iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001742

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ACTA01161100

Gene Name

USP33

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000007257.1	ENSAMET00000008006.1	ENSAMEP00000007685.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.10e-114	382.3	185	717

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tGlkN+gNtCYmN++LQ+Lsn+p+l++++l+     +   +++++k +++ks+ kl++elw ks+ ++v p++l++ +k++++ f+gy+
   Q: 185  TGLKNIGNTCYMNAALQALSNCPPLTQFFLD-----CGGLARTDKKPAICKSYLKLMTELWhKSRPGSVVPTTLFQGIKTVNPTFRGYS 268
           7******************************.....999999*******************99************************** PP
   S: 89   qqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsde........................................ 129
           qqDaqEfl++l+d l+eelk+         ++ ++ee++eedks+++ +                                        
   Q: 269  QQDAQEFLRCLMDLLHEELKEqvmeveedPQTITTEETMEEDKSQSDVDfqscescsssdkaenengsrgfsednnettmliqddenns 357
           *******************8899998887777777777788877777779*************************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 358  emskdwqkekmcnkinkvnsegeldkdrdsvsetvdlnnqetvkvqihsraseyitdvhlndlstsqilpsnegvnprlsasppksgnl 446
           ***************************************************************************************** PP
   S: 130  ...................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.............. 185
                              +++k++kk++s+isd+F+g++ s+++cl+cd+vs++ e+f+dlslp+pgke+ +k+              
   Q: 447  wpglapthkkvlaqsasspKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLhssshptsivkags 535
           *******************9**************************************************99888************** PP
   S: 186  ...................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsf 239
                                              +lqdcL++f++++el+g+n+y+cekckk+++ +k +k++k+Pe+L++hLkRf  
   Q: 536  cgeayapqgwiaffmeyvkrfvvscvpswfwgpivTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQKFPEILCIHLKRF-- 622
           ***************************************************************************************.. PP
   S: 240  seeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleet 326
           ++e ++++ki+++v+fple Ldl+pf+++++  q   ++Y+L++v++H+G++ssGHY+ay++n+ ++ W++fdD++Vtev+e++v++  
   Q: 623  RHELMFSTKISTHVSFPLEgLDLQPFLAKDSPVQ--IVTYDLLSVICHHGTASSGHYIAYCRNNLNNlWYEFDDQSVTEVSESTVQN-- 707
           9999*************************77776..9**************************88889*******************.. PP
   S: 327  gstaYvlfYkr 337
            ++aYvlfY++
   Q: 708  -AEAYVLFYRK 717
           .********98 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

INSVRLQSLV LTHKVLPHLE ILGRQEKISN RMAAFRNHCP HLDSVGEITK DDLIQKSHGT 60
CQDCKVRGPN LWACLENRCS YVGCGESQVD HSTIHSQETK HYLTVNLTTL RVWCYACSKE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCAATTCTG TTAGACTTCA GAGTCTTGTT CTTACCCATA AGATACATAG GTAGATCGAA 60
ATCCTTGTTC TGCCAAATGC TAACAATGGG AAGTCAGTCA GATTTGCCTC TCTTAGCCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005776--C:autophagosome
GO:0044297--C:cell body
GO:0005813--C:centrosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0007411--P:axon guidance
GO:0016477--P:cell migration
GO:0009267--P:cellular response to starvation
GO:0051298--P:centrosome duplication
GO:0032091--P:negative regulation of protein binding
GO:0032092--P:positive regulation of protein binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003987	Anas platyrhynchos	81.82	0.00e+00	1478.00
IUUC-Aca-004713	Anolis carolinensis	76.69	0.00e+00	1404.00
IUUC-Bta-013132	Bos taurus	97.27	0.00e+00	1785.00
IUUC-Cja-018811	Callithrix jacchus	96.16	0.00e+00	1806.00
IUUC-Cfa-021158	Canis familiaris	98.08	0.00e+00	1850.00
IUUC-Cpo-021910	Cavia porcellus	89.41	0.00e+00	1579.00
IUUC-Csa-023130	Chlorocebus sabaeus	97.05	0.00e+00	1775.00
IUUC-Cho-024383	Choloepus hoffmanni	79.30	0.00e+00	686.00
IUUC-Dre-028639	Danio rerio	69.80	0.00e+00	1239.00
IUUC-Dno-029416	Dasypus novemcinctus	94.32	0.00e+00	1716.00
IUUC-Ete-032994	Echinops telfairi	78.73	0.00e+00	861.00
IUUC-Eca-034248	Equus caballus	97.00	0.00e+00	1813.00
IUUC-Eeu-035357	Erinaceus europaeus	76.42	0.00e+00	1311.00
IUUC-Fca-036013	Felis catus	95.14	0.00e+00	1749.00
IUUC-Fal-037509	Ficedula albicollis	81.93	0.00e+00	1475.00
IUUC-Gmo-038944	Gadus morhua	65.13	0.00e+00	1178.00
IUUC-Gga-040647	Gallus gallus	81.70	0.00e+00	1464.00
IUUC-Gac-041752	Gasterosteus aculeatus	69.41	0.00e+00	1249.00
IUUC-Hsa-045694	Homo sapiens	96.06	0.00e+00	1795.00
IUUC-Itr-049041	Ictidomys tridecemlineatus	96.62	0.00e+00	1757.00
IUUC-Lch-050400	Latimeria chalumnae	70.61	0.00e+00	1267.00
IUUC-Loc-052616	Lepisosteus oculatus	70.19	0.00e+00	1320.00
IUUC-Laf-053493	Loxodonta africana	95.85	0.00e+00	1766.00
IUUC-Mcc-055542	Macaca mulatta	96.78	0.00e+00	1805.00
IUUC-Meu-056645	Macropus eugenii	73.97	0.00e+00	1303.00
IUUC-Mga-060019	Meleagris gallopavo	82.44	0.00e+00	1256.00
IUUC-Mmr-061241	Microcebus murinus	92.71	0.00e+00	1741.00
IUUC-Mmu-063786	Mus musculus	93.01	0.00e+00	1682.00
IUUC-Mpu-065772	Mustela putorius furo	98.01	0.00e+00	1488.00
IUUC-Mlu-067732	Myotis lucifugus	95.51	0.00e+00	1792.00
IUUC-Nle-069528	Nomascus leucogenys	95.52	0.00e+00	1775.00
IUUC-Opr-070606	Ochotona princeps	89.82	0.00e+00	1583.00
IUUC-Ont-071495	Oreochromis niloticus	70.59	0.00e+00	1256.00
IUUC-Oan-073695	Ornithorhynchus anatinus	84.47	0.00e+00	1043.00
IUUC-Ocu-074457	Oryctolagus cuniculus	93.49	0.00e+00	1728.00
IUUC-Ola-086739	Oryzias latipes	69.36	0.00e+00	1290.00
IUUC-Oga-088720	Otolemur garnettii	95.51	0.00e+00	1790.00
IUUC-Oar-089921	Ovis aries	96.38	0.00e+00	1808.00
IUUC-Ptr-090526	Pan troglodytes	96.06	0.00e+00	1795.00
IUUC-Pan-092396	Papio anubis	96.49	0.00e+00	1812.00
IUUC-Psi-092971	Pelodiscus sinensis	83.03	0.00e+00	1545.00
IUUC-Pfo-097415	Poecilia formosa	69.15	0.00e+00	1259.00
IUUC-Pab-098740	Pongo abelii	97.05	0.00e+00	1796.00
IUUC-Pca-100598	Procavia capensis	83.24	0.00e+00	900.00
IUUC-Pva-102820	Pteropus vampyrus	92.94	0.00e+00	1526.00
IUUC-Rno-104894	Rattus norvegicus	92.48	0.00e+00	1689.00
IUUC-Sce-106176	Saccharomyces cerevisiae	32.35	2.00e-25	111.00
IUUC-Sha-107244	Sarcophilus harrisii	78.35	0.00e+00	1405.00
IUUC-Sar-113665	Sorex araneus	93.35	0.00e+00	1770.00
IUUC-Ssc-115793	Sus scrofa	94.55	0.00e+00	1706.00
IUUC-Tgu-117487	Taeniopygia guttata	82.68	0.00e+00	1448.00
IUUC-Tru-117694	Takifugu rubripes	68.75	0.00e+00	1271.00
IUUC-Tsy-119598	Tarsius syrichta	83.35	0.00e+00	1483.00
IUUC-Tni-120189	Tetraodon nigroviridis	66.88	0.00e+00	1203.00
IUUC-Tbe-128125	Tupaia belangeri	84.77	2.00e-119	423.00
IUUC-Ttr-128269	Tursiops truncatus	92.39	0.00e+00	1659.00
IUUC-Vpa-130598	Vicugna pacos	94.43	0.00e+00	1754.00
IUUC-Xtr-132044	Xenopus tropicalis	74.76	0.00e+00	1313.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence