iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013124

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Rab5 GDP/GTP exchange factor; Rabex-5

Genbank Nucleotide ID

AJ001119

Gene Name

RABGEF1; RABEX5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000003842.5	ENSBTAT00000005011.5	ENSBTAP00000005011.5

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/ZnF_A20	ZnF_A20	16407276; 16462746
UBD/Alpha-Helix/MIU	MIU	16407276; 16462746

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/MIU	3.10e-08	33.5	47	70
UBD/ZnF/ZnF_A20	1.00e-18	67.1	13	47

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/MIU

   S: 1    rqkQprtDlELAqqLQqEeyqqfa 24
           rqkQ+++D+ELA++LQ+Ee+++fa
   Q: 47   RQKQIQEDWELAERLQREEEEAFA 70
           8********************986 PP

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkkgCgfYGnpetngyCSkCyreelrrrr 35
           d+s+llCkkgCg+YGnp+++g+CSkC+ree++++r
   Q: 13   DQSELLCKKGCGYYGNPAWQGFCSKCWREEYHKAR 47
           79*******************************86 PP

Organism

Bos taurus

Functional Description
(View)

Rab effector protein acting as linker between gamma-adaptin and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.

Protein Sequence
(Fasta)

MSLKSERRGI HVDQSELLCK KGCGYYGNPA WQGFCSKCWR EEYHKARQKQ IQEDWELAER 60
LQREEEEAFA SSQSSQGAQS LTFSKFEEKK TNEKTRKVTT VKKFFSASSR VGAKKEIQEA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCAGGAGGA AGATGAGCCT TAAGTCTGAA CGCCGAGGAA TTCATGTGGA TCAGTCGGAG 60
CTCCTATGCA AGAAAGGATG TGGTTACTAC GGCAACCCTG CTTGGCAGGG TTTCTGCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0254--Endocytosis
KW-0967--Endosome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003123--VPS9
IPR002653--Znf_A20

PROSITE

PS51205--VPS9
PS51036--ZF_A20

Pfam

PF02204--VPS9
PF01754--zf-A20

SMART

SM00167--VPS9
SM00259--ZnF_A20

Gene Ontology

GO:0005769--C:early endosome
GO:0055037--C:recycling endosome
GO:0003677--F:DNA binding
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0015031--P:protein transport

KEGG

bta:282335

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000198	Aegilops tauschii	31.96	2.00e-20	94.00
IUUC-Aml-001771	Ailuropoda melanoleuca	88.21	0.00e+00	754.00
IUUC-Atr-003154	Amborella trichopoda	36.52	2.00e-22	100.00
IUUC-Apl-004018	Anas platyrhynchos	92.07	0.00e+00	848.00
IUUC-Aca-005227	Anolis carolinensis	23.47	3.00e-09	57.40
IUUC-Aly-006138	Arabidopsis lyrata	35.45	1.00e-24	107.00
IUUC-Ath-006747	Arabidopsis thaliana	34.92	2.00e-24	107.00
IUUC-Ago-007776	Ashbya gossypii	30.00	7.00e-24	104.00
IUUC-Acl-008235	Aspergillus clavatus	31.12	1.00e-28	122.00
IUUC-Afl-008570	Aspergillus flavus	32.12	2.00e-31	130.00
IUUC-Afu-008815	Aspergillus fumigatus	29.66	2.00e-29	124.00
IUUC-Ani-009381	Aspergillus nidulans	30.39	1.00e-29	124.00
IUUC-Ang-009615	Aspergillus niger	30.82	1.00e-31	130.00
IUUC-Aor-010195	Aspergillus oryzae	31.79	5.00e-32	132.00
IUUC-Ate-010514	Aspergillus terreus	31.82	3.00e-30	126.00
IUUC-Ame-011365	Astyanax mexicanus	66.34	0.00e+00	672.00
IUUC-Bgr-012102	Blumeria graminis	28.75	1.00e-29	125.00
IUUC-Bci-013943	Botrytis cinerea	30.50	9.00e-30	125.00
IUUC-Bdi-014539	Brachypodium distachyon	33.94	5.00e-26	112.00
IUUC-Bol-016580	Brassica oleracea	35.14	5.00e-30	125.00
IUUC-Bra-017843	Brassica rapa	34.68	8.00e-30	124.00
IUUC-Cel-018199	Caenorhabditis elegans	34.10	1.00e-59	223.00
IUUC-Cja-019941	Callithrix jacchus	97.35	0.00e+00	885.00
IUUC-Cfa-020845	Canis familiaris	98.04	0.00e+00	818.00
IUUC-Cpo-022037	Cavia porcellus	96.33	0.00e+00	875.00
IUUC-Cre-022696	Chlamydomonas reinhardtii	32.49	2.00e-21	97.40
IUUC-Csa-023272	Chlorocebus sabaeus	96.54	0.00e+00	880.00
IUUC-Cho-025076	Choloepus hoffmanni	85.74	0.00e+00	743.00
IUUC-Cin-025400	Ciona intestinalis	45.22	2.00e-116	412.00
IUUC-Csv-025941	Ciona savignyi	37.63	8.00e-86	311.00
IUUC-Cgl-026725	Colletotrichum gloeosporioides	29.08	4.00e-27	116.00
IUUC-Cne-027057	Cryptococcus neoformans	31.42	3.00e-34	140.00
IUUC-Dre-028484	Danio rerio	71.29	0.00e+00	677.00
IUUC-Dno-028906	Dasypus novemcinctus	97.76	0.00e+00	875.00
IUUC-Dor-030124	Dipodomys ordii	86.33	0.00e+00	753.00
IUUC-Dse-031437	Dothistroma septosporum	28.32	8.00e-26	112.00
IUUC-Dme-031696	Drosophila melanogaster	32.36	9.00e-68	251.00
IUUC-Ete-032573	Echinops telfairi	92.00	0.00e+00	717.00
IUUC-Eca-033711	Equus caballus	98.78	0.00e+00	900.00
IUUC-Eeu-034459	Erinaceus europaeus	73.79	2.00e-79	290.00
IUUC-Fca-035447	Felis catus	95.72	0.00e+00	905.00
IUUC-Fal-036605	Ficedula albicollis	88.71	0.00e+00	787.00
IUUC-Fox-037967	Fusarium oxysporum	26.71	3.00e-18	87.00
IUUC-Fso-038110	Fusarium solani	29.68	8.00e-29	122.00
IUUC-Gmo-038785	Gadus morhua	67.19	0.00e+00	681.00
IUUC-Ggr-039760	Gaeumannomyces graminis	30.69	3.00e-27	117.00
IUUC-Gga-040584	Gallus gallus	92.68	0.00e+00	852.00
IUUC-Gac-042469	Gasterosteus aculeatus	64.19	1.00e-167	582.00
IUUC-Gma-044237	Glycine max	37.43	5.00e-26	112.00
IUUC-Ggo-044498	Gorilla gorilla	83.33	0.00e+00	731.00
IUUC-Hsa-046625	Homo sapiens	97.35	0.00e+00	886.00
IUUC-Hvu-047155	Hordeum vulgare	37.78	2.00e-26	113.00
IUUC-Itr-048753	Ictidomys tridecemlineatus	96.74	0.00e+00	880.00
IUUC-Kpa-049160	Komagataella pastoris	29.05	2.00e-24	107.00
IUUC-Lch-050529	Latimeria chalumnae	78.88	0.00e+00	855.00
IUUC-Lpe-051024	Leersia perrieri	34.39	2.00e-28	120.00
IUUC-Loc-052644	Lepisosteus oculatus	70.20	0.00e+00	669.00
IUUC-Lma-053102	Leptosphaeria maculans	30.65	2.00e-27	117.00
IUUC-Laf-054337	Loxodonta africana	95.11	0.00e+00	870.00
IUUC-Mcc-055659	Macaca mulatta	96.97	3.00e-179	620.00
IUUC-Meu-056084	Macropus eugenii	75.57	2.00e-93	336.00
IUUC-Mor-057255	Magnaporthe oryzae	29.60	1.00e-26	115.00
IUUC-Mpo-057454	Magnaporthe poae	30.69	5.00e-29	122.00
IUUC-Mtr-058098	Medicago truncatula	34.55	3.00e-30	126.00
IUUC-Mla-059068	Melampsora laricipopulina	29.79	3.00e-31	129.00
IUUC-Mga-059624	Meleagris gallopavo	79.03	0.00e+00	843.00
IUUC-Mvi-060282	Microbotryum violaceum	28.62	4.00e-26	113.00
IUUC-Mmr-061142	Microcebus murinus	97.96	0.00e+00	897.00
IUUC-Mdo-062289	Monodelphis domestica	93.08	0.00e+00	902.00
IUUC-Mmu-063961	Mus musculus	96.33	0.00e+00	877.00
IUUC-Mac-065188	Musa acuminata	33.07	7.00e-23	101.00
IUUC-Mpu-066291	Mustela putorius furo	96.95	0.00e+00	881.00
IUUC-Mlu-067431	Myotis lucifugus	93.50	0.00e+00	848.00
IUUC-Nfi-068422	Neosartorya fischeri	30.79	5.00e-30	126.00
IUUC-Ncr-068843	Neurospora crassa	29.89	2.00e-28	121.00
IUUC-Nle-069079	Nomascus leucogenys	96.74	0.00e+00	880.00
IUUC-Opr-070790	Ochotona princeps	92.59	3.00e-56	213.00
IUUC-Ont-071789	Oreochromis niloticus	67.65	4.00e-179	620.00
IUUC-Oan-072946	Ornithorhynchus anatinus	90.26	0.00e+00	816.00
IUUC-Ocu-073816	Oryctolagus cuniculus	97.97	0.00e+00	886.00
IUUC-Oba-075738	Oryza barthii	33.15	3.00e-17	82.80
IUUC-Obr-076355	Oryza brachyantha	37.91	3.00e-27	116.00
IUUC-Ogl-077592	Oryza glaberrima	28.35	8.00e-27	114.00
IUUC-Ogu-078197	Oryza glumaepatula	28.35	1.00e-26	114.00
IUUC-Oin-080047	Oryza indica	37.22	2.00e-25	110.00
IUUC-Olo-080317	Oryza longistaminata	28.35	1.00e-26	113.00
IUUC-Ome-081589	Oryza meridionalis	37.22	6.00e-26	112.00
IUUC-Oni-082700	Oryza nivara	33.15	3.00e-17	83.20
IUUC-Opu-083923	Oryza punctata	34.36	2.00e-21	95.90
IUUC-Oru-084318	Oryza rufipogon	33.15	3.00e-17	83.20
IUUC-Osa-086246	Oryza sativa	38.98	1.00e-06	43.90
IUUC-Ola-086730	Oryzias latipes	56.79	1.00e-150	526.00
IUUC-Olu-087719	Ostreococcus lucimarinus	34.46	2.00e-23	103.00
IUUC-Oga-088992	Otolemur garnettii	84.86	0.00e+00	885.00
IUUC-Oar-089789	Ovis aries	99.39	0.00e+00	896.00
IUUC-Ptr-091636	Pan troglodytes	97.35	0.00e+00	885.00
IUUC-Pan-092911	Papio anubis	96.74	0.00e+00	880.00
IUUC-Psi-093194	Pelodiscus sinensis	79.65	0.00e+00	842.00
IUUC-Pma-094212	Petromyzon marinus	48.49	3.00e-115	408.00
IUUC-Pno-094831	Phaeosphaeria nodorum	29.89	3.00e-27	117.00
IUUC-Ppa-095705	Physcomitrella patens	34.39	1.00e-28	121.00
IUUC-Pfo-096694	Poecilia formosa	65.42	1.00e-180	625.00
IUUC-Pab-097706	Pongo abelii	97.15	0.00e+00	884.00
IUUC-Pop-099891	Populus trichocarpa	32.84	8.00e-26	111.00
IUUC-Pca-100879	Procavia capensis	94.37	8.00e-93	333.00
IUUC-Ppe-101334	Prunus persica	33.78	2.00e-26	113.00
IUUC-Pva-103225	Pteropus vampyrus	82.63	0.00e+00	721.00
IUUC-Pgr-103564	Puccinia graminis	30.38	4.00e-31	129.00
IUUC-Ptt-103802	Puccinia triticina	30.23	4.00e-26	112.00
IUUC-Pte-104345	Pyrenophora teres	29.52	2.00e-27	118.00
IUUC-Pyt-104716	Pyrenophora triticirepentis	30.60	2.00e-28	120.00
IUUC-Rno-106101	Rattus norvegicus	95.93	0.00e+00	876.00
IUUC-Sce-106460	Saccharomyces cerevisiae	30.38	1.00e-24	107.00
IUUC-Sha-106919	Sarcophilus harrisii	78.62	0.00e+00	842.00
IUUC-Sja-107880	Schizosaccharomyces japonicus	32.17	7.00e-30	125.00
IUUC-Spo-108087	Schizosaccharomyces pombe	29.84	2.00e-27	117.00
IUUC-Ssl-108614	Sclerotinia sclerotiorum	29.82	2.00e-07	51.60
IUUC-Smo-109411	Selaginella moellendorffii	37.14	2.00e-28	120.00
IUUC-Sit-110678	Setaria italica	37.22	3.00e-26	112.00
IUUC-Sly-111526	Solanum lycopersicum	37.85	2.00e-25	110.00
IUUC-Stu-112494	Solanum tuberosum	38.42	5.00e-26	112.00
IUUC-Sar-112929	Sorex araneus	98.91	1.00e-164	573.00
IUUC-Sbi-114242	Sorghum bicolor	32.94	4.00e-28	119.00
IUUC-Sre-115224	Sporisorium reilianum	31.79	4.00e-30	127.00
IUUC-Ssc-115239	Sus scrofa	98.37	0.00e+00	894.00
IUUC-Tgu-117499	Taeniopygia guttata	90.43	0.00e+00	831.00
IUUC-Tru-118027	Takifugu rubripes	64.14	6.00e-144	504.00
IUUC-Tsy-119462	Tarsius syrichta	97.69	0.00e+00	867.00
IUUC-Tni-120855	Tetraodon nigroviridis	64.54	1.00e-174	605.00
IUUC-Tca-121213	Theobroma cacao	33.03	5.00e-25	108.00
IUUC-Tre-122186	Trichoderma reesei	29.32	2.00e-28	120.00
IUUC-Tvi-122541	Trichoderma virens	27.97	7.00e-29	122.00
IUUC-Tae-123631	Triticum aestivum	34.24	3.00e-27	116.00
IUUC-Tur-126572	Triticum urartu	31.77	1.00e-26	114.00
IUUC-Tme-127023	Tuber melanosporum	32.93	1.00e-31	131.00
IUUC-Tbe-127453	Tupaia belangeri	97.66	0.00e+00	782.00
IUUC-Ttr-128526	Tursiops truncatus	98.78	0.00e+00	897.00
IUUC-Uma-129660	Ustilago maydis	32.56	2.00e-30	127.00
IUUC-Vda-129737	Verticillium dahliae	28.33	4.00e-24	106.00
IUUC-Vpa-130505	Vicugna pacos	91.95	0.00e+00	722.00
IUUC-Vvi-131088	Vitis vinifera	37.08	1.00e-23	104.00
IUUC-Xtr-132799	Xenopus tropicalis	80.49	0.00e+00	746.00
IUUC-Xma-133345	Xiphophorus maculatus	65.82	3.00e-176	611.00
IUUC-Yli-134416	Yarrowia lipolytica	30.97	4.00e-32	132.00
IUUC-Zma-134750	Zea mays	37.22	6.00e-26	112.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence