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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045689
Ensembl Protein ID ENSP00000370150.4
UniProt Accession Q96S55; B2RDB0; Q53EP6; Q59ET8; Q5W0E2; Q5W0E4; Q8WV26; Q9H681; Q9NRJ6; WRIP1_HUMAN
Genbank Protein ID BAB60709.1; BAB15383.1; BAG37857.1; BAD92960.1; BAD97313.1; CAH73663.1; CAH73664.1; CAH73665.1; CAH73666.1; EAW55087.1; AAH18923.1; AAF80563.1
Protein Name ATPase WRNIP1; Werner helicase-interacting protein 1
Genbank Nucleotide ID AB056152; AK026179; AK315471; AB209723; AK223593; AL139092; AL139092; AL139092; AL139092; CH471087; BC018923; AF218313
Gene Name WRNIP1; WHIP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000124535.15 ENST00000380773.8 ENSP00000370150.4
ENSG00000124535.15 ENST00000380771.8 ENSP00000370148.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/ZnF/UBZ UBZ 17550899
Classification
Family E-value Score Start End
UBD/ZnF/UBZ 2.10e-08 35.9 17 40
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/UBZ
   S: 1    llvCPvCqkmvdqtdfeeHlDeCl 24
           +++CPvCq+m++  ++++HlD+Cl
   Q: 17   QVQCPVCQQMMPAAHINSHLDRCL 40
           699********************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased.
 Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased.
Protein Sequence
(Fasta)
MEVSGPEDDP FLSQLHQVQC PVCQQMMPAA HINSHLDRCL LLHPAGHAEP AAGSHRAGER 60
AKGPSPPGAK RRRLSESSAL KQPATPTAAE SSEGEGEEGD DGGETESRES YDAPPTPSGA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045689|UBD,UBZ|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGGCGCTGC CAGCGGCCGG CCGAGGGCGG GCGGACGCGG GAGCTGCGGA CGTGAGGCAT 60
GAGCGGCGCC CTCCTCCGGC CCGCGAGCGT CCTGCTGGTT CCCCGAGCGA GGGTCTCGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045689|UBD,UBZ|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0235--DNA replication
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003593--AAA+_ATPase
IPR032423--AAA_assoc_2
IPR003959--ATPase_AAA_core
IPR008921--DNA_pol3_clamp-load_cplx_C
IPR021886--MgsA_C
IPR027417--P-loop_NTPase
IPR006642--Znf_Rad18_put
Pfam

PF00004--AAA
PF16193--AAA_assoc_2
PF12002--MgsA_C
SMART

SM00382--AAA
SM00734--ZnF_Rad18
Gene Ontology

GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0003677--F:DNA binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0006260--P:DNA replication
GO:0000731--P:DNA synthesis involved in DNA repair
GO:0030174--P:regulation of DNA-dependent DNA replication initiation
KEGG hsa:56897
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002134 Ailuropoda melanoleuca 84.36 0.00e+00 999.00
IUUC-Atr-002635 Amborella trichopoda 46.08 3.00e-115 409.00
IUUC-Apl-003962 Anas platyrhynchos 80.04 0.00e+00 729.00
IUUC-Aca-005219 Anolis carolinensis 80.91 3.00e-167 580.00
IUUC-Aly-005664 Arabidopsis lyrata 49.89 7.00e-120 424.00
IUUC-Ath-007605 Arabidopsis thaliana 50.11 1.00e-119 423.00
IUUC-Ago-007747 Ashbya gossypii 45.12 6.00e-101 361.00
IUUC-Acl-008260 Aspergillus clavatus 45.52 6.00e-101 361.00
IUUC-Afl-008493 Aspergillus flavus 46.41 7.00e-105 374.00
IUUC-Afu-008892 Aspergillus fumigatus 47.05 5.00e-105 375.00
IUUC-Ani-009289 Aspergillus nidulans 45.07 2.00e-103 369.00
IUUC-Ang-009599 Aspergillus niger 45.91 2.00e-102 365.00
IUUC-Aor-009987 Aspergillus oryzae 46.41 7.00e-105 374.00
IUUC-Ate-010577 Aspergillus terreus 47.27 2.00e-105 376.00
IUUC-Ame-010756 Astyanax mexicanus 46.05 1.00e-101 363.00
IUUC-Bgr-012158 Blumeria graminis 46.05 9.00e-101 360.00
IUUC-Bta-013537 Bos taurus 89.33 0.00e+00 830.00
IUUC-Bci-013965 Botrytis cinerea 47.15 1.00e-106 380.00
IUUC-Bol-015473 Brassica oleracea 49.43 7.00e-115 407.00
IUUC-Bra-017208 Brassica rapa 48.42 9.00e-112 397.00
IUUC-Cja-019193 Callithrix jacchus 98.04 0.00e+00 919.00
IUUC-Cfa-020149 Canis familiaris 97.32 0.00e+00 887.00
IUUC-Cpo-021486 Cavia porcellus 96.51 0.00e+00 900.00
IUUC-Csa-024006 Chlorocebus sabaeus 99.10 0.00e+00 1131.00
IUUC-Cho-024632 Choloepus hoffmanni 88.49 0.00e+00 672.00
IUUC-Cne-026982 Cryptococcus neoformans 46.56 2.00e-81 295.00
IUUC-Dre-027822 Danio rerio 73.68 0.00e+00 653.00
IUUC-Dno-029727 Dasypus novemcinctus 95.78 0.00e+00 870.00
IUUC-Dor-030227 Dipodomys ordii 94.88 0.00e+00 738.00
IUUC-Dse-031247 Dothistroma septosporum 46.31 2.00e-99 356.00
IUUC-Ete-033089 Echinops telfairi 95.03 0.00e+00 857.00
IUUC-Eca-033998 Equus caballus 98.21 0.00e+00 776.00
IUUC-Eeu-035147 Erinaceus europaeus 96.28 0.00e+00 897.00
IUUC-Fca-036247 Felis catus 98.47 0.00e+00 776.00
IUUC-Fal-037605 Ficedula albicollis 79.47 2.00e-175 608.00
IUUC-Fox-038016 Fusarium oxysporum 47.15 4.00e-93 335.00
IUUC-Fso-038200 Fusarium solani 47.38 1.00e-96 347.00
IUUC-Gmo-039155 Gadus morhua 68.65 4.00e-172 597.00
IUUC-Ggr-040037 Gaeumannomyces graminis 47.63 3.00e-102 365.00
IUUC-Gga-041277 Gallus gallus 78.31 0.00e+00 728.00
IUUC-Gac-042576 Gasterosteus aculeatus 71.81 0.00e+00 671.00
IUUC-Gma-043574 Glycine max 49.66 4.00e-115 408.00
IUUC-Ggo-045359 Gorilla gorilla 99.79 0.00e+00 933.00
IUUC-Itr-048239 Ictidomys tridecemlineatus 97.17 0.00e+00 905.00
IUUC-Kpa-049277 Komagataella pastoris 43.89 6.00e-97 348.00
IUUC-Lch-049430 Latimeria chalumnae 78.26 8.00e-83 300.00
IUUC-Loc-052461 Lepisosteus oculatus 73.74 0.00e+00 676.00
IUUC-Lma-053060 Leptosphaeria maculans 43.53 3.00e-98 352.00
IUUC-Laf-053418 Loxodonta africana 95.86 0.00e+00 903.00
IUUC-Mcc-055094 Macaca mulatta 99.55 0.00e+00 1130.00
IUUC-Meu-056838 Macropus eugenii 66.88 7.00e-175 607.00
IUUC-Mor-057036 Magnaporthe oryzae 47.61 7.00e-101 361.00
IUUC-Mtr-057969 Medicago truncatula 48.76 2.00e-116 412.00
IUUC-Mla-059065 Melampsora laricipopulina 40.95 3.00e-84 305.00
IUUC-Mga-059360 Meleagris gallopavo 78.67 0.00e+00 677.00
IUUC-Mmr-060962 Microcebus murinus 96.95 0.00e+00 908.00
IUUC-Mdo-062007 Monodelphis domestica 85.50 0.00e+00 810.00
IUUC-Mmu-063806 Mus musculus 93.68 0.00e+00 1115.00
IUUC-Mac-064594 Musa acuminata 44.32 1.00e-37 150.00
IUUC-Mpu-066476 Mustela putorius furo 97.39 0.00e+00 915.00
IUUC-Mlu-067439 Myotis lucifugus 93.47 0.00e+00 785.00
IUUC-Nfi-068391 Neosartorya fischeri 46.39 5.00e-104 371.00
IUUC-Ncr-068746 Neurospora crassa 46.92 2.00e-96 346.00
IUUC-Nle-069387 Nomascus leucogenys 97.03 0.00e+00 1065.00
IUUC-Opr-070903 Ochotona princeps 74.88 2.00e-113 403.00
IUUC-Ont-071546 Oreochromis niloticus 72.44 0.00e+00 667.00
IUUC-Oan-073696 Ornithorhynchus anatinus 80.23 8.00e-165 572.00
IUUC-Ocu-074768 Oryctolagus cuniculus 95.03 0.00e+00 875.00
IUUC-Oin-079459 Oryza indica 41.57 6.00e-75 275.00
IUUC-Ola-087403 Oryzias latipes 74.26 0.00e+00 672.00
IUUC-Oga-088904 Otolemur garnettii 93.39 0.00e+00 1102.00
IUUC-Oar-089703 Ovis aries 87.61 2.00e-112 398.00
IUUC-Ptr-090666 Pan troglodytes 99.55 0.00e+00 1093.00
IUUC-Pan-092020 Papio anubis 99.49 0.00e+00 793.00
IUUC-Psi-092949 Pelodiscus sinensis 79.96 0.00e+00 743.00
IUUC-Pma-094432 Petromyzon marinus 59.13 2.00e-117 415.00
IUUC-Pno-095095 Phaeosphaeria nodorum 45.54 2.00e-103 370.00
IUUC-Ppa-095376 Physcomitrella patens 60.43 3.00e-63 236.00
IUUC-Pfo-096882 Poecilia formosa 77.35 0.00e+00 697.00
IUUC-Pab-098159 Pongo abelii 99.58 0.00e+00 933.00
IUUC-Pop-098867 Populus trichocarpa 51.25 7.00e-122 431.00
IUUC-Pca-100549 Procavia capensis 92.34 0.00e+00 1076.00
IUUC-Pva-102427 Pteropus vampyrus 95.62 0.00e+00 903.00
IUUC-Pgr-103584 Puccinia graminis 40.38 2.00e-89 323.00
IUUC-Ptt-103965 Puccinia triticina 43.28 1.00e-53 203.00
IUUC-Pte-104110 Pyrenophora teres 45.27 9.00e-102 363.00
IUUC-Pyt-104578 Pyrenophora triticirepentis 44.32 2.00e-102 366.00
IUUC-Rno-106096 Rattus norvegicus 93.23 0.00e+00 1059.00
IUUC-Sce-106299 Saccharomyces cerevisiae 45.64 1.00e-103 370.00
IUUC-Sha-106678 Sarcophilus harrisii 86.37 0.00e+00 807.00
IUUC-Sja-107709 Schizosaccharomyces japonicus 46.24 6.00e-103 367.00
IUUC-Spo-108286 Schizosaccharomyces pombe 47.03 4.00e-109 388.00
IUUC-Smo-109453 Selaginella moellendorffii 54.36 2.00e-121 429.00
IUUC-Sly-111329 Solanum lycopersicum 47.97 4.00e-118 418.00
IUUC-Stu-112498 Solanum tuberosum 48.39 2.00e-120 426.00
IUUC-Sre-115000 Sporisorium reilianum 45.13 6.00e-102 365.00
IUUC-Ssc-115336 Sus scrofa 91.33 0.00e+00 841.00
IUUC-Tgu-116596 Taeniopygia guttata 77.78 0.00e+00 717.00
IUUC-Tru-117850 Takifugu rubripes 74.60 0.00e+00 682.00
IUUC-Tsy-118903 Tarsius syrichta 98.47 0.00e+00 647.00
IUUC-Tni-120817 Tetraodon nigroviridis 73.41 0.00e+00 665.00
IUUC-Tca-121843 Theobroma cacao 47.26 1.00e-120 426.00
IUUC-Tre-121913 Trichoderma reesei 46.25 2.00e-95 343.00
IUUC-Tvi-122613 Trichoderma virens 48.53 9.00e-98 350.00
IUUC-Tme-127063 Tuber melanosporum 46.65 1.00e-98 353.00
IUUC-Tbe-127342 Tupaia belangeri 84.65 0.00e+00 635.00
IUUC-Ttr-128381 Tursiops truncatus 92.07 0.00e+00 740.00
IUUC-Uma-129504 Ustilago maydis 44.74 4.00e-102 365.00
IUUC-Vda-129930 Verticillium dahliae 46.47 1.00e-94 340.00
IUUC-Vvi-130851 Vitis vinifera 49.67 2.00e-119 423.00
IUUC-Xtr-131772 Xenopus tropicalis 66.08 4.00e-99 354.00
IUUC-Xma-133802 Xiphophorus maculatus 76.89 0.00e+00 694.00
IUUC-Yli-134331 Yarrowia lipolytica 52.38 3.00e-54 206.00
Created Date 25-Jun-2017

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