iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.90e-63	204.0	184	221
UBD/Beta-Prp	2.30e-77	258.6	136	330

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH ++v c+++ +d   +++Gs D+ti++WD+++g +l
   Q: 184  GHYNWVLCVSWsPDgEVIATGSMDNTIRLWDPKSGQCL 221
           799*********999********************997 PP

UBD/Beta-Prp

   S: 45   lrslsgheaevtavkfspdgk.ilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvv 144
            + + gh +++ +  f p+++  +vtg+ D+t+++wd +t +++htlkgh + vl++s+sp+g+++++Gs d+tir+wd ++gqcl + l+gh++++++++
   Q: 136  SSAIAGHGSTILCSAFAPHTSsRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLS 236
           344599************998899***************************************************************************99 PP
   S: 145  vhp......dg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfsp 232
           + p       +   l+s+s+D+t+++Wd  +  + +t++g ht+sv ++++  +g  l sgs+d+tv++wd+  +g+c+++l+ h  +v+ + +s 
   Q: 237  WEPihlvkpGSkPRLASSSKDGTIKIWDTVSRVCQYTMSG-HTNSVSCVKWGGQG-LLYSGSHDRTVRVWDINsQGRCINILKSHAHWVNHLSLST 330
           87533332233479************************99.************76.9***************999***************999983 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Involved in ribosome biogenesis. Required for processing and efficient intra-nuclear transport of pre-60S ribosomal subunits. Interacts with the AAA-ATPase Midasin (MDN1/REA1), which is essential for the ATP-dependent dissociation of a group of nonribosomal factors from the pre-60S particle.

Protein Sequence
(Fasta)

MSTLIPPPSK KQKKEAQLPR EVAIIPKDLP NVSIKFQALD TGDNVGGALR VPGAISEKQL 60
EELLNQLNGT SDDPVPYTFS CTIQGKKASD PVKTIDITDN LYSSLIKPGY NSTEDQITLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCACCC TGATTCCTCC ACCTTCTAAG AAACAAAAGA AAGAGGCTCA ACTTCCCAGA 60
GAAGTAGCTA TTATTCCGAA AGATTTACCC AATGTTTCAA TCAAGTTCCA AGCTTTAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0000027--P:ribosomal large subunit assembly

KEGG

sce:YCR072C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	50.64	9.00e-146	507.00
IUUC-Aml-001793	Ailuropoda melanoleuca	46.75	3.00e-132	462.00
IUUC-Atr-002507	Amborella trichopoda	49.58	3.00e-139	486.00
IUUC-Apl-003964	Anas platyrhynchos	48.94	3.00e-130	456.00
IUUC-Aca-005354	Anolis carolinensis	27.15	3.00e-36	144.00
IUUC-Aly-006396	Arabidopsis lyrata	48.09	3.00e-134	469.00
IUUC-Ath-007278	Arabidopsis thaliana	48.31	1.00e-134	471.00
IUUC-Ago-007951	Ashbya gossypii	80.39	0.00e+00	885.00
IUUC-Acl-008298	Aspergillus clavatus	57.66	6.00e-168	582.00
IUUC-Afl-008581	Aspergillus flavus	61.13	8.00e-134	467.00
IUUC-Afu-008906	Aspergillus fumigatus	56.81	3.00e-164	569.00
IUUC-Ani-009189	Aspergillus nidulans	56.92	8.00e-162	561.00
IUUC-Ang-009630	Aspergillus niger	56.65	8.00e-172	594.00
IUUC-Aor-010038	Aspergillus oryzae	56.65	4.00e-175	605.00
IUUC-Ate-010278	Aspergillus terreus	54.89	6.00e-166	575.00
IUUC-Ame-011890	Astyanax mexicanus	48.58	6.00e-134	468.00
IUUC-Bgr-012011	Blumeria graminis	53.93	2.00e-159	553.00
IUUC-Bta-012964	Bos taurus	47.46	8.00e-134	468.00
IUUC-Bci-013592	Botrytis cinerea	55.36	6.00e-157	545.00
IUUC-Bdi-015035	Brachypodium distachyon	50.42	1.00e-143	500.00
IUUC-Bol-015501	Brassica oleracea	48.52	2.00e-135	473.00
IUUC-Bra-017642	Brassica rapa	48.94	2.00e-136	476.00
IUUC-Cel-018430	Caenorhabditis elegans	47.94	3.00e-133	466.00
IUUC-Cja-019125	Callithrix jacchus	47.67	2.00e-133	467.00
IUUC-Cfa-021013	Canis familiaris	48.58	1.00e-129	454.00
IUUC-Cpo-021743	Cavia porcellus	47.56	7.00e-134	468.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	40.86	2.00e-108	384.00
IUUC-Csa-024270	Chlorocebus sabaeus	46.87	2.00e-132	463.00
IUUC-Cin-025795	Ciona intestinalis	48.73	3.00e-130	456.00
IUUC-Csv-025953	Ciona savignyi	50.00	4.00e-132	462.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	59.63	9.00e-127	444.00
IUUC-Cne-026901	Cryptococcus neoformans	46.79	3.00e-143	499.00
IUUC-Cme-027281	Cyanidioschyzon merolae	39.63	2.00e-101	361.00
IUUC-Dre-028515	Danio rerio	48.58	2.00e-131	460.00
IUUC-Dno-029596	Dasypus novemcinctus	47.97	2.00e-133	466.00
IUUC-Dor-030494	Dipodomys ordii	46.59	4.00e-135	472.00
IUUC-Dse-031538	Dothistroma septosporum	52.98	2.00e-154	537.00
IUUC-Dme-031974	Drosophila melanogaster	44.81	9.00e-117	411.00
IUUC-Ete-032948	Echinops telfairi	56.19	7.00e-69	252.00
IUUC-Eca-033399	Equus caballus	47.12	2.00e-131	460.00
IUUC-Eeu-035013	Erinaceus europaeus	55.24	4.00e-68	249.00
IUUC-Fca-035860	Felis catus	47.26	2.00e-132	463.00
IUUC-Fal-037069	Ficedula albicollis	55.38	9.00e-82	294.00
IUUC-Fox-038059	Fusarium oxysporum	53.46	1.00e-147	514.00
IUUC-Fso-038445	Fusarium solani	52.50	7.00e-145	504.00
IUUC-Gmo-039319	Gadus morhua	47.75	6.00e-125	438.00
IUUC-Ggr-040095	Gaeumannomyces graminis	51.05	1.00e-149	521.00
IUUC-Gga-040303	Gallus gallus	55.20	1.00e-81	293.00
IUUC-Gac-042267	Gasterosteus aculeatus	49.19	1.00e-131	461.00
IUUC-Gma-043974	Glycine max	48.94	3.00e-140	489.00
IUUC-Ggo-044637	Gorilla gorilla	47.93	6.00e-132	462.00
IUUC-Hsa-046128	Homo sapiens	46.81	4.00e-133	466.00
IUUC-Hvu-047373	Hordeum vulgare	50.64	1.00e-144	504.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	46.88	2.00e-132	463.00
IUUC-Kpa-049274	Komagataella pastoris	69.73	0.00e+00	765.00
IUUC-Lch-049907	Latimeria chalumnae	46.57	2.00e-125	440.00
IUUC-Lpe-050778	Leersia perrieri	46.82	2.00e-126	443.00
IUUC-Loc-051889	Lepisosteus oculatus	48.07	2.00e-130	457.00
IUUC-Lma-053041	Leptosphaeria maculans	51.58	5.00e-152	529.00
IUUC-Laf-053598	Loxodonta africana	47.26	4.00e-133	465.00
IUUC-Mcc-055660	Macaca mulatta	47.07	8.00e-133	464.00
IUUC-Meu-056197	Macropus eugenii	54.17	1.00e-114	404.00
IUUC-Mor-056949	Magnaporthe oryzae	51.52	2.00e-141	493.00
IUUC-Mpo-057571	Magnaporthe poae	59.91	1.00e-70	258.00
IUUC-Mtr-058530	Medicago truncatula	54.98	7.00e-137	478.00
IUUC-Mla-059133	Melampsora laricipopulina	48.69	2.00e-134	470.00
IUUC-Mga-059252	Meleagris gallopavo	53.24	1.00e-115	407.00
IUUC-Mvi-060522	Microbotryum violaceum	49.23	2.00e-149	520.00
IUUC-Mmr-061117	Microcebus murinus	46.63	1.00e-132	464.00
IUUC-Mdo-062892	Monodelphis domestica	47.87	3.00e-132	462.00
IUUC-Mmu-064108	Mus musculus	52.09	5.00e-128	449.00
IUUC-Mac-064430	Musa acuminata	49.79	5.00e-139	485.00
IUUC-Mpu-065882	Mustela putorius furo	46.75	1.00e-130	457.00
IUUC-Mlu-068123	Myotis lucifugus	47.66	2.00e-133	467.00
IUUC-Nfi-068484	Neosartorya fischeri	56.43	7.00e-165	571.00
IUUC-Ncr-068649	Neurospora crassa	49.52	7.00e-139	485.00
IUUC-Nle-069140	Nomascus leucogenys	47.52	2.00e-131	459.00
IUUC-Opr-070220	Ochotona princeps	54.17	8.00e-117	411.00
IUUC-Ont-072643	Oreochromis niloticus	48.68	9.00e-135	471.00
IUUC-Ocu-074007	Oryctolagus cuniculus	46.75	3.00e-130	456.00
IUUC-Oba-075904	Oryza barthii	51.27	7.00e-145	504.00
IUUC-Obr-076280	Oryza brachyantha	51.48	1.00e-145	507.00
IUUC-Ogl-077425	Oryza glaberrima	51.48	4.00e-145	506.00
IUUC-Ogu-078586	Oryza glumaepatula	51.27	1.00e-144	504.00
IUUC-Oin-079489	Oryza indica	49.58	3.00e-137	479.00
IUUC-Olo-080587	Oryza longistaminata	48.05	1.00e-143	502.00
IUUC-Ome-081905	Oryza meridionalis	51.27	6.00e-145	505.00
IUUC-Oni-083022	Oryza nivara	51.27	8.00e-145	504.00
IUUC-Opu-083615	Oryza punctata	51.27	5.00e-145	505.00
IUUC-Oru-085076	Oryza rufipogon	51.27	1.00e-144	504.00
IUUC-Osa-085744	Oryza sativa	51.48	4.00e-146	508.00
IUUC-Ola-087290	Oryzias latipes	48.59	1.00e-134	471.00
IUUC-Olu-087898	Ostreococcus lucimarinus	49.55	5.00e-138	482.00
IUUC-Oga-088980	Otolemur garnettii	47.33	5.00e-132	462.00
IUUC-Oar-089580	Ovis aries	44.08	6.00e-106	375.00
IUUC-Ptr-090845	Pan troglodytes	47.23	1.00e-130	457.00
IUUC-Pan-092836	Papio anubis	47.27	2.00e-133	466.00
IUUC-Psi-093232	Pelodiscus sinensis	27.42	6.00e-37	145.00
IUUC-Pma-094319	Petromyzon marinus	28.11	7.00e-32	129.00
IUUC-Pno-095052	Phaeosphaeria nodorum	51.74	2.00e-160	556.00
IUUC-Ppa-095432	Physcomitrella patens	49.79	5.00e-140	488.00
IUUC-Pfo-096963	Poecilia formosa	44.35	2.00e-107	380.00
IUUC-Pab-097716	Pongo abelii	45.66	9.00e-123	431.00
IUUC-Pop-099224	Populus trichocarpa	49.07	1.00e-139	488.00
IUUC-Pca-100682	Procavia capensis	54.06	1.00e-114	404.00
IUUC-Ppe-101819	Prunus persica	50.42	1.00e-140	491.00
IUUC-Pva-102338	Pteropus vampyrus	40.37	9.00e-81	291.00
IUUC-Pgr-103583	Puccinia graminis	53.20	5.00e-128	449.00
IUUC-Ptt-103737	Puccinia triticina	37.71	1.00e-97	348.00
IUUC-Pte-104150	Pyrenophora teres	52.50	8.00e-159	551.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	52.88	2.00e-159	553.00
IUUC-Rno-105987	Rattus norvegicus	47.74	9.00e-132	461.00
IUUC-Sha-107273	Sarcophilus harrisii	47.67	1.00e-132	464.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	58.25	2.00e-176	609.00
IUUC-Spo-108092	Schizosaccharomyces pombe	55.92	6.00e-169	585.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	52.16	4.00e-149	519.00
IUUC-Smo-108976	Selaginella moellendorffii	47.66	3.00e-134	469.00
IUUC-Sit-110329	Setaria italica	50.62	6.00e-146	508.00
IUUC-Sly-111830	Solanum lycopersicum	50.42	5.00e-142	495.00
IUUC-Stu-112603	Solanum tuberosum	50.42	9.00e-142	494.00
IUUC-Sbi-114560	Sorghum bicolor	50.84	2.00e-144	503.00
IUUC-Sre-115133	Sporisorium reilianum	42.18	8.00e-132	462.00
IUUC-Ssc-115903	Sus scrofa	47.57	2.00e-134	470.00
IUUC-Tgu-116798	Taeniopygia guttata	47.67	7.00e-132	461.00
IUUC-Tru-118361	Takifugu rubripes	48.50	2.00e-135	473.00
IUUC-Tsy-118849	Tarsius syrichta	47.05	3.00e-132	462.00
IUUC-Tni-120094	Tetraodon nigroviridis	49.20	7.00e-136	474.00
IUUC-Tca-121634	Theobroma cacao	49.89	3.00e-139	486.00
IUUC-Tre-122051	Trichoderma reesei	52.21	4.00e-141	492.00
IUUC-Tvi-122322	Trichoderma virens	52.78	3.00e-145	506.00
IUUC-Tae-125822	Triticum aestivum	50.64	6.00e-146	508.00
IUUC-Tur-126766	Triticum urartu	45.01	5.00e-138	482.00
IUUC-Tme-127175	Tuber melanosporum	59.42	3.00e-180	622.00
IUUC-Tbe-127779	Tupaia belangeri	52.84	5.00e-126	442.00
IUUC-Ttr-128224	Tursiops truncatus	48.67	1.00e-125	441.00
IUUC-Uma-129537	Ustilago maydis	42.61	8.00e-135	472.00
IUUC-Vda-129927	Verticillium dahliae	48.94	2.00e-137	480.00
IUUC-Vpa-130658	Vicugna pacos	40.65	7.00e-60	222.00
IUUC-Vvi-131659	Vitis vinifera	49.79	9.00e-142	494.00
IUUC-Xtr-132918	Xenopus tropicalis	46.08	1.00e-122	431.00
IUUC-Xma-133700	Xiphophorus maculatus	48.69	2.00e-131	459.00
IUUC-Yli-134478	Yarrowia lipolytica	68.34	0.00e+00	741.00
IUUC-Zma-135835	Zea mays	48.40	4.00e-140	489.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence