUC-Tme-127175	Tuber melanosporum	51.37	6.00e-130	457.00
IUUC-Tbe-127779	Tupaia belangeri	88.52	0.00e+00	791.00
IUUC-Ttr-128224	Tursiops truncatus	85.28	0.00e+00	767.00
IUUC-Uma-129537	Ustilago maydis	41.18	3.00e-125	442.00
IUUC-Vda-129927	Verticillium dahliae	45.19	3.00e-111	395.00
IUUC-Vpa-130658	Vicugna pacos	77.41	0.00e+00	749.00
IUUC-Vvi-131659	Vitis vinifera	58.18	4.00e-170	590.00
IUUC-Xtr-132918	Xenopus tropicalis	77.99	0.00e+00	793.00
IUUC-Xma-133700	Xiphophorus maculatus	79.54	0.00e+00	809.00
IUUC-Yli-134478	Yarrowia lipolytica	49.39	8.00e-137	480.00
IUUC-Zma-135835	Zea mays	55.38	4.00e-163	567.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence