iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108093

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin homeostasis protein lub1

Genbank Nucleotide ID

CU329671

Gene Name

lub1; SPBC887.04c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC887.04c	SPBC887.04c.1	SPBC887.04c.1:pep

Annotation

mRNA Expression
GEO
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/PFU	PFU	14993272

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.10e-26	88.5	218	248
UBD/Beta-Prp	1.30e-44	150.6	11	290
UBD/PFU	2.20e-51	170.3	353	448

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gHt+ v++l + ++  l++s++ D ti++W 
   Q: 218  GHTSFVYSLTYiHNqQLIASCGEDRTIRIWK 248
           8*********99666***************8 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl.sgheaevtavkfspdgk.....ilvtgseDrtikvwdlstgkcvhtlk 91
            gh+++v  +  +  +++l+ ++srdgt  vw+  +g     + ++he++v++v++ p  +     ++ +g++D+   + ++ t+++ + l 
   Q: 11   GGHKQDVRGVCSI--SNELIGSASRDGTYSVWEQINGEWTPHFyENHEGFVNCVCYVPAIDknsrgYIFSGGQDKCGILQEVGTNSPSYYLF 100
           5677777775555..8999******************99988889**********97766666778*********99999************ PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsv 183
           ghe++++s s    ++++++Gs+d+t+rvw    gqc + +l+gh+++v+ v   + ++++++Gs+D+ +++W+   +kl++     h+d v
   Q: 101  GHESNICSASALN-SETIITGSWDSTARVW--ALGQCKY-VLKGHQSSVWAVLALG-EDIFITGSADKLIKIWNG--EKLVKSILA-HNDCV 184
           *********9998.99**************..5689999.9***********9999.89**************87..9******98.***** PP
   S: 184  yslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsf 275
           +sl   + g  ++s+s+dg +klw    ge +++l+ght++v+s+    n+++++s+++D++iriW  + +++l++++l+ +sv+sv+   +
   Q: 185  RSLCQIPGG--FASCSNDGVIKLWTS-DGEFLYELHGHTSFVYSLTYIHNQQLIASCGEDRTIRIW--KGKECLQCITLPTTSVWSVSS--L 269
           ****99965..*************87.999************************************..89******************9..8 PP
   S: 276  gdnvlvlgsedskvniwklkk 296
            +  lv gs+d+ v+i+ ++k
   Q: 270  PNGDLVCGSSDGFVRIFTVDK 290
           8999*************9876 PP

UBD/PFU

   S: 1    qwsvsesewkkiGdvvgasGnnkkvlfeGkeydyvfdvdvedGkpplklpynvsdnpylaadnfleknelplsyldqvvkfilkntkGqsle 92
           qws++e+ewkkiG+vv+a+Gnn+k+lfeGkeydyvfdvdv+dG++plklpyn+++npy+aa++fle n+lplsy+d+vvkfi+knt+G+sle
   Q: 353  QWSQKENEWKKIGQVVDAVGNNRKQLFEGKEYDYVFDVDVADGQAPLKLPYNATENPYQAANRFLELNQLPLSYTDEVVKFIEKNTQGHSLE 444
           8******************************************************************************************* PP
   S: 93   lkne 96
           +k+e
   Q: 445  SKKE 448
           9986 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Acts as a negative regulator of vacuole-dependent ubiquitin degradation.

Protein Sequence
(Fasta)

MTSYELSREL GGHKQDVRGV CSISNELIGS ASRDGTYSVW EQINGEWTPH FYENHEGFVN 60
CVCYVPAIDK NSRGYIFSGG QDKCGILQEV GTNSPSYYLF GHESNICSAS ALNSETIITG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTAGAAGTA ATCTTTTAAG GGATTCTAAC GATGTCAATG ATATCAAGTT GTTCCTATGT 60
ATAAGCTGTG AAAGCCTGTT TAACTTCCTT CTGCGAAAAG CAAATATACC TTTATATTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR033510--PLAA/Doa1/Lub1
IPR015155--PLAA_fam_Ub-bd_PFU
IPR013535--PUL_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS51394--PFU
PS51396--PUL
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF09070--PFU
PF08324--PUL
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0043130--F:ubiquitin binding
GO:0006281--P:DNA repair
GO:0016574--P:histone ubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0010992--P:ubiquitin homeostasis

KEGG

spo:SPBC887.04c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000146	Aegilops tauschii	30.99	1.00e-87	315.00
IUUC-Aml-002125	Ailuropoda melanoleuca	34.52	4.00e-102	363.00
IUUC-Atr-002554	Amborella trichopoda	29.74	1.00e-81	295.00
IUUC-Apl-004094	Anas platyrhynchos	42.79	2.00e-92	331.00
IUUC-Aca-004726	Anolis carolinensis	39.56	2.00e-93	335.00
IUUC-Aly-005961	Arabidopsis lyrata	30.07	1.00e-86	312.00
IUUC-Ath-006639	Arabidopsis thaliana	30.21	1.00e-87	315.00
IUUC-Ago-007772	Ashbya gossypii	37.64	3.00e-113	400.00
IUUC-Acl-008316	Aspergillus clavatus	34.75	2.00e-103	367.00
IUUC-Afl-008532	Aspergillus flavus	34.94	2.00e-104	371.00
IUUC-Afu-008950	Aspergillus fumigatus	35.99	8.00e-105	372.00
IUUC-Ani-009186	Aspergillus nidulans	36.00	3.00e-112	397.00
IUUC-Ang-009575	Aspergillus niger	34.75	2.00e-109	388.00
IUUC-Aor-010086	Aspergillus oryzae	34.94	2.00e-104	371.00
IUUC-Ate-010541	Aspergillus terreus	33.33	2.00e-100	358.00
IUUC-Ame-011633	Astyanax mexicanus	40.31	8.00e-99	352.00
IUUC-Bgr-012292	Blumeria graminis	34.05	2.00e-103	367.00
IUUC-Bta-013218	Bos taurus	34.83	2.00e-102	364.00
IUUC-Bci-013876	Botrytis cinerea	35.19	4.00e-111	393.00
IUUC-Bdi-014810	Brachypodium distachyon	33.47	2.00e-100	358.00
IUUC-Bol-016006	Brassica oleracea	30.46	4.00e-90	323.00
IUUC-Bra-017593	Brassica rapa	31.02	2.00e-91	328.00
IUUC-Cel-018703	Caenorhabditis elegans	27.62	3.00e-39	154.00
IUUC-Cja-019270	Callithrix jacchus	34.52	1.00e-102	365.00
IUUC-Cfa-021262	Canis familiaris	34.34	4.00e-102	363.00
IUUC-Cpo-021449	Cavia porcellus	39.26	3.00e-86	310.00
IUUC-Csa-024140	Chlorocebus sabaeus	33.69	2.00e-100	358.00
IUUC-Cho-024923	Choloepus hoffmanni	39.15	3.00e-43	167.00
IUUC-Cin-025373	Ciona intestinalis	32.52	7.00e-106	375.00
IUUC-Csv-026324	Ciona savignyi	38.48	6.00e-90	323.00
IUUC-Cgl-026711	Colletotrichum gloeosporioides	31.88	2.00e-96	344.00
IUUC-Cne-026998	Cryptococcus neoformans	38.00	6.00e-82	296.00
IUUC-Cme-027154	Cyanidioschyzon merolae	33.33	9.00e-55	206.00
IUUC-Dre-028674	Danio rerio	41.06	3.00e-99	353.00
IUUC-Dno-028966	Dasypus novemcinctus	41.72	3.00e-99	354.00
IUUC-Dor-030343	Dipodomys ordii	44.71	5.00e-37	147.00
IUUC-Dse-031385	Dothistroma septosporum	31.08	2.00e-88	318.00
IUUC-Dme-032044	Drosophila melanogaster	38.77	7.00e-84	303.00
IUUC-Ete-032506	Echinops telfairi	42.94	2.00e-35	142.00
IUUC-Eca-033547	Equus caballus	34.57	1.00e-102	365.00
IUUC-Eeu-034462	Erinaceus europaeus	38.30	2.00e-40	158.00
IUUC-Fca-035893	Felis catus	34.56	2.00e-101	361.00
IUUC-Fal-037235	Ficedula albicollis	41.14	5.00e-98	350.00
IUUC-Fox-037836	Fusarium oxysporum	35.18	3.00e-109	387.00
IUUC-Fso-038251	Fusarium solani	34.91	4.00e-104	370.00
IUUC-Gmo-038648	Gadus morhua	34.84	5.00e-97	346.00
IUUC-Ggr-039867	Gaeumannomyces graminis	30.93	5.00e-96	343.00
IUUC-Gga-040989	Gallus gallus	33.56	1.00e-100	358.00
IUUC-Gac-041344	Gasterosteus aculeatus	41.50	2.00e-92	331.00
IUUC-Gma-043067	Glycine max	30.26	1.00e-85	308.00
IUUC-Ggo-045009	Gorilla gorilla	41.32	2.00e-97	347.00
IUUC-Hsa-046807	Homo sapiens	34.08	1.00e-100	358.00
IUUC-Itr-048636	Ictidomys tridecemlineatus	33.55	1.00e-99	355.00
IUUC-Kpa-049134	Komagataella pastoris	37.57	1.00e-111	395.00
IUUC-Lch-049597	Latimeria chalumnae	39.87	5.00e-88	316.00
IUUC-Lpe-050821	Leersia perrieri	31.43	3.00e-93	334.00
IUUC-Loc-051849	Lepisosteus oculatus	40.79	1.00e-97	348.00
IUUC-Lma-053297	Leptosphaeria maculans	36.16	2.00e-109	387.00
IUUC-Laf-053495	Loxodonta africana	41.94	2.00e-99	354.00
IUUC-Meu-055983	Macropus eugenii	39.25	9.00e-37	146.00
IUUC-Mor-057006	Magnaporthe oryzae	32.03	4.00e-97	347.00
IUUC-Mpo-057465	Magnaporthe poae	29.86	3.00e-91	327.00
IUUC-Mtr-058374	Medicago truncatula	30.06	7.00e-91	326.00
IUUC-Mla-058895	Melampsora laricipopulina	39.96	4.00e-94	336.00
IUUC-Mvi-060297	Microbotryum violaceum	35.35	2.00e-117	414.00
IUUC-Mmr-060810	Microcebus murinus	32.29	6.00e-86	310.00
IUUC-Mdo-062671	Monodelphis domestica	41.06	4.00e-96	343.00
IUUC-Mmu-063536	Mus musculus	33.86	9.00e-98	349.00
IUUC-Mac-064902	Musa acuminata	30.14	6.00e-91	326.00
IUUC-Mpu-066085	Mustela putorius furo	34.83	7.00e-103	366.00
IUUC-Mlu-067907	Myotis lucifugus	41.06	7.00e-96	342.00
IUUC-Nfi-068457	Neosartorya fischeri	48.09	3.00e-86	310.00
IUUC-Ncr-068622	Neurospora crassa	31.07	1.00e-97	348.00
IUUC-Nle-069049	Nomascus leucogenys	34.17	7.00e-99	353.00
IUUC-Opr-071013	Ochotona princeps	40.00	1.00e-30	126.00
IUUC-Ont-071339	Oreochromis niloticus	40.84	5.00e-97	347.00
IUUC-Oan-073353	Ornithorhynchus anatinus	43.26	7.00e-47	178.00
IUUC-Ocu-074625	Oryctolagus cuniculus	34.40	3.00e-102	363.00
IUUC-Oba-075226	Oryza barthii	28.07	3.00e-73	267.00
IUUC-Obr-076875	Oryza brachyantha	31.87	2.00e-98	351.00
IUUC-Ogl-077057	Oryza glaberrima	31.42	6.00e-96	343.00
IUUC-Ogu-078156	Oryza glumaepatula	31.28	1.00e-95	342.00
IUUC-Oin-079373	Oryza indica	31.28	1.00e-94	338.00
IUUC-Olo-080849	Oryza longistaminata	29.18	3.00e-64	238.00
IUUC-Ome-081654	Oryza meridionalis	28.07	4.00e-73	267.00
IUUC-Oni-082221	Oryza nivara	28.45	2.00e-74	271.00
IUUC-Opu-084103	Oryza punctata	28.28	6.00e-73	266.00
IUUC-Oru-084751	Oryza rufipogon	27.93	5.00e-72	263.00
IUUC-Osa-085584	Oryza sativa	31.69	1.00e-94	338.00
IUUC-Ola-086974	Oryzias latipes	41.72	6.00e-97	346.00
IUUC-Oga-088052	Otolemur garnettii	32.40	7.00e-89	319.00
IUUC-Oar-089509	Ovis aries	34.51	6.00e-101	359.00
IUUC-Ptr-090911	Pan troglodytes	34.08	1.00e-100	358.00
IUUC-Pan-092141	Papio anubis	41.32	2.00e-98	351.00
IUUC-Psi-093543	Pelodiscus sinensis	33.05	1.00e-95	342.00
IUUC-Pno-094952	Phaeosphaeria nodorum	36.14	1.00e-104	372.00
IUUC-Ppa-095881	Physcomitrella patens	31.46	6.00e-93	333.00
IUUC-Pfo-096739	Poecilia formosa	39.21	3.00e-90	324.00
IUUC-Pab-098641	Pongo abelii	33.68	3.00e-101	360.00
IUUC-Pop-099493	Populus trichocarpa	31.21	1.00e-89	322.00
IUUC-Pca-100599	Procavia capensis	37.81	2.00e-77	281.00
IUUC-Ppe-101874	Prunus persica	32.12	3.00e-87	313.00
IUUC-Pva-103009	Pteropus vampyrus	43.19	2.00e-80	291.00
IUUC-Pgr-103260	Puccinia graminis	35.31	6.00e-116	409.00
IUUC-Ptt-103711	Puccinia triticina	33.33	3.00e-97	347.00
IUUC-Pte-104337	Pyrenophora teres	35.59	5.00e-100	356.00
IUUC-Pyt-104475	Pyrenophora triticirepentis	35.69	1.00e-100	358.00
IUUC-Rno-105273	Rattus norvegicus	33.38	6.00e-99	353.00
IUUC-Sce-106351	Saccharomyces cerevisiae	36.19	4.00e-96	343.00
IUUC-Sha-106758	Sarcophilus harrisii	40.53	2.00e-94	338.00
IUUC-Sja-107687	Schizosaccharomyces japonicus	48.89	0.00e+00	704.00
IUUC-Ssl-108623	Sclerotinia sclerotiorum	34.01	5.00e-104	370.00
IUUC-Smo-109368	Selaginella moellendorffii	32.69	5.00e-94	337.00
IUUC-Sit-109699	Setaria italica	31.51	8.00e-96	342.00
IUUC-Sly-111063	Solanum lycopersicum	31.81	6.00e-85	306.00
IUUC-Sar-113199	Sorex araneus	40.86	5.00e-82	297.00
IUUC-Sbi-114745	Sorghum bicolor	31.27	4.00e-91	327.00
IUUC-Sre-115080	Sporisorium reilianum	43.94	2.00e-105	374.00
IUUC-Ssc-115666	Sus scrofa	34.52	3.00e-103	367.00
IUUC-Tgu-116877	Taeniopygia guttata	41.10	1.00e-96	345.00
IUUC-Tru-117580	Takifugu rubripes	41.72	2.00e-100	358.00
IUUC-Tsy-118946	Tarsius syrichta	34.05	5.00e-95	340.00
IUUC-Tni-119755	Tetraodon nigroviridis	33.79	5.00e-102	363.00
IUUC-Tca-120977	Theobroma cacao	30.39	7.00e-89	319.00
IUUC-Tre-122217	Trichoderma reesei	34.28	1.00e-107	382.00
IUUC-Tvi-122671	Trichoderma virens	33.47	8.00e-105	372.00
IUUC-Tae-125581	Triticum aestivum	33.01	4.00e-100	357.00
IUUC-Tur-126404	Triticum urartu	30.77	2.00e-24	105.00
IUUC-Tme-126971	Tuber melanosporum	38.84	1.00e-134	471.00
IUUC-Tbe-127858	Tupaia belangeri	38.89	9.00e-30	123.00
IUUC-Ttr-128173	Tursiops truncatus	34.70	4.00e-101	360.00
IUUC-Uma-129322	Ustilago maydis	43.85	1.00e-105	375.00
IUUC-Vda-129682	Verticillium dahliae	34.19	1.00e-103	368.00
IUUC-Vpa-130607	Vicugna pacos	34.23	1.00e-97	348.00
IUUC-Vvi-131153	Vitis vinifera	32.19	1.00e-96	345.00
IUUC-Xtr-132208	Xenopus tropicalis	41.28	3.00e-95	341.00
IUUC-Xma-133098	Xiphophorus maculatus	40.14	6.00e-92	330.00
IUUC-Yli-134646	Yarrowia lipolytica	37.77	3.00e-103	367.00
IUUC-Zma-135920	Zea mays	28.17	4.00e-78	283.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence