iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.90e-17	59.2	176	214

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvllk 37
           gH + vt++a    ++ ++s+s Dgti++W+  tg+ ++
   Q: 176  GHRATVTDIAIidRGRNVLSASLDGTIRLWECGTGTTIH 214
           8*********98755779*************99998766 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Is not a genuine component of the 26S proteasome, but an auxiliary factor that interacts with the proteasomal ATPase of 19S regulatory particle (RP). Acts as a chaperone which regulates the highly structured assembly of the 19S regulatory particle. Involved in the substrate specificity of the 26S proteasome and is especially involved in the degradation of ubiquitinated GCN4. May contribute to the stability of the 26S proteasome in some stress conditions.

Protein Sequence
(Fasta)

MTKTITVAHI QYDFKAVLEE NDENDDEFYI NVDKNLNEIK EHKIVVLGNS RGVDAGKGNT 60
FEKVGSHLYK ARLDGHDFLF NTIIRDGSKM LKRADYTAVD TAKLQMRRFI LGTTEGDIKV 120

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Nucleotide Sequence
(Fasta)

ATGACTAAGA CCATCACAGT TGCTCATATC CAGTATGATT TTAAAGCTGT TCTGGAAGAA 60
AATGATGAAA ATGACGATGA ATTTTACATC AATGTTGACA AAAACCTAAA TGAAATCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0070682--P:proteasome regulatory particle assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

sce:YGL004C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002247	Ailuropoda melanoleuca	31.86	6.00e-24	102.00
IUUC-Apl-003653	Anas platyrhynchos	35.05	9.00e-25	105.00
IUUC-Aca-004747	Anolis carolinensis	30.53	3.00e-24	103.00
IUUC-Ago-007984	Ashbya gossypii	40.28	6.00e-82	295.00
IUUC-Bta-013482	Bos taurus	29.05	5.00e-23	99.80
IUUC-Cel-018693	Caenorhabditis elegans	26.44	3.00e-14	70.90
IUUC-Cja-018842	Callithrix jacchus	30.53	5.00e-24	103.00
IUUC-Cfa-020708	Canis familiaris	31.30	1.00e-23	102.00
IUUC-Cpo-021469	Cavia porcellus	29.65	4.00e-23	100.00
IUUC-Csa-024109	Chlorocebus sabaeus	30.97	7.00e-24	102.00
IUUC-Cin-025576	Ciona intestinalis	30.00	2.00e-24	104.00
IUUC-Cne-027041	Cryptococcus neoformans	34.51	1.00e-17	82.40
IUUC-Dno-029167	Dasypus novemcinctus	29.96	1.00e-23	102.00
IUUC-Dor-030470	Dipodomys ordii	48.15	5.00e-20	89.70
IUUC-Eeu-035251	Erinaceus europaeus	31.82	8.00e-27	112.00
IUUC-Fca-035982	Felis catus	30.53	1.00e-23	102.00
IUUC-Fal-036938	Ficedula albicollis	35.07	5.00e-26	109.00
IUUC-Gga-040796	Gallus gallus	33.18	1.00e-25	108.00
IUUC-Hsa-046552	Homo sapiens	30.49	3.00e-26	110.00
IUUC-Itr-048359	Ictidomys tridecemlineatus	32.13	2.00e-23	100.00
IUUC-Lch-050291	Latimeria chalumnae	38.00	3.00e-24	103.00
IUUC-Loc-052254	Lepisosteus oculatus	29.27	5.00e-24	103.00
IUUC-Laf-053334	Loxodonta africana	31.86	1.00e-24	105.00
IUUC-Mcc-055257	Macaca mulatta	30.97	5.00e-24	103.00
IUUC-Meu-056613	Macropus eugenii	31.09	2.00e-23	100.00
IUUC-Mga-059647	Meleagris gallopavo	30.36	1.00e-25	108.00
IUUC-Mvi-060210	Microbotryum violaceum	37.50	1.00e-17	82.40
IUUC-Mmr-061119	Microcebus murinus	31.42	6.00e-24	102.00
IUUC-Mdo-062819	Monodelphis domestica	30.04	4.00e-22	96.70
IUUC-Mpu-066654	Mustela putorius furo	30.53	2.00e-23	101.00
IUUC-Mlu-067875	Myotis lucifugus	30.97	4.00e-24	103.00
IUUC-Nle-069290	Nomascus leucogenys	30.97	3.00e-24	103.00
IUUC-Opr-070348	Ochotona princeps	31.63	1.00e-20	92.00
IUUC-Oan-072693	Ornithorhynchus anatinus	28.57	5.00e-26	109.00
IUUC-Ocu-074103	Oryctolagus cuniculus	35.71	5.00e-20	89.70
IUUC-Oga-089096	Otolemur garnettii	31.14	2.00e-24	104.00
IUUC-Oar-089389	Ovis aries	29.46	1.00e-23	102.00
IUUC-Ptr-090483	Pan troglodytes	31.42	8.00e-25	105.00
IUUC-Pan-091915	Papio anubis	45.05	9.00e-21	91.70
IUUC-Psi-093034	Pelodiscus sinensis	31.72	7.00e-25	105.00
IUUC-Pab-097969	Pongo abelii	30.53	4.00e-24	103.00
IUUC-Pca-100381	Procavia capensis	32.47	8.00e-27	112.00
IUUC-Sha-106604	Sarcophilus harrisii	33.18	2.00e-25	107.00
IUUC-Sar-113535	Sorex araneus	31.03	5.00e-21	93.20
IUUC-Sre-115228	Sporisorium reilianum	29.02	6.00e-18	83.60
IUUC-Ssc-115947	Sus scrofa	29.65	6.00e-22	96.30
IUUC-Tgu-117085	Taeniopygia guttata	34.12	6.00e-26	109.00
IUUC-Ttr-129277	Tursiops truncatus	43.96	3.00e-20	90.50
IUUC-Uma-129603	Ustilago maydis	29.47	1.00e-17	82.40
IUUC-Vpa-130349	Vicugna pacos	41.67	9.00e-20	89.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence